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| Product | Description | |
|---|---|---|
| Glycogen Synthase Kinase 3β, Histidine-tagged, from rabbit, Recombinant | Glycogen synthase kinase-3 is a serine-threonine protein kinase involved in regulation of metabolic enzymes such as glycogen synthase and ATP-Citrate lyase, and of protein phosphatase-1. It also phosphorylates brain tau-proteins, inducing an Alzheimer-like state, and protooncogene transcription factors. GSK-3β is one of two isozymes. > 90% (sds-page), recombinant, expressed in e. coli. Group: Enzymes. Synonyms: Glycogen Synthase Kinase 3β; GSK-3β; GSK3B; 9059-09-0. CAS No. 9059-09-0. Purity: > 90% (SDS-PAGE). GSK-3&beta. Stability: -20°C. Source: E. coli. Species: Rabbit. Glycogen Synthase Kinase 3β; GSK-3β; GSK3B; 9059-09-0. Cat No: NATE-0324. |  |
| Anti-Glycogen Synthase Kinase-3? (GSK-3?) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. |  |
| Anti-phospho-Glycogen Synthase Kinase 3?/? (pTyr279/216) antibody produced in rabbit | affinity isolated antibody, aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-Glycogen Synthase (pSer645) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| glycogen(starch) synthase | The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase). Group: Enzymes. Synonyms: UDP-glucose-glycogen glucosyltransferase; glycogen (starch) synthetase; UDP-glucose-glycogen glucosyltransferase; UDP-glycogen synthase; UDPG-glycogen synthetase; UDPG-glycogen transglucosylase; uridine diphosphoglucose-glycogen glucosyltransferase. Enzyme Commission Number: EC 2.4.1.11. CAS No. 9014-56-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2336; glycogen(starch) synthase; EC 2.4.1.11; 9014-56-6; UDP-glucose-glycogen glucosyltransferase; glycogen (starch) synthetase; UDP-glucose-glycogen glucosyltransferase; UDP-glycogen synthase; UDPG-glycogen synthetase; UDPG-glycogen transglucosylase; uridine diphosphoglucose-glycogen glucosyltransferase. Cat No: EXWM-2336. | |
| [glycogen-synthase-D] phosphatase | The product is EC 2.4.1.11 glycogen(starch) synthase. Group: Enzymes. Synonyms: uridine diphosphoglucose-glycogen glucosyltransferase phosphatase; UDP-glycogen glucosyltransferase phosphatase; UDPglucose-glycogen glucosyltransferase phosphatase; glycogen glucosyltransferase phosphatase; glycogen synthetase phosphatase; glycogen synthase phosphatase; glycogen synthase D phosphatase; Mg2+ dependent glycogen synthase phosphatase; phosphatase type 2°C. Enzyme Commission Number: EC 3.1.3.42. CAS No. 9043-28-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3646; [glycogen-synthase-D] phosphatase; EC 3.1.3.42; 9043-28-1; uridine diphosphoglucose-glycogen glucosyltransferase phosphatase; UDP-glycogen glucosyltransferase phosphatase; UDPglucose-glycogen glucosyltransferase phosphatase; glycogen glucosyltransferase phosphatase; glycogen synthetase phosphatase; glycogen synthase phosphatase; glycogen synthase D phosphatase; Mg2+ dependent glycogen synthase phosphatase; phosphatase type 2°C. Cat No: EXWM-3646. | |
| Phospho-Glycogen Synthase Peptide-2 (substrate) | Phospho-Glycogen Synthase Peptide-2 (substrate). Group: Biochemicals. Grades: Purified. CAS No. 851366-97-7. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| 10Z-Hymenialdisine (Hymenialdisine, 4-(2-Amino-4-oxo-2-imidazolidin-5-ylidene)-2-bromo-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one) | Isolated from sponge Axinella carteri. A potent inhibitor of mitogen-activated protein kinase kinase-1 (MEK-1) (IC50=6nm). Blocks the in vivo phosphorylation of the microtubule-binding protein tau at sites that are hyperphosphorylated by glycogen synthase kinase-b (GSK-3b) and CDK5/p35 in Alzheimers disease. Inhibitor of DNA damage checkpoint at G2 phase (IC50=6uM), cyclin-dependent kinases CDK1/cyclin B (IC50=22nm), CDK2/cyclin A (IC50=70 nm), CDK2/cyclin E (IC50=40nm), CDK4/cyclin D1 (IC50 = 600nm), CDK5/p25 (IC50=28nm), GSK-3b (IC50=10nm), and casein kinase 1 (CK1) (IC50=35nm). Group: Biochemicals. Grades: Highly Purified. CAS No. 82005-12-7. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| 1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride | 1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3) for the study of stem cell differentiation, tumors and neurodegenerative diseases. Synonyms: N-(7-Carbamimidamidoheptyl)guanidine dihydrochloride; N1,N7-Bisguanyl-1,7-diaminoheptane dihydrochloride; 1-(7-carbamimidamidoheptyl)guanidine dihydrochloride. Grade: 95%. CAS No. 2193061-39-9. Molecular formula: C9H24Cl2N6. Mole weight: 287.23. |  |
| 1, 4-Dihydroxy-5, 8-bis (p-tolylamino) anthraquinone | 1, 4-Dihydroxy-5, 8-bis (p-tolylamino) anthraquinone is a glycogen synthase kinase-3 inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 23941-48-2. Pack Sizes: 100mg, 250mg. Molecular Formula: C28H22N2O4, Molecular Weight: 450.49. US Biological Life Sciences. | Worldwide |
| 1-Azakenpaullone | 1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β) , with an IC 50 value of 18 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Akp. CAS No. 676596-65-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-59090. |  |
| 1-Azakenpaullone | 1-Azakenpaullone inhibits glycogen synthase kinase 3β (GSK3β) more potently (IC50 = 18 nM) than CDK1/cyclin B or CDK5/p25 (IC50s = 2.0 and 4.2 μM, respectively). Synonyms: Azakenpaullone; 9-bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one; 14-bromo-3,8,18-triazatetracyclo[9.7.0.02,7.012,17]octadeca-1(11),2(7),3,5,12(17),13,15-heptaen-9-one. Grade: >98%. CAS No. 676596-65-9. Molecular formula: C15H10BrN3O. Mole weight: 328.169. | |
| 1-Azakenpaullone | A selective inhibitor of glycogen synthase kinase-3b. Group: Biochemicals. Alternative Names: 9-Bromo-7, 12-di hydropyridoazepinoi ndol-6 (5H) -one; 9-Bromo-7, 12-dihydropyrido[3', 2':2, 3]azepino[4, 5-b]indol-6(5H)-one. Grades: Highly Purified. CAS No. 676596-65-9. Pack Sizes: 2.5mg, 5mg. US Biological Life Sciences. | Worldwide |
| 1-Benzyl-3-naphthalen-1-yl-urea | 1-Benzyl-3-naphthalen-1-yl-urea is an impurity of Tideglusib (T438700); a compound used in the treatment of brain atrophy and movement disorder issues. 1-Benzyl-3-naphthalen-1-yl-urea is also a potential glycogen synthase kinase 3 β (GSK-3) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 13256-79-6. Pack Sizes: 50mg, 100mg. Molecular Formula: C18H16N2O, Molecular Weight: 276.33. US Biological Life Sciences. | Worldwide |
| 1-Benzyl-3-naphthalen-1-yl-urea-d7 | 1-Benzyl-3-naphthalen-1-yl-urea-d7 is the isotope labelled analog of 1-Benzyl-3-naphthalen-1-yl-urea (B285055); an impurity of Tideglusib (T438700) which is a compound used in the treatment of brain atrophy and movement disorder issues. 1-Benzyl-3-naphthalen-1-yl-urea is also a potential glycogen synthase kinase 3 β (GSK-3) inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2mg. Molecular Formula: C18H9D7N2O, Molecular Weight: 283.38. US Biological Life Sciences. | Worldwide |
| 2,3,5-Tri-O-benzyl-1,4-dideoxy-1,4-epithio-D-arabinitol | 2,3,5-Tri-O-benzyl-1,4-dideoxy-1,4-epithio-D-arabinitol, a promising therapeutic compound for diabetes mellitus, manifests an intricate mechanism of action. Acting as a reversible and competitive glycogen synthase kinase-3 (GSK-3) inhibitor, it regulates glucose metabolism robustly. In addition, the anti-proliferative impacts on cancer cells have rendered it a potential anti-cancer treatment candidate. Synonyms: (2R,3S,4S)-3,4-Bis(benzyloxy)-2-((benzyloxy)methyl)tetrahydrothiophene. CAS No. 187590-77-8. Molecular formula: C26H28O3S. Mole weight: 420.6. | |
| 2-(3-Aminopyridin-4-yloxy)ethanol | 2-(3-Aminopyridin-4-yloxy)ethanol is used as reactant in the synthetic preparation of isonicotinamides as highly selective, brain penetrable, and orally active glycogen synthase kinase 3 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1040316-57-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C7H10N2O2, Molecular Weight: 154.169999999999. US Biological Life Sciences. | Worldwide |
| 2,3'-Dichloroacetophenone | 2,3'-Dichloroacetophenone is used as a reagent in the synthesis of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3 β (GSK-3 β). Also used as a reagent in the synthesis of benzimidazolyl pyridinones as insulin-like growth factor I (IGF-1R) kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 21886-56-6. Pack Sizes: 1g, 5g. Molecular Formula: C8H6Cl2O. US Biological Life Sciences. | Worldwide |
| 2',4'-Dichloro-2-imidazole Acetophenone | Intermediate in the preparation of glycogen synthase kinase-3 (GSK-3). Group: Biochemicals. Alternative Names: 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-2-yl)ethanone. Grades: Highly Purified. CAS No. 252950-14-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 2B-(SP) | 2B-(SP) is a selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3). Synonyms: 186901-17-7; 2B-(SP)L-Leucine,L-arginyl-L-arginyl-L-alanyl-L-alanyl-L-a-glutamyl-L-a-glutamyl-L-leucyl-L-a-aspartyl-L-seryl-L-arginyl-L-alanylglycyl-O-phosphono-L-seryl-L-prolyl-L-glutaminyl-AKOS024456793L-Leucine,L-arginyl-L-arginyl-L-alanyl-L-alanyl-L-a-glutamyl-L-a-glutamyl-L-leucyl-L-a-aspartyl-L-seryl-L-arginyl-L-alanylglycyl-O-phosphono-L-seryl-L-prolyl-L-glutaminyl-(9CI). CAS No. 186901-17-7. Molecular formula: C71H123N26O29P. Mole weight: 1835.88. | |
| 2-Chloro-4(1H)-pyrimidinone | 2-Chloro-4(1H)-pyrimidinone is a reactant in the preparation of aminobenzamide derivatives as glycogen synthase kinase 3 β (GSK3 β) inhibitors for preventing or treating GSK3 β-mediated diseases (1). Group: Biochemicals. Grades: Highly Purified. CAS No. 55873-09-1. Pack Sizes: 1g, 10g. Molecular Formula: C4H3ClN2O, Molecular Weight: 130.53. US Biological Life Sciences. | Worldwide |
| 2-Chloroisonicotinic Acid | 2-Chloroisonicotinic Acid is a derivative of Isonicotinic Acid (I821760) and is used as a reagent in the synthesis of (phenylmorpholinyl) pyrimidinones as selective and orally active glycogen synthase kinase-3 β inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 6313-54-8. Pack Sizes: 1g, 5 g. Molecular Formula: C6H4ClNO2, Molecular Weight: 157.55. US Biological Life Sciences. | Worldwide |
| (2Z)-1-(2,4-Dichlorophenyl)-3-(dimethylamino)-2-(1H-imidazol-2-yl)-2-propen-1-one | Intermediate in the preparation of glycogen synthase kinase-3 (GSK-3). Group: Biochemicals. Grades: Highly Purified. CAS No. 252950-15-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 3-(2-Thienyl)acrylic Acid | 3-(2-Thienyl)acrylic Acid is used as a phenylalanine derivative which shows improved intestinal absorption of insulin in mice. In addition it has been used in the synthesis of novel benzothiazepinones as glycogen synthase kinase-3 β inhibitors. Group: Biochemicals. Alternative Names: 3-(2-Thienyl)-2-propenoic Acid; 2-Thiopheneacrylic Acid; 2-Thienylacrylic Acid; 3-(2-Thienyl)propenoic Acid; 3-(Thien-2-yl)acrylic Acid; 3-(Thiophene-2-yl)acrylic Acid; 3-Thiophen-2-ylacrylic Acid; NSC 4247. Grades: Highly Purified. CAS No. 1124-65-8. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| 3-((4-Fluorophenethyl)amino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione | 3-((4-Fluorophenethyl)amino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acts as an enhancer of Wnt signalling, involved in cell proliferation or differentiation, via inhibition of glycogen synthase kinase 3 beta (GSK-3 β). Group: Biochemicals. Grades: Highly Purified. CAS No. 1129669-05-1. Pack Sizes: 10mg, 50 mg. Molecular Formula: C22H20FN3O2, Molecular Weight: 377.41. US Biological Life Sciences. | Worldwide |
| 4- (2-Bromoacetyl) benzonitrile | 4- (2-Bromoacetyl) benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalo methyl ketones can be used in the study of novel GSK-3 inhibitors. Group: Biochemicals. Alternative Names: 2-Bromo-1-(4-cyanophenyl)ethanone; 2-Bromo-4'-cyanoacetophenone; 2-Bromo-p-cyanoacetophenone; 4- (2-Bromoacetyl) benzonitrile; 4- (2'-Bromoacetyl) benzonitrile; 4- (Bromoacetyl) benzonitrile; 4-Cyanophenacyl Bromide; NSC 157569; p-Cyano-α-bromoacetophenone; p-Cyano-ω-bromoacetophenone; p-Cyanophenacyl Bromide; α-Bromo-4-cyanoacetophenone. Grades: Highly Purified. CAS No. 20099-89-2. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 4- (2-Bromoacetyl) benzonitrile-d4 | Useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalo methyl ketones can be used in the study of novel GSK-3 inhibitors. Group: Biochemicals. Alternative Names: 2-Bromo-1-(4-cyanophenyl)ethanone-d4; 2-Bromo-4'-cyanoacetophenone-d4; 2-Bromo-p-cyanoacetophenone-d4; 4- (2-Bromoacetyl) benzonitrile-d4; 4- (2'-Bromoacetyl) benzonitrile-d4; 4- (Bromoacetyl) benzonitrile-d4; 4-Cyanophenacyl-d4 bromide; NSC 157569-d4; p-Cyano-α-bromoacetophenone-d4; p-Cyano-ω-bromoacetophenone-d4; p-Cyanophenacyl-d4 Bromide; α-Bromo-4-cyanoacetophenone-d4. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (GSK-3ß Inhibitor I, TDZD-8) | Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione, also known as TDZD-8, is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK3b (IC50 =2nM). It binds to the active site of GSK3b. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM). Group: Biochemicals. Alternative Names: GSK-3ß Inhibitor I, TDZD-8. Grades: Highly Purified. CAS No. 327036-89-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4'-Methylbiphenyl-2-carbonitrile | 4'-Methylbiphenyl-2-carbonitrile is an intermediate in the synthesis of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase 3α. Group: Biochemicals. Alternative Names: 2- (4-Methylphenyl) benzonitrile; 2-(p-Tolyl)benzonitrile; 2-Cyano-4'-methyl-1,1'-biphenyl; 2-Cyano-4'-methylbiphenyl; 2'-Cyano-4-methylbiphenyl; 4-Methyl-2'-cyanobiphenyl; 4'-Methyl-2-cyanobiphenyl; 4'-Methyl[1,1'-biphenyl]-2-carbonitrile; 4'-Methyl-[1,1'-biphenyl]-2-carbonitrile. Grades: Highly Purified. CAS No. 114772-53-1. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 5-Iodotubercidin | 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC 50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 113939; 5-ITu. CAS No. 24386-93-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 25 mg; 50 mg. Product ID: HY-15424. | |
| 6BIO | Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Apoptosis inducer. Potent antiproliferative agent in malignant lymphoid cell. Group: Biochemicals. Alternative Names: (2'Z,3'E)-6-Bromoindirubin-3'-oxime. Grades: Highly Purified. CAS No. 667463-62-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C16H10BrN3O2. US Biological Life Sciences. | Worldwide |
| 9-ing-41 | 9-ING-41 is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3). 9-ING-41 induces cell cycle arrest, autophagy and apoptosis in bladder cancer cells. Synonyms: elraglusib. CAS No. 1034895-42-5. Molecular formula: C22H13FN2O5. Mole weight: 404.35. | |
| 9-ING-41 | 9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC 50 of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic agents [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Elraglusib. CAS No. 1034895-42-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113914. | |
| A 1070722 | A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β) with 50-fold selectivity over other protein kinases such as CDK. It decreases phosphorylation of microtubule-associated protein Tau in vitro. A 1070722 exhibits neuroprotective activity thus is identified as a therapeutic drug candidate for neurodegenerative and psychiatric disorders. Uses: Potential treatment of neurodegenerative disorders. Synonyms: A 1070722; A1070722; A-1070722; 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea. Grade: ≥99% by HPLC. CAS No. 1384424-80-9. Molecular formula: C17H13F3N4O2. Mole weight: 362.31. | |
| ABC-1183 | ABC-1183 is an inhibitor of glycogen synthase kinase 3 (GSK-3) alpha, glycogen synthase kinase 3 (GSK-3) beta and cyclin dependent kinase 9 (CDK-9). It can induce cell apoptosis and various signaling pathways. ABC-1183 shows toxicity to many cell lines in humans and mice. Synonyms: ABC1183; ABC 1183; NSC797769; NSC-797769. Grade: > 99% by HPLC. CAS No. 1042735-18-1. Molecular formula: C18H14N4OS. Mole weight: 334.39. | |
| Acetoacetamide | A building block that has been used in the preparation of glycogen synthase kinase 3 (GSK-3) inhibitors. Synonyms: 3-Oxobutanamide; 3-Oxobutyramide; Acetoacetic acid amide. Grade: > 95%. CAS No. 5977-14-0. Molecular formula: C4H7NO2. Mole weight: 101.11. | |
| [acetyl-CoA carboxylase]-phosphatase | Simultaneously dephosphorylates and activates EC 6.4.1.2 acetyl-CoA carboxylase. Acts similarly on EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase), EC 2.4.1.1 (phosphorylase), EC 2.4.1.11 [glycogen(starch) synthase], and dephosphorylates phosphoprotamine and 4-nitrophenyl phosphate. Not identical to EC 3.1.3.17 ([phosphorylase] phosphatase ) or EC 3.1.3.43 {[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase}. Group: Enzymes. Enzyme Commission Number: EC 3.1.3.44. CAS No. 77000-10-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3648; [acetyl-CoA carboxylase]-phosphatase; EC 3.1.3.44; 77000-10-3. Cat No: EXWM-3648. | |
| Aloisine B | Aloisine B is a potent and selective CDK and GSK-3 inhibitor with highest affinity targets: Glycogen Synthase Kinase-3, Beta (Rattus norvegicus (rat)) (IC50=750.0 nM). Uses: A potent and selective cdk and gsk-3 inhibitor. Synonyms: 6-(4-chlorophenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-b]pyrazine; 6-phenyl[5H]pyrrolo[2,3-b]pyrazine (aloisine) 37; 6-(4-chlorophenyl)-7-isopropyl-5H-pyrrolo[2,3-b]pyrazine. Grade: ≥98%. CAS No. 496864-14-3. Molecular formula: C15H14ClN3. Mole weight: 271.75. | |
| α-1,4-glucan-protein synthase (ADP-forming) | The enzyme builds up α-1,4-glucan chains covalently bound to protein, thus acting as an initiator of glycogen synthesis. Group: Enzymes. Synonyms: ADP-glucose:protein glucosyltransferase; adenosine diphosphoglucose-protein glucosyltransferase. Enzyme Commission Number: EC 2.4.1.113. CAS No. 67053-99-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2339; α-1,4-glucan-protein synthase (ADP-forming); EC 2.4.1.113; 67053-99-0; ADP-glucose:protein glucosyltransferase; adenosine diphosphoglucose-protein glucosyltransferase. Cat No: EXWM-2339. | |
| Alsterpaullone | Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Synonyms: 9-Nitropaullone; NSC 705701; 7,12-Dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one. Grade: ≥98%. CAS No. 237430-03-4. Molecular formula: C16H11N3O3. Mole weight: 293.3. | |
| Alsterpaullone | Potent CDK1/cyclin B (IC50 = 35 nM) inhibitor. Anti-tumor compound Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E (IC50 = 200 nM), CDK5/p25 (IC50 = 40 nM), CDK5/p35 (IC50 = 40 nM). GSK-3beta (glycogen synthase kinase-3beta) inhibitor. Apoptosis inhibitor. Apoptosis inducer. Angiogenesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 237430-03-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C16H11N3O3. US Biological Life Sciences. | Worldwide |
| AR-A014418 | AR-A014418 is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β), a serine/threonine protein kinase involved in multiple diseases including Alzheimer's disease and type 2 diabetes. Synonyms: SN 4521; SN4521; SN-4521; AR-A 014418; AR-A014418; AR-A-014418; AR-AO-14418; GSK-3beta Inhibitor VIII; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea. Grade: ≥ 98%. CAS No. 487021-52-3. Molecular formula: C12H12N4O4S. Mole weight: 308.312. | |
| AR-AO 14418 | Glycogen Synthase Kinase 3 β (GSK-3 β) inhibitor. Group: Biochemicals. Alternative Names: N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea; AR 0133418; GSK 3B Inhibitor VIII. Grades: Highly Purified. CAS No. 487021-52-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| AR-AO 14418-[d3] | AR-AO 14418-[d3] is a labelled analogue of AR-AO 14418, a Glycogen Synthase Kinase 3β (GSK-3β) inhibitor. Synonyms: AR-AO 14418-d3; AR-A014418-d3. CAS No. 1216908-63-2. Molecular formula: C12H9D3N4O4S. Mole weight: 311.33. | |
| AZD 2858 hydrochloride | The hydrochloride salt form of AZD 2858. AZD 2858 is a potent and selective Glycogen Synthase Kinase-3β (GSK-3β; Ki = 4.9 nM) inhibitor used for Alzheimer's disease therapy with good BBB permeability in a bovine endothelial cell assay. AZD 2858 selectively inhibits GSK-3β-mediated tau phosphorylation (IC50 = 76 nM) in vitro. In rats, oral AZD2858 treatment caused a dose-dependent increase in trabecular bone mass by GSK-3 mediated inhibition of Wnt canonical signaling, making AZD2858 a possible therapeutic candidate for osteoporosis. Uses: The treatment of alzheimer's disease. Synonyms: AZD 2858 hydrochloride; AZD2858 hydrochloride; AZD-2858 hydrochloride; 3-amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide hydrochloride. Grade: 98%. CAS No. 486424-21-9. Molecular formula: C21H23N7O3S.HCl. Mole weight: 489.98. | |
| Bisindolylmaleimide I | Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Group: Biochemicals. Alternative Names: GF-109203X, Gö 6850, BIM I. Grades: Highly Purified. CAS No. 133052-90-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H24N4O2. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide I hydrochloride | Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competitive inhibitor for the ATP-binding site of PKC. Anti-inflammatory. Binds to P-glycoprotein. Telomerase activity inhibitor. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Necrosis inhibitor. Blocks hERG potassium channels. Group: Biochemicals. Alternative Names: GF 109203X, Gö 6850, BIM I. Grades: Highly Purified. CAS No. 176504-36-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H24N4O2. HCl. US Biological Life Sciences. | Worldwide |
| Bisindolylmaleimide IX methanesulfonate | Selective and cell permeable protein kinase C (PKC) inhibitor. Inhibits the stimulation of insulin secretion by glucose. Inhibits T cell activation. Apoptosis inducer. Potent glycogen synthase kinase-3 (GSK-3) inhibitor. Transcription inhibitor. Induces TNF receptor family-mediated cell death. Pim-1 kinase inhibitor. Antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 138489-18-6. Pack Sizes: 1mg, 5mg. Molecular Formula: C25H23N5O2S CH4O3S. US Biological Life Sciences. | Worldwide |
| BRD0705 | BRD0705 is a potent, paralog selective and orally active inhibitor of Glycogen synthase kinase 3α (GSK3α) with IC50 of 66 nM and Kd of 4.8 μM. Synonyms: BRD 0705; BRD-0705. CAS No. 2056261-41-5. Molecular formula: C20H23N3O. Mole weight: 321.42. | |
| Ca2+/calmodulin-dependent protein kinase | Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase). Group: Enzymes. Synonyms: ATP:caldesmon O-phosphotransferase; caldesmon kinase; caldesmon kinase (phosphorylating); Ca2+/calmodulin-dependent microtubule-associated pro. Enzyme Commission Number: EC 2.7.11.17. CAS No. 141467-21-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3136; Ca2+/calmodulin-dependent protein kinase; EC 2.7.11.17; 141467-21-2; ATP:caldesmon O-phosphotransferase; caldesmon kinase; caldesmon kinase (phosphorylating); Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase; Ca2+/calmodulin-dependent protein kinase 1; Ca2+/calmodulin-dependent protein kinase II; Ca2+/calmodulin-dependent protein kinase IV; Ca2+/calmodulin-dependent protein kinase kinase; Ca2+/calmodulin-dependent protein kinase kinase β; calmodulin-dependent kinase II; CaM kinase; CaM kinase II; CAM PKII; CaM-regulated serine/threonine kinase; CaMKI; CaMKII; CaMKIV; CaMKKα; CaMKKβ; microtubule-associated protein 2 kinase; STK20. Cat No: EXWM-3136. | |
| CHIR-98014 | A glycogen synthase kinase-3 (GSK-3). Group: Biochemicals. Alternative Names: N6- [2- [ [4- (2, 4-Dichlorophenyl) -5- (1H-imidazol-2-yl) -2-pyrimidinyl] amino] ethyl] -3-nitro-2, 6-pyridinediamine. Grades: Highly Purified. CAS No. 556813-39-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CHIR-98023 | CHIR-98023 is a glycogen synthase kinase 3 inhibitor developed for the treatment of Type 2 diabetes mellitus. Synonyms: N'-[4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl]-N-(5-nitropyridin-2-yl)ethane-1,2-diamine; CHIR-98023; CHIR98023; CHIR 98023; CT-98023; UNII-CMQ1L0E91Y; CHIR-837. Grade: >98%. CAS No. 252916-76-0. Molecular formula: C20H16Cl2N8O2. Mole weight: 471.3. | |
| CHIR-99021 | A potent and highly selective inhibitor of glycogen synthase kinase-3beta (GSK-3b) (IC50 = 6.7nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a chemically-defined medium in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402. Group: Biochemicals. Alternative Names: 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2- yl) pyrimidin-2-yl) amino) ethyl) amino) nicotinonitrile; CT99021; CHIR 911. Grades: Highly Purified. CAS No. 252917-06-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CHIR-99021 | CHIR-99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. It enhances reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs in combination with tranylcypromine. It also induces cardiomyocyte differentiation from human embryonic stem (ES). Uses: Potential antineoplastic agent. Synonyms: CHIR-99021; CT99021; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile. Grade: >98%. CAS No. 252917-06-9. Molecular formula: C22H18Cl2N8. Mole weight: 465.342. | |
| CHIR 99021 dihydrochloride | CHIR 99021 is a potent glycogen synthase kinase GSK-3 inhibitor. Synonyms: CHIR-99021 dihydrochloride; CHIR99021 dihydrochloride; CT-99021 dihydrochloride; CT 99021 dihydrochloride; CT99021 dihydrochloride; GSK-3 Inhibitor XVI dihydrochloride; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile dihydrochloride. Grade: 99%. CAS No. 2109414-84-6. Molecular formula: C22H18Cl2N8.2HCl. Mole weight: 538.26. | |
| CHIR-99021 Hydrochloride | CHIR-99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3). CHIR-99021 activates glycogen synthesis in CHO-IR cells and in isolated type 1 diabetic rat skeletal muscle. CHIR-99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells. Group: Biochemicals. Alternative Names: 6- [ [2- [ [4- (2, 4-Dichlorophenyl) -5- (5-methyl-1H-imidazol-2-yl) -2-pyrimidinyl] amino] ethyl] amino] -3-pyridinecarbonitrile Hydrochloride; CHIR 911 Hydrochloride; CT 99021 Hydrochloride. Grades: Highly Purified. CAS No. 1797989-42-4. Pack Sizes: 10mg. Molecular Formula: C22H19Cl3N8, Molecular Weight: 501.8. US Biological Life Sciences. | Worldwide |
| Crosstide | Crosstide, a peptide analog of glycogen synthase kinase α/β fusion protein sequence, acts as a substrate for Akt (PKB) (Km=4μM) and is useful in phosphocellulose kinase assays. Synonyms: H-Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH; glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-glycine. Grade: ≥96%. CAS No. 171783-05-4. Molecular formula: C48H77N17O17. Mole weight: 1164.23. | |
| Crosstide | Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt. Uses: Scientific research. Group: Peptides. CAS No. 171783-05-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0315. | |
| Crosstide TFA | Crosstide, a peptide analog of glycogen synthase kinase α/β fusion protein sequence, acts as a substrate for Akt (PKB) (Km=4μM) and is useful in phosphocellulose kinase assays. Synonyms: H-Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH.TFA; glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-glycine trifluoroacetic acid; Crosstide trifluoroacetate salt. Grade: ≥95%. Molecular formula: C50H78F3N17O19. Mole weight: 1278.25. | |
| Debromohymenialdisine | Debromohymenialdisine (DBH) is a marine sponge alkaloid that inhibits Chk1 and Chk2, blocking G2 arrest. DBH also inhibits cyclin-dependent kinase 5/p25, protein tyrosine kinase 6, MAP kinase kinase 1, glycogen synthase kinase 3β and other kinases largely unrelated to DNA damage/repair and cell cycling. Synonyms: DBH; SKF 108753. Grade: ≥95%. CAS No. 75593-17-8. Molecular formula: C11H11N5O2. Mole weight: 245.2. | |
| (E/Z)-GSK-3β inhibitor 1 | (E/Z)-GSK-3β inhibitor 1 is a racemic compound of (E)-GSK-3β inhibitor 1 and (Z)-GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor (IC50 = 4.9 nM) with high antidiabetic efficacy. Synonyms: 3-(2-Pyridinylmethylene)-indolin-2-one; 3-(2-Pyridinylmethylene)-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-. Grade: ≥98%. CAS No. 3367-88-2. Molecular formula: C14H10N2O. Mole weight: 222.24. | |
| Glycogen branching enzyme from Bacillus subtilis, Recombinant | Glycogen branching enzyme is an enzyme that adds branches to the growing glycogen molecule during the synthesis of glycogen, a storage form of glucose. More specifically, during glycogen synthesis, a glucose 1-phosphate molecule reacts with uridine triphosphate (UTP) to become UDP-glucose, an activated form of glucose. The activated glucosyl unit of UDP-glucose is then transferred to the hydroxyl group at the C-4 of a terminal residue of glycogen to form an α-1,4-glycosidic linkage, a reaction catalyzed by glycogen synthase. Importantly, glycogen synthase can only catalyze the synthesis of α-1,4-glycosidic linkages. Since glycogen is a readily mobil...;-1,4-glucan-6-glycosyltransferase; starch branching enzyme; 1,4-α-D-glucan:1,4-α-D-glucan 6-α-D-(1,4-α-D-glucano)-transferase. Enzyme Commission Number: EC 2.4.1.18. CAS No. 9001-97-2. Purity: > 95 % as judged by SDS-PAGE. Glycogen branching enzyme. Mole weight: 77485.4 Da. Activity: 38.04 U/mg. Storage: Store at 4°C (shipped at room temperature). Form: Supplied in 3.2 M ammonium sulphate. Source: Bacillus subtilis subsp. subtilis str. 168. Branching enzyme, amylo-(1,4?1,6)-transglycosylase; Q-enzyme; α-glucan-branching glycosyltransferase; amylose isomerase; enzymatic branching factor; branching glycosyltransferase; enzyme Q; gluc | |
| Glycogen branching enzyme from Bacteroides fragilis, Recombinant | Glycogen branching enzyme is an enzyme that adds branches to the growing glycogen molecule during the synthesis of glycogen, a storage form of glucose. More specifically, during glycogen synthesis, a glucose 1-phosphate molecule reacts with uridine triphosphate (UTP) to become UDP-glucose, an activated form of glucose. The activated glucosyl unit of UDP-glucose is then transferred to the hydroxyl group at the C-4 of a terminal residue of glycogen to form an α-1,4-glycosidic linkage, a reaction catalyzed by glycogen synthase. Importantly, glycogen synthase can only catalyze the synthesis of α-1,4-glycosidic linkages. Since glycogen is a readily mobi...1,4-glucan-6-glycosyltransferase; starch branching enzyme; 1,4-α-D-glucan:1,4-α-D-glucan 6-α-D-(1,4-α-D-glucano)-transferase. Enzyme Commission Number: EC 2.4.1.18. CAS No. 9001-97-2. Purity: > 95 % as judged by SDS-PAGE. Glycogen branching enzyme. Mole weight: 81104.6 Da. Activity: 50.88 U/mg (pH 7.0; 3.3 mg/mL starch). Storage: Store at 4°C (shipped at room temperature). Form: Supplied in 3.2 M ammonium sulphate, containing 0.5 M imidazole and 0.5 M NaCl, pH ~ 6.8. Source: Bacteroides fragilis NCTC 9343. Branching enzyme, amylo-(1,4?1,6)-transglycosylase; Q-enzyme; α-glucan-branching glycosyltransferase; amylose isomerase; enzym | |
| Glycogen branching enzyme from Escherichia coli, Recombinant | Glycogen branching enzyme is an enzyme that adds branches to the growing glycogen molecule during the synthesis of glycogen, a storage form of glucose. More specifically, during glycogen synthesis, a glucose 1-phosphate molecule reacts with uridine triphosphate (UTP) to become UDP-glucose, an activated form of glucose. The activated glucosyl unit of UDP-glucose is then transferred to the hydroxyl group at the C-4 of a terminal residue of glycogen to form an α-1,4-glycosidic linkage, a reaction catalyzed by glycogen synthase. Importantly, glycogen synthase can only catalyze the synthesis of α-1,4-glycosidic linkages. Since glycogen is a readily mobili...;-1,4-glucan-6-glycosyltransferase; starch branching enzyme; 1,4-α-D-glucan:1,4-α-D-glucan 6-α-D-(1,4-α-D-glucano)-transferase. Enzyme Commission Number: EC 2.4.1.18. CAS No. 9001-97-2. Purity: > 95 % as judged by SDS-PAGE. Glycogen branching enzyme. Mole weight: 88157.0 Da. Activity: 15.44 U/mg. Storage: Store at 4°C (shipped at room temperature). Form: Supplied in 3.2 M ammonium sulphate. Source: Escherichia coli str. K-12 substr. W3110. Branching enzyme, amylo-(1,4?1,6)-transglycosylase; Q-enzyme; α-glucan-branching glycosyltransferase; amylose isomerase; enzymatic branching factor; branching glycosyltransferase; enzyme Q; glucos | |
| glycogenin glucosyltransferase | The first reaction of this enzyme is to catalyse its own glucosylation, normally at Tyr-194 of the protein if this group is free. When Tyr-194 is replaced by Thr or Phe, the enzyme's Mn2+-dependent self-glucosylation activity is lost but its intermolecular transglucosylation ability remains. It continues to glucosylate an existing glucosyl group until a length of about 5-13 residues has been formed. Further lengthening of the glycogen chain is then carried out by EC 2.4.1.11, glycogen (starch) synthase. The enzyme is not highly specific for the donor, using UDP-xylose in addition to UDP-glucose (although not glucosylating or xylosylating a xylosyl group so added). It can also ...exist, and different forms predominate in different organs. Thus primate liver contains glycogenin-2, of molecular mass 66 kDa, whereas the more widespread form is glycogenin-1, with a molecular mass of 38 kDa. Group: Enzymes. Synonyms: glycogenin; priming glucosyltransferase; UDP-glucose:glycogenin glucosyltransferase. Enzyme Commission Number: EC 2.4.1.186. CAS No. 117590-73-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2412; glycogenin glucosyltransferase; EC 2.4.1.186; 117590-73-5; glycogenin; priming glucosyltransferase; UDP-glucose:glycogenin glucosyltransferase. Cat No: EXWM-2412. | |
| GSK-3β inhibitor 1 | GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor (IC50 = 4.9 nM) with high antidiabetic efficacy. Synonyms: 3-[(Z)-(2-Pyridinyl)methylene]indoline-2-one; (3Z)-3-(2-pyridinylmethylene)-1,3-dihydro-2H-indol-2-one; (3Z)-3-(pyridin-2-ylmethylene)-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-. Grade: ≥95%. CAS No. 187325-53-7. Molecular formula: C14H10N2O. Mole weight: 222.24. | |
| GSK-3β inhibitor 11 | GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β ( GSK-3β ) inhibitor ( IC 50 =10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 536731-65-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148132. | |
| GSK-3β inhibitor 3 | GSK-3β inhibitor 3, a potent, selective, irreversible and covalent glycogen synthase kinase 3β (GSK-3β) inhibitor (IC50 = 6.6 μM), is used in the study of acute promyelocytic leukemia. Synonyms: 5-Acryloyl-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one; 5-Acryloyl-2-(4-fluorophenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one; 1,5-Benzothiazepin-4(5H)-one, 2-(4-fluorophenyl)-2,3-dihydro-5-(1-oxo-2-propen-1-yl)-; 5-Acryloyl-2,3-dihydro-2-(4-fluorophenyl)-1,5-benzothiazepin-4(5H)-one. Grade: ≥95%. CAS No. 1448990-73-5. Molecular formula: C18H14FNO2S. Mole weight: 327.37. | |
| GSK-3β inhibitor 3 | GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β) , with an IC 50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1448990-73-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141480. | |
| GSK3β Inhibitor II | GSK3β Inhibitor II is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β) with an IC50 value of 390 nM. Synonyms: ?Glycogen Synthase Kinase 3β?? Inhibitor II; Tip-oxadiazole; 4-[5-[[(3-iodophenyl)methyl]thio]-1,3,4-oxadiazol-2-yl]-pyridine; 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole. Grade: ≥95%. CAS No. 478482-75-6. Molecular formula: C14H10IN3OS. Mole weight: 395.2. | |
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