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2-Hydroxyglutaric acid disodium salt 2-Hydroxyglutaric acid disodium salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-Hydroxypentanedioic Acid Sodium Salt. Product Category: Heterocyclic Organic Compound. Appearance: White to Off-White Solid. CAS No. 40951-21-1. Molecular formula: C5H6Na2O5. Mole weight: 192.08. Purity: 0.96. IUPACName: disodium;2-hydroxypentanedioate. Canonical SMILES: C(CC(=O)[O-])C(C(=O)[O-])O.[Na+].[Na+]. Density: 1.508g/cm³. Product ID: ACM40951211. Alfa Chemistry — ISO 9001:2015 Certified. Categories: disodium 2-hydroxypentanedioate. Alfa Chemistry. 3
2-Hydroxyglutaric Acid Disodium Salt-13C4 2-Hydroxyglutaric Acid Disodium Salt-13C4 is the isotope (13C) labelled analog of 2-Hydroxyglutaric Acid Disodium Salt (H942575) which is a potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1429051-81-9. Pack Sizes: 1mg. Molecular Formula: C13C4H6Na2O5, Molecular Weight: 196.05. US Biological Life Sciences. USBiological 10
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2-Hydroxyglutaric Acid Disodium Salt (contains up to 10% methanol) 2-Hydroxyglutaric acid is a potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Alternative Names: 2-Hydroxypentanedioic Acid Sodium Salt. Grades: Highly Purified. CAS No. 40951-21-1. Pack Sizes: 25mg. US Biological Life Sciences. USBiological 2
Worldwide
(2R)-2-Hydroxyglutaric Acid Disodium Salt A potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Grades: Highly Purified. CAS No. 103404-90-6. Pack Sizes: 10mg, 25mg, 100mg. Molecular Formula: C?H?Na?O?. US Biological Life Sciences. USBiological 2
Worldwide
(2R)-2-Hydroxyglutaric Acid Disodium Salt-13C5 (2R)-2-Hydroxyglutaric Acid Disodium Salt-13C5 is the isotope labelled analog of (2R)-2-Hydroxyglutaric Acid Disodium Salt (H942565); a potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1648909-80-1. Pack Sizes: 500ug, 5mg. Molecular Formula: 13C5H6Na2O5. US Biological Life Sciences. USBiological 10
Worldwide
(2R)-2-Hydroxyglutaric Acid Disodium Salt-d5 (2R)-2-Hydroxyglutaric Acid Disodium Salt-d5 is the isotope labelled analog of (2R)-2-Hydroxyglutaric Acid Disodium Salt (H942565); a potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C5HD5Na2O5. US Biological Life Sciences. USBiological 10
Worldwide
(2R)-2-Hydroxyglutaric Acid Octyl Ester Sodium Salt The octyl ester derivative of (2R)-2-Hydroxyglutaric Acid , the potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Alternative Names: (2R)-2-Hydroxypentanedioic Acid Octyl Ester Sodium Salt. Grades: Highly Purified. CAS No. 1391068-16-8. Pack Sizes: 1mg. US Biological Life Sciences. USBiological 2
Worldwide
(2S)-2-Hydroxyglutaric Acid (2S)-2-Hydroxyglutaric Acid is a potential glutamate carboxypeptidase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 13095-48-2. Pack Sizes: 25mg, 50mg. Molecular Formula: C5H8O5, Molecular Weight: 148.11. US Biological Life Sciences. USBiological 10
Worldwide
(2S)-2-Hydroxyglutaric Acid Benzyl Octyl Diester (2S)-2-Hydroxyglutaric Acid Benzyl Octyl Diester is the benzyl, octyl diester derivative of (2S)-2-Hydroxyglutaric Acid (H942570), the potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Alternative Names: Octyl L-2-Hydroxyglutarate Benzyl Ester. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. USBiological 3
Worldwide
(2S)-2-Hydroxyglutaric Acid Disodium Salt A potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Alternative Names: (2S)-2-Hydroxypentanedioic Acid; L-2-Hydroxyglutaric Acid Disodium Salt; (S)-α-Hydroxyglutaric Acid Disodium Salt; L-2-Hydroxyglutarate Disodium Salt. Grades: Highly Purified. CAS No. 63512-50-5. Pack Sizes: 25mg. US Biological Life Sciences. USBiological 2
Worldwide
(2S)-2-Hydroxyglutaric Acid Disodium Salt-13C5 (2S)-2-Hydroxyglutaric Acid Disodium Salt-13C5 is the isotope labelled analog of (2S)-2-Hydroxyglutaric Acid Disodium Salt (H942570); a potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: 13C5H6Na2O5. US Biological Life Sciences. USBiological 10
Worldwide
(2S)-2-Hydroxyglutaric Acid Disodium Salt-d5 (2S)-2-Hydroxyglutaric Acid Disodium Salt-d5 is the isotope labelled analog of (2S)-2-Hydroxyglutaric Acid Disodium Salt (H942570); a potential inhibitor of glutamate carboxypeptidase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C5HD5Na2O5. US Biological Life Sciences. USBiological 10
Worldwide
3-Hydroxyglutaric acid 3-Hydroxyglutaric acid is a glutaric acid derivative. Uses: Scientific research. Group: Natural products. CAS No. 638-18-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-113411. MedChemExpress MCE
3-Hydroxyglutaric Acid 3-Hydroxyglutaric Acid. Group: Biochemicals. Alternative Names: 3-Hydroxy-pentanedioic Acid; 2,4-Dideoxypentaric Acid; β-Hydroxyglutaric Acid. Grades: Highly Purified. CAS No. 638-18-6. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 2
Worldwide
3-Hydroxyglutaric Acid Dimethyl Ester Glutaric Acid derivative. Group: Biochemicals. Alternative Names: 3-Hydroxy-pentanedioic Acid Dimethyl Ester; Dimethyl 3-hydroxyglutarate; NSC 30047. Grades: Highly Purified. CAS No. 7250-55-7. Pack Sizes: 1g. US Biological Life Sciences. USBiological 2
Worldwide
α-Hydroxyglutaric acid α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid. CAS No. 2889-31-8. Pack Sizes: 5 mg (67.52 mM * 0.5mL in Ethanol); 10 mg (67.52 mM * 1mL in Ethanol); 25 mg (67.52 mM * 2.5mL in Ethanol). Product ID: HY-113038B. MedChemExpress MCE
α-Hydroxyglutaric acid-13C5 disodium α-Hydroxyglutaric acid- 13 C 5 (sodium) is the 13 C labeled α-Hydroxyglutaric acid sodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: 2-Hydroxyglutarate- 13 C5 disodium; 2-Hydroxyglutaric acid- 13 C5 sodium; 2-Hydroxypentanedioic acid- 13 C5 disodium. CAS No. 2482467-23-0. Pack Sizes: 1 mg. Product ID: HY-113038AS. MedChemExpress MCE
α-Hydroxyglutaric acid disodium α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Hydroxyglutarate disodium; 2-Hydroxyglutaric acid disodium; 2-Hydroxypentanedioic acid disodium. CAS No. 40951-21-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113038A. MedChemExpress MCE
D-α-Hydroxyglutaric acid disodium salt D-α-Hydroxyglutaric acid disodium salt. Uses: D-α-hydroxyglutaric acid disodium salt can be used as a reagent in peptide synthesis. Additional or Alternative Names: (R)-2-Hydroxypentanedioic acid disodium salt, Disodium (R)-2-hydroxyglutarate. Product Category: Amino Acids. CAS No. 103404-90-6. Molecular formula: C5H6O5Na2. Mole weight: 192.08. Canonical SMILES: [Na].O[C@H](CCC(O)=O)C(O)=O. Product ID: ACM103404906-1. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry. 2
L-2-Hydroxyglutaric acid L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation [1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase ( Mi-CK ) activity with K m and K i of 2.52 mM and 11.13 mM, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-2-Hydroxyglutaric acid. CAS No. 13095-48-2. Pack Sizes: 5 mg (67.52 mM * 0.5 mL in Ethanol); 10 mg (67.52 mM * 1 mL in Ethanol). Product ID: HY-113039. MedChemExpress MCE
L-2-Hydroxyglutaric Acid L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 13095-48-2. Molecular formula: C5H8O5. Mole weight: 148.11. Product ID: ACM13095482. Alfa Chemistry — ISO 9001:2015 Certified. Categories: (2S)-2-hydroxypentanedioic acid, L-2-hydroxyglutaric aciduria. Alfa Chemistry.
L-2-Hydroxyglutaric acid disodium L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation [1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase ( Mi-CK ) activity with K m and K i of 2.52 mM and 11.13 mM, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-2-Hydroxyglutaric acid disodium. CAS No. 63512-50-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W015114. MedChemExpress MCE
2-Hydroxy-2-methylbutanoic acid 2-Hydroxy-2-methylbutanoic acid, an unusual metabolite, is associated with 2-hydroxyglutaric aciduria and maple syrup urine disease. Uses: Scientific research. Group: Natural products. CAS No. 3739-30-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W015874. MedChemExpress MCE
2-hydroxyglutarate synthase This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. This enzyme participates in c5-branched dibasic acid metabolism. Group: Enzymes. Synonyms: 2-hydroxyglutaratic synthetase; 2-hydroxyglutaric synthetase; α-hydroxyglutarate synthase; hydroxyglutarate synthase; 2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating). Enzyme Commission Number: EC 2.3.3.11. CAS No. 9024-2-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2312; 2-hydroxyglutarate synthase; EC 2.3.3.11; 9024-02-6; 2-hydroxyglutaratic synthetase; 2-hydroxyglutaric synthetase; α-hydroxyglutarate synthase; hydroxyglutarate synthase; 2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating). Cat No: EXWM-2312. Creative Enzymes
(2R)-Octyl-α-hydroxyglutarate (2R)-Octyl-α-hydroxyglutarate is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1391194-67-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C13H24O5, Molecular Weight: 260.33. US Biological Life Sciences. USBiological 10
Worldwide
(2R)-Octyl-α-hydroxyglutarate-d17 (2R)-Octyl-α-hydroxyglutarate-d17 is labelled (2R)-Octyl-α-hydroxyglutarate (O287600) which is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C13H7D17O5, Molecular Weight: 277.43. US Biological Life Sciences. USBiological 10
Worldwide
(2S)-Octyl-α-hydroxyglutarate (2S)-Octyl-α-hydroxyglutarate is a cell permeable derivative of the L-isomer of 2-Hydroxyglutaric Acid (H942575), a potential inhibitor of glutamate carboxypeptidase. Also, being structurally similar to α-ketoglutarate, it competitively inhibits α-ketoglutarate dependent dioxygenases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1391194-64-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C13H24O5. US Biological Life Sciences. USBiological 10
Worldwide
(2S)-Octyl-α-hydroxyglutarate-d17 (2S)-Octyl-α-hydroxyglutarate-d17 is labelled (2R)-Octyl-α-hydroxyglutarate (O287600) which is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C13H7D17O5, Molecular Weight: 277.43. US Biological Life Sciences. USBiological 10
Worldwide
3-Hydroxy-3-methylglutaric-d3 Anhydride A 3-Alkyl-3-hydroxyglutaric acid; a new class of hypocholesterolemic HMG CoA reductase inhibitors. Group: Biochemicals. Alternative Names: 3-Hydroxy-3-methylpentane-1,5-dioic-d3 Anhydride; Dihydro-4-hydroxy-4-methyl-. Grades: Highly Purified. CAS No. 115135-38-1. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 2
Worldwide
Disodium (R)-2-Hydroxyglutarate Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM. In U-87MG cells, (R)-2-Hydroxyglutarate acts as a weak antagonist of α-KG to inhibit α-KG-dependent histone demethylases and increase dimethylation on both H3K9 and H3K79. Synonyms: MDK4906; MDK 4906; MDK-4906; d-α-hydroxyglutaric acid disodium salt; (2R)-2-Hydroxyglutaric Acid Disodium Salt; D-alpha-Hydroxyglutaric acid (disodium salt). Grades: 98%. CAS No. 103404-90-6. Molecular formula: C5H6Na2O5. Mole weight: 192.08. BOC Sciences 8
TC-E 5008 TC-E 5008 is a selective and cancer-associated mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor (Ki = 120-190 nM), displaying >60-fold selectivity for mIDH1 (found in ~75% of gliomas) over wild type IDH1. TC-E 5008 also inhibits D-2-hydroxyglutaric acid in cells expressing mIDH1 (EC50 = 2.4 μM). Synonyms: 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone; 6-benzyl-1-hydroxy-4-methylpyridin-2-one. CAS No. 50405-58-8. Molecular formula: C13H13NO2. Mole weight: 215.25. BOC Sciences 10
BAY 1436032 BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. BAY 1436032 strongly reduces 2-HG (2-hydroxyglutarate) levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations. BAY 1436032 showed a favourable selectivity profile against wtIDH1/2 and a large panel of off-targets in vitro. Synonyms: 3-(2-[[4-(Trifluoromethoxy)phenyl]amino]-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoic Acid; BAY-1436032. Grades: ≥98%. CAS No. 1803274-65-8. Molecular formula: C26H30F3N3O3. Mole weight: 489.53. BOC Sciences 10
D-2-Hydroxyglutarate Dehydrogenase from Acidaminococcus fermentans, Recombinant D-2-hydroxyglutarate (D2HG) level is significantly increased in metabolic diseases and various cancers such as acute myeloid leukemia. Studies suggest that the detection of D2HG serves as a biomarker assay related to IDH (isocitrate dehydrogenase) mutations. D2HGDH is a special NAD-dependent enzyme which reacts with D2HG specifically and converts D2HG to α-ketoglutarate. D2HGDH is a key enzyme to distinguish between two metabolites, D2HG and L-2-hydroxyglutarate (L2HG), during biomarker assays. Group: Enzymes. Synonyms: D-2-hydroxyglutarate dehydrogenase; D2HGDH; D2HGD. Enzyme Commission Number: EC 1.1.99.39. Purity: > 99% by SDS - PAGE. Mole weight: 39 kDa. Activity: > 90,000 mU/mg. Storage: Can be stored at 4°C up to 2 weeks. For long term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing cycles. Form: Lyophilized in 50mM Tris, pH 8 without any additives. Source: E. coli. Species: Acidaminococcus fermentans. D-2-hydroxyglutarate dehydrogenase; D2HGDH; D2HGD. Cat No: NATE-1660. Creative Enzymes
hydroxyacid-oxoacid transhydrogenase 4-Hydroxybutanoate and (R)-2-hydroxyglutarate can also act as donors; 4-oxobutanoate can also act as acceptor. Group: Enzymes. Synonyms: transhydrogenase, hydroxy acid-oxo acid. Enzyme Commission Number: EC 1.1.99.24. CAS No. 117698-31-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0453; hydroxyacid-oxoacid transhydrogenase; EC 1.1.99.24; 117698-31-4; transhydrogenase, hydroxy acid-oxo acid. Cat No: EXWM-0453. Creative Enzymes
Mutant Isocitrate Dehydrogenase 1 R132H from Human, Recombinant Mutations of the cytosolic IDH 1 are a common feature in primary human brain cancers. Arginine 132 (R132) of IDH is highly conserved among different isoforms of IDH and is most commonly mutated to Histidine. Mutation of IDH1 R132H leads to accumulation of R(-)-2-hydroxyglutarate (2HG), which correlates with an increased risk for malignant brain tumors. Full-length human idh1 (452 amino acids) with n-terminal hattag. arginine 132 is mutated to histidine. Group: Enzymes. Synonyms: Isocitrate dehydrogenase [NADP] cytoplasmic mutant, R132H; IDH 1 R132H. Purity: > 90% by SDS-PAGE. IDH. Mole weight: 50.9 kDa. Activity: >500 mU/mg. Storage: Lyophilized protein is stable for 1 year at -20°C. Once reconstituted aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. Form: Lyophilized powder with additives. Source: E. coli. Species: Human. Isocitrate dehydrogenase [NADP] cytoplasmic mutant, R132H; IDH 1 R132H; Isocitrate dehydrogenase; Isocitrate Dehydrogenase (NADP+). Cat No: NATE-1649. Creative Enzymes
phosphoglycerate dehydrogenase This enzyme catalyses the first committed step in the phosphoserine pathway of serine biosynthesis in Escherichia coli. Reaction (1) occurs predominantly in the reverse direction and is inhibited by serine and glycine. The enzyme is unusual in that it also acts as a D- and L-2-hydroxyglutarate dehydrogenase (with the D-form being the better substrate) and as a 2-oxoglutarate reductase. It has been postulated that the cellular 2-oxoglutarate concentration may regulate serine biosynthesis and one-carbon metabolism directly by modulating the activity of this enzyme. Group: Enzymes. Synonyms: D-3-phosphoglycerate:NAD+ oxidoreductase; . Enzyme Commission Number: EC 1.1.1.95. CAS No. 9075-29-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0379; phosphoglycerate dehydrogenase; EC 1.1.1.95; 9075-29-0; D-3-phosphoglycerate:NAD+ oxidoreductase; α-phosphoglycerate dehydrogenase; 3-phosphoglycerate dehydrogenase; 3-phosphoglyceric acid dehydrogenase; D-3-phosphoglycerate dehydrogenase; glycerate 3-phosphate dehydrogenase; glycerate-1,3-phosphate dehydrogenase; phosphoglycerate oxidoreductase; phosphoglyceric acid dehydrogenase; SerA; 3-phosphoglycerate:NAD+ 2-oxidoreductase; SerA 3PG dehydrogenase; 3PHP reductase; αKG reductase; D- and L-HGA. Cat No: EXWM-0379. Creative Enzymes
(R)-2-hydroxyglutaryl-CoA dehydratase The enzymes from the bacteria Acidaminococcus fermentans and Clostridium symbiosum are involved in the fermentation of L-glutamate. The enzyme contains [4F-4S] clusters, FMNH2 and riboflavin. It must be activated by an activator protein. Once activated, it can catalyse many turnovers. Group: Enzymes. Synonyms: hgdAB (gene names). Enzyme Commission Number: EC 4.2.1.167. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5008; (R)-2-hydroxyglutaryl-CoA dehydratase; EC 4.2.1.167; hgdAB (gene names). Cat No: EXWM-5008. Creative Enzymes
UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase This enzyme participates in the biosynthetic pathway for UDP-α-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-α-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the the enzyme catalysing the next step the pathway (EC 2.6.1.98, UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase). The enzyme also possesses an EC 1.1.99.2 (L-2-hydroxyglutarate dehydrogenase) activity, and utilizes the 2-oxoglutarate produced by EC 2.6.1.98 to regenerate the tightly bound NAD+. The enzymes from Bordetella pertussis and Chromobacterium violaceum do not bind NAD+ as tightly and do not require 2-oxoglutarate to function. Group: Enzymes. Synonyms: WlbA; WbpB. Enzyme Commission Number: EC 1.1.1.335. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0249; UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase; EC 1.1.1.335; WlbA; WbpB. Cat No: EXWM-0249. Creative Enzymes

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