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| Product | Description | |
|---|---|---|
| Glycinamide ribonucleotide | Glycineamide ribonucleotide (or GAR) is an intermediate in de novo purine biosynthesis. It is formed from phosphoribosylamine by the enzyme phosphoribosylamine-glycine ligase. In the next step of purine biosynthesis the enzyme phosphoribosylglycinamide formyltransferase acts on GAR to form FGAR. GAR formation is stimulated by Luteinizing hormone (LH) and Chorionic gonadotropin (HCG) via activation of Glc-6-P-dehydrogenase. Synonyms: 5'-Phosphoribosylglycinamide; N1-(5-Phospho-D-ribosyl)glycinamide; [(2R,3S,4R,5R)-5-[(2-aminoacetyl)amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate; n-glycyl-5-o-phosphono-|A-d-ribofuranosylamine; 5'-phosphoribosylglycinamide; GAR; N1-(5-Phospho-D-ribosyl)glycinamide; N1-(5-phospho-beta-D-ribosyl)glycinamide. CAS No. 10074-18-7. Molecular formula: C7H15N2O8P. Mole weight: 286.18. |  |
| [1,2-13C2,2-15N]-Glycinamide ribonucleotide | [1,2-13C2,2-15N]-Glycinamide ribonucleotide. | |
| [2-[[2,3-O-(1-Methylethylidene)-5-O-phosphono-D-ribofuranosyl]amino]-2-oxoethyl]carbamic Acid C-(Phenylmethyl) Ester Pyridinium Salt | [2-[[2,3-O-(1-Methylethylidene)-5-O-phosphono-D-ribofuranosyl]amino]-2-oxoethyl]carbamic Acid C-(Phenylmethyl) Ester is an intermediate in the synthesis of ribonucleotide derivative used in a substrate specificity study of glycinamide ribonucleotide synthetase and transformylase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C23H30N3O10P. US Biological Life Sciences. |  Worldwide |
| [2-[[2,3-O-(1-methylethylidene)-D-ribofuranosyl]amino]-2-oxoethyl]carbamic Acid Phenylmethyl Ester | [2-[[2,3-O-(1-methylethylidene)-D-ribofuranosyl]amino]-2-oxoethyl]carbamic Acid Phenylmethyl Ester is an intermediate in the synthesis of ribonucleotide derivative used in a substrate specificity study of glycinamide ribonucleotide synthetase and transformylase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 50mg. Molecular Formula: C18H24N2O7. US Biological Life Sciences. | Worldwide |
| 2, 3-O- (1-Methylethylidene) pentofuranosylamine 4-Methylbenzenesulfonate | 2, 3-O- (1-Methylethylidene) pentofuranosylamine 4-Methylbenzenesulfonate is an intermediate in the synthesis of ribonucleotide derivative used in a substrate specificity study of glycinamide ribonucleotide synthetase and transformylase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1172608-04-6. Pack Sizes: 100mg, 250mg. Molecular Formula: C15H23NO7S. US Biological Life Sciences. | Worldwide |
| [2-Oxo-2-[ (5-O-phosphono-D-ribofuranosyl) amino]ethyl]carbamic Acid C-(phenylmethyl) Ester Disodium Salt | [2-Oxo-2-[ (5-O-phosphono-D-ribofuranosyl) amino]ethyl]carbamic Acid C-(phenylmethyl) Ester Disodium Salt is an intermediate in the synthesis of ribonucleotide derivative used in a substrate specificity study of glycinamide ribonucleotide synthetase and transformylase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C15H19N2Na2O10P. US Biological Life Sciences. | Worldwide |
| 5-Carboxypentyl triphenylphosphonium bromide | 5-Carboxypentyl triphenylphosphonium bromide. Uses: (5-carboxypentyl)(triphenyl)phosphonium bromide is used in medicine and as pharmaceutical intermediate. it is also employed as catalyst. reactant for: preparation of inhibitor of protein tyrosine phosphatase 1b for treatment of diabetes and obesity. synthesis of folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. preparation of peptide nucleic acids (pna) with high specific activity. synthesis of roseophilin via wittig/aldol methodology. Additional or Alternative Names: (5-Carboxypentyl)(Triphenyl)Phosphonium Bromide. Product Category: Organic Phosphine Compounds. Appearance: Solid. CAS No. 50889-29-7. Molecular formula: C24H26BrO2P. Mole weight: 457.35. Purity: 0.98. IUPACName: 5-carboxypentyl(triphenyl)phosphanium;bromide. Canonical SMILES: C1=CC=C(C=C1)[P+](CCCCCC(=O)O)(C2=CC=CC=C2)C3=CC=CC=C3.[Br-]. Product ID: ACM50889297-3. Alfa Chemistry ISO 9001:2015 Certified. Categories: (5-carboxypentyl)triphenylphosphanium bromide. |  |
| Edatrexate | Edatrexate is a polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. Uses: Antineoplastic agents. Synonyms: 10-ethyl-deaza-aminopterin; 10-EDAM; 10 EDAM; 10EDAM; CGP-30694; CGP30694; CGP30694; D 03942; D-03942; D03942. CAS No. 80576-83-6. Molecular formula: C22H25N7O5. Mole weight: 467.49. | |
| Lometrexol | Lometrexol (DDATHF), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DDATHF. CAS No. 106400-81-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14521. |  |
| Pe litrexol | Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. Pelitrexol shows robust tumor growth suppression in mice[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG 2037. CAS No. 446022-33-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14530. | |
| Pemetrexed | Pemetrexed (LY231514) is an antifolate , the K i values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase ( TS ), dihydrofolate reductase ( DHFR ), and glycinamide ribonucleotide formyltransferase ( GARFT ), respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514. CAS No. 137281-23-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10820. | |
| Pemetrexed disodium | Pemetrexed disodium (LY231514 disodium) is an antifolate, the K i s of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514 disodium. CAS No. 150399-23-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-10820A. | |
| Pemetrexed disodium heptahydrate | Pemetrexed disodium heptahydrate is a novel antifolate , the K i values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase ( TS ), dihydrofolate reductase ( DHFR ), and glycinamide ribonucleotide formyltransferase ( GARFT ), respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514 disodium heptahydrate. CAS No. 357166-29-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10820B. | |
| Pemetrexed, Disodium Salt, Heptahydrate (N-[4-[(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium, LY-231514, Alimta) | Pemetrexed inhibits dihydrofolate reductase, thymidylate synthase and glycinamide ribonucleotide formyltransferase with Ki values of 7nM, 109nM and 9.3uM, respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 357166-29-1. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| phosphoribosylamine-glycine ligase | This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. Group: Enzymes. Synonyms: phosphoribosylglycinamide synthetase; glycinamide ribonucleotide synthetase; phosphoribosylglycineamide synthetase; glycineamide ribonucleotide synthetase; 2-amino-N-ribosylacetamide 5'-phosphate kinosynthase; 5'-phosphoribosylglycinamide synthetase; GAR. Enzyme Commission Number: EC 6.3.4.13. CAS No. 9032-1-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5782; phosphoribosylamine-glycine ligase; EC 6.3.4.13; 9032-01-3; phosphoribosylglycinamide synthetase; glycinamide ribonucleotide synthetase; phosphoribosylglycineamide synthetase; glycineamide ribonucleotide synthetase; 2-amino-N-ribosylacetamide 5'-phosphate kinosynthase; 5'-phosphoribosylglycinamide synthetase; GAR. Cat No: EXWM-5782. |  |
| phosphoribosylglycinamide formyltransferase | This THF dependent enzyme catalyzes a nucleophilic acyl substitution of the formyl group from 10-formyltetrahydrofolate (fTHF) to N1-(5-phospho-D-ribosyl)glycinamide (GAR) to form N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide (fGAR) as shown above. This reaction plays an important role in the formation of purine through the de novo purine biosynthesis pathway. This pathway creates inosine monophosphate (IMP), a precursor to adenosine monophosphate (AMP) and guanosine monophosphate (GMP). Group: Enzymes. Synonyms: 2-amino-N-ribosylacetamide 5'-phosphate transformylase; GAR formyltransferase; GAR transformylase; glycinamide ribonucleotide transformylase; GAR TFase; 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase. Enzyme Commission Number: EC 2.1.2.2. CAS No. 9032-2-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2004; phosphoribosylglycinamide formyltransferase; EC 2.1.2.2; 9032-02-4; 2-amino-N-ribosylacetamide 5'-phosphate transformylase; GAR formyltransferase; GAR transformylase; glycinamide ribonucleotide transformylase; GAR TFase; 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase. Cat No: EXWM-2004. | |
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