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| Product | Description | |
|---|---|---|
| Human immunoglobulin for anticomplementary activity | Human immunoglobulin for anticomplementary activity. Uses: For analytical and research use. Group: European pharmacopoeia (ph. eur.); pharmacopoeial standards. Alternative Names: Human normal immunoglobulin for intravenous administration, γ-Blood globulins,γ-Globulins, γ-Globulin, Globulins, γ-globulin, Blood plasma γ-globulins, Globulin, blood, γ-, Plasma γ-globulins, Human normal immunoglobulin, Gamma globulins, Globulin, blood, gamma-, Intacglobin, Blood gamma-globulin, Human normal immunoglobulin, Gamma- blood globulin, Globulins, γ-, conjugates, Globulins, blood-serum γ-, Globulins, γ-, Globulins, blood serum, γ-, Gamma globulin, Gamma- blood globulins. CAS No. 9007-83-4. Catalog: APS9007834B. Format: Neat. Shipping: +5°C. |  |
| Prepro-Killer Cell Immunoglobulin-Like Receptor 3DL3 (23-31) | Riteau et al. used rabbit antiserum to perform immunofluorescence analysis on the Prepro-Killer Cell Immunoglobulin-Like Receptor 3DL3 (23-31) corresponding to the N-terminal sequence of KIR2DL4. It did not differ between the p49 and KIR2DL4 receptor. Synonyms: KIR3DL3 (23-31) (human); H-Val-Gly-Gly-Gln-Asp-Lys-Pro-Phe-Leu-OH. Grades: ≥95%. Molecular formula: C44H69N11O13. Mole weight: 960.09. |  |
| 3-(Aminomethyl)-4-fluorophenol Hydrobromide | 3-(Aminomethyl)-4-fluorophenol Hydrobromide is derived from 2-Fluoro-5-methoxybenzaldehyde, which is versatile reactant used in the solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H8FNO; HBr, Molecular Weight: 141.148090999999. US Biological Life Sciences. |  Worldwide |
| AA 147 | AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM). Synonyms: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide; N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide. Grades: ≥98%. CAS No. 393121-74-9. Molecular formula: C16H17NO2. Mole weight: 255.31. | |
| AMP-224 | A fusion protein that contains the extracellular domain of PD-1 ligand 2 (B7-DC; PDCDILG2) and the Fc region of human immunoglobulin (Ig) G1. AMP-224 does not bind normal activated T-cells, but binds to PD-1 on chronically stimulated T-cells and reduces their proliferation. Synonyms: 2661380; AMP-244; GSK-2661380; AMP 244; GSK 2661380; AMP244; GSK2661380. | |
| Belrestotug | Belrestotug (EOS-448) is an antagonistic anti- TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: EOS-448; EOS884448; GSK4428859A. CAS No. 2574438-65-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990032. |  |
| Bovine Colostrum Powder | Colostrum is a milky fluid that comes from the breasts of humans, cows, and other mammals the first few days after giving birth, before true milk appears. It contains proteins, carbohydrates, fats, vitamins, minerals, and proteins (antibodies) that fight disease-causing agents such as bacteria and viruses. Antibody levels in colostrums can be 100 times higher than levels in regular cows milk. Group: Others. Synonyms: Bovine Colostrum; Bovine Immunoglobulin; Bovine Lacteal Compounds; Calostro; Colostrum Bovin; Colostrum Bovin Hyperimmune; Cow Milk Colostrum; Goat Colostrum; Hyperimmune Bovine Colostrum; Immunoglobuline Bovine; Lait Colostral; Protogala. Appearance: Yellow powder. Source: Bovine. Bovine Colostrum Powder. Cat No: BCP-0100. |  |
| CA-170 | A first-in-class oral, small molecule antagonist of PD-L1, PD-L2 and V-region immunoglobulin-containing suppressor of T cell activation (VISTA). Synonyms: CA-170; CA 170; CA170. Molecular formula: C12H20N6O7. Mole weight: 360.32. | |
| CEP-11981 | CEP-11981 is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death. VEGFR and Tie2 are frequently overexpressed by a variety of tumor cell types and play crucial roles in the regulation of angiogenesis and the maintenance of tumor blood vessels. Tie2 (tyrosine kinase with immunoglobulin-like and EGF-like domains) is activated by angiopoietin-1 (Ang-1). Synonyms: CEP-11981; CEP 11981; CEP11981. CAS No. 856691-93-5. Molecular formula: C28H27N7O. Mole weight: 477.57. | |
| chymosin | Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1(pepsin A family). Group: Enzymes. Synonyms: rennin (but this should be avoided since it leads to confusion with renin). Enzyme Commission Number: EC 3.4.23.4. CAS No. 9001-98-3. Rennin. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4276; chymosin; EC 3.4.23.4; 9001-98-3; rennin (but this should be avoided since it leads to confusion with renin). Cat No: EXWM-4276. | |
| Dihydroberberine | Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene ( hERG ) channel and significantly reduces the expression of heat shock protein 90 ( Hsp90 ) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 483-15-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N1934. | |
| Dilpacimab | Dilpacimab (ABT165) is a potent dual-variable domain immunoglobulin, targets both delta-like ligand 4 (DLL4) and VEGF pathways. Dilpacimab can be used in research of cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ABT165; PR1283233. CAS No. 1791420-09-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99852. | |
| durvalumab | Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody. It was approved by FDA for the treatment of patients with locally advanced or metastatic urothelial carcinoma who have disease progression during or following platinum-containing chemotherapy, or whose disease has progressed within 12 months of receiving platinum-containing chemotherapy before or after surgery. Uses: The treatment of locally advanced or metastatic urothelial carcinoma. Synonyms: Imfinzi. CAS No. 1428935-60-7. Molecular formula: C6502H10018N1742O2024S42. Mole weight: 146.3. | |
| Efbemalenograstim alfa | Efbemalenograstim alfa (F 627) is a recombinant fusion protein. Efbemalenograstim alfa is a long acting dimeric granulocyte colony-stimulating factor (G-CSF) that contains two human G-CSF fused to a human immunoglobulin G2 (hIgG2)-Fc fragment with a peptide linker. Efbemalenograstim alfa induces the production of white blood cells [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Benegrastim; Bineuta; F 627. CAS No. 2200269-79-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99879. | |
| Elastase, Human leukocytes | Elastase, Human leukocytes is a serine protease present in the nitrogen-loving granules of neutrophils. Elastase, Human leukocytes potential substrates include almost all components of the extracellular matrix, as well as a variety of proteins such as coagulation factors, complement, immunoglobulins and cytokines. It has a strong proteolytic function and participates in the pathogenesis of inflammatory tissue damage [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9004-6-2. Pack Sizes: 1 U. Product ID: HY-P2751. | |
| Endoproteinase Glu-C | Endoproteinase GluC (V8 protease) is a serine proteinase. Endoproteinase GluC is able to hydrolyze some serpins and all classes of mammalian immunoglobulins [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: V8 protease; Glu-C. CAS No. 137010-42-5. Pack Sizes: 100 μg. Product ID: HY-E70194. | |
| Enibarcimab | Enibarcimab is a humanised murine monoclonal immunoglobulin G1 ( IgG1 ) antibody, could be used for acute heart failure, COVID-19 infections and septic shock research [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2305638-98-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99177. | |
| Etanercept | Etanercept inhibits in vitro the activity of human TNF and is efficacious in many in vivo models of inflammation, including arthritis. Etanercept competitively inhibits the binding of both TNF-α and TNF-β (lymphotoxin-α) to cell surface TNF receptors, rendering TNF biologically inactive. It also modulates indirectly different biological responses that are induced or regulated by TNF, such as the expression of adhesion molecules E-selectin and to a lesser extent intercellular adhesion molecule 1 (ICAM-1), the production of interleukin-6 (IL-6) and matrix metalloproteinase 3 (MMP-3) (stromelysin), as well as IL1. Synonyms: 1-235-Tumor necrosisfactor receptor (human) fusion protein with 236-467-immunoglobulin G1 (human g1-chain Fc fragment); TNFR-Fc fusion protein; Etanercept; Embrel; Enbrel; rhu-TNFR-Fc. Grades: 95%. CAS No. 185243-69-0. Molecular formula: C2224H3472N618O701S36. | |
| Etentamig | Etentamig is a BCMA × CD3 bispecific T-cell engager (BiTE) that can inhibit the activity of B-cell maturation antigen ( BCMA ) and activate the T-cell surface glycoprotein CD3 complex. Etentamig can be used for research in multiple myeloma, immunoglobulin light chain amyloidosis, and cardiovascular diseases [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ABBV-383; TNB 383B. CAS No. 2490552-52-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P990785. | |
| Galiximab | Galiximab (IDEC 114) is a primatized immunoglobulin G1 (IgG1) lambda monoclonal antibody directed against the CD80 antigen and blocks CD80 - CD28 binding. Galiximab has variable regions are primatized (cynomologous monkeys), and the constant regions are human. Galiximab can be used in research of B-cell lymphoma [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IDEC 114; Anti-Human CD80 Recombinant Antibody. CAS No. 357613-77-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99293. | |
| Gemtuzumab ozogamicin | Gemtuzumab ozogamicin is an antibody-drug conjugate (ADC) consisting of a humanized immunoglobulin (IgG4) antibody directed against CD33 that is conjugated to the cytotoxic agent Calicheamicin (HY-19609). Calicheamicin is a cytotoxic antibiotic. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia (AML) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220578-59-6. Pack Sizes: 100 μg; 200 μg; 500 μg. Product ID: HY-109539. | |
| Hyaluronidase, Ovine testes | Hyaluronidase, Ovine testes is an enzyme responsible for catalyzing the degradation of hyaluronic acid. It is used to improve the absorption and dispersion of gastrointestinal fluids, drugs, and contrast agents. Hyaluronidase, Ovine testes can enhance the diffusion or delivery of local agent (LA) that can suppress or relieve pain or immunoglobulins (Igs) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 37326-33-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108903A. | |
| Ifinatamab | Ifinatamab is monoclonal immunoglobulin G1-kappa with anti-human B7 homolog 3 protein (Human B7-H3). Ifinatamab is a glycoforme α immunomodulateur [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2484870-90-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99367. | |
| IgA-specific metalloendopeptidase | A 190 kDa enzyme found in several pathogenic species of Streptococcus such as sanguis and pneumoniae. Type example of peptidase family M26. There is also an IgA-specific prolyl endopeptidase of the serine-type (see EC 3.4.21.72, IgA-specific serine endopeptidase). Group: Enzymes. Synonyms: immunoglobulin A1 proteinase; IgA protease; IgA1-specific proteinase; IgA1 protease; IgA1 proteinase. Enzyme Commission Number: EC 3.4.24.13. CAS No. 72231-73-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4294; IgA-specific metalloendopeptidase; EC 3.4.24.13; 72231-73-3; immunoglobulin A1 proteinase; IgA protease; IgA1-specific proteinase; IgA1 protease; IgA1 proteinase. Cat No: EXWM-4294. | |
| IgA-specific serine endopeptidase | Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. Type example of peptidase family S6. Some other bacterial endopeptidases with similar specificity are of metallo- type (see EC 3.4.24.13, IgA-specific metalloendopeptidase). Group: Enzymes. Synonyms: IgA protease; IgA proteinase; IgA-specific proteinase; immunoglobulin A protease; immunoglobulin A proteinase. Enzyme Commission Number: EC 3.4.21.72. CAS No. 55127-02-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4164; IgA-specific serine endopeptidase; EC 3.4.21.72; 55127-02-1; IgA protease; IgA proteinase; IgA-specific proteinase; immunoglobulin A protease; immunoglobulin A proteinase. Cat No: EXWM-4164. | |
| Infliximab | Infliximab is a monoclonal antibody drug that is used for the treatment of rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, Crohn's disease, and ankylosing spondylitis. It binds to tumor necrosis factor alpha (TNF-α), which plays a role in the autoimmune reation. Infliximab may lead to fatal infections yet. Synonyms: Immunoglobulin G, anti-(human tumor necrosis factor) (human-mouse monoclonal cA2 heavy chain), disulfide with human-mouse monoclonal cA2 light chain, dimer; Avakine; Remicade; Remsima. Grades: 95%. CAS No. 170277-31-3. | |
| Insulin efsitora alfa | Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR). Insulin efsitora alfa is a fusion protein composed of human IR agonists fused with the crystallizable (Fc) domain of human immunoglobulin G2 (IgG2) fragment, with a molecular weight of 64.1 kDa. Insulin efsitora alfa is well tolerated and has potential applications in diabetes [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LY-3209590. CAS No. 2131038-11-2. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P99665. | |
| Lenvervimab | Lenvervimab (GC1102) is a IgG1-type recombinant human hepatitis B Immunoglobulin. Lenvervimab can be used for research of hepatitis B virus infection [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: GC1102. CAS No. 2055006-79-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99693. | |
| lguratimod | It is a new type of anti-rheumatic drug that can relieve joint damage and immune abnormalities in chronic arthritis and autoimmune diseases, and inhibit the production of inflammatory cytokines and immunoglobulin. CAS No. 123663-49-0. Product ID: PAP-0092. Molecular formula: C17H14N2O6S. Product Keywords: Other Active Pharmaceutical Ingredients; lguratimod; PAP-0092; ; C17H14N2O6S; 123663-49-0. Appearance: Solid. Color: White to Off-White. EC Number: 808-127-0. Physical State: Solid. Solubility: DMSO (Slightly). Storage: under inert gas (nitrogen or Argon) at 2-8°C. Applications: It's an anti-rheumatic drug. It has anti-inflammatory, inhibition of immunoglobulin and cytokine production, anti-bone resorption and promoting bone formation. Boiling Point: 580.6±60.0 °C(Predicted). Melting Point: 238.0 to 242.0 °C. |  |
| Lirilumab | A fully humanized monoclonal antibody against killer-cell immunoglobulin-like receptors (KIR), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, lirilumab binds to KIR, thereby preventing the binding of KIR ligands to KIR on natural killer (NK) cells. By blocking these inhibitory receptors, NK cells become activated and attack cancer cells leading to tumor cell death. KIR, a member of the immunoglobulin superfamily, is expressed on the surface of NK cells. Synonyms: Anti-KIR (1-7F9); Anti-KIR monoclonal antibody - Innate Pharma; BMS-986015; BMS 986015; BMS986015; IPH-21; IPH 21; IPH21; IPH-2101; IPH2102; IPH 2102;LIRI; NN 1975; NN1975; NN-1975. CAS No. 1000676-41-4. | |
| Lixudebart | Lixudebart is a humanized immunoglobulin G1-kappa, anti-CLDN1 monoclonal antibody [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2749515-10-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990045. | |
| Lutikizumab | Lutikizumab (ABT-981) is an anti- IL-1α and IL-1β dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1&beta. Lutikizumab can be used for the research of osteoarthritis [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ABT-981. CAS No. 1791411-57-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99721. | |
| Maridebart | Maridebart is a human immunoglobulin G1-kappa, anti-GIPR (gastric inhibitory polypeptide receptor) monoclonal antibody [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AMG133 antibody. CAS No. 2761478-99-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990047. | |
| MEDI0680 | A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1), a transmembrane protein in the Ig superfamily expressed on T cells. MEDI0680 has potential immune checkpoint inhibitory and antineoplastic activities because it binds to and inhibits PD-1 and its downstream signaling pathways. Synonyms: AMP-514; AMP 514; AMP514; MEDI 0680; MEDI-0680; MEDI0680. | |
| Mosunetuzumab | Mosunetuzumab (BTCT-4465A) is a full-length, fully humanized immunoglobulin G1 (IgG1) T-cell-dependent bispecific (TDB) antibody targeting CD20 (B cells) and CD3 (T cells). Mosunetuzumab redirects T cells to engage and eliminate malignant B cells and can be used for the research of relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BTCT-4465A. CAS No. 1905409-39-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99033. | |
| Mouse Negative Control, Ascites | Mouse ascites obtained from mice bearing different hybridomas, delipidated, heat-inactivated, pooled and depleted of all immunoglobulins. Group: Biologicals. Grades: Purified. Pack Sizes: 500ul. US Biological Life Sciences. | Worldwide |
| Muzastotug | Muzastotug is a humanized immunoglobulin G1-kappa, anti-CTLA4 monoclonal antibody. Muzastotug is an immunostimulant and antineoplastic [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2750031-18-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990048. | |
| Narsoplimab | Narsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2 [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: OMS 721; Anti-MASP2 Reference Antibody (narsoplimab). CAS No. 2108782-45-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99376. | |
| Omalizumab | Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a K D of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a K D of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Olizumab; rhuMab-E25. CAS No. 242138-07-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9950. | |
| OMALIZUMAB | Omalizumab is a recombinant humanized monoclonal antibody against human immunoglobulin E (IgE). Synonyms: OMALIZUMAB. Grades: 95%. CAS No. 242138-07-4. Molecular formula: C48H80O4. | |
| Omburtamab | Omburtamab is an anti-CD276 (also known as B7-H3 ) monoclonal antibody, CD276 is a B7/CD28 immunoglobulin superfamily member expressed among solid human tumours. Omburtamab can bind tumor tissues and be used in various cancers research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1895083-75-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99157. | |
| Onvatilimab | Onvatilimab is a human monoclonal antibody that targets VISTA (V-domain immunoglobulin suppressor of T-cell activation). Onvatilimab inhibits VISTA signaling, abrogates the VISTA-induced suppression of T-lymphocyte-mediated immune responses, enhances cytotoxic T-cell responses against tumor cells and inhibits tumor cell growth. Synonyms: JNJ-61610588; JNJ 61610588; JNJ61610588. CAS No. 1969313-51-6. | |
| P1, Human | It is a cell-penetrating peptide (CPP) derived from the human immunoglobulin heavy chain sequence. At low molar concentration, it can permeate cell membrane without obvious influence on cell membrane. CPP can bind macromolecules and be used as drug delivery vectors. Synonyms: H-Met-Gly-Leu-Gly-Leu-His-Leu-Leu-Val-Leu-Ala-Ala-Ala-Leu-Gln-Gly-Ala-Trp-Ser-Gln-Pro-Lys-Lys-Lys-Arg-Lys-Val-OH; Human P1. Grades: 97%. Molecular formula: C134H229N39O31S. Mole weight: 2914.61. | |
| Panitumumab | Panitumumab is a humanized monoclonal antibody that binds to epidermal growth factor receptor (EGFR), which is often overexpressed in colorectal cancers. Combination of Panitumumab and EGFR reduces cell proliferation therefore inhibits colorectal cancers. It was approved for the treatment of EGFR-expressing metastatic colorectal cancer. Uses: The treatment of egfr-expressing metastatic colorectal cancer. Synonyms: Abenix; Abx-egf; Vectibix; Abx-egf mab; Unii-6A901E312a; Immunoglobulin, anti-(human epidermal growth factor receptor) (human monoclonal abx-egf heavy chain), disulfide with human monoclonal abx-egf light chain, dimer. CAS No. 339177-26-3. Molecular formula: C6398H9878N1694O2016S48. Mole weight: 144324.12. | |
| Pertuzumab | Pertuzumab is a humanized IgG1 monoclonal antibody and a HER2 dimerization inhibitor for the treatment of metastatic HER2-positive breast cancer. Synonyms: pertuzumab; 2C4; Immunoglobulin G1, anti-(human V (receptor)) (human-mouse monoclonal 2C4 heavy chain), disulfide with human-mouse monoclonal 2C4 kappa-chain, dimer; Omnitarg; Unii-K16aiq8ctm. Grades: 95%. CAS No. 380610-27-5. Mole weight: 145175.18. | |
| Phosphoric Acid Tributyl Ester | Phosphoric Acid Tributyl Ester is used as a solvent in the solvent-detergent method for production of immunoglobulin for inactivation of viruses with lipid envelope on the model of duck hepatitis B virus. It is also used as a ligand in the extraction of lanthanide ions from solid and liquid materials by supercritical CO2. Group: Biochemicals. Grades: Highly Purified. CAS No. 126-73-8. Pack Sizes: 5g, 25g. Molecular Formula: C12H27O4P. US Biological Life Sciences. | Worldwide |
| Phosphoric Acid Tributyl Ester-d27 | Isotope labelled Phosphoric Acid Tributyl Ester is used as a solvent in the solvent-detergent method for production of immunoglobulin for inactivation of viruses with lipid envelope on the model of duck hepatitis B virus. It is also used as a ligand in the extraction of lanthanide ions from solid and liquid materials by supercritical CO2. Group: Biochemicals. Grades: Highly Purified. CAS No. 61196-26-7. Pack Sizes: 25mg, 100mg. Molecular Formula: C12D27O4P. US Biological Life Sciences. | Worldwide |
| Pidilizumab | A humanized, immunoglobulin (Ig) G1 monoclonal antibody directed against human inhibitory receptor programmed cell death 1 (PD-1; PDCD1), with potential immune checkpoint inhibitory and antineoplastic activities. Pidilizumab binds to PD-1 and blocks the interaction between PD-1 and its ligands, PD-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of natural killer (NK) cells and cytotoxic T-lymphocytes (CTLs) against tumor cells. PD-1, an inhibitory receptor belonging to the B7-receptor family expressed on activated T-lymphocytes, B-cells and NK cells, negatively regulates T-cell activation and effector function when activated by its ligands; it plays an important role in tumor evasion from host immunity. Synonyms: CT-011; MDV 9300; CT 011; MDV9300; CT011; MDV-9300. CAS No. 1036730-42-3. | |
| Protein A | Protein A (SPA) is an immunoglobulin (Ig) binding protein that exists on the surface of bacteria and can be freely secreted into the extracellular environment. Protein A blocks opsonization and phagocytosis and induces B-cell death in vitro by binding to the Fc region of antibodies and the Fab region of B-cell receptors. Protein A has the ability to inhibit opsonization and phagocytosis in vitro [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: SPA. CAS No. 308083-69-4. Pack Sizes: 5 mg. Product ID: HY-NP006. | |
| Protein G (3xC), BioSeparation | BioSeparation rProtein G (3xC) is a 25.21kD synthetic derivative of the natural protein G molecule, produced by recombinant expression in E. coli and purified using a highly efficient, immunoglobulin-free process. rProtein G (3xC) comprises the Fc binding domain of natural Protein G, devoid of its BSA-binding region. Immobilized rProtein G (3xC) exhibits strong IgG binding capacity suitable for antibody capture and elution under standard conditions. Group: Molecular Biology. US Biological Life Sciences. | Worldwide |
| Pucotenlimab | Pucotenlimab (HX008) is a humanized immunoglobulin G4 (IgG4) anti programmed cell death protein 1 (anti-PD-1) monoclonal antibody. Pucotenlimab can be used for the research of tumor [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: HX008. CAS No. 2403647-03-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99938. | |
| Quilizumab | Quilizumab (Anti-Human IGHE Recombinant Antibody) is a humanized IgG1κ monoclonal antibody targeting immunoglobulin epsilon (also konwn as: IGHE, IgE). Quilizumab targets the M1-prime fragment of membrane-expressed IGHE/IgE , leading to IGHE/IgE switching and memory B cell depletion. Quilizumab has potential in asthma research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human IGHE Recombinant Antibody. CAS No. 1228538-47-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99313. | |
| R406 | R406 is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling (EC(50) for degranulation=56-64 nM). The primary target for R406 is the spleen tyrosine kinase (Syk). R406 inhibited phosphorylation of Syk substrate linker for activation of T cells in mast cells and B-cell linker protein/SLP65 in B cells. R406 bound to the ATP binding pocket of Syk and inhibited its kinase activity as an ATP-competitive inhibitor (K(I)=30 nM). Furthermore, R406 blocked Syk-dependent FcR-mediated activation of monocytes/macrophages and neutrophils and BCR-mediated activation of B lymphocytes. R406 is orally bioavailable, achieving exposures capable of inhibiting Syk-dependent IgE-mediated basophil activation. Collectively, the results show R406 potential for modulating Syk activity in human disease. Synonyms: R 406; R-406. CAS No. 841290-80-0. Molecular formula: C22H23FN6O5. Mole weight: 470.45. | |
| Raludotatug | Raludotatug is a humanized immunoglobulin G1-kappa, anti-CDH6 monoclonal antibody. Raludotatug is an antineoplastic [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2610074-56-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990028. | |
| Ramucirumab (anti-VEGFR) | Ramucirumab (anti-VEGFR) is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab (anti-VEGFR) is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab (anti-VEGFR) is also an angiogenesis inhibitor [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 947687-13-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9920A. | |
| ranibizumab | Ranibizumab is a monoclonal antibody fragment (Fab) which could inhibit angiogenesis via suppressing vascular endothelial growth factor (VEGF) A. In Dec. 2016, it was approved for the treatment of the age-related macular degeneration (AMD) and visual impairment caused by choroidal neovascularization (CNV). Synonyms: RG-6321; Lucentis; Immunoglobulin G1, anti-(human vascular endothelial growth factor) Fab fragment (human-mouse monoclonal rhuFAB V2 gamma1 chain), disulfide with human-mouse monoclonal rhuFAB V2 light chain. Grades: ≥95%. CAS No. 347396-82-1. Molecular formula: C2158H3282N562O681S12. Mole weight: 48350. | |
| Relatlimab | Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC 50 value of 0.67 nM and LAG-3/FGL1 interaction with an IC 50 value of 0.019 nM. Relatlimab can be used in research of cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BMS-986016. CAS No. 1673516-98-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99156. | |
| Remternetug | Remternetug is a human immunoglobulin G1-kappa, anti-APP (amyloid beta A4 precursor protein) Aβ42 N3pGlu peptide monoclonal antibody. Remternetug recognizes a pyroglutamated form of A&beta. Remternetug results in rapid and robust amyloid plaque reduction. Remternetug can be used for Alzheimer's disease research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LY3372993. CAS No. 2571940-41-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990078. | |
| Resistant to Gastric Acid Inactivated Probiotics for Freckle Reduction and Skin Brighten | Inactivated probiotics have good immune functions on human body, because they are rich inlipoteichoic acid, peptidoglycan, exopolysaccharides and fatty acid. For example, EPS of bifidobacterium longum BL21 can reduce the melanin formation of B16 cells significantly. EPS (3.3 mg/ml) inhibit melanin formation rate reducing to 50%.Inactivated probiotics can't be affected by gastric acid, bile and heat. It can be used infood processing as ingredients. The products have strong induced tumor necrosisfactor, interleukin, immunoglobulin and interferon. It can promote theintestinal epithelial tissue to stimulate the intestinal bifidobacteriumproliferation, inhibiting the growth of Clostridium in the large intestine,meanwhile playing a good role of prebiotics. Inactivated probiotics as a functional ingredient can be added infood, health food and medicine. Group: Others. Synonyms: Resistant to Gastric Acid Inactivated Probiotics for Freckle Reduction and Skin Brighten. Purity: 61%~90%. Resistant to Gastric Acid Inactivated Probiotics for Freckle Reduction and Skin Brighten. Cat No: PRBT-028. | |
| Rituximab | Rituximab is an anti-CD20 monoclonal antibody used for the treatment of certain autoimmune diseases and hematological cancers such as non-Hodgkin's lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, etc. Its binding to CD20, which exists on the surface of immune system B cells, leads to death of cells. Uses: The treatment of non-hodgkin's lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, etc. Synonyms: Immunoglobulin G1; Hsdb 7455; Hsdb-7455; Hsdb7455; Immunoglobulin G 1 (human-mouse monoclonal idec-C2B8 gamma1-chain anti-human antigen cd 20), disulfide with human-mouse monoclonal idec-C2B8 kappa-chain, dimer; Mab thera; Mabthera; Rituxan; Unii-4F4X42syq6; Retuxin. CAS No. 174722-31-7. Molecular formula: C6416H9874N1688O1987S44. Mole weight: 143859.7. | |
| Rocatinlimab | Rocatinlimab (AMG 451) (KHK4083) is a fully human, non-fucosylated, immunoglobulin G1 (IgG1) anti-OX40 monoclonal antibody. Rocatinlimab can be used for the research of atopic dermatitis (AD) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AMG 451; KHK4083. CAS No. 2431972-52-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99955. | |
| rProtein A (4xZ), BioSeparation | BioSeparation rProtein A (4xZ) is a synthetic derivative of the native protein A molecule, produced by recombinant expression in E. coli and purified using a highly efficient, immunoglobulin-free process. rProtein A (4xZ) contains four identical copies of an Fc region-binding domain assembled in a single 29.88kD polypeptide, and can be coupled to solid supports to produce affinity media suitable for antibody capture and elution under standard conditions. Protein A is an immunoglobulin-binding cell wall protein naturally produced by Staphylococcus aureus and widely used as a generic ligand for the purification of monoclonal and recombinant antibodies. Group: Molecular Biology. US Biological Life Sciences. | Worldwide |
| rProtein A Agarose Rapid Flow, BioSeparation | BioSeparation rProtein A Rapid Flow is an affinity medium coupled with Biomedal rProtein A (4xZ) and designed for immunoglobulin capture and purification. ProPure® rProtein A Rapid Flow medium is compatible with chromatography systems such as ÄKTA or FPLC, providing high binding capacity and a cost-efficient purification process. Group: Molecular Biology. US Biological Life Sciences. | Worldwide |
| rProtein A-Cys, BioSeparation | BioSeparation rProtein A-Cys (4xZc) is a variant of rProtein A (4xZ) in which the C-terminal residue has been replaced with a cysteine residue that can be used for single-point coupling to solid supports, via the thioether bond, to produce affinity media suitable for antibody capture and elution. Like rProtein A (4xZ), rProtein A-Cys (4xZc) can also be attached to solid supports via multi-point coupling. rProtein A-Cys (4xZc) is produced by recombinant expression in E. coli and purified using a highly efficient, immunoglobulin-free process. rProtein A-Cys (4xZc) contains four identical copies of an Fc region-binding domain assembled in a single 29.87kD polypeptide. Group: Molecular Biology. US Biological Life Sciences. | Worldwide |
| rProtein A LCL Agarose, BioSeparation | BioSeparation rProtein A LCL Agarose is an affinity medium coupled with rProtein A (4xZ) and designed for immunoglobulin capture and purification. This affinity medium can be packed in standard chromatography columns for antibody purification at any production scale. Group: Molecular Biology. US Biological Life Sciences. | Worldwide |
| rProtein G Agarose Rapid Flow, BioSeparation | BioSeparation rProtein G Rapid Flow is an affinity medium coupled with rProtein G (3xC) and designed for immunoglobulin capture and purification. rProtein G Rapid Flow medium is compatible with chromatography systems such as ÄKTA or FPLC, providing high binding capacity and a cost-efficient purification process. Group: Molecular Biology. US Biological Life Sciences. | Worldwide |
| rProtein G, Rapid Flow, Agarose, BioSeparation | BioSeparation rProtein A Rapid Flow are ready-to-use cartridges pre-packed with 1ml of rProtein A Rapid Flow and compatible with chromatography systems such as ÄKTA or FPLC, providing high binding capacity and a cost-efficient purification process. They are designed for rapid and cost-efficient immunoglobulin capture and purification. Group: Molecular Biology. US Biological Life Sciences. | Worldwide |
| Sabatolimab | Sabatolimab is a humanized monoclonal antibody directed against human T-cell immunoglobulin domain and mucin domain-3 (TIM-3). Sabatolimab has been approved for the treatment of adult patients with myelodysplastic syndromes (MDS). Synonyms: MBG453; NVP-MBG453. CAS No. 2252262-24-9. | |
| Sarilumab | Sarilumab (Anti-Human IL6Rα, Human Antibody) is a human immunoglobulin G1 monoclonal antibody. Sarilumab, a interleukin-6 (IL-6) receptor antagonist, binds to the IL-6 receptor with high affinity and inhibits cis and trans signaling by IL-6, resulting in reduced inflammation. Sarilumab can be used for the research of Rheumatoid arthritis [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human IL6Rα, Human Antibody. CAS No. 1189541-98-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9916. | |
| Sibeprenlimab | Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody which inhibits a proliferation-inducing ligand ( APRIL ). Sibeprenlimab suppresses pathogenic immunoglobulins ( IgA and IgM ), while preserving antibody responses to mRNA-based vaccines against SARS-COV-2. Sibeprenlimab reduces urinary protein-to-creatinine ratio (UPCR) and glomerular filtration rate (GFR). Sibeprenlimab is promising for the research of IgA nephropathy (IgAN) [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: VIS649. CAS No. 2382896-07-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99901. | |
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