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| Product | Description | |
|---|---|---|
| histone deacetylase | A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. May be identical to EC 3.5.1.17, acyl-lysine deacylase. Group: Enzymes. Synonyms: HDAC. Enzyme Commission Number: EC 3.5.1.98. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4490; histone deacetylase; EC 3.5.1.98; HDAC. Cat No: EXWM-4490. |  |
| HDAC Inhibitor XVII ((E)-N-Hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide, Histone Deacetylase Inhibitor XVII) | A cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC50 = 27nM), displaying much reduced or little potency against HDAC1/3 (IC50 = 3.0uM), HDAC2/4/6/10/11 (IC50 >20uM), or total HDAC activity in HeLa nuclear extract (IC50 >10uM). Reported to preferentially inhibit the proliferation of human lung cancer cells CL1-5, H1299, and A549 (IC50 from 7 to 8uM), while being much less toxic to normal human lung IMR-90 cells (73% inhibition at 40uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??NO?, Primary Target IC50: 27nM. US Biological Life Sciences. |  Worldwide |
| Sodium Butyrate, 0.5M (Histone Deacetylase Inhibitor) | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 10ml, 25ml, 50ml. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
| Sodium Butyrate, 1M (Histone Deacetylase Inhibitor) | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 10ml, 25ml, 50ml. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
| Trichostatin A (TSA) (Histone Deacetylase Inhibitor)89/1/20 | Trichostatin A is an antifungal antibiotic that is a reversible, potent and specific inhibitor of mammalian histone deacetylase (HDAC) both in vivo and in vitro. Histone deacetylase inhibition causes chromatin relaxation and gene expression modulation. May induce apoptosis. TSA inhibits the eukaryotic cell cycle and induces morphological reversion of transformed cells. It blocks cell cycle progression at G1 phase in Hela Cells. TSA causes accumulation of highly acetylated histones in vivo, while inhibiting the activity of partially purified histone deacetylase in vitro. Group: Biochemicals. Alternative Names: 4,6-Dimethyl-7-[p-dimethylaminophenyl]- 7-oxohepta-2, 4-dienohydroxamic acid). Grades: Highly Purified. CAS No. 58880-19-6. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole | Histone deacetylase (HDAC) inhibitors are able to interrupt cell cycle progression in transformed cell lines and may be explored as new clinical agents in cancer therapy. 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole has been shown to suppress the biological effects induced by the HDAC inhibitor, Trichostatin A (T774710). Group: Biochemicals. Grades: Highly Purified. CAS No. 200626-61-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C13H7Cl2N3O, Molecular Weight: 292.12. US Biological Life Sciences. | Worldwide |
| 1-(2-Aminothiazol-4-yl)ethanone | 1-(2-Aminothiazol-4-yl)ethanone is a versatile reactant, used as intermediate in preparation of multicyclic sulfonamide compounds as histone deacetylase inhibitors useful in treatment and prevention of diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 101258-16-6. Pack Sizes: 25mg, 50mg. Molecular Formula: C5H6N2OS, Molecular Weight: 142.18. US Biological Life Sciences. | Worldwide |
| 1- (4- (1, 3, 4-Oxadiazol-2-yl) phenyl) -3- ( (5- (2, 2, 2-trifluoroacetyl) thiophene-2-carbonyl) oxy) guanidine | 1- (4- (1, 3, 4-Oxadiazol-2-yl) phenyl) -3- ( (5- (2, 2, 2-trifluoroacetyl) thiophene-2-carbonyl) oxy) guanidine is an intermediate in the synthesis of potential class II human histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C16H10F3N5O4S. US Biological Life Sciences. | Worldwide |
| 1-(4-Hydroxyphenyl)-2-chloroethanol | 1-(4-Hydroxyphenyl)-2-chloroethanol is synthesized from 2-Chloro-1-(4-hydroxy-phenyl)-ethanone. 2-Chloro-1-(4-hydroxy-phenyl)-ethanone is a reagent that is used in the preparation of hydroxypyrimidine derivatives and their HDAC (histone deacetylases) inhibitory activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 4973-17-5. Pack Sizes: 250mg, 2.5g. Molecular Formula: C8H9ClO2, Molecular Weight: 172.61. US Biological Life Sciences. | Worldwide |
| 1-Alaninechlamydocin | It is a cyclic tetrapeptide antibiotic containing a single β-amino acid, which was isolated from diheterospora chlamydosporia in 1992. It is less widely characterised than the related chlamydocin. It exhibits potent antitumor activity and acts by inhibiting histone deacetylase. Synonyms: Cyclo[L-alanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxooxiraneoctanoyl]; (S)-Cyclo(L-alanyl-L-phenylalanyl-D-prolyl-η-oxo-L-α-aminooxiraneoctanoyl). Grades: >95% by HPLC. CAS No. 141446-96-0. Molecular formula: C27H36N4O6. Mole weight: 512.61. |  |
| 1-?Aminocycloheptane car?boxylic Acid | 1-?Aminocycloheptane car?boxylic Acid is used in the synthesis of chlamydocin-hydroxamic acid analogs with histone deacetylase inhibitory activities. It is also used to prepare imidazobioxazolium triflates as precursors for sterically hindered and electron-donating N-heterocyclic carbene ligands. Group: Biochemicals. Grades: Highly Purified. CAS No. 6949-77-5. Pack Sizes: 250mg, 1g. Molecular Formula: C8H15NO2, Molecular Weight: 157.21. US Biological Life Sciences. | Worldwide |
| 1-Methyl-1,8-diazaspiro[4.5]decane Dihydrochloride | 1-Methyl-1,8-diazaspiro[4.5]decane Dihydrochloride is used in the image-guided synthesis of potent blood-brain barrier permeable histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1432679-85-0. Pack Sizes: 10mg, 25mg. Molecular Formula: C9H18N2; HCi, Molecular Weight: 154.252364599999. US Biological Life Sciences. | Worldwide |
| 1-(Pyrazin-2-yl)-2-trifluoroacetyl Hydrazine | 1-(Pyrazin-2-yl)-2-trifluoroacetyl Hydrazine can be used as reactant/reagent in synthetic preparation of tricyclic hydroxamic acids as inhibitors of histone deacetylase. Group: Biochemicals. Grades: Highly Purified. CAS No. 837430-15-6. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C6H5F3N4O, Molecular Weight: 206.13. US Biological Life Sciences. | Worldwide |
| 2-?[[2-? (Dimethylamino) ?ethyl]?thio]?-acetic Acid | 2-?[[2-? (Dimethylamino) ?ethyl]?thio]?-acetic Acid functions as a co-drugs, and also acts as a reagent for the preparation of hydroxamate-based histone deacetylase inhibitors for enhancing activity of antifungal agents which inhibit a step in the ergosterol synthesis pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 933682-63-4. Pack Sizes: 1g, 10g. Molecular Formula: C6H13NO2S, Molecular Weight: 163.24. US Biological Life Sciences. | Worldwide |
| 2-[4- (1, 3, 4-Oxadiazol-2-yl) phenoxy]acetamidoxime | 2-[4- (1, 3, 4-Oxadiazole-2-yl) phenoxy]acetamidoxime is a reagent that is used to synthesize fluoroacetylthiophene oxadiazoles as class II human histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 258521-20-9. Pack Sizes: 100mg, 1g. Molecular Formula: C10H10N4O3. US Biological Life Sciences. | Worldwide |
| 2-[4- (1, 3, 4-Oxadiazol-2-yl) phenoxy]acetonitrile | 2-[4- (1, 3, 4-Oxadiazol-2-yl) phenoxy]acetonitrile is an intermediate in the synthesis of potential class II human histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 871218-36-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H7N3O2. US Biological Life Sciences. | Worldwide |
| 2,4,6-Tribromobenzyl Bromide | 2,4,6-Tribromobenzyl Bromide acts as a reagent for the design, synthesis and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry. Group: Biochemicals. Grades: Highly Purified. CAS No. 54459-64-2. Pack Sizes: 10g, 25g. Molecular Formula: C7H4Br4, Molecular Weight: 407.72. US Biological Life Sciences. | Worldwide |
| [2-(4-Fluorophenyl)thiazol-4-yl]methanol | [2-(4-Fluorophenyl)thiazol-4-yl]methanol is an intermediate used in preparation of azole compounds as histone deacetylase (HDAC) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 885280-13-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H8FNOS, Molecular Weight: 209.24. US Biological Life Sciences. | Worldwide |
| 2- [ (4-Nitrophenyl) methylene] hydrazinecarboxamide | 2- [ (4-Nitrophenyl) methylene] hydrazinecarboxamide can be used to prepare benzimidazole derivatives. It is also a useful compound for developing histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 5315-87-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H8N4O3, Molecular Weight: 208.17. US Biological Life Sciences. | Worldwide |
| 2-?Amino-?N-?(1-?phenyl-?ethyl)?-?benzamide | 2-?Amino-?N-?(1-?phenyl-?ethyl)?-?benzamide is a reagent used in the synthesis of potent inhibitors of class III histone/protein deacetylases. As well, used to prepare agents promoting anticonvulsant activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 85592-80-9. Pack Sizes: 250mg, 500mg. Molecular Formula: C15H16N2O. US Biological Life Sciences. | Worldwide |
| 2-Chloro-1-(4-hydroxy-phenyl)-ethanone | 2-Chloro-1-(4-hydroxy-phenyl)-ethanone is a reagent that is used in the preparation of hydroxypyrimidine derivatives and their HDAC (histone deacetylases) inhibitory activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 6305-04-0. Pack Sizes: 500mg, 5g. Molecular Formula: C8H7ClO2, Molecular Weight: 170.59. US Biological Life Sciences. | Worldwide |
| 2-Ethynylbiphenyl-13C6 | 2-Ethynylbiphenyl-13C6 is a reactant used in the preparation of labelled histone deacetylase (HDAC) inhibitors and EGFR tyrosine inhibitors. Group: Biochemicals. Alternative Names: 1-Ethynyl-2-phenylbenzene13C6; 2-Biphenylylacetylene 13C6. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 2-Formylcyclopropane-1-carboxylic Acid Ethyl Ester | 2-Formylcyclopropane-1-carboxylic Acid Ethyl Ester acts as a reagent for the design, synthesis and biological evaluation of first-in-class dual acting histone deacetylase (HDACs) and phosphodiesterase 5 (PDE5) inhibitors for treatment of Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 20417-61-2. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H10O3, Molecular Weight: 142.15. US Biological Life Sciences. | Worldwide |
| 2-Hexyl-4-pentynoic acid | 2-hexyl-4-pentynoic acid is a derivative of valproic acid, an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 μM) than valproic acid (IC50 = 398 μM). Synonyms: 2-(prop-2-yn-1-yl)octanoic acid. Grades: ≥95%. CAS No. 96017-59-3. Molecular formula: C11H18O2. Mole weight: 182.3. | |
| 2-?Nitrophenyl Isocyanate | 2-?Nitrophenyl Isocyanate is a reagent used in the synthesis of histone deacetylase class III inhibitors which exhibit antiproliferative activity against cancer cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 3320-86-3. Pack Sizes: 250mg, 1g. Molecular Formula: C7H4N2O3, Molecular Weight: 164.12. US Biological Life Sciences. | Worldwide |
| 2-Oxo-1,2,3,4-tetrahydroquinoline-6-sulfonyl Chloride | 2-Oxo-1,2,3,4-tetrahydroquinoline-6-sulfonyl Chloride is a reactant used in the synthesis of pan-histone deacetylase (pan-HDAC) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 66657-42-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H8ClNO3S, Molecular Weight: 245.68. US Biological Life Sciences. | Worldwide |
| (2-Thienylthio) acetonitrile | (2-Thienylthio) acetonitrile is an intermediate in the synthesis of possible class II human histone deacetylase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 26031-45-8. Pack Sizes: 1g, 5g. Molecular Formula: C6H5NS2. US Biological Life Sciences. | Worldwide |
| 3-[ (2-Thienylsulfonyl) methyl]-5-[5-trifluoroacetyl-thien-2-yl]-1, 2, 4-oxadiazole | 3-[ (2-Thienylsulfonyl) methyl]-5-[5-trifluoroacetyl-thien-2-yl]-1, 2, 4-oxadiazole is a possible class II human histone deacetylase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 946499-88-3. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C13H7F3N2O4S3. US Biological Life Sciences. | Worldwide |
| 3-[4-(1,3,4-Oxadiazol-2-yl)phenoxymethyl]-5-[5-trifluoroacetyl-thien-2-yl]-1,2,4-oxadiazole | 3-[4-(1,3,4-Oxadiazol-2-yl)phenoxymethyl]-5-[5-trifluoroacetyl-thien-2-yl]-1,2,4-oxadiazole is a possible class II human histone deacetylase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 946500-06-7. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C17H9F3N4O4S. US Biological Life Sciences. | Worldwide |
| 3-? ( (4-?Methylpiperazin-?1-?yl) ?methyl) ?benzonitrile | 3-? ( (4-?Methylpiperazin-?1-?yl) ?methyl) ?benzonitrile is involved in the preparation of N- hydroxyphenyl acryl amide s and N-Hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 859850-90-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C13H17N3, Molecular Weight: 215.29. US Biological Life Sciences. | Worldwide |
| 3-Bromo-4- (methoxymethoxy) benzaldehyde | 3-Bromo-4- (methoxymethoxy) benzaldehyde is an intermediate in synthesizing CARM1-IN-1 Hydrochloride (C183610), a mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 162269-90-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C9H9BrO3. US Biological Life Sciences. | Worldwide |
| 3-Pyridinemethanol | 3-Pyridinemethanol, an aromatic alcohol compound, is a widely used in the synthesis of some inhibitors like Chk1 and histone deacetylase inhibitors. Uses: 3-pyridinemethanol is a widely used in the synthesis of some inhibitors like chk1 and histone deacetylase inhibitors. Synonyms: pyridin-3-ylmethanol. Grades: 95 %. CAS No. 100-55-0. Molecular formula: C6H7NO. Mole weight: 109.13. | |
| 4,5-Diaminopyrimidine | 4,5-Diaminopyrimidine is an intermediate in the synthesis of Nisin, a compound that was first introduced as a good preservative and was later on discovered to have antibacterial activity against gram positive bacteria. 4,5-Diaminopyrimidine is also used as a reagent to synthesize uracil-based 2-aminoanilide derivatives, compounds that act as histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 13754-19-3. Pack Sizes: 1g, 5g. Molecular Formula: C4H6N4, Molecular Weight: 110.12. US Biological Life Sciences. | Worldwide |
| 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline (Compound 11 and 15) is a building block and synthetic intermediate, which can be used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer agents. 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline can also be used to synthesize EGFR inhibitors, including Erlotinib (HY-50896), with antiproliferative activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183322-18-1. Pack Sizes: 50 mg; 100 mg; 500 mg. Product ID: HY-W007977. |  |
| 4-Ethyl-2,3-dioxopiperazine-1-carbonyl Chloride | 4-Ethyl-2,3-dioxo-1-piperazinecarbonyl Chloride is used as a reagent in the synthesis of amino(thienyl)benzamide derivatives which are used as histone deacetylase inhibitors and have antitumor activity. 4-Ethyl-2,3-dioxo-1-piperazinecarbonyl Chloride is also a reagent in the synthesis of Cefbuperazone ; a second-generation cephalosporin antibiotic. Synonyms: 4-ethyl-2,3-dioxo-1-piperazinecarbonyl chloride; 4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride. Grades: > 95 %. CAS No. 59703-00-3. Molecular formula: C7H9ClN2O3. Mole weight: 204.61. | |
| 4-Iodo-SAHA | 4-Iodo-SAHA is a hydrophobic derivative of the class I and class II histone deacetylase (HDAC) inhibitor SAHA. Synonyms: N1-hydroxy-N8-(4-iodophenyl)octanediamide. Grades: ≥98%. CAS No. 1219807-87-0. Molecular formula: C14H19IN2O3. Mole weight: 390.2. | |
| 4SC-202 | 4SC-202 is a selective and potent, orallly available inhibitor of histone deacetylases (HDAC) specific for class 1 HDAC isoenzymes, with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. 4SC-202 also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM. Synonyms: 4SC202; 4SC-202; 4SC 202; domatinostat; (E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide. CAS No. 910462-43-0. Molecular formula: C23H21N5O3S. Mole weight: 447.51. | |
| 4SC-202 Tosylate | 4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones.This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins. Synonyms: 4SC-202; 4SC 202; 4SC202. Grades: 0.98. CAS No. 1186222-89-8. Molecular formula: C30H29N5O6S2. Mole weight: 619.711. | |
| 5-Phenylpentan-2-one | 5-Phenylpentan-2-one is a potent histone deacetylases (HDACs) inhibitor. 5-Phenylpentan-2-one can be used for urea cycle disorder research. Group: Inhibitors. Alternative Names: 2-Pentanone, 5-phenyl-, 5-Phenylpentan-2-one, Methyl 3-phenylpropyl ketone, 5-PHENYL-2-PENTANONE, NSC167086, CID16701, EINECS 218-794-4, ZINC01659989, AI3-11039, 2235-83-8. CAS No. 2235-83-8. Molecular formula: C11H14O. Mole weight: 162.228260 [g/mol]. Appearance: Liquid. Purity: 0.96. IUPACName: 5-phenylpentan-2-one. Canonical SMILES: CC(=O)CCCC1=CC=CC=C1. Density: 0.96g/cm³. ECNumber: 218-794-4. Catalog: ACM2235838. |  |
| 6-Bromobenzothiophene-2-carboxylic Acid Methyl Ester | 6-Bromobenzo[b]thiophene-2-carboxylic acid methyl ester is used in the synthesis of benzothiophene derivatives as histone deacetylase inhibitors. Group: Biochemicals. Alternative Names: 6-Bromo-1-benzothiophene-2-carboxylic Acid Methyl Ester; 6-Bromobenzo[b]thiophene-2-carboxylic Acid Methyl Ester; Methyl 6-bromo-1-benzothiophene-2-carboxylate; Methyl 6-Bromobenzo[b]thiophene-2-carboxylate. Grades: Highly Purified. CAS No. 360576-01-8. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Abexinostat | Abexinostat, also known as PCI-24781 or CRA-024781, is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling. Synonyms: CRA-024781; CRA 024781; CRA024781; PCI-24781; PCI24781; PCI 24781. Grades: 98%. CAS No. 783355-60-2. Molecular formula: C21H23N3O5. Mole weight: 397.431. | |
| Ac-Arg-Gly-Lys-AMC | Ac-Arg-Gly-Lys-AMC is a control for the two step histone deacetylase assay with Ac-Arg-Gly-Lys(Ac)-AMC. It corresponds to the product of the deacetylase reaction, which is subsequently cleaved by trypsin. Synonyms: Ac-RGK-AMC; N2-Acetyl-L-arginylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-Lysinamide; N2-Acetyl-L-arginylglycyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide; (S)-2-(2-((S)-2-acetamido-5-guanidinopentanamido)acetamido)-6-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide. Grades: ≥95%. CAS No. 660846-99-1. Molecular formula: C26H38N8O6. Mole weight: 558.64. | |
| Ac-Gly-Ala-Lys-AMC | Ac-Gly-Ala-Lys-AMC is the control peptide for protease-coupled histone deacetylase (HDAC) assay with Ac-Gly-Ala-Lys(Ac)-AMC. Synonyms: Ac-GAK-AMC; N-Acetylglycyl-L-alanyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide; L-lysinamide, N-acetylglycyl-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-. Grades: ≥95%. CAS No. 1926163-46-3. Molecular formula: C23H31N5O6. Mole weight: 473.52. | |
| Ac-Lys-AMC | Ac-Lys-AMC, also known as MAL, is a fluorescent substrate for histone deacetylases (HDACs). Synonyms: (S)-2-Acetamido-6-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide; N2-Acetyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide; Hexanamide, 2-(acetylamino)-6-amino-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, (2S)-. Grades: ≥98%. CAS No. 156661-42-6. Molecular formula: C18H23N3O4. Mole weight: 345.40. | |
| Ac-Lys-AMC | Ac-Lys-AMC (Hexanamide), also termed MAL, is a fluorescent substrate for histone deacetylase HDACs [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 156661-42-6. Pack Sizes: 10 mM * 1 mL; 5 mg. Product ID: HY-128919. | |
| ACY-775 | ACY-775 is a selective Histone Deacetylase 6 (HDAC6) inhbiitor with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. ACY-775 has the antidepressant-like properties of other HDAC inhibitors. Uses: Antidepressant. Synonyms: ACY-775; ACY 775; ACY775; 2-((1-(3-Fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide. Grades: 95%. CAS No. 1375466-18-4. Molecular formula: C17H19FN4O2. Mole weight: 330.36. | |
| AN-7 | AN-7 is a novel histone deacetylase inhibitor (HDACI) with anticancer activity in several cell lines. Synonyms: 3-(5-[1,2]dithiolan-3yl-pentanoylamino)-propyl]-amide. CAS No. 691410-93-2. Molecular formula: C19H34N2O2S4. Mole weight: 450.73. | |
| APHA Compound 8 | APHA Compound 8 is a synthetic HDAC (histone deacetylase) inhibitor, which is in the same structural class as SAHA. The IC50 for mouse HDAC1 is 0.5 μM. It induces histone hyperacetylation, growth inhibition, and terminal cell differentiation. Synonyms: MC-1353; MC1353; MC 1353; APHA-8; APHA Compound 8; Aroyl pyrrole hydroxy amide #8; APHA 8; APHA8. Grades: ≥98%. CAS No. 676599-90-9. Molecular formula: C16H16N2O3. Mole weight: 284.3. | |
| Apicidin | Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis. A potent, cell permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deacetylase). Inhibits HeLa cell proliferation (IC50 = 50 - 100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF-10A cells possibly by down regulating MMP-2 in a reversible manner. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin. Group: Biochemicals. Alternative Names: Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]; Cyclo(8-oxo-L-2-aminodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-D-2-piperidinecarbonyl); Apicidin Ia; OSI 2040. Grades: Highly Purified. CAS No. 183506-66-3. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
| Apicidin | Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 ( HDAC7/8 ) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: OSI 2040. CAS No. 183506-66-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6735. | |
| AR-42 | AR-42 is an orally available, broad-spectrum deactylation inhibitor of both histone and non-histone proteins which play an important role in the regulation of gene expression, cell growth and survival. In preclinical studies, AR-42 has demonstrated greater potency and activity in solid and liquid tumors when compared to vorinostat and other deacetylase inhibitors. AR-42 is currently being studied in an investigator-initiated Phase I/IIa clinical study in adult patients with relapsed or refractory multiple myeloma, chronic lymphocytic leukemia or lymphoma. Synonyms: HDAC-42; HDAC42; HDAC 42; OSU-HDAC-42; OSU HDAC 42; AR-42; AR42; AR 42. Grades: 98%. CAS No. 935881-37-1. Molecular formula: C18H20N2O3. Mole weight: 312.37. | |
| Belinostat | Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor. Belinostat targets HDAC enzymes to inhibit tumor cell proliferation and angiogenesis, induce apoptosis and promote cellular differentiation. Uses: Antineoplastic agents. Synonyms: Belinostat; PXD 101; Beleodaq; PDX101; PX 105684; PXD-101; PXD101; (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide. CAS No. 414864-00-9. Molecular formula: C15H14N2O4S. Mole weight: 318.347. | |
| β-Alanine methyl ester hydrochloride | β-Alanine Methyl Ester is an intermediate in the synthesis of Trichostatin A and Trapoxin B as histone deacetylase inhibitors. Synonyms: β-Ala-OMe HCl; Methyl 3-aminopropanoate Hydrochloride; beta-Alanine methyl ester hydrochloride; h-beta-ala-ome hydrochloride; beta-alanine methyl ester HCl; 3-aminopropanoic acid methyl ester hydrochloride; Methyl beta-alaninate hydrochloride; 3-aminopropionic acid methyl ester hydrochloride. Grades: ≥ 98% (HPLC). CAS No. 3196-73-4. Molecular formula: C4H9NO2·HCl. Mole weight: 139.62. | |
| β-Alanine Methyl Ester Hydrochloride | β-Alanine Methyl Ester is an intermediate in the synthesis of Trichostatin A (T774710) and Trapoxin B as histone deacetylase inhibitors. Group: Biochemicals. Alternative Names: (3-Methoxy-3-oxopropyl)ammonium Chloride; 3-Aminopropanoic Acid Methyl Ester Hydrochloride; 3-Aminopropionic Acid Methyl Ester Hydrochloride; 3-Aminopropionic Acid Methyl Ester Monohydrochloride; Methyl 3-Aminopropanoate Hydrochloride; Methyl 3-Aminopropionate Hydrochloride; Methyl β-Alaninate Hydrochloride. Grades: Highly Purified. CAS No. 3196-73-4. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| β-NADH, Reduced Disodium Salt (Nicotinamide Adenine Dinucleotide) | Beta-nicotinamide adenine dinucleotide hydrate. Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.NAD is a coenzyme formed from the nucleotide, nicotinamide, adenosine monophosphateand a phosphate group joining the first two components. NADP has the same structure with the addition of an extra phosphate group to AMP. NAD can be reduced to NADH during coupling with reactions which oxidize various organic substrates. For example, the reaction catalyzed by glyceraldehyde phosphate dehydrogenase during glycolysis. NADH then passes to the inside of mitochondria where it donates the electrons it is carrying to the electron tran...accomplished by the removal of hydrogen atoms. Both of these coenzymes play crucial roles in this. Each molecule of NAD+ (or NADP+) can acquire two electrons; that is, be reduced by two electrons. However, only one proton accompanies the reduction. The other proton produced as two hydrogen atoms are removed from the molecule being oxidized is liberated into the surrounding medium. Group: Biochemicals. Alternative Names: β-DPNH; β-NADH; DPNH; Diphosphopyridine nucleotide, reduced form; NADH. Grades: Highly Purified. CAS No. 606-68-8. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C21H27N7O14P2Na2, Molecular Weight: 709.41. US Biological Life Sciences. | Worldwide |
| BML-210 | BML-210 is a Histone deacetylase (HDAC) inhibitor (IC50 = 87 μM), inducingchanges in gene expression profile. Uses: A histone deacetylase (hdac) inhibitor. Synonyms: BML-210; BML 210; BML210; CAY10433; CAY-10433; CAY 10433N1-(2-aminophenyl)-N8-phenyloctanediamide; N-(2-aminophenyl)-N'-phenyl-octanediamide. Grades: ≥98%. CAS No. 537034-17-6. Molecular formula: C20H25N3O2. Mole weight: 339.43. | |
| Boc-Lys(Tfa)-AMC | Boc-Lys(Tfa)-AMC is a fluorogenic substrate for the assaying of histone deacetylase (HDAC) 4, 5 and 7 activity in a protease-coupled assay. Synonyms: tert-butyl N-[(2S)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxo-6-[(2,2,2-trifluoroacetyl)amino]hexan-2-yl]carbamate; (S)-tert-Butyl (1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxo-6-(2,2,2-trifluoroacetamido)hexan-2-yl)carbamate; Boc-L-Lys-MCA; Boc L Lys MCA. Grades: 98%. CAS No. 97885-44-4. Molecular formula: C23H28F3N3O6. Mole weight: 499.49. | |
| BRD 9757 | BRD9757 is a potent and selective histone deacetylases 6 (HDAC6) inhibitor with IC50 of 30 nM. It displays selectivity for HDAC6 over Class I HDACS (>20-fold) and Class II HDACs (>400-fold). Synonyms: N-Hydroxy-1-cyclopentene-1-carboxamide; BRD9757; BRD-9757. Grades: ≥98%. CAS No. 1423058-85-8. Molecular formula: C6H9NO2. Mole weight: 127.14. | |
| Bufexamac | Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Bufexamac is a non-steroidal anti-inflammatory drug used topically as well as rectally. Formulations containing Bufexamac is used by many patients with eczematous disorders as an alternative to topical corticosteroids. Group: Biochemicals. Alternative Names: 4-Butoxy-N-hydroxy Benzene acetamide; 2- (p-Butoxyphenyl) acetohydroxamic Acid; 4-Butoxyphenylacet hydroxamic Acid; Anderm; Bufexamic Acid; CP 1044J3; Droxarol; Droxaryl; Feximac; Flogocid; Flogocid N plastigel; Malipuran; Mofenar; Norfemac; Parfenac; Parfenal; Trolab; p-Butoxyphenylacet hydroxamic Acid; p-Butoxyphenylaceto hydroxamic Acid. Grades: Highly Purified. CAS No. 2438-72-4. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| CAY10398 | CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM. It has equivalent selectivity and is much more cost-effective for the inhibition of HDAC. The deacetylation of histones by HDAC is associated with transcriptional silencing. Synonyms: MD 85; PX 089274. Grades: ≥98%. CAS No. 193551-00-7. Molecular formula: C15H23N3O3. Mole weight: 293.4. | |
| CAY10603 | CAY10603 is a potent and selective inhibitor of HDAC6 with IC50 of 2 pM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively. Uses: Histone deacetylase inhibitors. Synonyms: CAY10603; CAY-10603; CAY 10603. Grades: >98%. CAS No. 1045792-66-2. Molecular formula: C22H30N4O6. Mole weight: 446.5. | |
| CAY10683 | Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs. Uses: Histone deacetylase inhibitors. Synonyms: CAY10683; CAY-10683; CAY 10683; Santacruzamate A. Grades: >98%. CAS No. 1477949-42-0. Molecular formula: C15H22N2O3. Mole weight: 278.35. | |
| CBHA | Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. CBHA is a cell-permeable second generation hybrid polar agent that acts as a HDAC inhibitor. It exhibits ID50 values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively. CBHA also induces apoptosis in nine different neuroblastoma cell lines in culture. Uses: Histone deacetylase inhibitors. Synonyms: Histone Deacetylase Inhibitor II; m-Carboxycinnamic acid bis-hydroxamide. Grades: ≥98%. CAS No. 174664-65-4. Molecular formula: C10H10N2O4. Mole weight: 222.2. | |
| CG200745 | CG200745 is a novel hydroxamate-based pan-histone deacetylase inhibitor (HDACI). Like other inhibitors, CG200745 has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. CG200745 inhibited deacetylation of histone H3 and tubulin as much as vorinostat and belinostat did. CG200745 also inhibited growth of prostate cancer cells, increased sub-G1 population, and activated caspase-9, -3 and -8 in LNCaP, DU145 and PC3 cells. These results indicate that CG200745 induces apoptosis. The preclinical results show that combination treatment with docetaxel and new HDACI, CG200745, potentiated anti-tumor effect in hormone-refractory prostate cancer (HRPC) cells via activation of apoptosis. Synonyms: Ivaltinostat; CG-200745; CG-2; (E)-N1-(3-(dimethylamino)propyl)-N8-hydroxy-2-((naphthalen-1-yloxy)methyl)oct-2-enediamide. CAS No. 936221-33-9. Molecular formula: C24H33N3O4. Mole weight: 427.55. | |
| Chidamide | Chidamide, also known as CS055 and HBI-8000, is an orally bioavailable benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Chidamide selectively binds to and inhibits HDAC leading to an increase of acetylation levels of histone protein H3. This agent also inhibits the expression of signaling kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, a class of enzymes that deacetylate chromatin histone proteins, are upregulated in many tumor types and play key roles in gene expression. Compared to some other benzamide type HDAC inhibitors, chidamide is more stable, more resistant to degradation and has a longer half-life. Synonyms: CS055; CS-055; CS 055; HBI-8000; HBI 8000; HBI8000; N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide. CAS No. 743420-02-2. Molecular formula: C22H19FN4O2. Mole weight: 390.418. | |
| CHR-3996 | CHR-3996 is an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins. Synonyms: CHR3996; CHR 3996; VRx-3996; VRx3996; VRx 3996; Nanatinostat; Tractinostat. CAS No. 1235859-13-8. Molecular formula: C21H20FN5O2. Mole weight: 393.42. | |
| CI-994 (4-(Acetylamino)-N-(2-aminophenyl)benzamide, Acetyldinaline, Gö 5549, PD 123654) | Cell-permeable. A histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100um for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Displays significant antitumor activity in vitro and in vivo against a broad spectrum of murine and human tumor models. Group: Biochemicals. Grades: Highly Purified. CAS No. 112522-64-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CI-994, Free Base (4-(Acetylamino)-N-(2-aminophenyl)benzamide, Acetyldinaline, 5'-Deoxy-5-fluoro-N- ( (pentyloxy) carbonyl) cytidine, Goe 5549, Gö 5549, PD 123654, Tacedinaline) | CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells. CI-994 inhibited HDAC-1 and HDAC-2 but not the prototypical histone acetyltransferase GCN5. Group: Biochemicals. Grades: Highly Purified. CAS No. 112522-64-2. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Corin | Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC) , with a K i (inact) of 110 nM for LSD1 and an IC 50 of 147 nM for HDAC1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1808113-09-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111048. | |
| CUDC-101 | CUDC-101 is a multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC. Synonyms: CUDC101; CUDC 101; CUDC-101. CAS No. 1012054-59-9. Molecular formula: C24H26N4O4. Mole weight: 434.496. | |
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