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| Product | Description | |
|---|---|---|
| histone acetyltransferase | A group of enzymes with differing specificities towards histone acceptors. Group: Enzymes. Synonyms: nucleosome-histone acetyltransferase; histone acetokinase; histone acetylase; histone transacetylase. Enzyme Commission Number: EC 2.3.1.48. CAS No. 9054-51-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2227; histone acetyltransferase; EC 2.3.1.48; 9054-51-7; nucleosome-histone acetyltransferase; histone acetokinase; histone acetylase; histone transacetylase. Cat No: EXWM-2227. |  |
| Histone Acetyltransferase Inhibitor II - CAS 932749-62-7 | The Histone Acetyltransferase Inhibitor II, also referenced under CAS 932749-62-7, controls the biological activity of Histone Acetyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. |  |
| Histone Acetyl Transferase Inhibitor VII, CTK7A | The Histone Acetyl Transferase Inhibitor VII, CTK7A controls the biological activity of Histone Acetyl Transferase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Acetyltransferase Inhibitor VIII, NU9056 (1,2-Bis(isothiazol-5-yl)disulfane, 1,2-di(isothiazol-5-yl)disulfane, KAT5 Inhibitor I, Tip60 Inhibitor I, HAT Inhibitor VIII, p300/CBP Inhibitor VII, PCAF Inhibitor V) | A cell-permeable disulfane compound that is reported to be more potent against KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC50 ≤2, ≤36, ≤60, and >100uM, respectively) and effectively reduce H3K14, H4K8, H4K16, but not alpha-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10uM). Shown to induce cell cycle arrest and apoptosis (17 to 24uM) in LNCaP cultures and exhibit antiproliferation activity in both androgen-responsive and androgen-independent CaP cultures (GI50 from 7.5 to 27uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C?H?N?S?, Primary Target: KAT5. US Biological Life Sciences. |  Worldwide |
| Histone Acetyltransferase p300 Inhibitor, C646 | Histone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400 nM). Competes with acetyl-CoA for the p300 Lys-CoA binding pocket. Group: Fluorescence/luminescence spectroscopy. | |
| histone deacetylase | A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. May be identical to EC 3.5.1.17, acyl-lysine deacylase. Group: Enzymes. Synonyms: HDAC. Enzyme Commission Number: EC 3.5.1.98. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4490; histone deacetylase; EC 3.5.1.98; HDAC. Cat No: EXWM-4490. | |
| Histone Deacetylase 6, GST-Fusion, Human Recombinant, S. frugiperda | Histone Deacetylase 6, GST-Fusion, Human Recombinant, S. frugiperda, is a full-length HDAC6 fused to GST at the N-terminus. Useful in the study of HDAC6 regulation and for inhibitor screening. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase 8, His Tag, Human Recombinant, S. frugiperda | Human Recombinant, S. frugiperda, is a full length HDAC8 fused to His-Tag at the C-terminus. Useful in the study of HDAC8 regulation and for inhibitor screening. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase Inhibitor II - CAS 174664-65-4 | The Histone Deacetylase Inhibitor II, also referenced under CAS 174664-65-4, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase Inhibitor III | The Histone Deacetylase Inhibitor III, also referenced under CAS 251456-60-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase Inhibitor IV - CAS 537034-15-4 | The Histone Deacetylase Inhibitor IV, also referenced under CAS 537034-15-4, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 | The Histone Deacetylase Inhibitor VI, HNHA, also referenced under CAS 926908-04-5, controls the biological activity of Histone Deacetylase. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 | The Histone Deacetylase Inhibitor VII, 106, also referenced under CAS 937039-45-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 | The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Histone H1-derived Peptide | Histone H1-derived Peptide is a phosphopeptide and the peptide substrates containes a sequence in accordance with the optimal recognition motif for CDK, can be used to detecting CDK1-cyclinB1 enzyme activity [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 889112-06-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2480. |  |
| Histone H2A | Histone H2A is an antibacterial peptide isolated from Oncorhynchus mykiss. It has activity against bacteria and fungi. Synonyms: Ala-Glu-Arg-Val-Gly-Ala-Gly-Ala-Pro-Val-Tyr-Leu. |  |
| Histone H2A (1-129) from Xanopus> sp. | recombinant, expressed in E. coli, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H2a full length human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H2B 1 | Histone H2B 1 is an antibacterial peptide isolated from Ictalurus punctatus. It has activity against bacteria and fungi. Molecular formula: C85H149N25O24. Mole weight: 2034.62. | |
| Histone H2B (1-123) from Xanopus> sp. | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H2B 3 | Histone H2B 3 is an antibacterial peptide isolated from Ictalurus punctatus. It has activity against bacteria and fungi. Synonyms: Pro-Asp-Pro-Ala-Lys-Thr-Ala-Pro-Lys-Lys-Lys-Ser-Lys-Lys-Ala-Val-Thr. Molecular formula: C80H143N23O23. Mole weight: 1795.16. | |
| Histone H2b full length human | recombinant, expressed in E. coli, ?65% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H3 (1-136) human | recombinant, expressed in E. coli, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H3 (1-20) | Synonyms: H3 (1-20); H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-OH; L-alanyl-L-arginyl-L-threonyl-L-lysyl-L-glutaminyl-L-threonyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-threonyl-glycyl-glycyl-L-lysyl-L-alanyl-L-prolyl-L-arginyl-L-lysyl-L-glutaminyl-L-leucine. Grades: ≥95% by HPLC. CAS No. 380598-30-1. Molecular formula: C91H167N35O27. Mole weight: 2183.52. | |
| Histone H3 (1-21)-Gly-Gly-Lys(biotinyl) amide | Synonyms: H3 (1-21), biotin-labeled; H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Gly-Gly-Lys(biotinyl)-NH2. CAS No. 2243207-10-3. Molecular formula: C114H205N43O32S. Mole weight: 2722.22. | |
| Histone H3 (1-34) | Histone H3 (1-34) is a histone peptide that acts as a substrate for methyltransferase/demethylase enzymes. Synonyms: Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Thr-Lys-Ala-Ala-Arg-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly. Molecular formula: C144H260N54O44. Mole weight: 3451.98. | |
| Histone H3 (21-44) | Histone H3 (21-44) is a histone fragment that is used as a substrate for the protein arginine methyltransferase PRMT4. Synonyms: H3 (21-44); H-Ala-Thr-Lys-Ala-Ala-Arg-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys-Lys-Pro-His-Arg-Tyr-Arg-Pro-Gly-OH; L-Alanyl-L-threonyl-L-lysyl-L-alanyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-prolyl-L-alanyl-L-threonylglycylglycyl-L-valyl-L-lysyl-L-lysyl-L-prolyl-L-histidyl-L-arginyl-L-tyrosyl-L-arginyl-L-prolylglycine. Grades: ≥95%. CAS No. 1373516-71-2. Molecular formula: C109H185N39O29. Mole weight: 2505.91. | |
| Histone H3 (2-58) human | recombinant, expressed in E. coli, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H3 full length human | recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H3 peptide (1-21), biotin | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H3 peptide (1-21) human | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H3 peptide (21-44), biotin | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H3 peptide (21-44) human | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H3 peptide (Di-methylated K9), biotin | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H3 peptide (Mono-methylated K9), biotin | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H3 peptide (Tri-methylated K9), biotin | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H4 (1-103) human | recombinant, expressed in E. coli, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H4 (2-58) human | recombinant, expressed in E. coli, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H4 full length human | recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H4 peptide (1-21), biotin | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H4 peptide (1-21) human | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone H4 peptide (Di-methylated R3), biotin | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Histone Lysine Demethylase Inhibitor IX, PBIT (2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one, JHDM Inhibitor V) | A cell-permeable iron chelating benzisothiazolone compound with microbicide and fungicide properties that acts as a potent, selective, and reversible inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases (IC50 = 3uM for JARID1B). Also blocks the activity of other related demethylases at higher concentration (IC50 = 6, 4.9, and 28uM for JARID1A, JARID1C, and JMJD2E, respectively). However, it does affect the activity of unrelated UTX and JMJD3 H3K27me3 demethylases. HeLa cells overexpressing full length JARID1B show a significant reduction in H3K4Me3 activity following PBIT treatment (~10uM). Blocks the proliferation of UACC-812 tumor cells expressing higher levels of JARDID1B, but does not significantly affect MCF7 or MCF10A cells expressing lower levels of JARDID1B. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??NOS, Primary Target: JARID1 Histone Demethylases. US Biological Life Sciences. | Worldwide |
| Histone Lysine Demethylase Inhibitor VII, GSK-J1 (3-(6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoic Acid, JHDM Inhibitor II) | A pyridinyl -pyrimidinyl aminopropanoic acid that effectively inhibits KDM6 family H3K27m3 demethylases JMJD3 and UTX (IC50 = 18 and 56uM, respectively, by MALDI Mass detection) in an alpha-ketoglutarate-competitive, peptide substrate-non-competitive manner, displaying much reduced potency against JARID1C, JMJD1a, JMJD2a, JMJD2c, JMJD2d, JMJD2e, as well as112 kinases and 60 non-kinase enzymes. Recommended for cell-free assays only. For culture treatment, use the cell-permeable pro-drug GSK-J4. Group: Biochemicals. Grades: Highly Purified. CAS No. 1373422-53-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Histone Lysine Demethylase Inhibitor VIII, GSK-J4 (Ethyl-3-(6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-ylamino)propanoate, GSK-J1 Pro-Drug, JHDM Inhibitor II Pro-Drug) | A cell-permeable GSK-J1 prodrug that is ineffective in cell-free assays, but is effectively converted to GSK-J1 intracellularly for effective JMJD3 and UTX inhibition (effective conc. 25 to 50uM in HeLa cultures). GSK-J4 treatment is shown to block LPS-induced TNF-alpha production in primary human macrophage cultures (IC50 = 9uM by ELISA). Group: Biochemicals. Grades: Highly Purified. CAS No. 1373423-53-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?, Primary Target: H3K27me3 demethylases JMJD3 & UTX. US Biological Life Sciences. | Worldwide |
| histone-lysine N-methyltransferase | One of a group of enzymes methylating proteins; see also EC 2.1.1.59, [cytochrome-c]-lysine N-methyltransferase and EC 2.1.1.60, calmodulin-lysine N-methyltransferase. Group: Enzymes. Synonyms: protein methylase III; protein methylase 3; protein (lysine) methyltransferase; protein methyltransferase II; protein-lysine N-methyltransferase; histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase; S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase. Enzyme Commission Number: EC 2.1.1.43. CAS No. 9055-8-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1947; histone-lysine N-methyltransferase; EC 2.1.1.43; 9055-08-7; protein methylase III; protein methylase 3; protein (lysine) methyltransferase; protein methyltransferase II; protein-lysine N-methyltransferase; histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase; S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase. Cat No: EXWM-1947. | |
| Histone Methyltransferase EZH2 Inhibitor, DZNep (3-deazaneplanocin A, HCl, (1S, 2R, 5R) -5- (4-amino-1H-imidazo[4, 5-c]pyridin-1-yl) -3- (hydroxymethyl) cyclopent-3-ene-1, 2-diol, HCl, HMTase Inhibitor X) | A cell-permeable compound that is shown (at 1uM concentrations) to inhibit EZH2-mediated trimethylation of K27 on histone H3 and induces the expression of cell-cycle regulatory genes, p21 and p27, as well as the cell death regulator, FBXO32, in OCI-AML3 and HL-60 cells, whereby treatment with inhibitor increases p16 levels in the former, but not the latter of the two cultures. At concentrations between 200nM and 2000nM, this compound is found to dose-dependently deplete the expression of polycomb group proteins EZH2, SUZ12, and EED in cultured and primary AML cell extracts. At concentrations up to ≥ 1000nM, DZNep dose-dependently increases the percentage of apoptotic cells up to > ~ 38%, with greater potency against OCI-AML3 than HL-60 cultures and inhibits colony growth up to > ~ 85% for both cell lines. In OCI-AML3 cultures, 1000nM of treatment demonstrates a significant increase in the accumulation of cells in the G0/G1 phase (58.5%) with a concomitant decrease in the number of c Group: Biochemicals. Grades: Highly Purified. CAS No. 102052-95-9. Pack Sizes: 2mg. Molecular Formula: C??H??N?O?; HCl; H?O. US Biological Life Sciences. | Worldwide |
| Histone Modification Compound Library | A unique collection of 362 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS); - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3500. Categories: Histone Modification Compounds Libraries. |  |
| Histone Octamer full length human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Anti-acetyl-Histone H1.4 (Ac-Lys26) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-acetyl-Histone H3 (Ac-Lys9) antibody, Mouse monoclonal | clone AH3-120, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-acetyl-Histone H3 (Ac-Lys9) antibody produced in rabbit | 2-2.5 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-acetyl- & phospho-Histone H3 (Ac-Lys9, pSer10) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-dimethyl-Histone H1.4 (diMe-Lys26) antibody produced in rabbit | ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-dimethyl-Histone H3 (diMe-Lys9) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-dimethyl, phospho-Histone H1.4 (diMe-Lys26, pSer27) antibody produced in rabbit | ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 10 (HDAC10) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 1 (HDAC1) antibody, Mouse monoclonal | clone HDAC1-21, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 1 (HDAC1) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal | clone HDAC2-62, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 2 (HDAC2) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 3 (HDAC3) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 4 (HDAC4) antibody, Mouse monoclonal | clone HDAC4-144, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 4 (HDAC4) (DM-15) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 4 (HDAC4) (ML-19) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 5 (HDAC5) antibody, Mouse monoclonal | clone HDAC5-35, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 5 (HDAC5) (NA-16) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 6 (HDAC6) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 7 (HDAC7) antibody, Mouse monoclonal | clone HDAC7-97, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
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