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| Product | Description | |
|---|---|---|
| hepsin | This type-II membrane-associated serine peptidase has been implicated in cell growth and development. The enzyme has been shown to activate blood coagulation factor VII by cleavage of the Arg152?Ile153 peptide bound in BHK cells, thus indicating a possible role in the initiation of blood coagulation. There is no cleavage after aromatic or aliphatic residues. The occupancy of the S2 site is an absolute requirement for catalysis and a basic residue at that site is preferred to an aliphaticresidue. The nature of the residue at S3 also affects hydrolysis, with Gln being much more favourable than Ala. Belongs in peptidase family S1A. Group: Enzymes. Enzyme Commission Number: EC 3.4.21.106. CAS No. 112398-23-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4101; hepsin; EC 3.4.21.106; 112398-23-9. Cat No: EXWM-4101. |  |
| Serine protease hepsin (191-199) | A peptide fragment of Serine protease hepsin. Hepsin is a membrane-anchored, trypsin-like serine protease with prominent expression in the human liver and tumors of the prostate and ovaries. |  |
| Serine protease hepsin (229-237) | A peptide fragment of Serine protease hepsin. Hepsin is a membrane-anchored, trypsin-like serine protease with prominent expression in the human liver and tumors of the prostate and ovaries. | |
| Serine protease hepsin (268-276) | A peptide fragment of Serine protease hepsin. Hepsin is a membrane-anchored, trypsin-like serine protease with prominent expression in the human liver and tumors of the prostate and ovaries. | |
| Ac-Lys-Gln-Leu-Arg-AFC | Ac-Lys-Gln-Leu-Arg-AFC is the optimal substrate for human Hepsin, because KQLR/VVNG corresponds to its cleavage site. Excitation at 395-400 nm, emission at 495-505 nm. Hepsin is a membrane-anchored serine protease that is overexpressed in ovarian, prostate cancer and renal cell carcinomas, and therefore can be used as a prognostic marker. Synonyms: Ac-KQLR-AFC; L-Argininamide, N2-acetyl-L-lysyl-L-glutaminyl-L-leucyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-; N2-Acetyl-L-lysyl-L-glutaminyl-L-leucyl-N-[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]-L-argininamide. Grades: ≥95%. CAS No. 1802078-38-1. Molecular formula: C35H51F3N10O8. Mole weight: 796.84. | |
| Boc-Gln-Arg-Arg-AMC | Boc-QRR-AMC is a substrate for the transmembrane serine protease hepsin, also is used for assaying kexin. Synonyms: Boc-Gln-Arg-Arg-Mca; tert-butyl (S)-5-amino-1-((S)-5-guanidino-1-((S)-5-guanidino-1-(4-methyl-2-oxo-2H-chromen-7-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1,5-dioxopentan-2-ylcarbamate; Boc-QRR-AMC. Grades: 95%. CAS No. 109376-05-8. Molecular formula: C32H49N11O8. Mole weight: 715.81. | |
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