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| Product | Description | |
|---|---|---|
| Hydroxycamptothecin, 10- | Hydroxycamptothecin, 10-. Group: Biochemicals. CAS No. 19685-09-7. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| (±)-10-Hydroxycamptothecin | (±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity. Uses: Scientific research. Group: Natural products. Alternative Names: (±)-10-HCPT. CAS No. 64439-81-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0275. |  |
| 10-Hydroxycamptothecin | 10-Hydroxycamptothecin. Group: Biochemicals. Grades: Highly Purified. CAS No. 64439-81-2. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C20H16N2O5. US Biological Life Sciences. | Worldwide |
| 10-Hydroxycamptothecin | 10mg Pack Size. Group: Analytical Reagents, Biochemicals. Formula: C20H16N2O5. CAS No. 64439-81-2. Prepack ID 23489857-10mg. Molecular Weight 115.1768. See USA prepack pricing. |  |
| 10-Hydroxycamptothecin | Cas No. 19685-09-7. |  |
| 10-?Hydroxycamptothecin Acetate | 10-?Hydroxycamptothecin Acetate is a derivative of Camptothecin (C175150), an antitumor compound used in the treatment of hyperproliferative diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 951770-22-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C22H18N2O6, Molecular Weight: 406.39. US Biological Life Sciences. | Worldwide |
| 10-Hydroxycamptothecine | therapeutic effects for liver cancer, stomach, and neck cancer and leukemia. CAS No. 64439-81-2. Product ID: 1-00923. Molecular formula: C20H16N2O5. Mole weight: 364.36. Purity: >95%. Properties: mp 268-270°C loss on drying <1%. Source : extracted from the nuts of the Camptotheca acuninata Decne. Reference: |  |
| 7,11-Diethyl-10-hydroxycamptothecin | 7,11-Diethyl-10-hydroxycamptothecin. Group: Biochemicals. Alternative Names: (4S)-4, 8, 11-Triethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 947687-01-6. Pack Sizes: 1mg. Molecular Formula: C24H24N2O5, Molecular Weight: 420.46. US Biological Life Sciences. | Worldwide |
| 7,11-Diethyl-10-hydroxycamptothecin | Cas No. 947687-01-6. | |
| 7-Ethyl-10-hydroxycamptothecin | 7-Ethyl-10-hydroxycamptothecin. Group: Biochemicals. Grades: Highly Purified. CAS No. 86639-52-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C22H20N2O5. US Biological Life Sciences. | Worldwide |
| 7-Ethyl-10-hydroxycamptothecin | 7-Ethyl-10-hydroxycamptothecin is a natural compound widely employed in the biomedical sector, showcasing remarkable potency in studying sundry malignancies such as colon, lung and ovarian cancers by impeding the functionality of topoisomerase I. Synonyms: CHEMBL93068; AC1LCGB7; 4-Ethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; DTXSID30348003. Grades: >98%. CAS No. 130194-92-2. Molecular formula: C20H16N2O5. Mole weight: 364.357. | |
| 7-Ethyl-10-hydroxycamptothecin | 7-Ethyl-10-hydroxycamptothecin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-10-Hydroxycamptothecin. Appearance: Powder. CAS No. 86639-52-3. Molecular formula: C22H20N2O5. Mole weight: 392.4. Purity: 0.98. IUPACName: (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione. Canonical SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O. Density: 1.51±0.1 g/ml. Product ID: ACM86639523. Alfa Chemistry ISO 9001:2015 Certified. Categories: 7-ethyl-10-hydroxy-camptothecin. |  |
| 7-Ethyl-10-hydroxycamptothecin | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| 7-Ethyl-10-hydroxycamptothecine | topoisomerase I inhibitor, inhibits DNA and RNA synthesis. CAS No. 86639-52-3. Product ID: 1-01625. Molecular formula: C22H20N2O5. Mole weight: 392.41. Purity: 0.99. | |
| rac-4,11-Diethyl-9-hydroxycamptothecin | Synonyms: 1H-Pyrano[3',?4':6,?7]?indolizino[1,?2-b]?quinoline-3,?14(4H,?12H)?-dione, 4,?11-diethyl-4,?9-dihydroxy-; (rac)-7-Ethyl-10-Hydroxy Camptothecin. Grades: >95%. CAS No. 130144-34-2. Molecular formula: C22H20N2O5. Mole weight: 392.411. | |
| (S)-10-Hydroxycamptothecin | (S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis -inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 10-HCPT; 10-Hydroxycamptothecin. CAS No. 19685-09-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N0095. | |
| SN-38. (7-Ethyl-10-hydroxycamptothecin) | A metabolite of Irinotecan, a DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 10-Hydroxy Camptothecin | A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: (4S)-4-Ethyl-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; (S)-10-Hydroxycamptothecin; Hydroxycamptothecin; NSC 107124. Grades: Highly Purified. CAS No. 19685-09-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 10-Hydroxy Camptothecin-d5 | A labeled Camptothecin derivative; a topoisomerase inhibitor for cancer therapy. Group: Biochemicals. Alternative Names: (4S)-4-(Ethyl-d5)-4, 9-dihydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; (S)-10-Hydroxycamptothecin-d5; Hydroxycamptothecin-d5; NSC 107124-d5. Grades: Highly Purified. CAS No. 1330277-66-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 10-O-Methoxymethyl SN-38 | Protected Irinotecan metabolite. Group: Biochemicals. Alternative Names: 7-Ethyl-10-O-methoxymethyl-10-hydroxycamptothecin; 10-Hydroxy-10-O-methoxymethyl-7-ethylcamptothecin; 10-MOM SN-38; (4S)-4, 11-Diethyl-4-hydroxy-9-(methoxymethoxy)-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione. Grades: Highly Purified. CAS No. 1246815-54-2. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Camptothecin | 10-hydroxycamptothecine precursor, topoisomerase inhibitor, binds irreversibly to DNA-topoisomerase I complex. CAS No. 7689-3-4. Product ID: 1-00921. Molecular formula: C20H16N2O4. Mole weight: 348.36. Purity: >99.0%. Properties: [a]D 31.3°. Reference: Biochem., 28, 4629, 1989. | |
| Irinotecan, Hydrochloride Salt, Trihydrate ([1,4-Bipiperidine]-1-carboxylic Acid (S)-4, 11-diethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3, 4, 6, 7]indolizino[1, 2-b]quinolin-9-yl Ester, HCl Trihydrate) | Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 136572-09-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Silatecan | Silatecan (formerly AR-67) is a synthetic, highly lipophilic derivative of camptothecin, with potential antineoplastic and radiosensitizing activities. Silatecan DB-67 binds to and stabilizes the topoisomerase I-DNA covalent complex, inhibiting the religation of topoisomerase I-mediated single-stranded DNA breaks and producing lethal double-stranded DNA breaks when encountered by the DNA replication machinery; inhibition of DNA replication and apoptosis follow. Camptothecin readily undergoes hydrolysis at physiological pH, changing its conformation from the active lactone structure to an inactive carboxylate form. Modifications on the E ring of camptothecin prevent binding of human serum albumin, which prefers the inactive carboxylate form, thereby enhancing the stability of the active lactone structure and resulting in prolonged agent activity. In addition, this agent may radiosensitize tumor cells. Synonyms: AR-67; AR 67; AR67; DB-67; DB 67; DB67; 7-t-Butyldimethylsilyl-10-hydroxycamptothecin. Grades: >98%. CAS No. 220913-32-6. Molecular formula: C26H30N2O5Si. Mole weight: 478.62. | |
| SN-38 | SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC 50 s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. CAS No. 86639-52-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13704. | |
| Tenifatecan | Tenifatecan, also known as SN2310, is an injectable emulsion composed of 7-ethyl-10-hydroxycamptothecin (SN-38) conjugate with vitamin E through a succinate linker. SN-38 is the active metabolite of irinotecan. SN-38 binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and apoptosis. SN-38 has been reported to exhibit up to 1,000-fold more cytotoxic activity against various cancer cells in vitro than irinotecan. SN2310 Injectable Emulsion is being developed with the objective of demonstrating improved anti-tumor activity as a result of increased exposure to SN-38 based on a longer half-life. Synonyms: SN 2300; SN2300; SN-2300; BEL2310; BEL 2310; BEL-2310. CAS No. 850728-17-5. Molecular formula: C53H68N2O8. Mole weight: 861.12. | |
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