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| Product | Description | |
|---|---|---|
| Histone H2A | Histone H2A is an antibacterial peptide isolated from Oncorhynchus mykiss. It has activity against bacteria and fungi. Synonyms: Ala-Glu-Arg-Val-Gly-Ala-Gly-Ala-Pro-Val-Tyr-Leu. |  |
| Histone H2A (1-129) from Xanopus> sp. | recombinant, expressed in E. coli, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| Histone H2a full length human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-Histone H2A (pThr121) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-Histone H2A.X (pSer139) antibody produced in rabbit | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-phospho-Histone H2AX (pSer139) antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Buforin-1 | The source of Buforin-1 is Bufo gargarizans. Buforin I is generated from histone H2A by pepsin-directed proteolysis in the cytoplasm of gastric gland cells. After secretion into the gastric lumen, buforin I remains adhered to the mucous biofilm that lines the stomach, thus providing a protective antimicrobial coat. Buforins also are known to possess anti-endotoxin and anticancer activities, thus making these peptides attractive reagents for pharmaceutical applications. | |
| FEN1-IN-1 | FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 824983-91-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-123834. |  |
| HI TOPK 032 | HI TOPK 032 is a novel TOPK inhibitor as a T-LAK-cell-originated protein kinase (TOPK) inhibitor, blocking phosphorylation of the substrate histone H2AX with an IC50 value of ~2 μM and providing complete inhibition at 5 μM. Uses: A novel topk inhibitor. Synonyms: HI-TOPK-032; HI-TOPK032; HI-TOPK 032. N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide. Grade: ≥98%. CAS No. 487020-03-1. Molecular formula: C20H11N5OS. Mole weight: 369.4. | |
| OTS193320 | OTS193320, a imidazo[1,2-a]pyridine compound, is a SUV39H2 methyltransferase activity inhibitor. OTS193320 decreases global histone H3 lysine 9 tri-methylation levels in breast cancer cells and triggers apoptotic cell death. Combination of OTS193320 with Doxorubicin (DOX; HY-15142A) results in reduction of ?-H2AX levels as well as cancer cell viability compared to a single agent OTS193320 or DOX[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2093401-33-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-122182. | |
| Parasin I | Parasin I, a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, is a cell permeable cationic antimicrobial agent. Synonyms: H-Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser-OH; L-lysyl-glycyl-L-arginyl-glycyl-L-lysyl-L-glutaminyl-glycyl-glycyl-L-lysyl-L-valyl-L-arginyl-L-alanyl-L-lysyl-L-alanyl-L-lysyl-L-threonyl-L-arginyl-L-seryl-L-serine. Grade: ≥95%. CAS No. 219552-69-9. Molecular formula: C82H154N34O24. Mole weight: 2000.31. | |
| Parasin I acetate | Parasin I acetate, a 19-amino acid histone H2A-derived peptide isolated from the skin mucus of wounded catfish (Parasilurus asotus), is a cell-permeable cationic antimicrobial agent. Synonyms: H-Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser-OH.CH3CO2H; L-lysyl-glycyl-L-arginyl-glycyl-L-lysyl-L-glutaminyl-glycyl-glycyl-L-lysyl-L-valyl-L-arginyl-L-alanyl-L-lysyl-L-alanyl-L-lysyl-L-threonyl-L-arginyl-L-seryl-L-serine acetate; Parasin I (Parasilurus asotus) acetate; Antiviral polypeptide (Silurus asotus) acetate. Grade: ≥95%. Molecular formula: C84H158N34O26. Mole weight: 2060.36. | |
| Parasin I TFA | Parasin I, a 19-amino acid histone H2A-derived peptide isolated from the skin of the catfish, is a cell permeable cationic antimicrobial agent. Synonyms: Parasin I trifluoroacetate salt; H-Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-D-aThr-Arg-Ser-Ser-OH.TFA. Grade: 98%. Molecular formula: C84H155F3N34O26. Mole weight: 2114.33. | |
| Rigosertib | Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle [1] [2]. Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC 50 of 9 nM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ON-01910. CAS No. 592542-59-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12037A. | |
| Rigosertib sodium | Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle [1] [2]. Rigosertib sodium is a selective and non-ATP-competitive inhibitor of PLK1 with an IC 50 of 9 nM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ON-01910 sodium. CAS No. 592542-60-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12037. | |
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