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| Product | Description | |
|---|---|---|
| histone acetyltransferase | A group of enzymes with differing specificities towards histone acceptors. Group: Enzymes. Synonyms: nucleosome-histone acetyltransferase; histone acetokinase; histone acetylase; histone transacetylase. Enzyme Commission Number: EC 2.3.1.48. CAS No. 9054-51-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2227; histone acetyltransferase; EC 2.3.1.48; 9054-51-7; nucleosome-histone acetyltransferase; histone acetokinase; histone acetylase; histone transacetylase. Cat No: EXWM-2227. |  |
| Histone Acetyltransferase Inhibitor VIII, NU9056 (1,2-Bis(isothiazol-5-yl)disulfane, 1,2-di(isothiazol-5-yl)disulfane, KAT5 Inhibitor I, Tip60 Inhibitor I, HAT Inhibitor VIII, p300/CBP Inhibitor VII, PCAF Inhibitor V) | A cell-permeable disulfane compound that is reported to be more potent against KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC50 ≤2, ≤36, ≤60, and >100uM, respectively) and effectively reduce H3K14, H4K8, H4K16, but not alpha-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10uM). Shown to induce cell cycle arrest and apoptosis (17 to 24uM) in LNCaP cultures and exhibit antiproliferation activity in both androgen-responsive and androgen-independent CaP cultures (GI50 from 7.5 to 27uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C?H?N?S?, Primary Target: KAT5. US Biological Life Sciences. |  Worldwide |
| p300/CBP Inhibitor VI, L002 (4- (4-Methoxyphenyl sulfonyl oxyimino) -2, 6-di methyl -2, 5-cyclohexadien-1-one, GCN5 Inhibitor III, Histone Acetyltransferase Inhibitor IX, PCAF Inhibitor IV) | A cell-permeable phenyl sulfonyl oxyimi nocyclohexadienone compound that acts as a potent, selective, and reversible inhibitor of p300 histone acetyl transferase (IC50 = 1.98uM). Shown to occupy Ac-CoA binding pocket of p300, and less potent to CBP, PCAF, GCN5 and GNAT. Suppresses Histone H3 and H4 acetylation in triple negative breast cancer cell line MDAMB-468 as well as in HCT116 cell line and blocks p300-mediated STAT3 phosphorylation in pancreatic cancer cell line MIA Paca-2. Does neither inhibit the activities of histone deacetylases 1, 6, and 11 nor 8-diverse histone methyltransferases tested (DOT1, EZH1, G9a, PRMT1, SETD2, SET7-9, SMYD2, and SUV39H2). Reported to suppress tumor growth in mice bearing tumor xenografts of MDAMB-468 cell line (at 500ug/100ul, i.p. twice a week). Group: Biochemicals. Grades: Highly Purified. CAS No. 321695-57-2. Pack Sizes: 10mg. Molecular Formula: C??H??NO?S. US Biological Life Sciences. | Worldwide |
| 2-Amino-4-chlorobenzotrifluoride | 2-Amino-4-chlorobenzotrifluoride is a potent activator of the histone acetyltransferase (HAT) of p300. Group: Biochemicals. Grades: Highly Purified. CAS No. 445-14-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H5ClF3N. US Biological Life Sciences. | Worldwide |
| 3-Bromo-4- (methoxymethoxy) benzaldehyde | 3-Bromo-4- (methoxymethoxy) benzaldehyde is an intermediate in synthesizing CARM1-IN-1 Hydrochloride (C183610), a mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 162269-90-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C9H9BrO3. US Biological Life Sciences. | Worldwide |
| A-485 | A-485 is an inhibitor of the histone acetyltransferase p300/CBP (IC50 = 60 nM). Synonyms: (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide. Grades: ≥98%. CAS No. 1889279-16-6. Molecular formula: C25H24F4N4O5. Mole weight: 536.48. |  |
| Anacardic acid | Potent histone acetyltransferase (HAT) inhibitor. Antibacterial. SUMOylation inhibitor. Lipoxygenase inhibitor. NF-kappaB inhibitor. Anti-tumor compound. Anti-inflammatory. Apoptosis inducer. Antiproliferative. Group: Biochemicals. Grades: Highly Purified. CAS No. 16611-84-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C22H36O3. US Biological Life Sciences. | Worldwide |
| Anacardic Acid | Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC50s of ~8.5 μM and ~5 μM, respectively. Group: Inhibitors. Alternative Names: Hydroginkgolic Acid. CAS No. 16611-84-0. Molecular formula: C22H36O3. Mole weight: 348.52. Purity: 0.98. Catalog: ACM16611840. |  |
| Anacardic Acid | Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC 50 s of ?8.5 μM and ?5 μM, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: Hydroginkgolic acid; Ginkgolic Acid C15:0. CAS No. 16611-84-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N2020. |  |
| Anacardic Acid (2-Hydroxy-6-pentadecylbenzoic Acid, 6-Pentadecylsalicylic Acid, AA) | Cell-permeable. A potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC50~8.5uM and ~5uM, respectively. Inhibits SUMOylation of RanGAP1-C2 with an IC50=2.2uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 16611-84-0. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| BRD32048 | The ETV1 transcription factor is phosphorylated downstream of MAPK signaling and is acetylated at lysines 33 and 116 by the histone acetyltransferase p300. BRD32048 is an inhibitor of the ETV1 transcription factor oncoprotein. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 is a substituted [1,3,5]triazine derivative that inhibits ETV1 transcriptional activity by binding to ETV1 with KD of 17.1 μM, which reduces p300-dependent acetylation and stability of ETV1. Synonyms: BRD-32048; BRD 32048. Grades: ≥98%. CAS No. 433694-46-3. Molecular formula: C16H22N6O. Mole weight: 314.4. | |
| Butyrolactone 3 | Specific histone acetyltransferase Gcn5 inhibitor. Anticancer compound. Pre-mRNA splicing inhibitor. Blocks splicing before the first catalytic steps. Potential anti-inflammatory compound. Group: Biochemicals. Alternative Names: (2R,3S)-rel-Tetrahydro-4-methylene-5-oxo-2-propyl-3-furancarboxylic Acid; 4-Methylene-5-oxo-2-propyl-tetrahydrofuran-3-carboxylic Acid. Grades: Highly Purified. CAS No. 778649-18-6. Pack Sizes: 2mg. Molecular Formula: C?H??O?, Molecular Weight: 184.19. US Biological Life Sciences. | Worldwide |
| C646 | C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. Preferentially selective for p300 versus other acetyltransferases. Synonyms: C646; C-646; C 646. Grades: >98%. CAS No. 328968-36-1. Molecular formula: C24H19N3O6. Mole weight: 445.42. | |
| C646 | Reversible cell permeable p300/CBP histone acetyltransferase (HAT) inhibitor. Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%). Cell growth inhibitor in melanoma and non-small-cell-lung (NSCL) human cancer cell lines. Group: Biochemicals. Alternative Names: (E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid. Grades: Highly Purified. CAS No. 328968-36-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H19N3O6. US Biological Life Sciences. | Worldwide |
| CAY10669 | P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a co-activator of p53-target genes and moreover it regulates p53 activity by acetylating K320, which promotes p53-dependent p21 transcription and cell cycle arrest during DNA damage. CAY10669 is an inhibitor of the histone acetyltransferase PCAF, which displays 2-fold improvement in inhibitory potency over anacardic acid. Synonyms: CAY 10669; CAY-10669. Grades: ≥98%. CAS No. 1243583-88-1. Molecular formula: C20H22O4. Mole weight: 326.4. | |
| CAY10685 | CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. CAY10685 is a cell-active analog of the lysine acetyltransferase inhibitor CPTH2 that contains an alkyne moiety. It can inhibit N-acetyltransferase, which shows potential applicaiton in studying the changes in nuclear architecture associated with cancer and certain laminopathies. Synonyms: CAY 10685; CAY-10685. Grades: ≥98%. CAS No. 1613116-16-7. Molecular formula: C17H16ClN3S. Mole weight: 329.8. | |
| CI-994, Free Base (4-(Acetylamino)-N-(2-aminophenyl)benzamide, Acetyldinaline, 5'-Deoxy-5-fluoro-N- ( (pentyloxy) carbonyl) cytidine, Goe 5549, Gö 5549, PD 123654, Tacedinaline) | CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells. CI-994 inhibited HDAC-1 and HDAC-2 but not the prototypical histone acetyltransferase GCN5. Group: Biochemicals. Grades: Highly Purified. CAS No. 112522-64-2. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Cpth2 | CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B). Group: Inhibitors. CAS No. 357649-93-5. Molecular formula: C14H14ClN3S. Mole weight: 291.8. Purity: ≥98%. Catalog: ACM357649935. | |
| CPTH2 | CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating Gcn5p network in vitro and in vivo. HAT is an enzyme playing an important role in histone acetylation and multiple cancer development. Uses: Antitumor agent. Synonyms: CPTH2; CPTH 2; CPTH-2; Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone. Grades: 99%. CAS No. 357649-93-5. Molecular formula: C14H14ClN3S. Mole weight: 291.8. | |
| CPTH2 | CPTH2 is a histone acetyltransferase inhibitor that modulates Gcn5p dependent functional network in vitro and in vivo. Group: Biochemicals. Alternative Names: 2-[4-(4-Chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone; 4- (4-Chlorophenyl) -2 (3H) -thiazolone-cyclopentylidene hydrazone. Grades: Highly Purified. CAS No. 357649-93-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| CTB | CTB is a potent p300 histone acetyltransferase activator [1]. CTB can effectively induce apoptosis in MCF-7 cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 451491-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134964. | |
| CTB ACT activator | Histone Acetyltransferase Activator, CTB, also referenced under CAS 451491-47-7, modulates the biological activity of Histone. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Activators. Alternative Names: CTB ACT activator; CTB; Histone Acetyltransferase Activator. CAS No. 451491-47-7. Molecular formula: C16H13ClF3NO2. Mole weight: 343.73. Appearance: Solid powder. Purity: >98%. IUPACName: N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide. Canonical SMILES: O=C (NC1=CC=C (Cl)C (C (F) (F)F)=C1)C2=CC=CC=C2OCC. Catalog: ACM451491477-1. | |
| CTPB | CTPB is an amide derivative that acts as a selectively activator of the histone acetyltransferase (HAT) p300, with maximal activation at 275 μM. Synonyms: N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-6-pentadecyl-benzamide. Grades: ≥98%. CAS No. 586976-24-1. Molecular formula: C31H43ClF3NO2. Mole weight: 554.1. | |
| Curcumin | Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs , and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. Uses: Scientific research. Group: Natural products. Alternative Names: Diferuloylmethane; Natural Yellow 3; Turmeric yellow. CAS No. 458-37-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-N0005. | |
| Curcumin (Standard) | Curcumin (Standard) is the analytical standard of Curcumin. This product is intended for research and analytical applications. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. Uses: Scientific research. Group: Natural products. CAS No. 458-37-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0005R. | |
| Garcinol | Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica , exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC 50 s of 0.66 μM and 7.39 μM, respectively [1]. Garcinol also inhibits histone acetyltransferases ( HATs , IC 50 = 7 μM) and p300/CPB-associated factor ( PCAF , IC 50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity [2]. Uses: Scientific research. Group: Natural products. CAS No. 78824-30-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-107569. | |
| Garcinol | Garcinol is an inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 = 5 and 7 μM, respectively), which is isolated from Garcinia indica. It also inhibits the HAT GCN5 in Cryptococcus neoformans. Garcinol promotes expansion of human HSCs ex vivo. It induces apoptosis in some cancer cells thus can be used as a cancer therapy. Synonyms: Camboginol; (1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione. Grades: ≥98% by HPLC. CAS No. 78824-30-3. Molecular formula: C38H50O6. Mole weight: 602.8. | |
| HAT Inhibitor II | HAT Inhibitor II is a cell-permeable and selective inhibitor of the histone acetyltransferase p300 (IC50 = 5 μM). It has been shown to decrease histone H3 acetylation (IC50 ≤ 40 μM) and induce chromatin condensation in HeLa cells. Synonyms: Histone Acetyltransferase Inhibitor II; (2E,6E)-2,6-bis[(3-bromo-4-hydroxyphenyl)methylidene]cyclohexan-1-one. Grades: ≥98%. CAS No. 932749-62-7. Molecular formula: C20H16Br2O3. Mole weight: 464.2. | |
| histone deacetylase | A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. May be identical to EC 3.5.1.17, acyl-lysine deacylase. Group: Enzymes. Synonyms: HDAC. Enzyme Commission Number: EC 3.5.1.98. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4490; histone deacetylase; EC 3.5.1.98; HDAC. Cat No: EXWM-4490. | |
| I-CBP112 hydrochloride | I-CBP112 is a selective inhibitor of CBP and EP300 bromodomain (Kds = 0.142 and 0.625 μM, respectively). CBP and EP300 are histone acetyltransferase (HAT) enzymes that serve as transcriptional coactivators and have been found to be dysregulated in cancer and other diseases. Synonyms: 1-[7-(3,4-dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]propan-1-one hydrochloride. Grades: ≥90%. CAS No. 2147701-33-3. Molecular formula: C27H36N2O5·HCl. Mole weight: 505.1. | |
| Inobrodib | Inobrodib is an inhibitor of the histone acetyltransferase p300 and CREB-binding protein and has antineoplastic activity. Synonyms: (6S)-1-(3,4-difluorophenyl)-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(trans-4-methoxycyclohexyl)-1H-benzimidazol-2-yl]piperidin-2-one; (S)-1-(3,4-difluorophenyl)-6-(5-(3,5-dimethylisoxazol-4-yl)-1-((1R,4S)-4-methoxycyclohexyl)-1H-benzo[d]imidazol-2-yl)piperidin-2-one; CBP-IN-1; CCS-1477; (6S)-1-(3,4-Difluorophenyl)-6-[5-(3,5-dimethyl-4-isoxazolyl)-1-(trans-4-methoxycyclohexyl)-1H-benzimidazol-2-yl]-2-piperidinone; CCS 1477; CCS1477. Grades: >98%. CAS No. 2222941-37-7. Molecular formula: C30H32F2N4O3. Mole weight: 534.60. | |
| L002 | L002 is an inhibitor of p300 histone acetyltransferase with IC50 value of 1.98 μM in vitro, which is a lysine acetyltransferase that catalyzes acetyl group attachment to lysine residues of a variety of proteins. It has weaker inhibitory effects against PCAF and GCN5. It acts as a critical coactivator of several oncogenic transcription factors involved in cancer cell survival and proliferation. It blocks acetylation of histones and p53, and reduces STAT3 phosphorylation in MDA-MB-468 xenografts, leukemia and lymphoma cell lines. It induces growth arrest and apoptosis in certain cancer cell lines and suppresses the growth of triple-negative breast cancer xenografts. Synonyms: 2,6-Dimethyl-2,5-cyclohexadiene-1,4-dione 4-[O-[(4-methoxyphenyl)sulfonyl]oxime]; 4-[O-[(4-Methoxyphenyl)sulfonyl]oxime]-2,6-dimethyl-2,5-cyclohexadiene-1,4-dione; NSC764414; NSC 764414; NSC-764414; L002; L 002; L-002. Grades: ≥98% by HPLC. CAS No. 321695-57-2. Molecular formula: C15H15NO5S. Mole weight: 321.35. | |
| MG149 | MG149 is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively. Synonyms: MG149; MG 149; MG-149. Grades: >98%. CAS No. 1243583-85-8. Molecular formula: C22H28O3. Mole weight: 340.46. | |
| Na-Acetyl-L-lysine Amide Hydrochloride (Ac-L-Lys-NH2·HCl) | A lysine analog used in the preparation of selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Group: Biochemicals. Alternative Names: Ac-L-Lys-NH2·HCl; Ac-Lys-NH? HCl; (2S)-2-(Acetylamino)-6-aminohexanamide Hydrochloride; (S)-2-(Acetylamino)-6-aminohexanamide Monohydrochloride; N-Acetyllysine Amide Hydrochloride. Grades: Highly Purified. CAS No. 104584-11-4. Pack Sizes: 100mg, 250mg, 1g. Molecular Formula: C8H17N3O2·HCl, Molecular Weight: 223.7. US Biological Life Sciences. | Worldwide |
| Nα-Acetyl-L-lysine amide hydrochloride | A lysine analog used in the preparation of selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Synonyms: Ac-L-Lys-NH2 HCl; N-Acetyl-L-Lysine Amide Hydrochloride; (2S)-2-acetamido-6-aminohexanamide hydrochloride. Grades: ≥ 99% (TLC). CAS No. 104584-11-4. Molecular formula: C8H17N3O2·HCl. Mole weight: 223.70. | |
| NU 9056 | NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 = < 2, 60, 36, and>100 μM for KAT5, p300, pCAF and GCN5, respectively). NU 9056 treatment inhibited cellular proliferation in a panel of prostate cancer cell lines (50% growth inhibition, 8-27 μM) and induced apoptosis via activation of caspase 3 and caspase 9 in a concentration- and time-dependent manner. Also, decreased androgen receptor, prostate specific antigen, p53 and p21 protein levels were demonstrated in response to treatment with NU 9056. Synonyms: NU 9056; NU9056; NU-9056; 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole. CAS No. 1450644-28-6. Molecular formula: C6H4N2S4. Mole weight: 232.37. | |
| Procyanidin B3 | Procyanidin B3 is a natural product with antioxidant activity and oral bioavailability, possessing good blood-brain barrier penetration. Procyanidin B3 is a selective inhibitor of histone acetyltransferase ( HAT ). By inhibiting p300 HAT -mediated acetylation of the androgen receptor ( androgen receptor ). Procyanidin B3 alleviates intervertebral disc degeneration (IVDD) by inhibiting the formation of the TLR4/MD-2 complex. Procyanidin B3 can be used in research on prostate cancer and arthritis [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 23567-23-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N2345. | |
| (S,S)-CPI-1612 | (S,S)-CPI-1612 is the isomer of CPI-1612 (HY-136285), and can be used as an experimental control. CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC 50 of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2374971-82-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145386. | |
| TH 1834 | TH 1834 is a Tip60 histone acetyltransferase inhibitor. TH 1834 causes apoptosis and increases unrepaired DNA damage (following ionizing radiation treatment) in breast cancer cells, yet not control cell lines or affect the activity of related HAT MOF. Synonyms: TH 1834; TH1834; TH-1834; 2-[5- (4-{[ (2-phenylethyl) ({4-[4- (pyrrolidin-1-ylmethyl) phenoxy]butyl}) amino]methyl}phenyl) -2H-1, 2, 3, 4-tetrazol-2-yl]acetic acid. Grades: 99%. Molecular formula: C33H40N6O3.2HCl. Mole weight: 641.63. | |
| TTK21 | TTK21 is an activator of CBP/p300 histone acetyltransferase activity. Group: Activators. Alternative Names: TTK21; TTK-21; TTK 21. CAS No. 709676-56-2. Molecular formula: C17H15ClF3NO2. Mole weight: 357.76. Appearance: Solid powder. Purity: >98%. IUPACName: N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-benzamide. Canonical SMILES: O=C (NC1=CC=C (Cl)C (C (F) (F)F)=C1)C2=CC=CC=C2OCCC. Catalog: ACM709676562. | |
| TTK21 | TTK21 is an activator of CBP/p300 histone acetyltransferase activity that activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner. Synonyms: N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide. Grades: ≥98%. CAS No. 709676-56-2. Molecular formula: C17H15ClF3NO2. Mole weight: 357.8. | |
| YF-2 | YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC 50 s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1311423-89-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16531. | |
| YF-2 hydrochloride | YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC 50 s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1312005-62-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-16531A. | |
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