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| Product | Description | |
|---|---|---|
| Hydroxycamptothecin, 10- | Hydroxycamptothecin, 10-. Group: Biochemicals. CAS No. 19685-09-7. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| (±)-10-Hydroxycamptothecin | (±)-10-Hydroxycamptothecin is an alkaloid derived from the seed or root bark of the deciduous plant Camptotheca acuminata. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. It exhibits anticancer and antiangiogenic activities. It can be used in cosmetics material. Synonyms: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (±)-; (+/-)-10-Hydroxycamptothecin; 4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. Grade: ≥95%. CAS No. 64439-81-2. Molecular formula: C20H16N2O5. Mole weight: 364.35. |  |
| (±)-10-Hydroxycamptothecin | (±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity. Uses: Scientific research. Group: Natural products. Alternative Names: (±)-10-HCPT. CAS No. 64439-81-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0275. |  |
| 10-Hydroxycamptothecin | 10-Hydroxycamptothecin. Group: Biochemicals. Grades: Highly Purified. CAS No. 64439-81-2. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C20H16N2O5. US Biological Life Sciences. | Worldwide |
| 10-Hydroxycamptothecin | 10mg Pack Size. Group: Analytical Reagents, Biochemicals. Formula: C20H16N2O5. CAS No. 64439-81-2. Prepack ID 23489857-10mg. Molecular Weight 115.1768. See USA prepack pricing. |  |
| 10-?Hydroxycamptothecin Acetate | 10-?Hydroxycamptothecin Acetate is a derivative of Camptothecin (C175150), an antitumor compound used in the treatment of hyperproliferative diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 951770-22-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C22H18N2O6, Molecular Weight: 406.39. US Biological Life Sciences. | Worldwide |
| 7,11-Diethyl-10-hydroxycamptothecin | 7,11-Diethyl-10-hydroxycamptothecin. Group: Biochemicals. Alternative Names: (4S)-4, 8, 11-Triethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 947687-01-6. Pack Sizes: 1mg. Molecular Formula: C24H24N2O5, Molecular Weight: 420.46. US Biological Life Sciences. | Worldwide |
| 7-Ethyl-10-hydroxycamptothecin | 7-Ethyl-10-hydroxycamptothecin. Group: Biochemicals. Grades: Highly Purified. CAS No. 86639-52-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C22H20N2O5. US Biological Life Sciences. | Worldwide |
| 7-Ethyl-10-hydroxycamptothecin | 7-Ethyl-10-hydroxycamptothecin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-10-Hydroxycamptothecin. Appearance: Powder. CAS No. 86639-52-3. Molecular formula: C22H20N2O5. Mole weight: 392.4. Purity: 0.98. IUPACName: (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione. Canonical SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O. Density: 1.51±0.1 g/ml. Product ID: ACM86639523. Alfa Chemistry ISO 9001:2015 Certified. Categories: 7-ethyl-10-hydroxy-camptothecin. |  |
| 7-Ethyl-10-hydroxycamptothecin | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| 7-Ethyl-10-hydroxycamptothecin-[d5] | 7-Ethyl-10-hydroxycamptothecin-[d5] is the labelled analogue of 7-Ethyl-10-hydroxycamptothecin, which is the active metabolite of irinotecan, a DNA topoisomerase inhibitor. Synonyms: 7-Ethyl-10-hydroxycamptothecin-d5 (SN 38-D5); 1H-Pyrano[3',?4':6,?7]?indolizino[1,?2-b]?quinoline-3,?14(4H,?12H)?-dione, 4-ethyl-11-(ethyl-d5)?-4,?9-dihydroxy-, (4S)?-; 10-Hydroxy-7-ethylcamptothecin-d5; SN 38 Lactone-d5; USP Irinotecan Related Compound B-d5. Grade: >95%. CAS No. 718612-51-2. Molecular formula: C22H15D5N2O5. Mole weight: 397.45. | |
| (S)-10-Hydroxycamptothecin | (S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis -inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 10-HCPT; 10-Hydroxycamptothecin. CAS No. 19685-09-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N0095. | |
| SN-38. (7-Ethyl-10-hydroxycamptothecin) | A metabolite of Irinotecan, a DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 10-Hydroxy Camptothecin | A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; (S)-10-Hydroxycamptothecin; Hydroxycamptothecin; NSC 107124. Grades: Highly Purified. CAS No. 19685-09-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 10-Hydroxy Camptothecin-d5 | A labeled Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: (4S)-4-(Ethyl-d5)-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; (S)-10-Hydroxycamptothecin-d5; Hydroxycamptothecin-d5; NSC 107124-d5. Grades: Highly Purified. CAS No. 1330277-66-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 10-O-Methoxymethyl SN-38 | Protected Irinotecan metabolite. Group: Biochemicals. Alternative Names: 7-Ethyl-10-O-methoxymethyl-10-hydroxycamptothecin; 10-Hydroxy-10-O-methoxymethyl-7-ethylcamptothecin; 10-MOM SN-38; (4S)-4, 11-Diethyl-4-hydroxy-9-(methoxymethoxy)-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 1246815-54-2. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Chimmitecan | Chimmitecan is a potent topoisomerase I inhibitor. Chimmitecan is also an active metabolite of simmitecan. Chimmitecan displays outstanding activity in vitro and in vivo. The substitution at the 9-position benefits chimmitecan a salient anti-MDR activity, stability in human serum albumin, improved solubility, and oral availability, which might favorably promise its therapeutic potential in clinical settings. Synonyms: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-10-(2-propen-1-yl)-, (4S)-; (4S)-4-Ethyl-4,9-dihydroxy-10-(2-propen-1-yl)-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-10-(2-propenyl)-, (4S)-; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-10-(2-propenyl)-, (S)-; (S)-9-Allyl-10-Hydroxycamptothecin; (S)-10-allyl-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. Grade: ≥95%. CAS No. 185425-25-6. Molecular formula: C23H20N2O5. Mole weight: 404.42. | |
| Irinotecan, Hydrochloride Salt, Trihydrate ([1,4-Bipiperidine]-1-carboxylic Acid (S)-4, 11-diethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3, 4, 6, 7]indolizino[1, 2-b]quinolin-9-yl Ester, HCl Trihydrate) | Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 136572-09-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| SN-38 | SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC 50 s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. CAS No. 86639-52-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13704. | |
| Topotecan | Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions. It has also been used for in vitro apoptosis assays in PA317 cells. Synonyms: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-; (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)-; (S)-Topotecan; 10-Hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin; 9-(N,N-Dimethylaminomethyl)-10-hydroxycamptothecin; Evotopin; Hycamptamine; Hycamptin; Nogitecan; NSC 609699; Potactasol; SKF 104864; SKF-S 104864; TopoCED; Topophore C; Topotecan lactone; ZINC 1611274. Grade: ≥95%. CAS No. 123948-87-8. Molecular formula: C23H23N3O5. Mole weight: 421.45. | |
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