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| Product | Description | |
|---|---|---|
| Human Factor IX | The zymogen factor IX is a single chain vitamin K-dependent glycoprotein which is synthesized in the liver. The domain structure of factor IX is similar to that of the other vitamin K dependent coagulation factors. The NH2-terminal region contains 12 γ-carboxyglutamic acid (gla) residues which facilitate the calcium dependent binding of factor IX to negatively charged phospholipid surfaces. Two domains which are homologous to epidermal growth factor (EGF) span the region between the NH2-terminal gla domain and the activation peptide (Ala-146 to Arg-180).Factor IX is activated by either factor XIa or the factor VIIa/tissue factor/phospholipid complex. Cleavage at site A (see fig...lly activates factor X to factor Xa.Human factor IX is prepared from fresh frozen plasma by a combination of conventional procedures and immunoaffinity chromatography. Bovine factor IX is prepared from fresh citrated bovine plasma by a modification of the method described by Fujikawa et al. The purified proteins are supplied in 50% (vol/vol) glycerol/H2O and should be stored at -20°C. Purity is determined by SDS-PAGE analysis and activity is measured using a factor IX clotting assay. Group: Zymogens. CAS No. 9001-28-9. Purity: >95% by SDS-PAGE. Factor IX. Mole weight: 55000. Stability: 12 months. Storage: -20°C. Source: Human. Human Factor IX; Factor IX. Pack: 100 ug. Cat No: CZY-002. |  |
| Human Factor X | Factor X is a vitamin K-dependent protein zymogen which is synthesized in the liver and circulates in plasma as a two chain molecule linked by a disulfide bond. Prior to secretion into plasma, post-translational modifications produce 11 gamma-carboxyglutamic acid (gla) residues and a single b-hydroxyaspartic acid residue, which are located within the NH2-terminal light chain. The light chain also contains two epidermal growth factor (EGF) homology domains. The COOH-terminal heavy chain of factor X contains most of the carbohydrate moieties, as well as the latent serine protease domain. The activation of factor X is catalyzed by either the intrinsic factor Xase complex (factor IXa, fac...y of the prothrombinase complex. The first EGF homology domain contains a Ca2+ binding site which acts as a hinge to fold the EGF and GLA domains towards each other. This region of the molecule is involved in the recognition of cellular binding domains.Human factor X is isolated from fresh frozen human plasma by a combination of conventional techniques and immunoaffinity chromatography. In addition to the standard human factor X preparation, Gla-domainless human factor X is also available. Bovine factor X is isolated from fresh bovine plasma using a modification of the procedure reported by Bajaj et al. The purified zymogen is supplied in 50% (vol/vol) glycerol/H2O and should be store | |
| Human Factor XI | Factor XI is a plasma glycoprotein which circulates in a non-covalent complex with high molecular weight kininogen. The mature molecule is synthesized in the liver and is a two-chain homodimer with a molecular weight of approximately 160,000. It is estimated that 5% of the total mass is attributable to carbohydrate. The two identical monomers have molecular weights of 80,000, and are joined together by disulfide bonds. Thus by SDS-PAGE analysis, factor XI appears as a single band both non-reduced (Mr=160,000), and reduced (Mr=80,000).Factor XI circulates as a zymogen and requires proteolytic activation to acquire serine protease activity. The conversion of factor XI to factor XIa is ...activity or antigen levels. This latter observation may be related to the ability of the tissue factor/factor VIIa complex to also activate factor IX to IXa.Historically, factor XI has been difficult to purify due to its relatively low concentration in plasma, and its susceptibility to proteolysis. Factor XI is purified from fresh frozen plasma that is stabilized by added inhibitors. The plasma is first treated with BaCl2 to remove the vitamin K-dependent proteins, and factor XI is then isolated by affinity chromatography. A final chromatography step on heparin sepharose yields a homogeneous preparation of intact factor XI. The finished product is supplied in 50% (vol/vol) glycerol/H2 | |
| Human Factor XII | Factor XII (XII) (Hageman Factor) is a single chain (Mr=78,000) glycoprotein zymogen that circulates in plasma at a concentration of 40 ug/ml. Reciprical activation of XII to the active serine protease factor XIIa (XIIa) by kallikrein is central to initiation of the intrinsic coagulation pathway. Surface bound α-XIIa in turn activates factor XI to XIa. Secondary cleavage of α-XIIa by kallikrein yields β-XIIa, which catalyzes solution phase activation of kallikrein, factor VII and the classical complement cascade.The ability of a variety of negatively charged substances, both physiological and nonphysiological to promote XII activation and, thus, initiation of the int...ain (Mr=28,000) contains the catalytic triad (His-40, Asp-89, Ser-191), while the NH2-terminal heavy chain (Mr=52,000) conatins the anionic surface binding portion of the molecule. A secondary cleavage of α-XIIa by kallikrein outside the disulfide bond yields β-XIIa (XIIf, BHFa, HFf, hageman factor fragments) (Mr=28,000), which no longer binds anionic surfaces. β-XIIa can activate prekallikrein, but has little procoagulant activity. Several other minor intermediate forms of XIIa are indicated in the figure above.Inhibitors of XIIa include C1-INH, α2-antiplasmin, α2-macroglobulin and antithrombin III. At physiological concentrations, the relative effectiven | |
| Human Factor XIII | Factor XIII is the zymogenic form of the glutaminyl-peptide g-glutamyl transferase factor XIIIa (fibrinoligase, plasma transglutaminase, fibrin stabilizing factor, E.C. 2.3.2.13). Factor XIII is unique among transamidases in that it is a zymogen in vivo. Factor XIII is found both extracellularly in plasma and intracellularly in platelets, megakaryocytes, monocytes, placenta, uterus, liver and prostrate tissues. Plasma factor XIII is synthesized in the liver and circulates as a tetramer (Mr=320,000), composed of 2 pairs of nonidentical subunits (A2B2). The intra-cellular forms are synthesized in the tissues where they reside as dimers (Mr=146,000) of 2 identical A chains (A2). The A ...nly after the Ca2+ (Kd=10-3M) and fibrin(ogen) (Kd=10-8M) dependent dissociation of the B subunit dimer from the A2' dimer.In the coagulation cascade, factor XIIIa functions to stabilize the fibrin clot by crosslinking the a and g-chains of fibrin. Other proteins known to be substrates for Factor XIIIa which may be hemostatically important include fibronectin, α2-antiplasmin, collagen, factor V, von Willebrand Factor and thrombospondin.Factor XIII is purified from fresh frozen human plasma by a modification of the procedures described by Folke and Lorand involving barium citrate, ammonium sulfate and glycine precipitations, ion exchange chromatography and gel filtration. Factor | |
| α-epidermal growth factor, human | Recombinant human epidermal growth factor has the same structure as the human epidermal growth factor. EGF binds to epidermal growth factor receptor (EGFR) and stimulates cell growth and proliferation. Recombinant human epidermal growth factor is approved for the treatment of diabetic foot ulcers. Uses: The treatment of diabetic foot ulcers. Synonyms: Human EGF; Nepidermin. CAS No. 62253-63-8. Molecular formula: C270H401N73O83S7. Mole weight: 6222. |  |
| Atrial natriuretic factor (1-28) (human, porcine) | Atrial natriuretic factor (1-28) (human, porcine) is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendocrine cells of the heart from which it is released into the circulation. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, increase sodium excretion and inhibit renin secretion. It decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels at 8 μg/kg. It also inhibits arginine vasopressin-induced increase in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng. It produces diuretic, natriuretic and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure regulation. Synonyms: ANF 1-28; hANF; Atrial Natriuretic Peptide human. CAS No. 91917-63-4. Molecular formula: C127H205N45O39S3. Mole weight: 3080.46. | |
| Atrial Natriuretic Factor (5-27) (human) | Synonyms: Atrial Natriuretic Peptide-23 (human); H-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-OH (Disulfide bridge: Cys3-Cys19); L-seryl-L-seryl-L-cysteinyl-L-phenylalanyl-glycyl-glycyl-L-arginyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-glycyl-L-alanyl-L-glutaminyl-L-seryl-glycyl-L-leucyl-glycyl-L-cysteinyl-L-asparagyl-L-seryl-L-phenylalanyl-L-arginine (3->19)-disulfide. Grades: ≥95%. CAS No. 98929-56-7. Molecular formula: C97H154N34O32S3. Mole weight: 2404.67. | |
| COAGULATION FACTOR XII, HUMAN | COAGULATION FACTOR XII, HUMAN. Uses: Designed for use in research and industrial production. Additional or Alternative Names: HUMAN PLASMA ACTIVATED HAGEMAN FACTOR;HUMAN PLASMA FACTOR XII;HUMAN PLASMA FACTOR XIIA;HUMAN PLASMA HAGEMAN FACTOR;HAGEMAN FACTOR, HUMAN;FACTOR XIIA, HUMAN;FACTOR XII (HUMAN);COAGULATION FACTOR XII, HUMAN. Product Category: Heterocyclic Organic Compound. CAS No. 9001-30-3. Product ID: ACM9001303. Alfa Chemistry ISO 9001:2015 Certified. |  |
| COAGULATION FACTOR XIII, HUMAN | COAGULATION FACTOR XIII, HUMAN. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FIBRIN-STABILIZING FACTOR;FIBRIN-STABILIZING FACTOR, HUMAN;FACTOR XIII (HUMAN);HUMAN PLASMA FACTOR XIII;COAGULATION FACTOR XIII, HUMAN;COAGULATION FACTOR XIII, HUMAN PLASMA. Product Category: Heterocyclic Organic Compound. CAS No. 9013-56-3. Product ID: ACM9013563. Alfa Chemistry ISO 9001:2015 Certified. | |
| FIBROBLAST GROWTH FACTOR-4 HUMAN RECOMBI | FIBROBLAST GROWTH FACTOR-4 HUMAN RECOMBI. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FIBROBLAST GROWTH FACTOR-4 HUMAN RECOMBI;fibroblast growth factor-4 human*recombinant cell;FIBROBLAST GROWTH FACTOR-4, HUMAN RECOMB INANT, CELL CULTURE TESTED. Product Category: Heterocyclic Organic Compound. CAS No. 123584-45-2. Product ID: ACM123584452. Alfa Chemistry ISO 9001:2015 Certified. | |
| Human Coagulation Factor VII | Human factor VII is a single chain, vitamin K-dependent, plasma glycoprotein which is synthesized in the liver. Prior to secretion into the blood, post translational modification by a vitamin K-dependent carboxylase produces ten-carboxyglutamic acid (gla) residues located in the NH2-terminal portion of the molecule, which facilitate cell membrane binding. Factor VII is proteolytically activated to the serine protease, factor VIIa, during coagulation. Factor VII can be activated by thrombin, factor IXa, factor Xa or factor XIIa. The activation results in cleavage of the single chain molecule on the COOH-terminal side of arginine-152, to produce an NH2-terminal derived light chai...nzyme complex catalyzes the conversion of both factor IX to factor IXa and factor X to factor Xa. The cDNA for factor VII has been isolated and the nucleotide sequence determined. Factor VII shares extensive sequence homology with other serine proteases including factor IX, factor X and protein C.Human factor VII is purified using a combination of conventional techniques and immunoaffinity chromatography. The purified protein is supplied in 50% (vol/vol) glycerol/H2O and should be stored at -20°C. Purity is determined by SDS-PAGE analysis and activity is measured in a factor VII clotting assay. Group: Zymogens. CAS No. 9001-25-6. Purity: >95% by SDS-PAGE. Factor VII. Mole weigh | |
| Human gla-domainless Factor X | Factor X is a vitamin K-dependent protein zymogen which is synthesized in the liver and circulates in plasma as a two chain molecule linked by a disulfide bond. Prior to secretion into plasma, post-translational modifications produce 11 gamma-carboxyglutamic acid (gla) residues and a single b-hydroxyaspartic acid residue, which are located within the NH2-terminal light chain. The light chain also contains two epidermal growth factor (EGF) homology domains. The COOH-terminal heavy chain of factor X contains most of the carbohydrate moieties, as well as the latent serine protease domain. The activation of factor X is catalyzed by either the intrinsic factor Xase complex (factor ...e prothrombinase complex. The first EGF homology domain contains a Ca2+ binding site which acts as a hinge to fold the EGF and GLA domains towards each other. This region of the molecule is involved in the recognition of cellular binding domains.Human factor X is isolated from fresh frozen human plasma by a combination of conventional techniques and immunoaffinity chromatography. In addition to the standard human factor X preparation, Gla-domainless human factor X is also available. Bovine factor X is isolated from fresh bovine plasma using a modification of the procedure reported by Bajaj et al. The purified zymogen is supplied in 50% (vol/vol) glycerol/H2O and should be store | |
| Hypercalcemia of malignancy factor fragment 1-34 amide human | Hypercalcemia of malignancy factor fragment 1-34 amide is an extraordinary biomedical innovation exhibiting remarkable potential in the research of hypercalcemia linked to malignancies. Synonyms: Hypercalcemia of Malignancy Factor (1-34) amide (human, mouse, rat); H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-NH2; pTH-Related Protein (1-34) amide (human, mouse, rat); L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-leucyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-lysyl-glycyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-isoleucyl-L-alanyl-L-alpha-glutamyl-L-isoleucyl-L-histidyl-L-threonyl-L-alaninamide; PTHrP (1-34) amide. Grades: 95%. CAS No. 112955-31-4. Molecular formula: C180H288N58O47. Mole weight: 4016.57. | |
| Native Human Factor α-XIIa | Human Factor α-XIIa is a serine protease responsible for the activation of Factor XI to XIa in the contact activation system. Human Factor XII and prekallikrein are thought to be involved in a reciprocal activation mechanism in which Factor XIIa activates prekallikrein to kallikrein, which in turn converts Factor XII to XIIa. Factor XIIa activates Factor XI to XIa thereby triggering the Contact Factor cascade. ERL offers Factor α-XIIa which is activated by the autoactivation process with Dextran Sulfate and re-purified to remove the activator. The protein purity is determined by SDS-PAGE and activity is determined via clotting assay. Group: Enzymes. Synonyms: Human Factor Alpha-XIIa; Factor Alpha-XIIa; Factor α-XIIa. Factor α-XIIa. Mole weight: 80 kDa. Activity: 69.51 PEU/mg. Storage: < -60°C. Source: Human. Species: Human. Human Factor Alpha-XIIa; Factor Alpha-XIIa; Factor α-XIIa. Cat No: NATE-0882. | |
| Native Human Factor IXa β | Prepared from Human Factor IX by activation with Bovine Factor XIa. This Bovine Factor XIa is removed after activation. Complete activation is observed by SDS-PAGE. The Factor XIa activates Factor IX in a two-step reaction. In the first step, an internal Arg-Ala bond is cleaved, and in the second step, an Arg-Val bond is cleaved. The second cleavage leads to the liberation of an activation peptide from the NH2-terminal portion of the heavy chain to produce Factor IXa&beta. Group: Enzymes. Synonyms: Human Factor IXa Beta; Factor IXa Beta; Factor IXa. Factor IXa Beta. Mole weight: 45 kDa. Activity: 12500.00 PEU/mg. Storage: < -60°C. Source: Human. Species: Human. Human Factor IXa Beta; Factor IXa Beta; Factor IXa. Cat No: NATE-0883. | |
| Native Human Factor VIIa | Prepared from purified Human Factor VII using Human Factor XIIa. The Factor Xlla is removed using affinity chromatography. Purity is determined by SDS-PAGE. Human Factor VIIa reduces to 29,500 and 23,500 with the addition of 2-mercaptoethanol. Activity is determined via clotting assay. Factor Vlla, in the presence of calcium ions and Tissue factor, activates Factors IX and X to their enzymatically active forms, Factor IXa and Xa. Group: Enzymes. Synonyms: Human Factor VII; Factor VII. Factor VIIa. Mole weight: 50 kDa. Activity: 53833.00 PEU/mg. Storage: < -60°C. Source: Human. Species: Human. Human Factor VII; Factor VII. Cat No: NATE-0884. | |
| Native Human Factor Xa | Human Factor Xa is prepared from Human Factor X by activation with Russell's Viper Venom. This RVV-X is removed after activation. Complete activation is observed by SDS-PAGE. Factor Xa along with cofactor Va, phospholipids and calcium ions, (the prothrombinase complex) catalyzes the rapid conversion of prothrombin to thrombin. Group: Enzymes. Synonyms: Human Factor Xa; Factor Xa. Factor Xa. Mole weight: 46 kDa. Activity: 218.00 IU/mg. Storage: < -60°C. Source: Human. Species: Human. Human Factor Xa; Factor Xa. Cat No: NATE-0885. | |
| Native Human Factor XIa | Prepared from Human Factor XI using Human Factor Xlla. This Xlla was removed using a corn trypsin inhibitor column. Complete activation is observed by SDS-PAGE. Factor XI, through the contact factor pathway cascade, is activated to Factor XIa via Factor Xlla and High Molecular Weight Kininogen. During activation by Factor Xlla and HK, FXI undergoes proteolytic cleavage in which the Mr=80,000 chain reportedly is cleaved to a heavy and light chain with Mr of about 48,000 and 33,000. This Factor XIa is responsible for the activation of Factor IX to Factor IXa. Unlike other examples of activation of Vitamin K-dependent blood-clotting proteins, Factor XIa proteolysis of Factor IX does not require membrane surfaces. Group: Enzymes. Synonyms: Human Factor XIa; Factor XIa. Factor XIa. Mole weight: 160 kDa. Storage: < -60°C. Source: Human. Species: Human. Human Factor XIa; Factor XIa. Cat No: NATE-0886. | |
| Native Human Factor XIIIa | Human Factor XIII is cleaved with human alpha thrombin. The thrombin is subsequently removed via chromatography. The above protein was purified from Human plasma that was tested and found negative by FDA accepted methods fro Anti-HIV1/2, Anti-HTLV I & II, HBsAg, Anti-HCV, Syphilis, ABC ab, HIV-1 p24 Ag or HIV-1 RNA, HCV RNA and HBV RNA. Donors are screened for CJD (Creutzfeldt-Jakob Disease). Group: Enzymes. Synonyms: Human Factor XIIIa; Factor XIIIa. Factor XIIIa. Mole weight: 312 kDa. Activity: 1968.00 Loewy u/mg. Storage: -20°C. Source: Human. Species: Human. Human Factor XIIIa; Factor XIIIa. Cat No: NATE-0887. | |
| Platelet Factor 4 (58-70), human | It is the 58-70 amino acid fragment of Platelet Factor 4 (PF-4) that contains the major heparin-binding domain and is insufficient to fully exert its antiangiogenic activity. Synonyms: PF4 (58-70) (human); Pro-Leu-Tyr-Lys-Lys-Ile-Ile-Lys-Lys-Leu-Leu-Glu-Ser; L-prolyl-L-leucyl-L-tyrosyl-L-lysyl-L-lysyl-L-isoleucyl-L-isoleucyl-L-lysyl-L-lysyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-serine; platelet factor 4 fragment 58-70 human. Grades: 95%. CAS No. 82989-21-7. Molecular formula: C76H133N17O18. Mole weight: 1572.97. | |
| Prepro-Atrial Natriuretic Factor (26-55) (human) | Prepro-Atrial Natriuretic Factor (26-55) (human) is a polypeptide that increases renal cortical and medullary cyclic GMP levels. Prepro-Atrial Natriuretic Factor (26-55) (human) increases renal guanylate cyclase activity [1]. Uses: Scientific research. Group: Peptides. CAS No. 112160-82-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4811. |  |
| Prepro-Atrial Natriuretic Factor (26-55) (human) | Prepro-Atrial Natriuretic Factor (human) can reduce adenylate cyclase activity. Synonyms: PREPRO-HANF (26-55) CARDIODILATIN-RELATED PEPTIDE (HUMAN); PREPRO-HANF FRAGMENT 26-55, HUMAN; PREPRO-ANF (26-55), HUMAN; PREPRO-ATRIAL NATRIURETIC FACTOR (26-55) (HUMAN); PREPRO-ATRIAL NATRIURETIC PEPTIDE, FRAGMENT 26-55 HUMAN; H-ASN-PRO-MET-TYR-ASN-ALA-VAL-S. Grades: 95%. CAS No. 112160-82-4. Molecular formula: C152H236N38O51S3. Mole weight: 3507.92. | |
| rec Brain-Derived Neurotrophic Factor (human) | Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has its expression in the human central nervous system and is altered in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It promotes the survival of dopaminergic neurons and protects against Aβ-induced neurotoxicity in vivo and in vitro. Synonyms: rec BDNF (human). | |
| Recombinant human epidermal growth factor | rhEGF, human Oligopeptide-1. antirheumatic. CAS No. 62253-63-8. Product ID: 8-01731. Purity: 98% activity 6*105IU/mg. Source : |  |
| Rheumatoid Factor, Control Serum, Human | Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology. Rheumatoid arthritis is a systemic disease characterized by chronic proliferation and inflammation of joint cartilage and supporting structures. RA is mainly defined by clinical criteria, in which systematic pathogenetic studies have been hampered by doubts about the presence of common pathogenetic mechanisms and the relative lack of unique laboratory findings. IgG rheumatoid factor has been reported to be present in sera of patients with rheumatoid arthritis both with and without IgM rheumatoid factor activity. Group: Biologicals. Grades: Serum. Pack Sizes: 2ml. US Biological Life Sciences. |  Worldwide |
| (Tyr0)-prepro-atrial natriuretic factor (104-123) (human) | Synonyms: (Tyr0)-kaliuretic peptide (human). CAS No. 309245-24-7. Molecular formula: C103H180N32O30. Mole weight: 2346.72. | |
| 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarbonyl Chloride | 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarbonyl Chloride is used in the synthesis of 6-substituted-4- (3-bromophenylamino) quinazoline derivatives which functions as irreversible inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases. Group: Biochemicals. Grades: Highly Purified. CAS No. 59826-28-7. Pack Sizes: 25mg, 50mg. Molecular Formula: C7H10ClNO, Molecular Weight: 159.61. US Biological Life Sciences. | Worldwide |
| 1-Chloro-N,N-2-trimethylpropenylamine | 1-Chloro-N,N-2-trimethylpropenylamine acts as a reagent in the synthesis and antitumor activity of (-)-bassianolide in human cancer cells through cell cycle arrest. Enantioselective total synthesis of nannocystins A and A0 as elongation factor 1 inhibitors. Total synthesis of (-)-caprazamycin A with antibacterial activity against Mycobacterium tuberculosis (TB) via diastereoselective aldol reaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 26189-59-3. Pack Sizes: 500mg, 1g. Molecular Formula: C6H12ClN. US Biological Life Sciences. | Worldwide |
| 2,3-Diaminobenzoic Acid Methyl Ester Hydrochloride | 1,2-Dibenzamidobenzene inhibitors of Human Factor Xa. Group: Biochemicals. Alternative Names: Methyl 2,3-Diaminobenzoate Hydrochloride. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| 24-Hydroxycholesterol | 24-Hydroxycholesterol, also known as 24-OH-Chol, a natural sterol, is the main cholesterol elimination product of the brain. 24-Hydroxycholesterol is a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR. 24-Hydroxycholesterol acts as a neurotoxin to SH-SY5Y human neuroblastoma cells which showed corresponding morphological changes: the cells became round, lost adhesion to the petri-dish, and neurite outgrowth degenerated. Synonyms: (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; 24-hydroxycholesterol; 24S-hydroxycholesterol; cerebrosterol; cholest-5-ene-3,24-diol. CAS No. 30271-38-6. Molecular formula: C27H46O2. Mole weight: 402.65. | |
| 2-Bromo-5-methyl-4-thiazolecarboxylic Acid | 2-Bromo-5-methyl-4-thiazolecarboxylic Acid is a derivative of 4-Thiazolecarboxylic Acid (T344195); a chemical reagent used in the synthesis of novel benzimidazole analogs as highly potent hypoxia inducible factor-1α inhibitors that show comparable potency in inhibition of human breast cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1194374-25-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C5H4BrNO2S, Molecular Weight: 222.06. US Biological Life Sciences. | Worldwide |
| (2E)-N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide | (2E)-N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide was used in the study for preparation of disubstituted (arylamino) quinolinecarbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 848133-88-0. Pack Sizes: 25mg, 100mg. Molecular Formula: C18H19ClN4O2, Molecular Weight: 358.82. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy-4-methylpyridine-d3 | 2-Hydroxy-4-methylpyridine-d3 is the isotope labelled analog of 2-Hydroxy-4-methylpyridine (H949890); an intermediate used to prepare oxobenzopyrancarboxyl ate derivatives as inhibitors of serine proteases and human leukocyte elastase. It is also used in the synthesis of (indanylamino) (pyridinyloxy) pyrazines and analogs as corticotropin releasing factor type-1 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1185316-03-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C6H4D3NO, Molecular Weight: 112.14. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy-4-methylpyridine-d6 | 2-Hydroxy-4-methylpyridine-d6 is the isotope labelled analog of 2-Hydroxy-4-methylpyridine (H949890); an intermediate used to prepare oxobenzopyrancarboxyl ate derivatives as inhibitors of serine proteases and human leukocyte elastase. It is also used in the synthesis of (indanylamino) (pyridinyloxy) pyrazines and analogs as corticotropin releasing factor type-1 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 916979-13-0. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C6HD6NO, Molecular Weight: 115.16. US Biological Life Sciences. | Worldwide |
| (2R)-N-Boc-4-oxo-proline | (2R)-N-Boc-4-oxo-proline was used as a reactant in the preparation of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides which are potent factor Xa inhibitors with increased human half life. Also used in the synthesis of azacyclic FTY720 analogues which show potential for use in strategy to kill cancer cells as they restrict access to extracellular nutrients. Group: Biochemicals. Grades: Highly Purified. CAS No. 364077-84-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H15NO5, Molecular Weight: 229.23. US Biological Life Sciences. | Worldwide |
| (2S, 4R) -1- ( (S) -2- (1-Cyanocyclopropane carboxamido) -3, 3-di methyl butanoyl) -4-hydroxy-N- (4- (4- methyl thiazol-5-yl) benzyl) pyrrolidine-2-carboxamide | (2S, 4R) -1- ( (S) -2- (1-Cyanocyclopropane carboxamido) -3, 3-di methyl butanoyl) -4-hydroxy-N- (4- (4- methyl thiazol-5-yl) benzyl) pyrrolidine-2-carboxamide is a VHL inhibitors that decreases hypoxia inducible factor-α during hypoxia associated signaling in human cervical cancer, osteosarcoma HeLa and U2OS. cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 2097381-85-4. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C27H33N5O4S, Molecular Weight: 523.65. US Biological Life Sciences. | Worldwide |
| (2S)-N-Nitrosonornicotine | A tobacco alkaloid as risk factor of human cancer. Group: Biochemicals. Alternative Names: N-Nitrosonornicotine; (S)-3-(1-Nitroso-2-pyrrolidinyl)pyridine; 1-Demethyl-1-nitroso-nicotine. Grades: Highly Purified. CAS No. 16543-55-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3,4-Diaminobenzoic Acid Methyl Ester Hydrochloride | 1,2-Dibenzamidobenzene inhibitors of Human Factor Xa. Group: Biochemicals. Alternative Names: 4-(Methoxycarbonyl)-1,2-benzenediamine Hydrochloride; 4-Carbomethoxy-o-phenylenediamine Hydrochloride; 4-Methoxycarbonyl-o-phenylenediamine Hydrochloride; Methyl 3, 4-Diamino Benzene carboxylate Hydrochloride; Methyl 3,4-Diaminobenzoate Hydrochloride. Grades: Highly Purified. CAS No. 1210824-92-2. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| 3,?5,?6,?7,?8,?3',?4'-?Heptemthoxyflavone | 3,5,6,7,8,3',4'-Heptemthoxyflavone, a flavonoid from satsuma peel, is an orally available CREB activator with anti-tumor and anti-neuroinflammatory activity. 3,5,6,7,8,3',4'-Heptemthoxyflavone inhibits collagenase activity and increases the content of type I procollagen in human dermal fibroblast neoblast (HDFn) cells. 3,5,6,7,8,3',4'-Heptemthoxyflavone induces brain-derived neurotrophic factor (BDNF) expression through the cAMP/ERK/CREB signaling pathway and reduces phosphodiesterase activity in C6 glioma [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 1178-24-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2038. | |
| 3-Amino-2,4-dibromopyridine | 3-Amino-2,4-dibromopyridine is a versatile reactant used in the synthesis of novel indolizine 2-oxoacetamides that are inhibitors of phosphodiesterase IV and tumor necrosis factor-α production in human peripheral blood mononuclear cell. Group: Biochemicals. Grades: Highly Purified. CAS No. 102249-45-6. Pack Sizes: 50mg, 250mg. Molecular Formula: C5H4Br2N2, Molecular Weight: 251.91. US Biological Life Sciences. | Worldwide |
| 3-Aminopropyl-24,25-dihydroxy Vitamin D3 | 3-Aminopropyl-24,25-dihydroxy Vitamin D3 is a derivative of Vitamin D3 (V676045), an important factor in maintaining bone health, and has also been associated with cardiovascular health in humans. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250ug, 1mg. Molecular Formula: C30H51NO3. US Biological Life Sciences. | Worldwide |
| 3-Chloro-4-(2-pyridylmethoxy)aniline | 3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino) quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 524955-09-7. Pack Sizes: 1g, 5g. Molecular Formula: C12H11ClN2O, Molecular Weight: 234.68. US Biological Life Sciences. | Worldwide |
| 4-IPP | 4-IPP is a potent and cell-permeable macrophage migration inhibitory factor (MIF) antagonist. It covalently modifies MIF N-terminal proline. It inhibits MIF-associated liver enzyme activity in vivo and acts as a suicide substrate to inactivate MIF biological and catalytic functions. It also inhibits anchorage and migration independence of human lung adenocarcinoma cell lines in vitro. Synonyms: 4-IPP; 4 IPP; 4IPP; 4-Iodo-6-phenylpyrimidine. Grades: ≥99% by HPLC. CAS No. 41270-96-6. Molecular formula: C10H7IN2. Mole weight: 282.08. | |
| 5'-O-Acetyl-2',3'-dideoxyinosine | 5'-O-Acetyl-2',3'-dideoxyinosine is an extensively utilized potent antiviral compound within the biomedical field, exhibiting impressive efficacy in research of viral infections induced by the human immunodeficiency virus (HIV). By impeding the reverse transcriptase enzyme, a pivotal factor for viral replication, this compound effectively impedes viral multiplication. Synonyms: 5'-O-Acetyldidanosine; 5'-O-Acetyl-2',3'-dideoxy-D-inosine. CAS No. 130676-58-3. Molecular formula: C12H14N4O4. Mole weight: 278.26. | |
| ABT-491 Hydrochloride | ABT-491 Hydrochloride is a potent, selective and orally active platelet-activating factor receptor (PAF-R) antagonist (Ki = 0.6 nM in human platelets). Synonyms: 4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-N,N-dimethylindole-1-carboxamide;hydrochloride; ABT 491 hydrochloride; ABT 491; ABT-491; ABT491. Grades: >98%. CAS No. 189689-94-9. Molecular formula: C28H23ClFN5O2. Mole weight: 515.97. | |
| AC480 | AC480, also known as BMS-599626, is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. Synonyms: BMS-599626; BMS 599626; BMS599626; AC 480; AC-480; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; (3S)-3-Morpholinylmethyl N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate; Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid, (3S)-3-morpholinylmethyl ester. Grades: ≥95%. CAS No. 714971-09-2. Molecular formula: C27H27FN8O3. Mole weight: 530.55. | |
| Adalimumab | Adalimumab is a human monoclonal IgG1 antibody targeting tumour necrosis factor?α ( TNF-α ). Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human TNF-alpha, Human Antibody. CAS No. 331731-18-1. Pack Sizes: 1 mg; 5 mg; 25 mg; 50 mg. Product ID: HY-P9908. | |
| Adaptaquin | Adaptaquin is an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) with IC50 value of 2 μM in a reporter assay using SH-SY5Y-ODD-Luc cells. It displays neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models by inhibition of ATF4 dependent genes. It reduces neuronal death and behavioral deficits after intracerebral hemorrhage (ICH) in several rodent models. It blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. It stabilizes HIF-1α protein and induces expression of the HIF1-regulated genes EPO and VEGF in SH-SY5Y human neuroblastoma cells. It is used in ischemic injury research, renal anemia, and used as an antioxidant. It is also used in pyruvate dehydrogenase (PDH) related research. Synonyms: 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol. Grades: ≥97% by HPLC. CAS No. 385786-48-1. Molecular formula: C21H16ClN3O2. Mole weight: 377.82. | |
| Adenosine-3',5'-cyclic Monophosphate Sodium Salt (A-3:5-MP, cAMP, Na) | A key regulator of many cellular reactions. Released in response to hormonal stimulation. An activator of protein kinase A. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Acts as a second messenger in signal transduction mechanisms. Promotes apoptosis in resting human B lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 37839-81-9. Pack Sizes: 100mg, 1g. US Biological Life Sciences. | Worldwide |
| Adenosine-3,5-cyclic Monophosphate Sodium Salt (A-3:5-MP, cAMP, Na) | A key regulator of many cellular reactions. Released in response to hormonal stimulation. An activator of protein kinase A. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Acts as a second messenger in signal transduction mechanisms. Promotes apoptosis in resting human B lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 37839-81-9. Pack Sizes: 1g. Molecular Formula: C??H??N?O?P · Na. US Biological Life Sciences. | Worldwide |
| AEE-788 | AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. Synonyms: AEE 788; AEE788; 6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine. Grades: >98%. CAS No. 497839-62-0. Molecular formula: C27H32N6. Mole weight: 440.595. | |
| AG-183 | AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 0.8 μM in the human epidermoid carcinoma cell line A431. Synonyms: Tyrphostin 51; Tyrphostin AG 183. Grades: ≥98%. CAS No. 122520-90-5. Molecular formula: C13H8N4O3. Mole weight: 268.2. | |
| AG-213 | AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 2.4 μM in the human epidermoid carcinoma cell line A431. Uses: Enzyme inhibitors. Synonyms: Tyrphostin AG-213; Tyrphostin 47; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide. Grades: ≥97%. CAS No. 122520-86-9. Molecular formula: C10H8N2O2S. Mole weight: 220.2. | |
| AG-82 | AG-82 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 3 μM in the human epidermoid carcinoma cell line A431. Uses: Antineoplastic agents. Synonyms: NSC 676484; RG-50875; Tyrphostin 25; Tyrphostin AG-82. Grades: ≥95%. CAS No. 118409-58-8. Molecular formula: C10H6N2O3. Mole weight: 202.2. | |
| AGI-B4 | AGI-B4 is a substance produced by Aspergillus sp. Y80118 that inhibits the growth of endothelial cells. It inhibits the proliferation of human umbilical vein endothelial cells (HUVECs) induced by vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and endothelial cell growth factor (ECGS) with IC50 of 1.4 μmol/ L, 2.8 μmol/L and 6.2 μmol/L. Synonyms: (7R,8R)-AGI-B4. CAS No. 1313588-44-1. Molecular formula: C16H14O7. Mole weight: 318.28. | |
| AhR Agonist V, VAF347 | A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation. Group: Biochemicals. Alternative Names: ((4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine). Grades: Highly Purified. CAS No. 574759-62-9. Pack Sizes: 10mg. Molecular Formula: C??H??ClF?N?, Molecular Weight: 349.7. US Biological Life Sciences. | Worldwide |
| α-helical CRF 9-41 | α-helical CRF 9-41 has been found to be a corticotropin-releasing factor receptor antagonist. Synonyms: Corticotropin-releasing factor (human), 1-de-L-serine-2-de-L-glutamicacid-3-de-L-glutamicacid-4-de-L-proline-5-de-L-proline-6-de-L-isoleucine-7-de-L-serine-8-de-L-leucine-18-L-methionine-23-L-lysine-27-L-glutamic acid-29-L-glutamicacid-32-L-alanine-33-L-leucine-36-L-leucine-38-L-leucine-40-L-glutamicacid-41-L-alaninamide-; CHEMBL526149. Grades: ≥95% by HPLC. CAS No. 90880-23-2. Molecular formula: C166H274N46O53S2. Mole weight: 3827.00. | |
| AMPK Signaling Agonist, F17 (4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide) | A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~0.1uM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-a1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25uM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C. Group: Biochemicals. Grades: Highly Purified. CAS No. 280112-24-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Anaritide | Anaritide is a synthetic form of atrial natriuretic peptide (ANP) composed of 25 amino acids. Anaritide increases glomerular filtration rate by dilating into and contracting out the bulbar arterioles. Anaritide can be used to study the effects on patients with acute tubular necrosis, particularly in improving dialysis free survival [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Human atrial natriuretic factor (102 - 126). CAS No. 95896-08-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10279. | |
| Andrographolide | Andrographolide is a labdane diterpenoid. Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata. Andrographolide showed significant antihepatotoxic action in P. berghei K173- induced hepatic damage in M. natalensis. Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases. These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent. Group: Biochemicals. Alternative Names: (3E, 4S) -3- [2- [ (1R, 4aS, 5R, 6R, 8aS) -Decahydro-6-hydroxy-5- (hydroxymethyl) -5, 8a-dimethyl-2-methylene-1-naphthalenyl] ethylidene] dihydro-4-hydroxy-2 (3H) -furanone; [1R-[1α[E(S*)],4a β , 5α , 6α , 8aα ] ] -3- [2- [Decahydro-6-hydroxy-5- (hydroxymethyl) -5, 8a-dimethyl-2-methylene-1-naphthalenyl] ethylidene] dihydro-4-hydroxy-2 (3H) -furanone; 3α,14,15,18-Tetrahydroxy-5 β,9 βH,10α-labda-8(20),12-dien-16-oic Acid γ-Lactone; Andrographis; Andrographolid. Grades: Highly Purified. CAS No. 5508-58-7. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Apixaban | Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with K i of 0.08 nM and 0.17 nM in human and rabbit, respectively [1]. Apixaban is in development for the prevention and treatment of various thromboembolic diseases [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-562247-01. CAS No. 503612-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50667. | |
| Apixaban-13C,d3 | Apixaban- 13 C,d 3 is a deuterium and 13 C labeled Apixaban. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: BMS-562247-01- 13 C,d3. CAS No. 1261393-15-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-50667S. | |
| Asiatic acid | Asiatic acid, a pentacyclic triterpene found in Centella asiatica ( Centella asiatica ), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 464-92-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0194. | |
| Asiaticoside | Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor. Group: Biochemicals. Alternative Names: Blastostimulina, Centelase, Emdecassol, Madecassol, Marticassol, FK1080, BRN 0078195, NSC 166062. Grades: Highly Purified. CAS No. 16830-15-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C48H78O19. US Biological Life Sciences. | Worldwide |
| (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) | (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) is an effective antagonist against pTH-stimulated cAMP production in ROS cells and shows no partial agonism effect. Synonyms: (Asn10,Leu11,D-Trp12)-Hypercalcemia of Malignancy Factor (7-34) amide (human, mouse, rat); H-Leu-Leu-His-Asn-Leu-D-Trp-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-NH2; L-Leucyl-L-leucyl-L-histidyl-L-asparaginyl-L-leucyl-D-tryptophyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-α-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-isoleucyl-L-alanyl-L-α-glutamyl-L-isoleucyl-L-histidyl-L-threonyl-L-alaninamide; (Asn10,Leu11,D-Trp12)-pTHrP (7-34) amide. Grades: ≥95%. CAS No. 129622-68-0. Molecular formula: C162H254N50O36. Mole weight: 3478.06. | |
| Asterric Acid (Dimethylosoic acid, Antibiotic TAN 1415A, Antibiotic WF 12880A) | A fungal metabolite, asterric acid is isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF). Asterric acid is an angiogenesis inhibitor acting on VEGF-induced tube formation of human umbilical vein endothelial cells. Group: Biochemicals. Alternative Names: Dimethylosoic acid, Antibiotic TAN 1415A, Antibiotic WF 12880A. Grades: Highly Purified. CAS No. 577-64-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Astressin | Astressin is a novel potent corticotropin releasing factor (CRF) antagonist. Astressin may be a useful tool to explore functional CRF-dependent physiological pathways in specific brain nuclei. Uses: Neuroprotective agents. Synonyms: (D-Phe12,Nle21·38,Glu30,Lys33)-CRF (12-41) (human, rat); H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu(1)-Ala-His-Lys(1)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2. Grades: ≥95%. CAS No. 170809-51-5. Molecular formula: C161H269N49O42. Mole weight: 3563.16. | |
| Asundexian | Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC 50 of 1 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY-2433334. CAS No. 2064121-65-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137431. | |
| AT7867 dihydrochloride | AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50 of 20 nM and 85 nM, respectively. AT7867 shows ATP-competitive activity to Akt2 with Ki of 18 nM. AT7867 exhibits antiproliferation in cell lines with PTEN or PIK3CA mutations and shows great potent to MES-SA, MDA-MB-468, MCF-7, HCT116 and HT29 with IC50 of 0.94 μM, 2.26 μM, 1.86 μM, 1.76 μM and 3.04 μM, respectively. AT7867 also suppresses the cell growth of U87MG, PC-3 and DU145 cells with IC50 of 8.22 μM, 10.37 μM and 11.86 μM, respectively. AT7867 suppresses Akt activity by inhibiting phosphorylation of GSK-3β in human tumor cells with IC50 of 2-4 μM. AT7867 also induces the phosphorylation of the following Akt direct substrates including proapoptotic transcription factors FKHR (FoxO1a), FKHRL1 (FoxO3a) and the downstream target S6RP in U87MG cells. AT7867 shows bioavailability of 44% in mice by p.o. route. AT7867 could increase the cleaved PARP in MES-SA xenografts at 20 mg/kg i.p. or 90 mg/kg p.o. AT7867 significantly inhibits the tumor growth in MES-SA xenografts or U87MG xenografts with T/C of 0.37 and 0.51, respectively. Synonyms: AT-7867 dihydrochloride; AT 7867 dihydrochloride. Grades: >98%. CAS No. 1431697-86-7. Molecular formula: C20H22Cl3N3. Mole weight: 410.77. | |
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