Histone Acetyltransferase Suppliers USA
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Product | Description | |
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Histone Acetyltransferase Inhibitor VIII, NU9056 (1,2-Bis(isothiazol-5-yl)disulfane, 1,2-di(isothiazol-5-yl)disulfane, KAT5 Inhibitor I, Tip60 Inhibitor I, HAT Inhibitor VIII, p300/CBP Inhibitor VII, PCAF Inhibitor V) Quick inquiry Where to buy Suppliers range | A cell-permeable disulfane compound that is reported to be more potent against KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC50 ≤2, ≤36, ≤60, and >100uM, respectively) and effectively reduce H3K14, H4K8, H4K16, but not alpha-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10uM). Shown to induce cell cycle arrest and apoptosis (17 to 24uM) in LNCaP cultures and exhibit antiproliferation activity in both androgen-responsive and androgen-independent CaP cultures (GI50 from 7.5 to 27uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C?H?N?S?, Primary Target: KAT5. US Biological Life Sciences. | Worldwide |
p300/CBP Inhibitor VI, L002 (4- (4-Methoxyphenyl sulfonyl oxyimino) -2, 6-di methyl -2, 5-cyclohexadien-1-one, GCN5 Inhibitor III, Histone Acetyltransferase Inhibitor IX, PCAF Inhibitor IV) Quick inquiry Where to buy Suppliers range | A cell-permeable phenyl sulfonyl oxyimi nocyclohexadienone compound that acts as a potent, selective, and reversible inhibitor of p300 histone acetyl transferase (IC50 = 1.98uM). Shown to occupy Ac-CoA binding pocket of p300, and less potent to CBP, PCAF, GCN5 and GNAT. Suppresses Histone H3 and H4 acetylation in triple negative breast cancer cell line MDAMB-468 as well as in HCT116 cell line and blocks p300-mediated STAT3 phosphorylation in pancreatic cancer cell line MIA Paca-2. Does neither inhibit the activities of histone deacetylases 1, 6, and 11 nor 8-diverse histone methyltransferases tested (DOT1, EZH1, G9a, PRMT1, SETD2, SET7-9, SMYD2, and SUV39H2). Reported to suppress tumor growth in mice bearing tumor xenografts of MDAMB-468 cell line (at 500ug/100ul, i.p. twice a week). Group: Biochemicals. Grades: Highly Purified. CAS No. 321695-57-2. Pack Sizes: 10mg. Molecular Formula: C??H??NO?S. US Biological Life Sciences. | Worldwide |
2-Amino-4-chlorobenzotrifluoride Quick inquiry Where to buy Suppliers range | 2-Amino-4-chlorobenzotrifluoride is a potent activator of the histone acetyltransferase (HAT) of p300. Group: Biochemicals. Grades: Highly Purified. CAS No. 445-14-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H5ClF3N. US Biological Life Sciences. | Worldwide |
3-Bromo-4- (methoxymethoxy) benzaldehyde Quick inquiry Where to buy Suppliers range | 3-Bromo-4- (methoxymethoxy) benzaldehyde is an intermediate in synthesizing CARM1-IN-1 Hydrochloride (C183610), a mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 162269-90-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C9H9BrO3. US Biological Life Sciences. | Worldwide |
A-485 Quick inquiry Where to buy Suppliers range | A-485 is an inhibitor of the histone acetyltransferase p300/CBP (IC50 = 60 nM). Synonyms: (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide. Grades: ≥98%. CAS No. 1889279-16-6. Molecular formula: C25H24F4N4O5. Mole weight: 536.48. | |
Anacardic acid Quick inquiry Where to buy Suppliers range | Potent histone acetyltransferase (HAT) inhibitor. Antibacterial. SUMOylation inhibitor. Lipoxygenase inhibitor. NF-kappaB inhibitor. Anti-tumor compound. Anti-inflammatory. Apoptosis inducer. Antiproliferative. Group: Biochemicals. Grades: Highly Purified. CAS No. 16611-84-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C22H36O3. US Biological Life Sciences. | Worldwide |
Anacardic Acid (2-Hydroxy-6-pentadecylbenzoic Acid, 6-Pentadecylsalicylic Acid, AA) Quick inquiry Where to buy Suppliers range | Cell-permeable. A potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC50~8.5uM and ~5uM, respectively. Inhibits SUMOylation of RanGAP1-C2 with an IC50=2.2uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 16611-84-0. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
BRD32048 Quick inquiry Where to buy Suppliers range | The ETV1 transcription factor is phosphorylated downstream of MAPK signaling and is acetylated at lysines 33 and 116 by the histone acetyltransferase p300. BRD32048 is an inhibitor of the ETV1 transcription factor oncoprotein. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 is a substituted [1,3,5]triazine derivative that inhibits ETV1 transcriptional activity by binding to ETV1 with KD of 17.1 μM, which reduces p300-dependent acetylation and stability of ETV1. Synonyms: BRD-32048; BRD 32048. Grades: ≥98%. CAS No. 433694-46-3. Molecular formula: C16H22N6O. Mole weight: 314.4. | |
Butyrolactone 3 Quick inquiry Where to buy Suppliers range | Specific histone acetyltransferase Gcn5 inhibitor. Anticancer compound. Pre-mRNA splicing inhibitor. Blocks splicing before the first catalytic steps. Potential anti-inflammatory compound. Group: Biochemicals. Alternative Names: (2R,3S)-rel-Tetrahydro-4-methylene-5-oxo-2-propyl-3-furancarboxylic Acid; 4-Methylene-5-oxo-2-propyl-tetrahydrofuran-3-carboxylic Acid. Grades: Highly Purified. CAS No. 778649-18-6. Pack Sizes: 2mg. Molecular Formula: C?H??O?, Molecular Weight: 184.19. US Biological Life Sciences. | Worldwide |
C646 Quick inquiry Where to buy Suppliers range | C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. Preferentially selective for p300 versus other acetyltransferases. Synonyms: C646; C-646; C 646. Grades: >98%. CAS No. 328968-36-1. Molecular formula: C24H19N3O6. Mole weight: 445.42. | |
C646 Quick inquiry Where to buy Suppliers range | Reversible cell permeable p300/CBP histone acetyltransferase (HAT) inhibitor. Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%). Cell growth inhibitor in melanoma and non-small-cell-lung (NSCL) human cancer cell lines. Group: Biochemicals. Alternative Names: (E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid. Grades: Highly Purified. CAS No. 328968-36-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H19N3O6. US Biological Life Sciences. | Worldwide |
CAY10669 Quick inquiry Where to buy Suppliers range | P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a co-activator of p53-target genes and moreover it regulates p53 activity by acetylating K320, which promotes p53-dependent p21 transcription and cell cycle arrest during DNA damage. CAY10669 is an inhibitor of the histone acetyltransferase PCAF, which displays 2-fold improvement in inhibitory potency over anacardic acid. Synonyms: CAY 10669; CAY-10669. Grades: ≥98%. CAS No. 1243583-88-1. Molecular formula: C20H22O4. Mole weight: 326.4. | |
CAY10685 Quick inquiry Where to buy Suppliers range | CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 that contains an alkyne moiety. It can inhibit N-acetyltransferase, which shows potential applicaiton in studying the changes in nuclear architecture associated with cancer and certain laminopathies. Synonyms: CAY 10685; CAY-10685. Grades: ≥98%. CAS No. 1613116-16-7. Molecular formula: C17H16ClN3S. Mole weight: 329.8. | |
CI-994, Free Base (4-(Acetylamino)-N-(2-aminophenyl)benzamide, Acetyldinaline, 5'-Deoxy-5-fluoro-N- ( (pentyloxy) carbonyl) cytidine, Goe 5549, Gö 5549, PD 123654, Tacedinaline) Quick inquiry Where to buy Suppliers range | CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells. CI-994 inhibited HDAC-1 and HDAC-2 but not the prototypical histone acetyltransferase GCN5. Group: Biochemicals. Grades: Highly Purified. CAS No. 112522-64-2. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
CPTH2 Quick inquiry Where to buy Suppliers range | CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating Gcn5p network in vitro and in vivo. HAT is an enzyme playing an important role in histone acetylation and multiple cancer development. Uses: Antitumor agent. Synonyms: CPTH2; CPTH 2; CPTH-2; Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone. Grades: 99%. CAS No. 357649-93-5. Molecular formula: C14H14ClN3S. Mole weight: 291.8. | |
CPTH2 Quick inquiry Where to buy Suppliers range | CPTH2 is a histone acetyltransferase inhibitor that modulates Gcn5p dependent functional network in vitro and in vivo. Group: Biochemicals. Alternative Names: 2-[4-(4-Chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone; 4- (4-Chlorophenyl) -2 (3H) -thiazolone-cyclopentylidene hydrazone. Grades: Highly Purified. CAS No. 357649-93-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
CTPB Quick inquiry Where to buy Suppliers range | CTPB is an amide derivative that acts as a selectively activator of the histone acetyltransferase (HAT) p300, with maximal activation at 275 μM. Synonyms: N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl-benzamide. Grades: ≥98%. CAS No. 586976-24-1. Molecular formula: C31H43ClF3NO2. Mole weight: 554.1. | |
Garcinol Quick inquiry Where to buy Suppliers range | Garcinol is an inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 = 5 and 7 μM, respectively), which is isolated from Garcinia indica. It also inhibits the HAT GCN5 in Cryptococcus neoformans. Garcinol promotes expansion of human HSCs ex vivo. It induces apoptosis in some cancer cells thus can be used as a cancer therapy. Synonyms: Camboginol; (1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione. Grades: ≥98% by HPLC. CAS No. 78824-30-3. Molecular formula: C38H50O6. Mole weight: 602.8. | |
HAT Inhibitor II Quick inquiry Where to buy Suppliers range | HAT Inhibitor II is a cell-permeable and selective inhibitor of the histone acetyltransferase p300 (IC50 = 5 μM). It has been shown to decrease histone H3 acetylation (IC50 ≤ 40 μM) and induce chromatin condensation in HeLa cells. Synonyms: Histone Acetyltransferase Inhibitor II; (2E,6E)-2,6-bis[(3-bromo-4-hydroxyphenyl)methylidene]cyclohexan-1-one. Grades: ≥98%. CAS No. 932749-62-7. Molecular formula: C20H16Br2O3. Mole weight: 464.2. | |
I-CBP112 hydrochloride Quick inquiry Where to buy Suppliers range | I-CBP112 is a selective inhibitor of CBP and EP300 bromodomain (Kds = 0.142 and 0.625 μM, respectively). CBP and EP300 are histone acetyltransferase (HAT) enzymes that serve as transcriptional coactivators and have been found to be dysregulated in cancer and other diseases. Synonyms: 1-[7-(3,4-dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]propan-1-one hydrochloride. Grades: ≥90%. CAS No. 2147701-33-3. Molecular formula: C27H36N2O5·HCl. Mole weight: 505.1. | |
Inobrodib Quick inquiry Where to buy Suppliers range | Inobrodib is an inhibitor of the histone acetyltransferase p300 and CREB-binding protein and has antineoplastic activity. Synonyms: (6S)-1-(3,4-difluorophenyl)-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(trans-4-methoxycyclohexyl)-1H-benzimidazol-2-yl]piperidin-2-one; (S)-1-(3,4-difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-((1R,4S)-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)piperidin-2-one; CBP-IN-1; CCS-1477; (6S)-1-(3,4-Difluorophenyl)-6-[5-(3,5-dimethyl-4-isoxazolyl)-1-(trans-4-methoxycyclohexyl)-1H-benzimidazol-2-yl]-2-piperidinone; CCS 1477; CCS1477. Grades: >98%. CAS No. 2222941-37-7. Molecular formula: C30H32F2N4O3. Mole weight: 534.60. | |
L002 Quick inquiry Where to buy Suppliers range | L002 is an inhibitor of p300 histone acetyltransferase with IC50 value of 1.98 μM in vitro, which is a lysine acetyltransferase that catalyzes acetyl group attachment to lysine residues of a variety of proteins. It has weaker inhibitory effects against PCAF and GCN5. It acts as a critical coactivator of several oncogenic transcription factors involved in cancer cell survival and proliferation. It blocks acetylation of histones and p53, and reduces STAT3 phosphorylation in MDA-MB-468 xenografts, leukemia and lymphoma cell lines. It induces growth arrest and apoptosis in certain cancer cell lines and suppresses the growth of triple-negative breast cancer xenografts. Synonyms: 2,6-Dimethyl-2,5-cyclohexadiene-1,4-dione 4-[O-[(4-methoxyphenyl)sulfonyl]oxime]; 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione; NSC764414; NSC 764414; NSC-764414; L002; L 002; L-002. Grades: ≥98% by HPLC. CAS No. 321695-57-2. Molecular formula: C15H15NO5S. Mole weight: 321.35. | |
MG149 Quick inquiry Where to buy Suppliers range | MG149 is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively. Synonyms: MG149; MG 149; MG-149. Grades: >98%. CAS No. 1243583-85-8. Molecular formula: C22H28O3. Mole weight: 340.46. | |
Na-Acetyl-L-lysine Amide Hydrochloride (Ac-L-Lys-NH2·HCl) Quick inquiry Where to buy Suppliers range | A lysine analog used in the preparation of selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Group: Biochemicals. Alternative Names: Ac-L-Lys-NH2·HCl; Ac-Lys-NH? HCl; (2S)-2-(Acetylamino)-6-aminohexanamide Hydrochloride; (S)-2-(Acetylamino)-6-aminohexanamide Monohydrochloride; N-Acetyllysine Amide Hydrochloride. Grades: Highly Purified. CAS No. 104584-11-4. Pack Sizes: 100mg, 250mg, 1g. Molecular Formula: C8H17N3O2·HCl, Molecular Weight: 223.7. US Biological Life Sciences. | Worldwide |
Nα-Acetyl-L-lysine amide hydrochloride Quick inquiry Where to buy Suppliers range | A lysine analog used in the preparation of selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Synonyms: Ac-L-Lys-NH2 HCl; N-Acetyl-L-Lysine Amide Hydrochloride; (2S)-2-acetamido-6-aminohexanamide hydrochloride. Grades: ≥ 99% (TLC). CAS No. 104584-11-4. Molecular formula: C8H17N3O2·HCl. Mole weight: 223.70. | |
NU 9056 Quick inquiry Where to buy Suppliers range | NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 = < 2, 60, 36, and>100 μM for KAT5, p300, pCAF and GCN5, respectively). NU 9056 treatment inhibited cellular proliferation in a panel of prostate cancer cell lines (50% growth inhibition, 8-27 μM) and induced apoptosis via activation of caspase 3 and caspase 9 in a concentration- and time-dependent manner. Also, decreased androgen receptor, prostate specific antigen, p53 and p21 protein levels were demonstrated in response to treatment with NU 9056. Synonyms: NU 9056; NU9056; NU-9056; 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole. CAS No. 1450644-28-6. Molecular formula: C6H4N2S4. Mole weight: 232.37. | |
TH 1834 Quick inquiry Where to buy Suppliers range | TH 1834 is a Tip60 histone acetyltransferase inhibitor. TH 1834 causes apoptosis and increases unrepaired DNA damage (following ionizing radiation treatment) in breast cancer cells, yet not control cell lines or affect the activity of related HAT MOF. Synonyms: TH 1834; TH1834; TH-1834; 2-[5- (4-{[ (2-phenylethyl) ({4-[4- (pyrrolidin-1-ylmethyl) phenoxy]butyl}) amino]methyl}phenyl) -2H-1, 2, 3, 4-tetrazol-2-yl]acetic acid. Grades: 99%. Molecular formula: C33H40N6O3.2HCl. Mole weight: 641.63. | |
TTK21 Quick inquiry Where to buy Suppliers range | TTK21 is an activator of CBP/p300 histone acetyltransferase activity that activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner. Synonyms: N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide. Grades: ≥98%. CAS No. 709676-56-2. Molecular formula: C17H15ClF3NO2. Mole weight: 357.8. |