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| Product | Description | |
|---|---|---|
| HKI 357 | HKI 357. Group: Biochemicals. Grades: Purified. CAS No. 848133-17-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| HKI 357 | HKI 357 is a potent and irreversible dual inhibitor of ErbB2 (HER2) and EGFR (IC50 = 33 and 34 nM, respectively). It inhibits EGFR autophosphorylation and proliferation of NCI-H1975 cells containing L858R and T790M mutations. Uses: Antitumor agent. Synonyms: HKI 357; HKI357; HKI-357; (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide. Grades: ≥98% by HPLC. CAS No. 848133-17-5. Molecular formula: C31H29ClFN5O3. Mole weight: 574.05. |  |
| HKI-357 | HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HKI-357; HKI357; HKI 357. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 848133-17-5. Molecular formula: C31H29ClFN5O3. Mole weight: 574.05. Purity: >98%. IUPACName: (E)-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide. Canonical SMILES: O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)C2=C1)/C=C/CN(C)C. Product ID: ACM848133175. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Antibiotic 0231A | It is a 3-α-hydroxysteroid dehydrogenase inhibitor produced by the strain of Strptomyces sp. HKI 0231. It can inhibit 3-α-hydroxysteroid dehydrogenase with IC50 of 10.5 μg/mL. It has weak antimicrobial and antifungal activity (MIC is less than 100 μg/mL). Synonyms: 0231A; Benz[cd]isoindolo[2,1-a]indol-1(8H)-one, 8,8,9-trimethoxy-5-methyl-. CAS No. 357924-11-9. Molecular formula: C22H19NO4. Mole weight: 361.39. | |
| Antibiotic 0231B | It is a 3-α-hydroxysteroid dehydrogenase inhibitor produced by the strain of Strptomyces sp. HKI 0231. It can inhibit 3-α-hydroxysteroid dehydrogenase with IC50 of 2.5 μg/mL. It has weak antimicrobial and antifungal activity (MIC is less than 100 μg/mL). Synonyms: 0231B; Benz[cd]isoindolo[2,1-a]indol-1(8H)-one, 8,9-dimethoxy-5-methyl-. CAS No. 357924-12-0. Molecular formula: C21H17NO3. Mole weight: 331.36. | |
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