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Ifenprodil is a NMDA receptor antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 23210-56-2. Pack Sizes: 5mg, 10mg. Molecular Formula: C21H27NO2, Molecular Weight: 325.44. US Biological Life Sciences.
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Ifenprodil
Ifenprodil is an NMDA receptor antagonist and acts at the polyamine site. It is also an α2 adrenergic receptor ligand. It is selective for σ2 ligand over σ1 sites. It is used as a neuroprotective agent and peripheral vasodilator. Uses: Excitatory amino acid antagonists. Synonyms: 4-[2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl]phenol; (1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol; α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidineethanol; 1-Methyl-2-hydroxy-2-(4-hydroxyphenyl)ethyl-1-(4-benzylpiperidine); 2-(4-Benzylpiperidino)-1-(1-hydroxyphenyl)-1-propanol; RC 61-91. Grades: ≥99% by HPLC. CAS No. 23210-56-2. Molecular formula: C21H27NO2. Mole weight: 325.44.
Ifenprodil hemitartrate
Ifenprodil hemitartrate. Group: Biochemicals. Grades: Purified. CAS No. 23210-56-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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Ifenprodil Hemitartrate.
Vasodilator (cerebral and peripheral). Group: Biochemicals. Alternative Names: α-(4-Hydroxyphenyl)- β-methyl-4-(phenylmethyl)-1-piperidineethanol (2R,3R)-2,3-Dihydroxybutanedioate. Grades: Highly Purified. CAS No. 23210-58-4. Pack Sizes: 10mg. US Biological Life Sciences.
A partial non-competitive antagonist highly selective for GluN1/N2B subtype nMDA receptors (IC50 = 0.15uM, maximal inhibition 90%) over other subtypes (IC50 = 39, 29, 76uM for GluN1/N2A, GluN1/N2C and GluN1/N2D subtype receptors, respectively). Frequently used in studies of various brain functions and disorders involving neural transmissions mediated by GluN1/N2B subtype nMDA receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 23210-58-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Ifenprodil tartrate
Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors ( IC 50 =0.34 μM) over 400-fold than at NR1A/NR2A receptors ( IC 50 =146 μM) [1]. Ifenprodil tartrate inhibits GIRK (Kir3) , reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator [2]. Uses: Scientific research. Group: Natural products. CAS No. 23210-58-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-12882A.
Ifenprodil Tartrate
Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM. Uses: Adrenergic alpha-antagonists. Synonyms: Ifenprodil (tartrate). Grades: >98%. CAS No. 23210-58-4. Molecular formula: 2(C21H27NO2).C4H6O6. Mole weight: 800.98.
threo Ifenprodil hemitartrate
threo Ifenprodil hemitartrate. Group: Biochemicals. Grades: Purified. CAS No. 1312991-83-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
threo Ifenprodil hemitartrate
Threo Ifenprodil hemitartrate is the hemitartrate salt of threo ifenprodil, which is a NR2B subunit-selective NMDA receptor antagonist, as well as a potent σ receptor agonist. It inhibits the hERG potassium channel and shows antiarrhythmic activity in vivo. It also can be used for the treatment of Alzheimer's disease in combination with AMPA inhibitors. Synonyms: (1S*,2S*)-threo-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol Hemitartrate; (αR,βR)-rel- α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidineethanol (2R,3R)-2,3-Dihydroxybutanedioate (2:1). CAS No. 1312991-83-5. Molecular formula: C23H30NO5. Mole weight: 400.49.
Co 101244 hydrochloride
Co 101244 hydrochloride, with strongly neuroprotective effect in vivo and in vitro, is an ifenprodil-like noncompetitive, highly selective antagonist of NR2B-containing NMDA receptors (IC5= 43 nM). Synonyms: 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]piperidin-4-ol;hydrochloride; 4-hydroxy-N-(2-(4-hydroxyphenoxy)ethyl)-4-(4-methylbenzyl)piperidine; Co 101244; 193359-26-1 (Co 101244 free base); Co-101244; Co101244;PD 174494; PD-174494; PD174494. Grades: >98%. CAS No. 193356-17-1. Molecular formula: C21H27NO3.HCl. Mole weight: 377.91.
Ro 25-6981
Ro 25-6981, structurally related to ifenprodil and with no affinity for the known binding sites of non-competitive antagonists such as phencyclidine or MK-801, is a selective and activity-dependent blocker of NMDA receptors containing the NR2B subunit. Synonyms: 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol;(Z)-but-2-enedioic acid Ro 25-6981 (Maleate) Ro 25-6981 maleate 169274-78-6 1312991-76-6 SCHEMBL16669133 C22H29NO2.C4H4O4 4008AH 4-((1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methyl. Grades: >98 %. CAS No. 169274-78-6. Molecular formula: C22H29NO2.C4H4O4. Mole weight: 455.54.
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