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| Product | Description | |
|---|---|---|
| Guggulsterone | Guggulsterone. Group: Biochemicals. Grades: Purified. CAS No. 95975-55-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Guggulsterone | Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products ( IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin ), modulation of cell cycle proteins ( cyclin D1 and c-Myc ), activation of caspases and JNK , inhibition of Akt [1]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC 50 s of 17 and 15 μM for Z- and E-Guggulsterone, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Z/E-Guggulsterone. CAS No. 95975-55-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107738. |  |
| Guggulsterone E&Z | Guggulsterone E&Z. Group: Biochemicals. Alternative Names: (E&Z)-Guggulsterone. Grades: Plant Grade. CAS No. 95975-55-6. Pack Sizes: 20mg. Molecular Formula: C21H28O2, Molecular Weight: 312.446. US Biological Life Sciences. | Worldwide |
| Guggulsterone Z | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. |  |
| (-)-(E)-Guggulsterone | (-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic agent derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (E)-Guggulsterone. CAS No. 39025-24-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7781. | |
| (E)-Guggulsterone | ?95% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| (E)-Guggulsterone | (E)-Guggulsterone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TRANS-GUGGULSTERONE; Z-guggulsterone; GUGGULSTERONE; (17E)-Pregna-4,17(20)-diene-3,16-dione; GUGGULSTERONE E; Z-Guggulsteron; GUGGULESTERONE E; E-GUGGULSTERONE; GS,TRANS. Product Category: Steroidal Compounds. CAS No. 39025-24-6. Molecular formula: C21H28O2. Mole weight: 312.45. Purity: 0.98. IUPACName: (8R,9S,10R,13S,14S,17E)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione. Canonical SMILES: CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C. Density: 1.1g/cm³. ECNumber: 609-606-5. Product ID: ACM39025246. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Guggul P.E. 2.5% & 10% Guggulsterones UV | Guggul P.E. 2.5% & 10% Guggulsterones UV. |  CA, FL & NJ |
| (Z)-Guggulsterone | (Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul , inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF - VEGF-R2 - Akt signaling axis [1]. (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection [2]. Uses: Scientific research. Group: Natural products. CAS No. 39025-23-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110066. | |
| (Z)-Guggulsterone | (Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling axis. (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 39025-23-5. Molecular formula: C21H28O2. Mole weight: 312.45. Purity: 0.98. Product ID: ACM39025235-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| Z-Guggulsterone | Z-Guggulsterone. Group: Biochemicals. Alternative Names: (17Z)-Pregna-4,17(20)-diene-3,16-dione; (17Z)-Guggulsterone; 4,17(20)-cis-Pregnadiene-3,6-dione; cis-Guggulsterone. Grades: Highly Purified. CAS No. 39025-23-5. Pack Sizes: 5mg. Molecular Formula: C21H28O2, Molecular Weight: 312.45. US Biological Life Sciences. | Worldwide |
| Z-Guggulsterone | Z-Guggulsterone is a broad spectrum steroid receptor ligand that acts as a mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki = 37, 224 and 252 nM, respectively) and weak androgen receptor agonist (Ki = 315 nM). Z-Guggulsterone is also a selective antagonist of farnesoid X receptor (FXR) exhibiting antilipidemic, antiseptic, antirheumatic and anti-inflammatory activity in vivo. Synonyms: (Z)-Pregna-4,17(20)-diene-3,16-dione. Grades: ≥98% by HPLC. CAS No. 39025-23-5. Molecular formula: C21H28O2. Mole weight: 312.45. |  |
| Z-Guggulsterone | Z-Guggulsterone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Guggulsterone. Appearance: Off-White to Light Yellow powder. CAS No. 39025-23-5. Molecular formula: C21H28O2. Mole weight: 312.45. Purity: 0.95. Product ID: ACM39025235. Alfa Chemistry ISO 9001:2015 Certified. | |
| Alisol B 23-Acetate | Alisol B 23-acetate (23-Acetylalismol B), a natural triterpenoid, produces protective effects against EE-induced cholestasis, due to FXR-mediated gene regulation.IC50 Value:Target: Anti-hepatotoxic natural product.In vitro: Alisol-B 23-acetate has an effect on FXR activation in a dose-dependent manner using luciferase reporter assay in HepG2 cells.In vivo: In alisol B 23-acetate-treated mice, the changes in transporters and enzymes, as well as ameliorative liver histology were abrogated by FXR antagonist guggulsterone. Alisol B 23-acetate treatment in a dose-dependent manner resulted in protection against hepatotoxicity induced by CCl4via FXR activation. Through FXR activation, alisol B 23-acetate promoted hepatocyte proliferation via an induction in hepatic levels of FoxM1b, Cyclin D1 and Cyclin B1. Alisol B 23-acetate also reduced hepatic bile acids through a decrease in hepatic uptake transporter Ntcp, bile acid synthetic enzymes Cyp7a1, Cyp8b1, and an increase in efflux transporter Bsep, Mrp2 expression. In addition, alisol B 23-acetate induced the expression of STAT3 phosphorylation, and STAT3 target genes Bcl-xl and SOCS3, resulting in decreased hepatocyte apoptosis. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: White powder. CAS No. 26575-95-1. Molecular formula: C32H50O5. Mole weight: 514.8. Purity: 0.98. IUPACName: [1-(3,3-dimethyloxiran-2-yl)-3-[(8S,1 | |
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