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A peptide coupling reagent. Group: Biochemicals. Alternative Names: 1-[Bis (dimethylamino) methylene]-1H-1, 2, 3-triazolo[4, 5-b]pyridinium 3-Oxide Hexafluorophosphate. Grades: Highly Purified. CAS No. 148893-10-1. Pack Sizes: 5g. US Biological Life Sciences.
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HATU
HATU (1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU can be used along with Hünig's base (N,N-diisopropylethylamine, DIPEA) to form amide bonds [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 148893-10-1. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-Y1703.
HATU
HATU, a triazolopyridine dirivative, has been found to be a peptide coupling reagent and could be used in the formation of of Aurora A kinase inhibitors. Synonyms: HATU; 2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; O-(7-Azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, 3-oxide, hexafluorophosphate(1-) (1:1); O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyl uronium hexafluorophosphate; 1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, hexafluorophosphate(1-), 3-oxide; 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate. Grades: 98%. CAS No. 148893-10-1. Molecular formula: C10H15F6N6OP. Mole weight: 380.23.
HATU
Similar to HBTU, but reacts faster with less epimerization during coupling. Nevertheless, HATU is preferred to HBTU in most rapid coupling protocols (while it is utilized in the same manner as HBTU). Uses: Peptide Synthesis. Group: Coupling Reagents. Alternative Names: 1- [Bis (Dimethylamino) Methylene] -1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate. CAS No. 148893-10-1.
5g Pack Size. Group: Biochemicals, Peptide Reagents. Formula: C10H15F6N6OP. CAS No. 148893-10-1. Prepack ID 40746229-5g. Molecular Weight 380.23. See USA prepack pricing.
Acid-PEG4-S-S-PEG4-acid
Acid-PEG4-SS-PEG4-acid is a homobifunctional cleavable linker with carboxylic acid groups at both sides. The terminal carboxylic acids can be reacted with primary amines in the presences of activators such as EDC and HATU to form stable amide bonds. The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent. Synonyms: 4,7,10,13,20,23,26,29-octaoxa-16,17-dithiadotriacontanedioic acid; 4,7,10,13,20,23,26,29-Octaoxa-16,17-dithiadotriacontane-1,32-dioic acid. Grades: ≥95%. CAS No. 2055015-40-0. Molecular formula: C22H42O12S2. Mole weight: 562.69.
Fmoc-ACA-OH
Fmoc-ACA-OH is a useful tool for the SPPS of AMC fluorogenic protease substrates by Fmoc SPPS. Fmoc-ACA-OH must be first loaded onto a Wang-type resin. Any unreacted linker hydroxyls must be capped using acetic anhydride. Following Fmoc removal, the first amino acid should be coupled with HATU/collidine. Insertion of ACA into the middle of a peptide provides fluorogenic substrates for endopeptidases. Treatment of the ACC peptide obtained after TFA cleavage with an aqueous base causes facile decarboxylation and formation of the AMC peptide. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-ACA-OH, 7-N-Fmoc-aminocoumarin-4-acetic acid. Product Category: Amino Acids. CAS No. 378247-75-7. Mole weight: 441.43. Product ID: ACM378247757. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-N-Me-Cys(Trt)-OH
Building block for introduction of N-α-methyl-cysteine amino-acid residues by Fmoc SPPS. Fmoc SPPS of Cysteine-Containing Peptides. Uses: Fmoc-n-me-cys(trt)-oh is a fmoc-protected derivative of n-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. the residue attached to the amino group of n-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. the introduction of this fmoc-protected derivative is best achieved using hatu as a coupling reagent in the presence of dipea (n, n-diisopropylethylamine). it can also be used to prepare fmoc-n-me-cys(trt)-oallyl intermediate for the solid-phase synthesis of dithiol triostin a. Additional or Alternative Names: N-α-Fmoc-N-α-methyl-S-trityl-L-cysteine. Product Category: Amino Acids. CAS No. 944797-51-7. Mole weight: 599.74. Product ID: ACM944797517. Alfa Chemistry ISO 9001:2015 Certified.
Fmoc-TOAC-OH
Fmoc-TOAC-OH is a useful tool for the incorporation of the ESR spin-label TOAC into peptide sequences by Fmoc SPPS. Incorporation of this derivative and the following residue is best achieved using HATU activation. TFA/water/TIS should be used for cleavage of TOAC-containing peptides. The use of EDT should be avoided as it can cause permanent reduction of the nitroxide radical. Following cleavage, the TOAC peptide should be treated with aqueous ammonia in air to regenerate the nitroxide from the hydroxylamine that is generated by the TFA treatment. Uses: Peptide synthesis. Additional or Alternative Names: Fmoc-TOAC-OH, 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-(9-fluorenylmethyloxycarbonyl-amino)-4-carboxylic acid. Product Category: Amino Acids. CAS No. 93372-25-9. Mole weight: 437.51. Product ID: ACM93372259-1. Alfa Chemistry ISO 9001:2015 Certified.
HDMA
Increased coupling efficiency and lower racemization compared to HATU. Uses: Peptide Synthesis. Group: Coupling Reagents. Alternative Names: 1- [ (Dimethylamino) (Morpholino) Methylene] -1H-[1,2,3]triazolo[4,5-b]pyridine-1-ium 3-oxide hexafluorophosphate. CAS No. 958029-37-3. Registered patent of Luxembourg Bio Technologies.
PyOxim is a novel reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. It is has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days. Unlike HATU and HBTU, it cannot cause chain terminating side reactions and is, therefore, ideal for the synthesis of cyclic peptides. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Synonyms: pyoxime; AS-10531; SC-13336; CS-0068035; K-4853; J-009012; (Ethyl cyano(hydroxyimino)acetato)-tri-(1-pyrrolidinyl)-phosphonium hexafluorophosphate; [cyano- (ethoxycarbonyl) methyleneaminooxy]tris (1-pyrrolidinyl) phosphonium hexafluorophosphate; (T-4)-[ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(1-); (T-4)?-[ethyl 2-cyano-2-[(hydroxy-κO)?imino]?acetato]?tri-1-pyrrolidinyl-Phosphorus(1+) hexafluorophosphate(?1-). Grades: > 98% (HPLC). CAS No. 153433-21-7. Molecular formula: C17H29F6N5O3P2. Mole weight: 527.38.
PyOxim®
Highly efficient coupling reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. Uses: Peptide Synthesis. Group: Coupling Reagents. Alternative Names: [Ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinylphosphonium hexafluorophosphate. CAS No. 153433-21-7.
Luxembourg Bio Technologies
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