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Product | Description | |
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α-epidermal growth factor, human Quick inquiry Where to buy Suppliers range | Recombinant human epidermal growth factor has the same structure as the human epidermal growth factor. EGF binds to epidermal growth factor receptor (EGFR) and stimulates cell growth and proliferation. Recombinant human epidermal growth factor is approved for the treatment of diabetic foot ulcers. Uses: The treatment of diabetic foot ulcers. Synonyms: Human EGF; Nepidermin. CAS No. 62253-63-8. Molecular formula: C270H401N73O83S7. Mole weight: 6222. | |
α-epidermal growth factor, human Quick inquiry Where to buy Suppliers range | Nepidermin is a recombinant form of the naturally-occurring polypeptide human epidermal growth factor with potential epithelial regenerative and cytoprotective activities. Upon topical application, recombinant human epidermal growth factor (rhEGF) may stimulate epithelial proliferation, differentiation and migration, which may result in the acceleration of epithelial regeneration and wound healing. In addition, rhEGF may attenuate epithelial cytotoxicities related to chemotherapy and/or radiotherapy. Uses: Peptide Inhibitors. CAS No. 62253-63-8. Product ID: R1936. | |
BETA-NERVE GROWTH FACTOR, HUMAN Quick inquiry Where to buy Suppliers range | BETA-NERVE GROWTH FACTOR, HUMAN. Group: Heterocyclic Organic Compound. CAS No. 86923-98-0. | |
rec Brain-Derived Neurotrophic Factor (human) Quick inquiry Where to buy Suppliers range | Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has its expression in the human central nervous system and is altered in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It promotes the survival of dopaminergic neurons and protects against Aβ-induced neurotoxicity in vivo and in vitro. Synonyms: rec BDNF (human). | |
Transforming Growth Factor-α human Quick inquiry Where to buy Suppliers range | TGF-α, recombinant, expressed in E. coli, powder, suitable for cell culture. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 105186-99-0. Pack Sizes: 0.1MG. Mole weight: 5546.14. Catalog: AP105186990. Assay: ≥98% (SDS-PAGE and HPLC). | |
Human coagulation Factor IX concentrate BRP Quick inquiry Where to buy Suppliers range | Human coagulation Factor IX concentrate BRP. Uses: For analytical and research use. Group: European Pharmacopoeia (Ph. Eur.); Pharmacopoeial Standards. CAS No. 9001-28-4. Catalog: APS9001284A. Format: Neat. Product Type: Other. Shipping: Ice pack (-20°C). | |
Human coagulation factor IX (rDNA) Quick inquiry Where to buy Suppliers range | Human coagulation factor IX (rDNA). Uses: For analytical and research use. Group: European Pharmacopoeia (Ph. Eur.); Pharmacopoeial Standards. CAS No. 9001-28-4. Catalog: APS9001284. Format: Neat. Shipping: Ice pack (-20°C). | |
Human coagulation factor VIIa (rDNA) Quick inquiry Where to buy Suppliers range | Human coagulation factor VIIa (rDNA). Uses: For analytical and research use. Group: European Pharmacopoeia (Ph. Eur.); Pharmacopoeial Standards. Alternative Names: Human coagulation factor VIIa (rDNA). CAS No. 102786-61-8. Catalog: APS102786618. Format: Neat. Product Type: API. Shipping: Ice pack (-20°C). | |
Human coagulation factor VII concentrate BRP Quick inquiry Where to buy Suppliers range | Human coagulation factor VII concentrate BRP. Uses: For analytical and research use. Group: European Pharmacopoeia (Ph. Eur.); Pharmacopoeial Standards. Alternative Names: Blood-coagulation factor VII, Coagulation factor VII, Blood clotting factor VII, Serum prothrombin conversion accelerators,Human coagulation factor VII, F7 coagulation factor VII, Proconvertin, Factor VII, Blood coagulation factor VIIc. CAS No. 9001-25-6. Catalog: APS9001256. Format: Neat. Product Type: Other. Shipping: Ice pack (-20°C). | |
Human coagulation factor VIII concentrate BRP Quick inquiry Where to buy Suppliers range | Human coagulation factor VIII concentrate BRP. Uses: For analytical and research use. Group: European Pharmacopoeia (Ph. Eur.); Pharmacopoeial Standards. Alternative Names: Haemate P, AHG, Factor VIII/von Willebrand factor complex, Immunate STIM Plus, Hemofil T, Facteur Willebrand-LFB, Blood-coagulation factor VIII, complex, Biostate P, Blood-coagulation factor VIII, Humafactor 8, Beroctocog alfa, Octanate, Alphanate, Factor VIII, Wiloctin, Amofil, Humate P, Humafac, Wilate, Octonativ-M7, Thromboplastinogen, Biostate, Haemate, Nordiocto, Hemate P, Koate HP, Hemofil, FVIII-THP/SD,Human coagulation factor VIII, Optivate, Haemoctin SDH, Profilate, Haemate HS, Hemofil M, Fanhdi, Beriate HS, Factorate, AHF-HP, Beriate P, AHF. CAS No. 9001-27-8. Catalog: APS9001278. Format: Neat. Product Type: Other. Shipping: Ice pack (-20°C). | |
Human Platelet Factor IV 18, C18G Quick inquiry Where to buy Suppliers range | C18G is a synthetic α-helical peptide derived from human platelet factor IV. This peptide was found to be antibacterial and is active against Salmonella. Uses: Antimicrobial Peptides. Product ID: AF3345. | |
Atrial natriuretic factor (1-28) (human, porcine) Quick inquiry Where to buy Suppliers range | Atrial natriuretic factor (1-28) (human, porcine) is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendocrine cells of the heart from which it is released into the circulation. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, increase sodium excretion and inhibit renin secretion. It decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels at 8 μg/kg. It also inhibits arginine vasopressin-induced increase in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng. It produces diuretic, natriuretic and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure regulation. Synonyms: ANF 1-28; hANF; Atrial Natriuretic Peptide human. CAS No. 91917-63-4. Molecular formula: C127H205N45O39S3. Mole weight: 3080.46. | |
Atrial Natriuretic Factor (5-27) (human) Quick inquiry Where to buy Suppliers range | Synonyms: Atrial Natriuretic Peptide-23 (human); H-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-OH (Disulfide bridge: Cys3-Cys19); L-seryl-L-seryl-L-cysteinyl-L-phenylalanyl-glycyl-glycyl-L-arginyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-glycyl-L-alanyl-L-glutaminyl-L-seryl-glycyl-L-leucyl-glycyl-L-cysteinyl-L-asparagyl-L-seryl-L-phenylalanyl-L-arginine (3->19)-disulfide. Grades: ≥95%. CAS No. 98929-56-7. Molecular formula: C97H154N34O32S3. Mole weight: 2404.67. | |
Corticotropin-releasing Factor TFA Salt (Human, rat) (Technical Grade) Quick inquiry Where to buy Suppliers range | Corticotropin-releasing Factor TFA Salt (Human, rat) (Technical Grade). Uses: For analytical and research use. Group: Phytochemicals. Alternative Names: Corticorelin Human Trifluoroacetic Acid Salt, Corticorelin Trifluoroacetic Acid Salt,Corticobiss Trifluoroacetic Acid Salt, Human CRF Trifluoroacetic Acid Salt, Corticotropin-releasing Ractor (Rat) Trifluoroacetic Acid Salt, Corticotropin-releasing Factor (Mesocricetus Auratus) Trifluoroacetic Acid Salt, Human ACTH-releasing Factor Trifluoroacetic Acid Salt. Pack Sizes: 1MG. Molecular formula: C208H344N60O63S2.xC2HF3O2. Mole weight: 4757.45. Catalog: APS007067. SMILES: ['Ser'] ['Glu'] ['Glu'] ['Pro'] ['Pro'] ['Ile'] ['Ser'] ['Leu'] ['Asp'] ['Leu'] ['Thr'] ['Phe'] ['His'] ['Leu'] ['Leu'] ['Arg'] ['Glu'] ['Val'] ['Leu'] ['Glu'] ['Met'] ['Ala'] ['Arg'] ['Ala'] ['Glu'] ['Gln'] ['Leu'] ['Ala'] ['Gln'] ['Gln'] ['Ala'] ['His'] ['Ser'] ['Asn'] ['Arg'] ['Lys'] ['Leu'] ['Met'] ['Glu'] ['Ile'] ['Ile']N. OC (=O) C (F) (F) F. Format: Neat. Shipping: Room Temperature. | |
Prepro-Atrial Natriuretic Factor (26-55) (human) Quick inquiry Where to buy Suppliers range | Prepro-Atrial Natriuretic Factor (human) can reduce adenylate cyclase activity. Synonyms: PREPRO-HANF (26-55) CARDIODILATIN-RELATED PEPTIDE (HUMAN); PREPRO-HANF FRAGMENT 26-55, HUMAN; PREPRO-ANF (26-55), HUMAN; PREPRO-ATRIAL NATRIURETIC FACTOR (26-55) (HUMAN); PREPRO-ATRIAL NATRIURETIC PEPTIDE, FRAGMENT 26-55 HUMAN; H-ASN-PRO-MET-TYR-ASN-ALA-VAL-S. Grades: 95%. CAS No. 112160-82-4. Molecular formula: C152H236N38O51S3. Mole weight: 3507.92. | |
Rheumatoid Factor, Control Serum, Human Quick inquiry Where to buy Suppliers range | Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology. Rheumatoid arthritis is a systemic disease characterized by chronic proliferation and inflammation of joint cartilage and supporting structures. RA is mainly defined by clinical criteria, in which systematic pathogenetic studies have been hampered by doubts about the presence of common pathogenetic mechanisms and the relative lack of unique laboratory findings. IgG rheumatoid factor has been reported to be present in sera of patients with rheumatoid arthritis both with and without IgM rheumatoid factor activity. Group: Biologicals. Grades: Serum. Pack Sizes: 2ml. US Biological Life Sciences. | Worldwide |
(Tyr0)-prepro-atrial natriuretic factor (104-123) (human) Quick inquiry Where to buy Suppliers range | Synonyms: (Tyr0)-kaliuretic peptide (human). CAS No. 309245-24-7. Molecular formula: C103H180N32O30. Mole weight: 2346.72. | |
Platelet Factor 4 (58-70), human Quick inquiry Where to buy Suppliers range | Platelet Factor 4 (58-70), human, a peptide based on the amino acid sequence corresponding to residues 58-70 of platelet factor-4 (PF-4), contains the major heparin-binding domain, which is not sufficient for full antiangiogenic activity. Uses: Peptide Inhibitors. CAS No. 82989-21-7. Product ID: R1621. | |
Platelet Factor 4 (58-70), human Quick inquiry Where to buy Suppliers range | It is the 58-70 amino acid fragment of Platelet Factor 4 (PF-4) that contains the major heparin-binding domain and is insufficient to fully exert its antiangiogenic activity. Synonyms: PF4 (58-70) (human); Pro-Leu-Tyr-Lys-Lys-Ile-Ile-Lys-Lys-Leu-Leu-Glu-Ser; L-prolyl-L-leucyl-L-tyrosyl-L-lysyl-L-lysyl-L-isoleucyl-L-isoleucyl-L-lysyl-L-lysyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-serine; platelet factor 4 fragment 58-70 human. Grades: 95%. CAS No. 82989-21-7. Molecular formula: C76H133N17O18. Mole weight: 1572.97. | |
Human growth hormone-releasing factor Quick inquiry Where to buy Suppliers range | Human growth hormone-releasing factor stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary. Uses: Peptide Inhibitors. CAS No. 83930-13-6. Product ID: R1435. | |
Hypercalcemia of malignancy factor fragment 1-34 amide human Quick inquiry Where to buy Suppliers range | Hypercalcemia of malignancy factor fragment 1-34 amide is an extraordinary biomedical innovation exhibiting remarkable potential in the research of hypercalcemia linked to malignancies. Synonyms: Hypercalcemia of Malignancy Factor (1-34) amide (human, mouse, rat); H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-NH2; pTH-Related Protein (1-34) amide (human, mouse, rat); L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-leucyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-lysyl-glycyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-isoleucyl-L-alanyl-L-alpha-glutamyl-L-isoleucyl-L-histidyl-L-threonyl-L-alaninamide; PTHrP (1-34) amide. Grades: 95%. CAS No. 112955-31-4. Molecular formula: C180H288N58O47. Mole weight: 4016.57. | |
1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarbonyl Chloride Quick inquiry Where to buy Suppliers range | 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarbonyl Chloride is used in the synthesis of 6-substituted-4- (3-bromophenylamino) quinazoline derivatives which functions as irreversible inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases. Group: Biochemicals. Grades: Highly Purified. CAS No. 59826-28-7. Pack Sizes: 25mg, 50mg. Molecular Formula: C7H10ClNO, Molecular Weight: 159.61. US Biological Life Sciences. | Worldwide |
1-Chloro-N,N-2-trimethylpropenylamine Quick inquiry Where to buy Suppliers range | 1-Chloro-N,N-2-trimethylpropenylamine acts as a reagent in the synthesis and antitumor activity of (-)-bassianolide in human cancer cells through cell cycle arrest. Enantioselective total synthesis of nannocystins A and A0 as elongation factor 1 inhibitors. Total synthesis of (-)-caprazamycin A with antibacterial activity against Mycobacterium tuberculosis (TB) via diastereoselective aldol reaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 26189-59-3. Pack Sizes: 500mg, 1g. Molecular Formula: C6H12ClN. US Biological Life Sciences. | Worldwide |
2,3-Diaminobenzoic Acid Methyl Ester Hydrochloride Quick inquiry Where to buy Suppliers range | 1,2-Dibenzamidobenzene inhibitors of Human Factor Xa. Group: Biochemicals. Alternative Names: Methyl 2,3-Diaminobenzoate Hydrochloride. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
24-Hydroxycholesterol Quick inquiry Where to buy Suppliers range | 24-Hydroxycholesterol, also known as 24-OH-Chol, a natural sterol, is the main cholesterol elimination product of the brain. 24-Hydroxycholesterol is a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR. 24-Hydroxycholesterol acts as a neurotoxin to SH-SY5Y human neuroblastoma cells which showed corresponding morphological changes: the cells became round, lost adhesion to the petri-dish, and neurite outgrowth degenerated. Synonyms: (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; 24-hydroxycholesterol; 24S-hydroxycholesterol; cerebrosterol; cholest-5-ene-3,24-diol. CAS No. 30271-38-6. Molecular formula: C27H46O2. Mole weight: 402.65. | |
293 Cell Lysate, Human Insulin Treated Quick inquiry Where to buy Suppliers range | Positive control (insulin treated 293 cells) for I7661-18M, Insulin-Like Growth Factor I Receptor, phosphorylated (Tyr1316). Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
2-Bromo-5-methyl-4-thiazolecarboxylic Acid Quick inquiry Where to buy Suppliers range | 2-Bromo-5-methyl-4-thiazolecarboxylic Acid is a derivative of 4-Thiazolecarboxylic Acid (T344195); a chemical reagent used in the synthesis of novel benzimidazole analogs as highly potent hypoxia inducible factor-1α inhibitors that show comparable potency in inhibition of human breast cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1194374-25-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C5H4BrNO2S, Molecular Weight: 222.06. US Biological Life Sciences. | Worldwide |
(2E)-N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide Quick inquiry Where to buy Suppliers range | (2E)-N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)-4-(dimethylamino)-2-butenamide was used in the study for preparation of disubstituted (arylamino) quinolinecarbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 848133-88-0. Pack Sizes: 25mg, 100mg. Molecular Formula: C18H19ClN4O2, Molecular Weight: 358.82. US Biological Life Sciences. | Worldwide |
2-Hydroxy-4-methylpyridine-d3 Quick inquiry Where to buy Suppliers range | 2-Hydroxy-4-methylpyridine-d3 is the isotope labelled analog of 2-Hydroxy-4-methylpyridine (H949890); an intermediate used to prepare oxobenzopyrancarboxyl ate derivatives as inhibitors of serine proteases and human leukocyte elastase. It is also used in the synthesis of (indanylamino) (pyridinyloxy) pyrazines and analogs as corticotropin releasing factor type-1 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1185316-03-3. Pack Sizes: 5mg, 10mg. Molecular Formula: C6H4D3NO, Molecular Weight: 112.14. US Biological Life Sciences. | Worldwide |
2-Hydroxy-4-methylpyridine-d6 Quick inquiry Where to buy Suppliers range | 2-Hydroxy-4-methylpyridine-d6 is the isotope labelled analog of 2-Hydroxy-4-methylpyridine (H949890); an intermediate used to prepare oxobenzopyrancarboxyl ate derivatives as inhibitors of serine proteases and human leukocyte elastase. It is also used in the synthesis of (indanylamino) (pyridinyloxy) pyrazines and analogs as corticotropin releasing factor type-1 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 916979-13-0. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C6HD6NO, Molecular Weight: 115.16. US Biological Life Sciences. | Worldwide |
(2R)-N-Boc-4-oxo-proline Quick inquiry Where to buy Suppliers range | (2R)-N-Boc-4-oxo-proline was used as a reactant in the preparation of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides which are potent factor Xa inhibitors with increased human half life. Also used in the synthesis of azacyclic FTY720 analogues which show potential for use in strategy to kill cancer cells as they restrict access to extracellular nutrients. Group: Biochemicals. Grades: Highly Purified. CAS No. 364077-84-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C10H15NO5, Molecular Weight: 229.23. US Biological Life Sciences. | Worldwide |
(2S, 4R) -1- ( (S) -2- (1-Cyanocyclopropane carboxamido) -3, 3-di methyl butanoyl) -4-hydroxy-N- (4- (4- methyl thiazol-5-yl) benzyl) pyrrolidine-2-carboxamide Quick inquiry Where to buy Suppliers range | (2S, 4R) -1- ( (S) -2- (1-Cyanocyclopropane carboxamido) -3, 3-di methyl butanoyl) -4-hydroxy-N- (4- (4- methyl thiazol-5-yl) benzyl) pyrrolidine-2-carboxamide is a VHL inhibitors that decreases hypoxia inducible factor-α during hypoxia associated signaling in human cervical cancer, osteosarcoma HeLa and U2OS. cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 2097381-85-4. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C27H33N5O4S, Molecular Weight: 523.65. US Biological Life Sciences. | Worldwide |
(2S)-N-Nitrosonornicotine Quick inquiry Where to buy Suppliers range | A tobacco alkaloid as risk factor of human cancer. Group: Biochemicals. Alternative Names: N-Nitrosonornicotine; (S)-3-(1-Nitroso-2-pyrrolidinyl)pyridine; 1-Demethyl-1-nitroso-nicotine. Grades: Highly Purified. CAS No. 16543-55-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
3,4-Diaminobenzoic Acid Methyl Ester Hydrochloride Quick inquiry Where to buy Suppliers range | 1,2-Dibenzamidobenzene inhibitors of Human Factor Xa. Group: Biochemicals. Alternative Names: 4-(Methoxycarbonyl)-1,2-benzenediamine Hydrochloride; 4-Carbomethoxy-o-phenylenediamine Hydrochloride; 4-Methoxycarbonyl-o-phenylenediamine Hydrochloride; Methyl 3, 4-Diamino Benzene carboxylate Hydrochloride; Methyl 3,4-Diaminobenzoate Hydrochloride. Grades: Highly Purified. CAS No. 1210824-92-2. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
3-Amino-2,4-dibromopyridine Quick inquiry Where to buy Suppliers range | 3-Amino-2,4-dibromopyridine is a versatile reactant used in the synthesis of novel indolizine 2-oxoacetamides that are inhibitors of phosphodiesterase IV and tumor necrosis factor-α production in human peripheral blood mononuclear cell. Group: Biochemicals. Grades: Highly Purified. CAS No. 102249-45-6. Pack Sizes: 50mg, 250mg. Molecular Formula: C5H4Br2N2, Molecular Weight: 251.91. US Biological Life Sciences. | Worldwide |
3-Aminopropyl-24,25-dihydroxy Vitamin D3 Quick inquiry Where to buy Suppliers range | 3-Aminopropyl-24,25-dihydroxy Vitamin D3 is a derivative of Vitamin D3 (V676045), an important factor in maintaining bone health, and has also been associated with cardiovascular health in humans. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250ug, 1mg. Molecular Formula: C30H51NO3. US Biological Life Sciences. | Worldwide |
3-Chloro-4-(2-pyridylmethoxy)aniline Quick inquiry Where to buy Suppliers range | 3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino) quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 524955-09-7. Pack Sizes: 1g, 5g. Molecular Formula: C12H11ClN2O, Molecular Weight: 234.68. US Biological Life Sciences. | Worldwide |
4-IPP Quick inquiry Where to buy Suppliers range | 4-IPP is a potent and cell-permeable macrophage migration inhibitory factor (MIF) antagonist. It covalently modifies MIF N-terminal proline. It inhibits MIF-associated liver enzyme activity in vivo and acts as a suicide substrate to inactivate MIF biological and catalytic functions. It also inhibits anchorage and migration independence of human lung adenocarcinoma cell lines in vitro. Synonyms: 4-IPP; 4 IPP; 4IPP; 4-Iodo-6-phenylpyrimidine. Grades: ≥99% by HPLC. CAS No. 41270-96-6. Molecular formula: C10H7IN2. Mole weight: 282.08. | |
5'-O-Acetyl-2',3'-dideoxyinosine Quick inquiry Where to buy Suppliers range | 5'-O-Acetyl-2',3'-dideoxyinosine is an extensively utilized potent antiviral compound within the biomedical field, exhibiting impressive efficacy in research of viral infections induced by the human immunodeficiency virus (HIV). By impeding the reverse transcriptase enzyme, a pivotal factor for viral replication, this compound effectively impedes viral multiplication. Synonyms: 5'-O-Acetyldidanosine; 5'-O-Acetyl-2',3'-dideoxy-D-inosine. CAS No. 130676-58-3. Molecular formula: C12H14N4O4. Mole weight: 278.26. | |
ABT-491 Hydrochloride Quick inquiry Where to buy Suppliers range | ABT-491 Hydrochloride is a potent, selective and orally active platelet-activating factor receptor (PAF-R) antagonist (Ki = 0.6 nM in human platelets). Synonyms: 4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-N,N-dimethylindole-1-carboxamide;hydrochloride; ABT 491 hydrochloride; ABT 491; ABT-491; ABT491. Grades: >98%. CAS No. 189689-94-9. Molecular formula: C28H23ClFN5O2. Mole weight: 515.97. | |
AC480 Quick inquiry Where to buy Suppliers range | AC480, also known as BMS-599626, is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. Synonyms: BMS-599626; BMS 599626; BMS599626; AC 480; AC-480; Carbamic acid, N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; (3S)-3-Morpholinylmethyl N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate; Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester; N-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid, (3S)-3-morpholinylmethyl ester. Grades: ≥95%. CAS No. 714971-09-2. Molecular formula: C27H27FN8O3. Mole weight: 530.55. | |
Adaptaquin Quick inquiry Where to buy Suppliers range | Adaptaquin is an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) with IC50 value of 2 μM in a reporter assay using SH-SY5Y-ODD-Luc cells. It displays neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models by inhibition of ATF4 dependent genes. It reduces neuronal death and behavioral deficits after intracerebral hemorrhage (ICH) in several rodent models. It blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. It stabilizes HIF-1α protein and induces expression of the HIF1-regulated genes EPO and VEGF in SH-SY5Y human neuroblastoma cells. It is used in ischemic injury research, renal anemia, and used as an antioxidant. It is also used in pyruvate dehydrogenase (PDH) related research. Synonyms: 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol. Grades: ≥97% by HPLC. CAS No. 385786-48-1. Molecular formula: C21H16ClN3O2. Mole weight: 377.82. | |
Adenosine-3,5-cyclic Monophosphate Sodium Salt (A-3:5-MP, cAMP, Na) Quick inquiry Where to buy Suppliers range | A key regulator of many cellular reactions. Released in response to hormonal stimulation. An activator of protein kinase A. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Acts as a second messenger in signal transduction mechanisms. Promotes apoptosis in resting human B lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 37839-81-9. Pack Sizes: 1g. Molecular Formula: C??H??N?O?P · Na. US Biological Life Sciences. | Worldwide |
Adenosine-3',5'-cyclic Monophosphate Sodium Salt (A-3:5-MP, cAMP, Na) Quick inquiry Where to buy Suppliers range | A key regulator of many cellular reactions. Released in response to hormonal stimulation. An activator of protein kinase A. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Acts as a second messenger in signal transduction mechanisms. Promotes apoptosis in resting human B lymphocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 37839-81-9. Pack Sizes: 100mg, 1g. US Biological Life Sciences. | Worldwide |
Adropin (34-76) (human, mouse, rat) Quick inquiry Where to buy Suppliers range | Adropin, a secreted factor involved in energy homeostasis and lipid metabolism, is encoded by the energy homeostasis-related gene (Enho) and expressed in the liver and brain. In diet-induced obesity (DIO) mice, adropin (34-76) reduced hepatosteatosis and insulin resistance, regardless of obesity or food intake. In addition, adropin could be a regulator of endothelial function. Synonyms: H-Cys-His-Ser-Arg-Ser-Ala-Asp-Val-Asp-Ser-Leu-Ser-Glu-Ser-Ser-Pro-Asn-Ser-Ser-Pro-Gly-Pro-Cys-Pro-Glu-Lys-Ala-Pro-Pro-Pro-Gln-Lys-Pro-Ser-His-Glu-Gly-Ser-Tyr-Leu-Leu-Gln-Pro-OH (Disulfide bridge: Cys1-Cys23); L-Cysteinyl-L-histidyl-L-seryl-L-arginyl-L-seryl-L-alanyl-L-alpha-aspartyl-L-valyl-L-alpha-aspartyl-L-seryl-L-leucyl-L-seryl-L-alpha-glutamyl-L-seryl-L-seryl-L-prolyl-L-asparaginyl-L-seryl-L-seryl-L-prolylglycyl-L-prolyl-L-cysteinyl-L-prolyl-L-alpha-glutamyl-L-lysyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-glutaminyl-L-lysyl-L-prolyl-L-seryl-L-histidyl-L-alpha-glutamylglycyl-L-seryl-L-tyrosyl-L-leucyl-L-leucyl-L-glutaminyl-L-proline cyclic (1?23)-disulfide. Grades: ≥95%. CAS No. 1802086-30-1. Molecular formula: C190H293N55O68S2. Mole weight: 4499.82. | |
AEE-788 Quick inquiry Where to buy Suppliers range | AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. Synonyms: AEE 788; AEE788; 6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine. Grades: >98%. CAS No. 497839-62-0. Molecular formula: C27H32N6. Mole weight: 440.595. | |
AG-183 Quick inquiry Where to buy Suppliers range | AG-183 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 0.8 μM in the human epidermoid carcinoma cell line A431. Synonyms: Tyrphostin 51; Tyrphostin AG 183. Grades: ≥98%. CAS No. 122520-90-5. Molecular formula: C13H8N4O3. Mole weight: 268.2. | |
AG-213 Quick inquiry Where to buy Suppliers range | AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 2.4 μM in the human epidermoid carcinoma cell line A431. Uses: Enzyme inhibitors. Synonyms: Tyrphostin AG-213; Tyrphostin 47; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide. Grades: ≥97%. CAS No. 122520-86-9. Molecular formula: C10H8N2O2S. Mole weight: 220.2. | |
AG-82 Quick inquiry Where to buy Suppliers range | AG-82 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 3 μM in the human epidermoid carcinoma cell line A431. Uses: Antineoplastic agents. Synonyms: NSC 676484; RG-50875; Tyrphostin 25; Tyrphostin AG-82. Grades: ≥95%. CAS No. 118409-58-8. Molecular formula: C10H6N2O3. Mole weight: 202.2. | |
AGI-B4 Quick inquiry Where to buy Suppliers range | AGI-B4 is a substance produced by Aspergillus sp. Y80118 that inhibits the growth of endothelial cells. It inhibits the proliferation of human umbilical vein endothelial cells (HUVECs) induced by vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and endothelial cell growth factor (ECGS) with IC50 of 1.4 μmol/ L, 2.8 μmol/L and 6.2 μmol/L. Synonyms: (7R,8R)-AGI-B4. CAS No. 1313588-44-1. Molecular formula: C16H14O7. Mole weight: 318.28. | |
AhR Agonist V, VAF347 Quick inquiry Where to buy Suppliers range | A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation. Group: Biochemicals. Alternative Names: ((4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine). Grades: Highly Purified. CAS No. 574759-62-9. Pack Sizes: 10mg. Molecular Formula: C??H??ClF?N?, Molecular Weight: 349.7. US Biological Life Sciences. | Worldwide |
AITRL human Quick inquiry Where to buy Suppliers range | AITRL, a cytokine belonging to the tumor necrosis factor (TNF) ligand superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. AITRL is a ligand for receptor TNFRSF18/AITR/GITR. GITR/AITRL interaction plays a role in the pathogenesis of tumors, inflammation, and autoimmune diseases. In addition, AITRL is involved in endothelial cell (EC) activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1). Synonyms: Activation-induced TNFR member Ligand; TNFSF18; rHuActivation-inducible TNF-related Ligand/AITRL; GITRL; TL-6; Tumor necrosis factor ligand superfamily member 18; rHuAITRL; GITR Ligand. Grades: ≥98% by HPLC. Mole weight: ~14.3 kDa. | |
α-helical CRF 9-41 Quick inquiry Where to buy Suppliers range | α-helical CRF 9-41 has been found to be a corticotropin-releasing factor receptor antagonist. Synonyms: Corticotropin-releasing factor (human), 1-de-L-serine-2-de-L-glutamicacid-3-de-L-glutamicacid-4-de-L-proline-5-de-L-proline-6-de-L-isoleucine-7-de-L-serine-8-de-L-leucine-18-L-methionine-23-L-lysine-27-L-glutamic acid-29-L-glutamicacid-32-L-alanine-33-L-leucine-36-L-leucine-38-L-leucine-40-L-glutamicacid-41-L-alaninamide-; CHEMBL526149. Grades: ≥95% by HPLC. CAS No. 90880-23-2. Molecular formula: C166H274N46O53S2. Mole weight: 3827.00. | |
AMPK Signaling Agonist, F17 (4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide) Quick inquiry Where to buy Suppliers range | A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~0.1uM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-a1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25uM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C. Group: Biochemicals. Grades: Highly Purified. CAS No. 280112-24-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Andrographolide Quick inquiry Where to buy Suppliers range | Andrographolide is a labdane diterpenoid. Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata. Andrographolide showed significant antihepatotoxic action in P. berghei K173- induced hepatic damage in M. natalensis. Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases. These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent. Group: Biochemicals. Alternative Names: (3E, 4S) -3- [2- [ (1R, 4aS, 5R, 6R, 8aS) -Decahydro-6-hydroxy-5- (hydroxymethyl) -5, 8a-dimethyl-2-methylene-1-naphthalenyl] ethylidene] dihydro-4-hydroxy-2 (3H) -furanone; [1R-[1α[E(S*)],4a β , 5α , 6α , 8aα ] ] -3- [2- [Decahydro-6-hydroxy-5- (hydroxymethyl) -5, 8a-dimethyl-2-methylene-1-naphthalenyl] ethylidene] dihydro-4-hydroxy-2 (3H) -furanone; 3α,14,15,18-Tetrahydroxy-5 β,9 βH,10α-labda-8(20),12-dien-16-oic Acid γ-Lactone; Andrographis; Andrographolid. Grades: Highly Purified. CAS No. 5508-58-7. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
APRIL human Quick inquiry Where to buy Suppliers range | APRIL (a proliferation-inducing ligand), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI. APRIL protein (CD256) can induce proliferation, regulate tumor cell growth, and may participate in mononuclear/macrophage-mediated immune process. APRIL protein has been widely used in the study of lymphatic malignancies. Synonyms: A Proliferating-inducing Ligand; TNFSF13; TRDL-1a; APRIL/TNFSF13 Protein, Mouse; rMuApril/TNFSF13; TNFSF 13; TNFSF-13; CD256; TALL-2; TALL2; TNLG7B; TRDL-1; UNQ383/PRO715; ZTNF2. Grades: ≥95% by HPLC. Mole weight: ~16.3 kDa. | |
ARE Activator, BTZO-1 (Macrophage Migration Inhibitory Factor Antagonist II, 2-Pyridin-2-yl-4H-1,3-benzothiazin-4-one, MIF Antagonist II) Quick inquiry Where to buy Suppliers range | A cell-permeable benzothiazinone that is shown to interact with MIF homotrimer (=68.6nM and 157nM toward human and rat MIF, respectively, at pH 7.3) via the N-terminal proline in a pH-dependent manner, limiting its inhibitory capability against MIF tautomerase activity (13% inhibition at pH 6.0; [BTZO-1] = 30uM) due to reduced MIF binding at acidic pH. Shown to protect primary rat cardiomyocytes (330nM) from apoptotic death upon serum deprivation or DOX (200nM) treatment via activation of ARE- (antioxidant response element) mediated cytoprotective genes transcription in a MIF-dependent manner. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?N?OS, Molecular Weight: 240.3. US Biological Life Sciences. | Worldwide |
Asiaticoside Quick inquiry Where to buy Suppliers range | Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor. Group: Biochemicals. Alternative Names: Blastostimulina, Centelase, Emdecassol, Madecassol, Marticassol, FK1080, BRN 0078195, NSC 166062. Grades: Highly Purified. CAS No. 16830-15-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C48H78O19. US Biological Life Sciences. | Worldwide |
(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) Quick inquiry Where to buy Suppliers range | (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) is an effective antagonist against pTH-stimulated cAMP production in ROS cells and shows no partial agonism effect. Synonyms: (Asn10,Leu11,D-Trp12)-Hypercalcemia of Malignancy Factor (7-34) amide (human, mouse, rat); H-Leu-Leu-His-Asn-Leu-D-Trp-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-NH2; L-Leucyl-L-leucyl-L-histidyl-L-asparaginyl-L-leucyl-D-tryptophyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-α-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-histidyl-L-histidyl-L-leucyl-L-isoleucyl-L-alanyl-L-α-glutamyl-L-isoleucyl-L-histidyl-L-threonyl-L-alaninamide; (Asn10,Leu11,D-Trp12)-pTHrP (7-34) amide. Grades: ≥95%. CAS No. 129622-68-0. Molecular formula: C162H254N50O36. Mole weight: 3478.06. | |
Asterric Acid (Dimethylosoic acid, Antibiotic TAN 1415A, Antibiotic WF 12880A) Quick inquiry Where to buy Suppliers range | A fungal metabolite, asterric acid is isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF). Asterric acid is an angiogenesis inhibitor acting on VEGF-induced tube formation of human umbilical vein endothelial cells. Group: Biochemicals. Alternative Names: Dimethylosoic acid, Antibiotic TAN 1415A, Antibiotic WF 12880A. Grades: Highly Purified. CAS No. 577-64-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Astressin Quick inquiry Where to buy Suppliers range | Astressin is a novel potent corticotropin releasing factor (CRF) antagonist. Astressin may be a useful tool to explore functional CRF-dependent physiological pathways in specific brain nuclei. Uses: Neuroprotective agents. Synonyms: (D-Phe12,Nle21·38,Glu30,Lys33)-CRF (12-41) (human, rat); H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu(1)-Ala-His-Lys(1)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2. Grades: ≥95%. CAS No. 170809-51-5. Molecular formula: C161H269N49O42. Mole weight: 3563.16. | |
AT7867 dihydrochloride Quick inquiry Where to buy Suppliers range | AT7867 also inhibits structurally related AGC kinases p70S6K and PKA with IC50 of 20 nM and 85 nM, respectively. AT7867 shows ATP-competitive activity to Akt2 with Ki of 18 nM. AT7867 exhibits antiproliferation in cell lines with PTEN or PIK3CA mutations and shows great potent to MES-SA, MDA-MB-468, MCF-7, HCT116 and HT29 with IC50 of 0.94 μM, 2.26 μM, 1.86 μM, 1.76 μM and 3.04 μM, respectively. AT7867 also suppresses the cell growth of U87MG, PC-3 and DU145 cells with IC50 of 8.22 μM, 10.37 μM and 11.86 μM, respectively. AT7867 suppresses Akt activity by inhibiting phosphorylation of GSK-3β in human tumor cells with IC50 of 2-4 μM. AT7867 also induces the phosphorylation of the following Akt direct substrates including proapoptotic transcription factors FKHR (FoxO1a), FKHRL1 (FoxO3a) and the downstream target S6RP in U87MG cells. AT7867 shows bioavailability of 44% in mice by p.o. route. AT7867 could increase the cleaved PARP in MES-SA xenografts at 20 mg/kg i.p. or 90 mg/kg p.o. AT7867 significantly inhibits the tumor growth in MES-SA xenografts or U87MG xenografts with T/C of 0.37 and 0.51, respectively. Synonyms: AT-7867 dihydrochloride; AT 7867 dihydrochloride. Grades: >98%. CAS No. 1431697-86-7. Molecular formula: C20H22Cl3N3. Mole weight: 410.77. | |
Atractyloside, Calcium Salt Quick inquiry Where to buy Suppliers range | Atractyloside Calcium Salt is a specific inhibitor of the adenine nucleotide translocase (ANT), which is a mitochondrial ADP/ATP carrier. It is also a proapoptotic ligand of ANT that induces pore formation by ANT, and results in permeabilization of the mitochondria membrane. Studies on rat hearts suggest that Atractyloside inhibits chloride channels from the mitochondrial membrane. It is used to probe the source of procaspase 8 in human fibroblasts and mouse clonal striatal cells, as related to death receptor-mediated apoptosis. Atractyloside induces the release of ahyaluronidase-induced murine WW domain-containing oxidoreductase from cultured COS-7 cells, with respect to tumor necrosis factor cytotoxicity. Group: Biochemicals. Alternative Names: (2 β,15α)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo- β-D-glucopyranosyl]oxy]-19-Norkaur-16-en-18-oic Acid Calcium Salt; 19-Norkaur-16-en-18-oic acid deriv. 1H-2,10a-Ethanophenanthrene Calcium Salt. Grades: Highly Purified. CAS No. 772298-35-8 free acid. Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate Quick inquiry Where to buy Suppliers range | It is a 28-amino acid hormone that inhibits the secretion of endothelin-1 in a dose-dependent manner. Normally, it is produced and secreted by the human heart in response to cardiac injury and mechanical stretching. Synonyms: Atrial Natriuretic Factor (1-28) (human) acetate salt; H-Ser-Leu-Arg-Arg-Ser-Ser-Cys(1)-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys(1)-Asn-Ser-Phe-Arg-Tyr-OH.CH3CO2H; L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanyl-glycyl-glycyl-L-arginyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-glycyl-L-alanyl-L-glutaminyl-L-seryl-glycyl-L-leucyl-glycyl-L-cysteinyl-L-asparagyl-L-seryl-L-phenylalanyl-L-arginyl-L-tyrosine (7->23)-disulfide acetic acid. Grades: ≥95%. CAS No. 1366000-58-9. Molecular formula: C127H203N45O39S3.C2H4O2. Mole weight: 3140.50. | |
AV-412 Quick inquiry Where to buy Suppliers range | AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Synonyms: AV 412; AV412; N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide. CAS No. 451492-95-8. Molecular formula: C27H28ClFN6O. Mole weight: 507.01. | |
BAW2881 Quick inquiry Where to buy Suppliers range | BAW 2881 is a VEGFR (vascular endothelial growth factor receptor) inhibitor (IC50 = 0.82, 0.037, and 0.42 μM for VEGFR1, 2, and 3, respectively).It can inhibit proliferation, migration, and tube formation by human umbilical vein endothelial cells and lymphatic endothelial cells in vitro. Synonyms: BAW2881; BAW-2881; BAW 2881; NVP-BAW2881; NVP-BAW-2881; NVP-BAW 2881. 6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide. Grades: 98%. CAS No. 861875-60-7. Molecular formula: C22H15F3N4O2. Mole weight: 424.38. | |
BDNF (human) Quick inquiry Where to buy Suppliers range | Brain-derived neurotrophic factor, also known as BDNF, is a protein that, in humans, is encoded by the BDNF Gene. BDNF is a member of the neurotrophin growth factor family, which binds and activates TrkB and p75 neurotrophin receptors. It can enhances the survival, growth and differentiation of neurons. BDNF has been shown to play a role in neuroplasticity, which allows nerve cells in the brain to compensate for injury. Synonyms: BDNF. Grades: ≥96%. CAS No. 218441-99-7. Mole weight: 26984. | |
Beclin-1 Activator I, TAT-Beclin-1 (Atg6 Activator I, Beclin1-GAPR-1 Interaction Blocker I, Vps30 Activator I, H2N-YGRKKRRQRRR-GG-TNVFNATFEIWHDGEFGT-CO2H) Quick inquiry Where to buy Suppliers range | A cell-permeable autophagy-inducing peptide (Effective conc. 30 to 100uM) that is designed based on the essential HIV-1 virulence factor Nef-binding sequence of atg6/beclin1 and N-terminally fused to the HIV-1 Tat protein transduction domain sequence. Tat-Beclin1 is reported to compete against Beclin1 for binding to its negative regulator GAPR-1/GLIPR2 on the Golgi surface. Shown to effectively induce autophagy-mediated clearance of small (<1uM) CFP-htt103Q aggregates in HeLa cells (20uM/4h/d for 2 d) and inhibit RNA viral replications both in cultures (4h 10uM peptide treatment 4h post CHIKV, SINV, or WNV infection in HeLa cultures; 24h 0.5-5uM peptide pre-treatment before HIV infection in human MDM cultures) in vitro and in mice (15-20mg/kg/day i.p.) in vivo. The in vivo bioavailability of Tat-Beclin1 is limited to the peripheral tissues in mice, while a peptide based on Tat-Beclin1 retro-inverso sequence is demonstrated to effectively target CNS. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C???H???N??O??, Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly-Gly~Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr-OH. US Biological Life Sciences. | Worldwide |
Benzamidine hydrochloride Quick inquiry Where to buy Suppliers range | Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 μM, respectively). Benzamidine inhibits the autoactivation of human blood coagulation factor VII, useful as a tool for studying the interactions between this and other relevant growth factors. Uses: Serine proteinase inhibitors. Synonyms: Benzenecarboximidamide, hydrochloride (1:1); Benzamidine, monohydrochloride; Benzenecarboximidamide, monohydrochloride; Amidinobenzene hydrochloride; Benzamidinium chloride; Benzimidamide hydrochloride. Grades: ≥98%. CAS No. 1670-14-0. Molecular formula: C7H8N2.HCl. Mole weight: 156.61. | |
BGB-283 Quick inquiry Where to buy Suppliers range | BGB-283 is a selective Epidermal growth factor receptor and Proto oncogene protein b raf inhibitor under the development of BeiGene. BGB-283 shows antitumor activity in B-RAF Mutated Colorectal Cancers. In vitro, BGB-283 can inhibit B-RAFV600E-activated ERK phosphorylation and cell proliferation. In vivo, BGB-283 can lead to dose-dependent tumor growth inhibition accompanied by partial and complete tumor regressions in both cell-line derived and primary human colorectal tumor xenografts bearing B-RAFV600E mutation. Phase I clinical trials for the treatment of solid tumours are on-going. Uses: Solid tumours. Synonyms: UNII-8762XZS5ZF; 8762XZS5ZF; BGB-283; BGB 283; BGB283; Beigene-283; Beigene283; Beigene 283; Lifirafenib; Compound 2.2b; Beigene-283; GTPL8958;5-[[(1R,1aS,6bR)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one. Grades: 98%. CAS No. 1446090-77-2. Molecular formula: C25H17F3N4O3. Mole weight: 478.31. |