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| Product | Description | |
|---|---|---|
| histone deacetylase | A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. May be identical to EC 3.5.1.17, acyl-lysine deacylase. Group: Enzymes. Synonyms: HDAC. Enzyme Commission Number: EC 3.5.1.98. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4490; histone deacetylase; EC 3.5.1.98; HDAC. Cat No: EXWM-4490. |  |
| Histone Deacetylase 6, GST-Fusion, Human Recombinant, S. frugiperda | Histone Deacetylase 6, GST-Fusion, Human Recombinant, S. frugiperda, is a full-length HDAC6 fused to GST at the N-terminus. Useful in the study of HDAC6 regulation and for inhibitor screening. Group: Fluorescence/luminescence spectroscopy. |  |
| Histone Deacetylase 8, His Tag, Human Recombinant, S. frugiperda | Human Recombinant, S. frugiperda, is a full length HDAC8 fused to His-Tag at the C-terminus. Useful in the study of HDAC8 regulation and for inhibitor screening. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase Inhibitor II - CAS 174664-65-4 | The Histone Deacetylase Inhibitor II, also referenced under CAS 174664-65-4, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase Inhibitor III | The Histone Deacetylase Inhibitor III, also referenced under CAS 251456-60-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase Inhibitor IV - CAS 537034-15-4 | The Histone Deacetylase Inhibitor IV, also referenced under CAS 537034-15-4, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 | The Histone Deacetylase Inhibitor VI, HNHA, also referenced under CAS 926908-04-5, controls the biological activity of Histone Deacetylase. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 | The Histone Deacetylase Inhibitor VII, 106, also referenced under CAS 937039-45-7, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 | The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 10 (HDAC10) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 1 (HDAC1) antibody, Mouse monoclonal | clone HDAC1-21, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 1 (HDAC1) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 2 (HDAC2) antibody, Mouse monoclonal | clone HDAC2-62, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 2 (HDAC2) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 3 (HDAC3) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 4 (HDAC4) antibody, Mouse monoclonal | clone HDAC4-144, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 4 (HDAC4) (DM-15) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 4 (HDAC4) (ML-19) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 5 (HDAC5) antibody, Mouse monoclonal | clone HDAC5-35, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 5 (HDAC5) (NA-16) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 6 (HDAC6) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 7 (HDAC7) antibody, Mouse monoclonal | clone HDAC7-97, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 7 (HDAC7) (KG-17) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 7 (HDAC7) (YS-19) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Histone Deacetylase 8 (HDAC8) antibody produced in rabbit | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| HDAC Inhibitor XVII ((E)-N-Hydroxy-4-methoxy-2-(biphenyl-4-yl)cinnamide, Histone Deacetylase Inhibitor XVII) | A cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC50 = 27nM), displaying much reduced or little potency against HDAC1/3 (IC50 = 3.0uM), HDAC2/4/6/10/11 (IC50 >20uM), or total HDAC activity in HeLa nuclear extract (IC50 >10uM). Reported to preferentially inhibit the proliferation of human lung cancer cells CL1-5, H1299, and A549 (IC50 from 7 to 8uM), while being much less toxic to normal human lung IMR-90 cells (73% inhibition at 40uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??NO?, Primary Target IC50: 27nM. US Biological Life Sciences. |  Worldwide |
| Monoclonal Anti-Histone Deacetylase 3 (HDAC3) antibody produced in mouse | ~1 mg/mL, clone HDAC3-83, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Monoclonal Anti-Histone Deacetylase 8 (HDAC8) antibody produced in mouse | 2.0-2.5 mg/mL, clone HDAC8-48, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Sodium Butyrate, 0.5M (Histone Deacetylase Inhibitor) | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 10ml, 25ml, 50ml. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
| Sodium Butyrate, 1M (Histone Deacetylase Inhibitor) | A short chain fatty acid shown to be an inhibitor of histone deacetylase (HDAC). Induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and inteferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protease kinase casein kinase II in HT29 cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 156-54-7. Pack Sizes: 10ml, 25ml, 50ml. Molecular Formula: C?H?NaO?, Molecular Weight: 110.09. US Biological Life Sciences. | Worldwide |
| Trichostatin A (TSA) (Histone Deacetylase Inhibitor)89/1/20 | Trichostatin A is an antifungal antibiotic that is a reversible, potent and specific inhibitor of mammalian histone deacetylase (HDAC) both in vivo and in vitro. Histone deacetylase inhibition causes chromatin relaxation and gene expression modulation. May induce apoptosis. TSA inhibits the eukaryotic cell cycle and induces morphological reversion of transformed cells. It blocks cell cycle progression at G1 phase in Hela Cells. TSA causes accumulation of highly acetylated histones in vivo, while inhibiting the activity of partially purified histone deacetylase in vitro. Group: Biochemicals. Alternative Names: 4,6-Dimethyl-7-[p-dimethylaminophenyl]- 7-oxohepta-2, 4-dienohydroxamic acid). Grades: Highly Purified. CAS No. 58880-19-6. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole | Histone deacetylase (HDAC) inhibitors are able to interrupt cell cycle progression in transformed cell lines and may be explored as new clinical agents in cancer therapy. 1-(2,4-Dichlorobenzoyl)-1H-benzotriazole has been shown to suppress the biological effects induced by the HDAC inhibitor, Trichostatin A (T774710). Group: Biochemicals. Grades: Highly Purified. CAS No. 200626-61-5. Pack Sizes: 10mg, 25mg. Molecular Formula: C13H7Cl2N3O, Molecular Weight: 292.12. US Biological Life Sciences. | Worldwide |
| 1-(2-Aminothiazol-4-yl)ethanone | 1-(2-Aminothiazol-4-yl)ethanone is a versatile reactant, used as intermediate in preparation of multicyclic sulfonamide compounds as histone deacetylase inhibitors useful in treatment and prevention of diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 101258-16-6. Pack Sizes: 25mg, 50mg. Molecular Formula: C5H6N2OS, Molecular Weight: 142.18. US Biological Life Sciences. | Worldwide |
| 1- (4- (1, 3, 4-Oxadiazol-2-yl) phenyl) -3- ( (5- (2, 2, 2-trifluoroacetyl) thiophene-2-carbonyl) oxy) guanidine | 1- (4- (1, 3, 4-Oxadiazol-2-yl) phenyl) -3- ( (5- (2, 2, 2-trifluoroacetyl) thiophene-2-carbonyl) oxy) guanidine is an intermediate in the synthesis of potential class II human histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 10mg. Molecular Formula: C16H10F3N5O4S. US Biological Life Sciences. | Worldwide |
| 1-(4-Hydroxyphenyl)-2-chloroethanol | 1-(4-Hydroxyphenyl)-2-chloroethanol is synthesized from 2-Chloro-1-(4-hydroxy-phenyl)-ethanone. 2-Chloro-1-(4-hydroxy-phenyl)-ethanone is a reagent that is used in the preparation of hydroxypyrimidine derivatives and their HDAC (histone deacetylases) inhibitory activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 4973-17-5. Pack Sizes: 250mg, 2.5g. Molecular Formula: C8H9ClO2, Molecular Weight: 172.61. US Biological Life Sciences. | Worldwide |
| 1-Alaninechlamydocin | It is a cyclic tetrapeptide antibiotic containing a single β-amino acid, which was isolated from diheterospora chlamydosporia in 1992. It is less widely characterised than the related chlamydocin. It exhibits potent antitumor activity and acts by inhibiting histone deacetylase. Synonyms: Cyclo[L-alanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxooxiraneoctanoyl]; (S)-Cyclo(L-alanyl-L-phenylalanyl-D-prolyl-η-oxo-L-α-aminooxiraneoctanoyl). Grades: >95% by HPLC. CAS No. 141446-96-0. Molecular formula: C27H36N4O6. Mole weight: 512.61. |  |
| 1-?Aminocycloheptane car?boxylic Acid | 1-?Aminocycloheptane car?boxylic Acid is used in the synthesis of chlamydocin-hydroxamic acid analogs with histone deacetylase inhibitory activities. It is also used to prepare imidazobioxazolium triflates as precursors for sterically hindered and electron-donating N-heterocyclic carbene ligands. Group: Biochemicals. Grades: Highly Purified. CAS No. 6949-77-5. Pack Sizes: 250mg, 1g. Molecular Formula: C8H15NO2, Molecular Weight: 157.21. US Biological Life Sciences. | Worldwide |
| 1-Methyl-1,8-diazaspiro[4.5]decane Dihydrochloride | 1-Methyl-1,8-diazaspiro[4.5]decane Dihydrochloride is used in the image-guided synthesis of potent blood-brain barrier permeable histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1432679-85-0. Pack Sizes: 10mg, 25mg. Molecular Formula: C9H18N2; HCi, Molecular Weight: 154.252364599999. US Biological Life Sciences. | Worldwide |
| 1-(Pyrazin-2-yl)-2-trifluoroacetyl Hydrazine | 1-(Pyrazin-2-yl)-2-trifluoroacetyl Hydrazine can be used as reactant/reagent in synthetic preparation of tricyclic hydroxamic acids as inhibitors of histone deacetylase. Group: Biochemicals. Grades: Highly Purified. CAS No. 837430-15-6. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C6H5F3N4O, Molecular Weight: 206.13. US Biological Life Sciences. | Worldwide |
| 2-?[[2-? (Dimethylamino) ?ethyl]?thio]?-acetic Acid | 2-?[[2-? (Dimethylamino) ?ethyl]?thio]?-acetic Acid functions as a co-drugs, and also acts as a reagent for the preparation of hydroxamate-based histone deacetylase inhibitors for enhancing activity of antifungal agents which inhibit a step in the ergosterol synthesis pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 933682-63-4. Pack Sizes: 1g, 10g. Molecular Formula: C6H13NO2S, Molecular Weight: 163.24. US Biological Life Sciences. | Worldwide |
| 2-[4- (1, 3, 4-Oxadiazol-2-yl) phenoxy]acetamidoxime | 2-[4- (1, 3, 4-Oxadiazole-2-yl) phenoxy]acetamidoxime is a reagent that is used to synthesize fluoroacetylthiophene oxadiazoles as class II human histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 258521-20-9. Pack Sizes: 100mg, 1g. Molecular Formula: C10H10N4O3. US Biological Life Sciences. | Worldwide |
| 2-[4- (1, 3, 4-Oxadiazol-2-yl) phenoxy]acetonitrile | 2-[4- (1, 3, 4-Oxadiazol-2-yl) phenoxy]acetonitrile is an intermediate in the synthesis of potential class II human histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 871218-36-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H7N3O2. US Biological Life Sciences. | Worldwide |
| 2,4,6-Tribromobenzyl Bromide | 2,4,6-Tribromobenzyl Bromide acts as a reagent for the design, synthesis and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry. Group: Biochemicals. Grades: Highly Purified. CAS No. 54459-64-2. Pack Sizes: 10g, 25g. Molecular Formula: C7H4Br4, Molecular Weight: 407.72. US Biological Life Sciences. | Worldwide |
| [2-(4-Fluorophenyl)thiazol-4-yl]methanol | [2-(4-Fluorophenyl)thiazol-4-yl]methanol is an intermediate used in preparation of azole compounds as histone deacetylase (HDAC) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 885280-13-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H8FNOS, Molecular Weight: 209.24. US Biological Life Sciences. | Worldwide |
| 2- [ (4-Nitrophenyl) methylene] hydrazinecarboxamide | 2- [ (4-Nitrophenyl) methylene] hydrazinecarboxamide can be used to prepare benzimidazole derivatives. It is also a useful compound for developing histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 5315-87-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H8N4O3, Molecular Weight: 208.17. US Biological Life Sciences. | Worldwide |
| 2-?Amino-?N-?(1-?phenyl-?ethyl)?-?benzamide | 2-?Amino-?N-?(1-?phenyl-?ethyl)?-?benzamide is a reagent used in the synthesis of potent inhibitors of class III histone/protein deacetylases. As well, used to prepare agents promoting anticonvulsant activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 85592-80-9. Pack Sizes: 250mg, 500mg. Molecular Formula: C15H16N2O. US Biological Life Sciences. | Worldwide |
| 2-Chloro-1-(4-hydroxy-phenyl)-ethanone | 2-Chloro-1-(4-hydroxy-phenyl)-ethanone is a reagent that is used in the preparation of hydroxypyrimidine derivatives and their HDAC (histone deacetylases) inhibitory activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 6305-04-0. Pack Sizes: 500mg, 5g. Molecular Formula: C8H7ClO2, Molecular Weight: 170.59. US Biological Life Sciences. | Worldwide |
| 2-Ethynylbiphenyl-13C6 | 2-Ethynylbiphenyl-13C6 is a reactant used in the preparation of labelled histone deacetylase (HDAC) inhibitors and EGFR tyrosine inhibitors. Group: Biochemicals. Alternative Names: 1-Ethynyl-2-phenylbenzene13C6; 2-Biphenylylacetylene 13C6. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 2-Formylcyclopropane-1-carboxylic Acid Ethyl Ester | 2-Formylcyclopropane-1-carboxylic Acid Ethyl Ester acts as a reagent for the design, synthesis and biological evaluation of first-in-class dual acting histone deacetylase (HDACs) and phosphodiesterase 5 (PDE5) inhibitors for treatment of Alzheimers disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 20417-61-2. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H10O3, Molecular Weight: 142.15. US Biological Life Sciences. | Worldwide |
| 2-Hexyl-4-pentynoic acid | 2-hexyl-4-pentynoic acid is a derivative of valproic acid, an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 μM) than valproic acid (IC50 = 398 μM). Synonyms: 2-(prop-2-yn-1-yl)octanoic acid. Grades: ≥95%. CAS No. 96017-59-3. Molecular formula: C11H18O2. Mole weight: 182.3. | |
| 2-?Nitrophenyl Isocyanate | 2-?Nitrophenyl Isocyanate is a reagent used in the synthesis of histone deacetylase class III inhibitors which exhibit antiproliferative activity against cancer cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 3320-86-3. Pack Sizes: 250mg, 1g. Molecular Formula: C7H4N2O3, Molecular Weight: 164.12. US Biological Life Sciences. | Worldwide |
| 2-Oxo-1,2,3,4-tetrahydroquinoline-6-sulfonyl Chloride | 2-Oxo-1,2,3,4-tetrahydroquinoline-6-sulfonyl Chloride is a reactant used in the synthesis of pan-histone deacetylase (pan-HDAC) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 66657-42-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H8ClNO3S, Molecular Weight: 245.68. US Biological Life Sciences. | Worldwide |
| (2-Thienylthio) acetonitrile | (2-Thienylthio) acetonitrile is an intermediate in the synthesis of possible class II human histone deacetylase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 26031-45-8. Pack Sizes: 1g, 5g. Molecular Formula: C6H5NS2. US Biological Life Sciences. | Worldwide |
| 3-[ (2-Thienylsulfonyl) methyl]-5-[5-trifluoroacetyl-thien-2-yl]-1, 2, 4-oxadiazole | 3-[ (2-Thienylsulfonyl) methyl]-5-[5-trifluoroacetyl-thien-2-yl]-1, 2, 4-oxadiazole is a possible class II human histone deacetylase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 946499-88-3. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C13H7F3N2O4S3. US Biological Life Sciences. | Worldwide |
| 3-[4-(1,3,4-Oxadiazol-2-yl)phenoxymethyl]-5-[5-trifluoroacetyl-thien-2-yl]-1,2,4-oxadiazole | 3-[4-(1,3,4-Oxadiazol-2-yl)phenoxymethyl]-5-[5-trifluoroacetyl-thien-2-yl]-1,2,4-oxadiazole is a possible class II human histone deacetylase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 946500-06-7. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C17H9F3N4O4S. US Biological Life Sciences. | Worldwide |
| 3-? ( (4-?Methylpiperazin-?1-?yl) ?methyl) ?benzonitrile | 3-? ( (4-?Methylpiperazin-?1-?yl) ?methyl) ?benzonitrile is involved in the preparation of N- hydroxyphenyl acryl amide s and N-Hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 859850-90-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C13H17N3, Molecular Weight: 215.29. US Biological Life Sciences. | Worldwide |
| 3-Bromo-4- (methoxymethoxy) benzaldehyde | 3-Bromo-4- (methoxymethoxy) benzaldehyde is an intermediate in synthesizing CARM1-IN-1 Hydrochloride (C183610), a mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 162269-90-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C9H9BrO3. US Biological Life Sciences. | Worldwide |
| 3-Pyridinemethanol | 3-Pyridinemethanol, an aromatic alcohol compound, is a widely used in the synthesis of some inhibitors like Chk1 and histone deacetylase inhibitors. Uses: 3-pyridinemethanol is a widely used in the synthesis of some inhibitors like chk1 and histone deacetylase inhibitors. Synonyms: pyridin-3-ylmethanol. Grades: 95 %. CAS No. 100-55-0. Molecular formula: C6H7NO. Mole weight: 109.13. | |
| 4,5-Diaminopyrimidine | 4,5-Diaminopyrimidine is an intermediate in the synthesis of Nisin, a compound that was first introduced as a good preservative and was later on discovered to have antibacterial activity against gram positive bacteria. 4,5-Diaminopyrimidine is also used as a reagent to synthesize uracil-based 2-aminoanilide derivatives, compounds that act as histone deacetylase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 13754-19-3. Pack Sizes: 1g, 5g. Molecular Formula: C4H6N4, Molecular Weight: 110.12. US Biological Life Sciences. | Worldwide |
| 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline (Compound 11 and 15) is a building block and synthetic intermediate, which can be used as a precursor in the synthesis of receptor tyrosine kinase (RTK) inhibitors, dual RTK and histone deacetylase (HDAC) inhibitors, and anticancer agents. 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline can also be used to synthesize EGFR inhibitors, including Erlotinib (HY-50896), with antiproliferative activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183322-18-1. Pack Sizes: 50 mg; 100 mg; 500 mg. Product ID: HY-W007977. |  |
| 4-Ethyl-2,3-dioxopiperazine-1-carbonyl Chloride | 4-Ethyl-2,3-dioxo-1-piperazinecarbonyl Chloride is used as a reagent in the synthesis of amino(thienyl)benzamide derivatives which are used as histone deacetylase inhibitors and have antitumor activity. 4-Ethyl-2,3-dioxo-1-piperazinecarbonyl Chloride is also a reagent in the synthesis of Cefbuperazone ; a second-generation cephalosporin antibiotic. Synonyms: 4-ethyl-2,3-dioxo-1-piperazinecarbonyl chloride; 4-ethyl-2,3-dioxopiperazine-1-carbonyl chloride. Grades: > 95 %. CAS No. 59703-00-3. Molecular formula: C7H9ClN2O3. Mole weight: 204.61. | |
| 4-Iodo-SAHA | 4-Iodo-SAHA is a hydrophobic derivative of the class I and class II histone deacetylase (HDAC) inhibitor SAHA. Synonyms: N1-hydroxy-N8-(4-iodophenyl)octanediamide. Grades: ≥98%. CAS No. 1219807-87-0. Molecular formula: C14H19IN2O3. Mole weight: 390.2. | |
| 4SC-202 | 4SC-202 is a selective and potent, orallly available inhibitor of histone deacetylases (HDAC) specific for class 1 HDAC isoenzymes, with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. 4SC-202 also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM. Synonyms: 4SC202; 4SC-202; 4SC 202; domatinostat; (E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide. CAS No. 910462-43-0. Molecular formula: C23H21N5O3S. Mole weight: 447.51. | |
| 4SC-202 Tosylate | 4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones.This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins. Synonyms: 4SC-202; 4SC 202; 4SC202. Grades: 0.98. CAS No. 1186222-89-8. Molecular formula: C30H29N5O6S2. Mole weight: 619.711. | |
| 5-Phenylpentan-2-one | 5-Phenylpentan-2-one is a potent histone deacetylases (HDACs) inhibitor. 5-Phenylpentan-2-one can be used for urea cycle disorder research. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-Pentanone, 5-phenyl-, 5-Phenylpentan-2-one, Methyl 3-phenylpropyl ketone, 5-PHENYL-2-PENTANONE, NSC167086, CID16701, EINECS 218-794-4, ZINC01659989, AI3-11039, 2235-83-8. Product Category: Inhibitors. Appearance: Liquid. CAS No. 2235-83-8. Molecular formula: C11H14O. Mole weight: 162.228260 [g/mol]. Purity: 0.96. IUPACName: 5-phenylpentan-2-one. Canonical SMILES: CC(=O)CCCC1=CC=CC=C1. Density: 0.96g/cm³. ECNumber: 218-794-4. Product ID: ACM2235838. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 6-Bromobenzothiophene-2-carboxylic Acid Methyl Ester | 6-Bromobenzo[b]thiophene-2-carboxylic acid methyl ester is used in the synthesis of benzothiophene derivatives as histone deacetylase inhibitors. Group: Biochemicals. Alternative Names: 6-Bromo-1-benzothiophene-2-carboxylic Acid Methyl Ester; 6-Bromobenzo[b]thiophene-2-carboxylic Acid Methyl Ester; Methyl 6-bromo-1-benzothiophene-2-carboxylate; Methyl 6-Bromobenzo[b]thiophene-2-carboxylate. Grades: Highly Purified. CAS No. 360576-01-8. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Abexinostat | Abexinostat, also known as PCI-24781 or CRA-024781, is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling. Synonyms: CRA-024781; CRA 024781; CRA024781; PCI-24781; PCI24781; PCI 24781. Grades: 98%. CAS No. 783355-60-2. Molecular formula: C21H23N3O5. Mole weight: 397.431. | |
| Ac-Arg-Gly-Lys-AMC | Ac-Arg-Gly-Lys-AMC is a control for the two step histone deacetylase assay with Ac-Arg-Gly-Lys(Ac)-AMC. It corresponds to the product of the deacetylase reaction, which is subsequently cleaved by trypsin. Synonyms: Ac-RGK-AMC; N2-Acetyl-L-arginylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-Lysinamide; N2-Acetyl-L-arginylglycyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide; (S)-2-(2-((S)-2-acetamido-5-guanidinopentanamido)acetamido)-6-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide. Grades: ≥95%. CAS No. 660846-99-1. Molecular formula: C26H38N8O6. Mole weight: 558.64. | |
| Ac-Gly-Ala-Lys-AMC | Ac-Gly-Ala-Lys-AMC is the control peptide for protease-coupled histone deacetylase (HDAC) assay with Ac-Gly-Ala-Lys(Ac)-AMC. Synonyms: Ac-GAK-AMC; N-Acetylglycyl-L-alanyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-lysinamide; L-lysinamide, N-acetylglycyl-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-. Grades: ≥95%. CAS No. 1926163-46-3. Molecular formula: C23H31N5O6. Mole weight: 473.52. | |
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