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Process impurity of Darunavir-d9 synthesis. Group: Biochemicals. Alternative Names: Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Process impurity of Darunavir synthesis. Group: Biochemicals. Alternative Names: Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide is a metabolite of Darunavir. Synonyms: 4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)benzenesulfonamide; 4-amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-(2-methylpropyl)benzenesulfonamide. Grades: > 95 %. CAS No. 169280-56-2. Molecular formula: C20H29N3O3S. Mole weight: 391.53.
Brecanavir
Brecanavir is a tyrosyl-based arylsulfonamide, high-affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type-1. This compound potently inhibited HIV-1 in cell culture assays with 50% effective concentrations (EC(50)s) of 0.2 to 0.53 nM and was equally active against HIV strains utilizing either the CXCR4 or CCR5 coreceptor, as was found with other PIs. Brecanavir had a <5-fold increase in EC(50)s against 80% of patient isolates tested and had a greater mean in vitro potency than amprenavir, indinavir, lopinavir, atazanavir, tipranavir, and darunavir. Brecanavir is by a substantial margin the most potent and broadly active antiviral agent among the PIs tested in vitro. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Brecanavir; GW-0385; GW-0385; GW0385; GW-640385; GW 640385; GW640385; GW-640385X; VX-385; VX 385; VX385. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 313682-08-5. Molecular formula: C33H41N3O10S2. Mole weight: 703.82. Purity:>98%. IUPACName: [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[1,3-benzodioxol-5-ylsulfonyl(2-methylpropyl)amino]-3-hydroxy-1-[4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl]butan-2-yl]carbamate. Canonical SMILES: Cc1nc(cs1)COc2ccc(cc2)C[C@@H]([C@@H](CN(CC(C)C)S(=O)(=O)c3ccc4c(c3)OCO4)O)NC(=O)O[C@H]5CO[C@@H]6[C@H]5CCO6. Product ID: ACM313682085-1. Alfa Chemistry ISO 9001
Brecanavir
Brecanavir is a tyrosyl-based arylsulfonamide, high-affinity, protease inhibitor (PI) for the treatment of human immunodeficiency virus type-1. This compound potently inhibited HIV-1 in cell culture assays with 50% effective concentrations (EC(50)s) of 0.2 to 0.53 nM and was equally active against HIV strains utilizing either the CXCR4 or CCR5 coreceptor, as was found with other PIs. Brecanavir had a <5-fold increase in EC(50)s against 80% of patient isolates tested and had a greater mean in vitro potency than amprenavir, indinavir, lopinavir, atazanavir, tipranavir, and darunavir. Uses: Hiv-1 protease inhibitor. Synonyms: Brecanavir; UNII-E367I8C7FI; CHEMBL206031; GW-0385; GW-640385; GW-640385X; VX-385; GW0385; GW640385; GW640385X; VX385; GW 0385; GW 640385; GW 640385X; VX 385; [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[1,3-benzodioxol-5-ylsulfonyl(2-methylpropyl)amino]-3-hydroxy-1-[4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl]butan-2-yl]carbamate. Grades: ≥98%. CAS No. 313682-08-5. Molecular formula: C33H41N3O10S2. Mole weight: 703.82.
Darunavir Ethanolate. Group: Biochemicals. Alternative Names: N-[ (1S, 2R) -3-[[ (4-aminophenyl) sulfonyl] (2-methylpropyl) amino]-2-hydroxy-1- (phenylmethyl) propyl]carbamic Acid (3R, 3aS, 6aR)Hexahydrofuro[2, 3-b]furan-3-yl Ester compd. with Ethanol. Grades: Highly Purified. CAS No. 635728-49-3. Pack Sizes: 5mg. Molecular Formula: C29H43N3O8S, Molecular Weight: 593.73. US Biological Life Sciences.
Worldwide
Darunavir Impurity 2
Darunavir Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: methyl ((2S,3R)-4-(4-amino-N-isobutylphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl)carbamate. CAS No. 1526916-57-3. Molecular formula: C22H31N3O5S. Mole weight: 449.56. Catalog: APB1526916573.
Darunavir Impurity A
Darunavir Impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide. CAS No. 169280-56-2. Molecular formula: C20H29N3O3S. Mole weight: 391.53. Catalog: APB169280562.
Darunavir N-β-D-Glucuronide
Darunavir N-β-D-Glucuronide is a metabolite of Darunavir, an inhibitor of human immunodeficiency virus protease. Synonyms: 1-Deoxy-1-[[4-[[[ (2R, 3S) -3-[[[[ (3R, 3aS, 6aR) -hexahydrofuro[2, 3-b]furan-3-yl]oxy]carbonyl]amino]-2-hydroxy-4-phenylbutyl] (2-methylpropyl) amino]sulfonyl]phenyl]amino]-β -D-glucopyranuronic Acid. Grades: > 95%. CAS No. 1159613-25-8. Molecular formula: C33H45N3O13S. Mole weight: 723.79.
N-[(1R,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic acid 1,1-dimethylethyl ester is an impurity of Darunavir, a human immunodeficiency virus (HIV) protease inhibitor that is used to treat patients with drug-resistant HIV. Synonyms: N-[(1R,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester. Grades: > 95%. CAS No. 1005324-46-8. Molecular formula: C25H35N3O7S. Mole weight: 521.63.
DNV-II impurity 2
N-[(1S,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic acid 1,1-dimethylethyl ester is an impurity of Darunavir, a human immunodeficiency virus (HIV) protease inhibitor that is used to treat patients with drug-resistant HIV. Synonyms: N-[(1S,2S)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester. Grades: > 95%. CAS No. 1133153-38-4. Molecular formula: C25H35N3O7S. Mole weight: 521.63.
tert-Butyl ((1S)-1-Hydroxy-1(isobutylamino)-3-phenylpropan-2-yl)carbamate is an protected intermediate in the synthesis of Darunavir (D193500), a second generation HIV-1-protease inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.