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| Product | Description | |
|---|---|---|
| granzyme A | From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family). The human enzyme does not cleave Phe?-. Group: Enzymes. Synonyms: CTLA3; HuTPS; T-cell associated protease 1; cytotoxic T lymphocyte serine protease; TSP-1; T-cell derived serine proteinase. Enzyme Commission Number: EC 3.4.21.78. CAS No. 143180-73-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4170; granzyme A; EC 3.4.21.78; 143180-73-8; CTLA3; HuTPS; T-cell associated protease 1; cytotoxic T lymphocyte serine protease; TSP-1; T-cell derived serine proteinase. Cat No: EXWM-4170. |  |
| Granzyme A from Human, Recombinant (carrier-free) | Granzyme A is a serine protease belonging to the granzyme family and is expressed exclusively by cytotoxic T cells (CTL) and NK cells. Most circulating CD56+CD8- NK cells, and approximately half of circulating CD8+ T cells, coexpress both granzymes A and B. Group: Enzymes. Synonyms: Hanukah factor serine protease (HFSP); Cytolytic T cell-and natural killer cell-specific trypsin-like serine protease; Cytotoxic T-lymphocyte-associated serine esterase 3; CTLA3; Granzyme A; Granzyme. Enzyme Commission Number: EC 3.4.21.78. CAS No. 143180-73-8. Purity: >90%, as determined by Coomassie stained SDS-PAGE. Granzyme A. Mole weight: 55 kD in non-reducing conditions by SDS-PAGE. Activity: >5,000 pmol/min/ug. Storage: Unopened vial can be stored at -70°C for six months. For maximum results, quick spin vial prior to opening. Avoid repeated freeze/thaw cycles. Form: 0.22 um filtered protein solution is in 20 mM Tris, 150 mM NaCl, pH 7.5. Source: 293E cell line. Species: Human. Hanukah factor serine protease (HFSP); Cytolytic T cell-and natural killer cell-specific trypsin-like serine protease; Cytotoxic T-lymphocyte-associated serine esterase 3; CTLA3; Granzyme A; Granzyme. Cat No: NATE-1934. | |
| Granzyme A Positive Control (GZMA, Granzyme-1, CTL Tryptase, Cytotoxic T-lymphocyte-associated Serine Esterase 3, CTLA3, Cytotoxic T-lymphocyte Proteinase 1, Fragmentin-1, Hanukkah Factor, H Factor, HF, HFSP) | Granzyme A Positive Control (GZMA, Granzyme-1, CTL Tryptase, Cytotoxic T-lymphocyte-associated Serine Esterase 3, CTLA3, Cytotoxic T-lymphocyte Proteinase 1, Fragmentin-1, Hanukkah Factor, H Factor, HF, HFSP). Group: Molecular Biology. US Biological Life Sciences. |  Worldwide |
| granzyme B | From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: CTLA1; CCPII; cytotoxic cell proteinase-1; granzyme G; granzyme H; CCP1 proteinase. Enzyme Commission Number: EC 3.4.21.79. CAS No. 143180-74-9. Granzyme B. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4171; granzyme B; EC 3.4.21.79; 143180-74-9; CTLA1; CCPII; cytotoxic cell proteinase-1; granzyme G; granzyme H; CCP1 proteinase. Cat No: EXWM-4171. | |
| Granzyme B from Human, Recombinant | Granzyme B is a component of the cytolytic granules of cytotoxic T lymphocytes and natural killer cells. Group: Enzymes. Synonyms: CTLA1; CCPII; cytotoxic cell proteinase-1; granzyme G; granzyme H; CCP1 proteinase; GzmB. Enzyme Commission Number: EC 3.4.21.79. CAS No. 143180-74-9. Purity: Partially purified by single-step affinity chromatography and gel filtration. Granzyme B. Mole weight: 25.4 kDa. Storage: -80°C. Form: Liquid. In 50mM TRIS, pH 7.4, 100mM NaCl, 10% glycerol. Source: Yeast. Species: Human. granzyme B; CTLA1; CCPII; cytotoxic cell proteinase-1; granzyme G; granzyme H; CCP1 proteinase; GzmB; EC 3.4.21.79. Cat No: NATE-1622. | |
| Granzyme B from Mouse, Recombinant | Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis. > 90% (sds-page), recombinant, expressed in pichia pastoris, buffered aqueous solution. pichia expressed recombinant granzyme b has the advantage over native granzyme b as the latter can be purified only in limited amounts, and over e. coli and vaccinia virus expressed enzymes that failed to generate soluble active enzyme. Group: Enzymes. Synonyms: g. CAS No. 143180-74-9. Granzyme B. Mole weight: 28.9 kDa. Activity: > 10,000 units/mg protein. Storage: -70°C. Form: buffered aqueous solution. Source: Pichia pastoris. Species: Mouse. granzyme B; CTLA1; CCPII; cytotoxic cell proteinase-1; granzyme G; granzyme H; CCP1 proteinase; GzmB. Cat No: NATE-0333. | |
| Granzyme H from Human, Recombinant (carrier-free) | Granzyme H is a member of the granzyme family of serine proteases found specifically in the cytotoxic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme Hs functions are largely unknown. The more abundant expression of Granzyme H than Granzyme B in NK cells suggests that Granzyme H may complement the pro-apoptotic function of Granzyme B in this cell type. Group: Enzymes. Synonyms: Granzyme H; GZMH; Granzyme. Enzyme Commission Number: EC 3.4.21.-. Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Alkalophilic proteinase. Mole weight: Multiple bands between 38-40 kDa, reducing conditions by SDS-PAGE. Activity: >5,000 pmol/min/ug. Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.6 months from date of receipt, -70 °C as supplied.3 months, -70 °C under sterile conditions after opening. Form: Supplied as a 0.2 μm filtered solution in HEPES, NaCl and Brij-35. Source: Mouse myeloma cell line. Species: Human. Granzyme H; GZMH; Granzyme. Cat No: NATE-1935. | |
| Granzyme K from Human, Recombinant | Granzyme K is a protein that in humans is encoded by the GZMK gene. This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. Group: Enzymes. Synonyms: Granzyme K; GZMK; GZMK. Enzyme Commission Number: EC 3.4.21.-. Purity: >98% (SDS-PAGE). Alkalophilic proteinase. Activity: ~29 U/ug protein. Stability: Stable for at least 6 months when stored at -80°C. Dilute solutions (e. g. 1-1000ng/ml) should be used within 24 hours. Storage: at -80°C. Form: Liquid. In PBS containing 10% sucrose and ~0.5M sodium chloride. Contains no preservatives. Source: E. coli. Species: Human. Granzyme K; GZMK; GZMK. Cat No: NATE-1936. | |
| Acetyl-glutamyl-serinyl-methionyl-aspartal | Acetyl-glutamyl-serinyl-methionyl-aspartal. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-ACETYL-GLU-SER-MET-ASPARTINAL;CASPASE-3 PROCESSING ENZYME INHIBITOR II (ALDEHYDE);CASPASE-3 PROCESSING INHIBITOR II (ALDEHYDE);GRANZYME B INHIBITOR (ALDEHYDE);AC-ESMD-ALDEHYDE;AC-ESMD-CHO;ACETYL-GLU-SER-MET-ASPARTINAL;AC-GLU-SER-MET-ASP-ALDEHYDE. Product Category: Heterocyclic Organic Compound. CAS No. 191338-87-1. Molecular formula: C19H30N4O10S. Mole weight: 506.53. Product ID: ACM191338871. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Ac-IEPD-AFC | Ac-IEPD-AFC is a peptide whose sequence is preferred recognition motif for the serine protease granzyme B. It is a fluorogenic substrate. Synonyms: IEPD; N-Acetyl-Ile-Glu-Pro-Asp-(7-amino-4-trifluoromethylcoumarin); Ac-Ile-Glu-Pro-Asp-7-Amino-4-trifluoromethylcoumarin. Grades: ≥95%. CAS No. 1135417-31-0. Molecular formula: C32H38F3N5O11. Mole weight: 725.67. |  |
| Boc-Ala-Ala-Asp-pNA | Boc-Ala-Ala-Asp-pNA is a chromogenic substrate for human and murine granzyme B. CAS No. 201732-83-4. Molecular formula: C21H29N5O9. Mole weight: 495.48. | |
| caspase-3 | Caspase-3 is an effector/executioner caspase, as are caspase-6 (EC 3.4.22.59) and caspase-7 (EC 3.4.22.60). These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype. Procaspase-3 can be activated by caspase-1 (EC 3.4.22.36), caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63) as well as by the serine protease granzyme B. Caspase-3 can activate procaspase-2 (EC 3.4.22.55). Activation occurs by inter-domain cleavage followed by removal of the N-terminal prodomain. Although Asp-Glu-(Val/Ile)-Asp is thought to be the preferred cleavage sequence, the enzyme can accommodate different residues at P2 and P3 of the substrate. Like caspase-2, a hydrophobic residue at P5 of caspase-3 leads to more efficient hydrolysis, e.g. (Val/Leu)-Asp-Val-Ala-Asp? is a better substrate than Asp-Val-Ala-Asp?. This is not the case for caspase-7. Belongs in peptidase family C14. Group: Enzymes. Synonyms: CPP32; apopain; yama protein. Enzyme Commission Number: EC 3.4.22.56. CAS No. 169592-56-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4231; caspase-3; EC 3.4.22.56; 169592-56-7; CPP32; apopain; yama protein. Cat No: EXWM-4231. | |
| Caspase 3 Human, Recombinant | Caspase 3 is a member of the CED-3 subfamily of caspases and is responsible for the cleavage of many key proteins such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP), the inhibitor of caspase-activated deoxyribonuclease (ICAD), and gelsolin, a protein involved in apoptosis regulation. Caspase 3 is considered to be an effector caspase, activating pro-caspase 6 and pro-caspase 9 in vitro. Caspase 3 can be activated by caspase 8, caspase 6, and granzyme B. Human recombinant c-terminal histidine tagged caspase 3 is a fully active protein consisting of 17 kda and 13.5 kda subunits; the 13.5 kda subunit contains the histidine tag. Applications: Caspase-3 is a caspase prote...ve enzyme. this protein cleaves and activates caspases 6 and 7; and the protein itself is processed and activated by caspases 8, 9, and 10. it is the predominant caspase involved in the cleavage of amyloid-beta 4a precursor protein, which is associated with neuronal death in alzheimer's disease. alternative splicing of this gene results in two transcript variants that encode the same protein. caspase-3 shares many of the typical characteristics common to all currently-known caspases. for example, its active site contains a cysteine residue (cys-163) and histidine residue (his-121) that stabilize the peptide bond cleavage of a protein sequence to the carboxy-terminal side of an | |
| Native Human Cathepsin G | Cathepsin G is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, but it is most closely related to other immune serine proteases, such as neutrophil elastase and the granzymes. Cathepsin G may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. It also localizes to Neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases. Transcript variants utilizing alternative polyadenylation signals exist for this gene. Group: Enzymes. Synonyms: CTSG; cathepsin G; CG; CATG; EC 3.4.21.20; chymotrypsin-like proteinase; neutral proteinase. Enzyme Commission Number: EC 3.4.21.20. CAS No. 56645-49-9. Purity: > 96% (SDS-PAGE). CTSG. Activity: > 5 U/mL. Appearance: Clear, colorless solution. Storage: 2-8°C. Form: Liquid. Source: Human Neutrophils. Species: Human. CTSG; cathepsin G; CG; CATG; EC 3.4.21.20; chymotrypsin-like proteinase; neutral proteinase. Cat No: NATE-0173. | |
| Z-Gly-Pro-Arg-Mca Hydrochloride | Z-GPR-AMC is a fluorogenic substrate for cathepsin K, granzyme A, and thrombin. Synonyms: Z-Gly-Pro-Arg-AMC HCl; L-Argininamide, N-[(phenylmethoxy)carbonyl]glycyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-,monohydrochloride(9ci). CAS No. 201928-42-9. Molecular formula: C31H38ClN7O7. Mole weight: 656.13. | |
| Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone | Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone is a cell permeable inhibitor of caspase-8 and granzyme B. The bis-methyl ester of Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone blocks CD95-induced apoptosis. Synonyms: Z-IETD-FMK; Z-IE(OMe)TD(OMe)-FMK; Methyl (5S,8S,11S)-5-[(2S)-2-butanyl]-14-(fluoroacetyl)-11-[(1R)-1-hydroxyethyl]-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate. Grades: ≥95%. CAS No. 1926163-59-8. Molecular formula: C30H43FN4O11. Mole weight: 654.69. | |
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