heliquinomycin suppliers USA

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Heliquinomycin It is produced by the strain of Streptomyces sp. MJ929-SF2. It has anti-DNA helicase activity with Ki value of 6.8 X 10-6 mol/L. It has strong anti-gram-positive bacteria (including MR-SA) activity (MIC is 0.05-0.39 μg/mL), but has no effect on gram-negative bacteria and fungi. It has anti-tumor activity on HeLa S3, L1210, IMC, B16 and FS-3 cells with IC50 (μg/mL) of 1.6, 0.97, 1.56, 0.88 and 0.83, respectively. Its acute toxicity is low, LD50 is 100 mg/kg (mouse, enterocoelia). Synonyms: NSC 702208; Rubymycin. Grades: >95%. CAS No. 178182-49-5. Molecular formula: C33H30O17. Mole weight: 698.58. BOC Sciences 5
Heliquinomycin (Rubymycin, NSC 702208) Antibiotic. DNA helicase inhibitor. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex. Topoisomerase I and II inhibitor (weaker than DNA helicase). DNA and RNA synthesis inhibitor in cell culture. Does not inhibit protein synthesis. Induces cell cycle arrest. Anticancer compound. Antibacterial against Gram-positive bacteria. Group: Biochemicals. Grades: Purified. CAS No. 178182-49-5. Pack Sizes: 250ug, 500ug. Molecular Formula: C33H30O17. US Biological Life Sciences. USBiological 4
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