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Riteau et al. used rabbit antiserum to perform immunofluorescence analysis on the Prepro-Killer Cell Immunoglobulin-Like Receptor 3DL3 (23-31) corresponding to the N-terminal sequence of KIR2DL4. It did not differ between the p49 and KIR2DL4 receptor. Synonyms: KIR3DL3 (23-31) (human); H-Val-Gly-Gly-Gln-Asp-Lys-Pro-Phe-Leu-OH. Grades: ≥95%. Molecular formula: C44H69N11O13. Mole weight: 960.09.
3-(Aminomethyl)-4-fluorophenol Hydrobromide
3-(Aminomethyl)-4-fluorophenol Hydrobromide is derived from 2-Fluoro-5-methoxybenzaldehyde, which is versatile reactant used in the solid-phase synthesis of BODIPY dyes and development of an immunoglobulin fluorescent sensor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H8FNO; HBr, Molecular Weight: 141.148090999999. US Biological Life Sciences.
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AA 147
AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM). Synonyms: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide; N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide. Grades: ≥98%. CAS No. 393121-74-9. Molecular formula: C16H17NO2. Mole weight: 255.31.
AMP-224
A fusion protein that contains the extracellular domain of PD-1 ligand 2 (B7-DC; PDCDILG2) and the Fc region of human immunoglobulin (Ig) G1. AMP-224 does not bind normal activated T-cells, but binds to PD-1 on chronically stimulated T-cells and reduces their proliferation. Synonyms: 2661380; AMP-244; GSK-2661380; AMP 244; GSK 2661380; AMP244; GSK2661380.
Belrestotug (EOS-448) is an antagonistic anti- TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: EOS-448; EOS884448; GSK4428859A. CAS No. 2574438-65-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990032.
Bertilimumab
Bertilimumab. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Bertilimumab;Bertilimumab [inn];Cat-213;Human anti-eotaxin 1 monoclonal antibody;Immunoglobulin G4, anti-(human eotaxin 1) (human monoclonal cat-213 gamma 4-chain), disulfide with human monoclonal cat-213 kappachain, dimer. Product Category: Heterocyclic Organic Compound. CAS No. 375348-49-5. Product ID: ACM375348495. Alfa Chemistry ISO 9001:2015 Certified.
Bovine Colostrum Powder
Colostrum is a milky fluid that comes from the breasts of humans, cows, and other mammals the first few days after giving birth, before true milk appears. It contains proteins, carbohydrates, fats, vitamins, minerals, and proteins (antibodies) that fight disease-causing agents such as bacteria and viruses. Antibody levels in colostrums can be 100 times higher than levels in regular cows milk. Group: Others. Synonyms: Bovine Colostrum; Bovine Immunoglobulin; Bovine Lacteal Compounds; Calostro; Colostrum Bovin; Colostrum Bovin Hyperimmune; Cow Milk Colostrum; Goat Colostrum; Hyperimmune Bovine Colostrum; Immunoglobuline Bovine; Lait Colostral; Protogala. Appearance: Yellow powder. Source: Bovine. Bovine Colostrum Powder. Cat No: BCP-0100.
CA-170
A first-in-class oral, small molecule antagonist of PD-L1, PD-L2 and V-region immunoglobulin-containing suppressor of T cell activation (VISTA). Synonyms: CA-170; CA 170; CA170. Molecular formula: C12H20N6O7. Mole weight: 360.32.
CEP-11981
CEP-11981 is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death. VEGFR and Tie2 are frequently overexpressed by a variety of tumor cell types and play crucial roles in the regulation of angiogenesis and the maintenance of tumor blood vessels. Tie2 (tyrosine kinase with immunoglobulin-like and EGF-like domains) is activated by angiopoietin-1 (Ang-1). Synonyms: CEP-11981; CEP 11981; CEP11981. CAS No. 856691-93-5. Molecular formula: C28H27N7O. Mole weight: 477.57.
chymosin
Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1(pepsin A family). Group: Enzymes. Synonyms: rennin (but this should be avoided since it leads to confusion with renin). Enzyme Commission Number: EC 3.4.23.4. CAS No. 9001-98-3. Rennin. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4276; chymosin; EC 3.4.23.4; 9001-98-3; rennin (but this should be avoided since it leads to confusion with renin). Cat No: EXWM-4276.
Dihydroberberine
Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene ( hERG ) channel and significantly reduces the expression of heat shock protein 90 ( Hsp90 ) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 483-15-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N1934.
Dilpacimab
Dilpacimab (ABT165) is a potent dual-variable domain immunoglobulin, targets both delta-like ligand 4 (DLL4) and VEGF pathways. Dilpacimab can be used in research of cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ABT165; PR1283233. CAS No. 1791420-09-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99852.
durvalumab
Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody. It was approved by FDA for the treatment of patients with locally advanced or metastatic urothelial carcinoma who have disease progression during or following platinum-containing chemotherapy, or whose disease has progressed within 12 months of receiving platinum-containing chemotherapy before or after surgery. Uses: The treatment of locally advanced or metastatic urothelial carcinoma. Synonyms: Imfinzi. CAS No. 1428935-60-7. Molecular formula: C6502H10018N1742O2024S42. Mole weight: 146.3.
Efbemalenograstim alfa
Efbemalenograstim alfa (F 627) is a recombinant fusion protein. Efbemalenograstim alfa is a long acting dimeric granulocyte colony-stimulating factor (G-CSF) that contains two human G-CSF fused to a human immunoglobulin G2 (hIgG2)-Fc fragment with a peptide linker. Efbemalenograstim alfa induces the production of white blood cells [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Benegrastim; Bineuta; F 627. CAS No. 2200269-79-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99879.
Elastase, Human leukocytes
Elastase, Human leukocytes is a serine protease present in the nitrogen-loving granules of neutrophils. Elastase, Human leukocytes potential substrates include almost all components of the extracellular matrix, as well as a variety of proteins such as coagulation factors, complement, immunoglobulins and cytokines. It has a strong proteolytic function and participates in the pathogenesis of inflammatory tissue damage [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9004-6-2. Pack Sizes: 1 U. Product ID: HY-P2751.
Endoproteinase Glu-C
Endoproteinase GluC (V8 protease) is a serine proteinase. Endoproteinase GluC is able to hydrolyze some serpins and all classes of mammalian immunoglobulins [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: V8 protease; Glu-C. CAS No. 137010-42-5. Pack Sizes: 100 μg. Product ID: HY-E70194.
Enibarcimab
Enibarcimab is a humanised murine monoclonal immunoglobulin G1 ( IgG1 ) antibody, could be used for acute heart failure, COVID-19 infections and septic shock research [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2305638-98-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99177.
Etanercept
Etanercept inhibits in vitro the activity of human TNF and is efficacious in many in vivo models of inflammation, including arthritis. Etanercept competitively inhibits the binding of both TNF-α and TNF-β (lymphotoxin-α) to cell surface TNF receptors, rendering TNF biologically inactive. It also modulates indirectly different biological responses that are induced or regulated by TNF, such as the expression of adhesion molecules E-selectin and to a lesser extent intercellular adhesion molecule 1 (ICAM-1), the production of interleukin-6 (IL-6) and matrix metalloproteinase 3 (MMP-3) (stromelysin), as well as IL1. Synonyms: 1-235-Tumor necrosisfactor receptor (human) fusion protein with 236-467-immunoglobulin G1 (human g1-chain Fc fragment); TNFR-Fc fusion protein; Etanercept; Embrel; Enbrel; rhu-TNFR-Fc. Grades: 95%. CAS No. 185243-69-0. Molecular formula: C2224H3472N618O701S36.
Etentamig
Etentamig is a BCMA × CD3 bispecific T-cell engager (BiTE) that can inhibit the activity of B-cell maturation antigen ( BCMA ) and activate the T-cell surface glycoprotein CD3 complex. Etentamig can be used for research in multiple myeloma, immunoglobulin light chain amyloidosis, and cardiovascular diseases [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ABBV-383; TNB 383B. CAS No. 2490552-52-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P990785.
Galiximab
Galiximab (IDEC 114) is a primatized immunoglobulin G1 (IgG1) lambda monoclonal antibody directed against the CD80 antigen and blocks CD80 - CD28 binding. Galiximab has variable regions are primatized (cynomologous monkeys), and the constant regions are human. Galiximab can be used in research of B-cell lymphoma [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IDEC 114; Anti-Human CD80 Recombinant Antibody. CAS No. 357613-77-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99293.
Gemtuzumab ozogamicin
Gemtuzumab ozogamicin is an antibody-drug conjugate (ADC) consisting of a humanized immunoglobulin (IgG4) antibody directed against CD33 that is conjugated to the cytotoxic agent Calicheamicin (HY-19609). Calicheamicin is a cytotoxic antibiotic. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia (AML) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220578-59-6. Pack Sizes: 100 μg; 200 μg; 500 μg. Product ID: HY-109539.
Hyaluronidase, Ovine testes
Hyaluronidase, Ovine testes is an enzyme responsible for catalyzing the degradation of hyaluronic acid. It is used to improve the absorption and dispersion of gastrointestinal fluids, drugs, and contrast agents. Hyaluronidase, Ovine testes can enhance the diffusion or delivery of local agent (LA) that can suppress or relieve pain or immunoglobulins (Igs) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 37326-33-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108903A.
Ifinatamab
Ifinatamab is monoclonal immunoglobulin G1-kappa with anti-human B7 homolog 3 protein (Human B7-H3). Ifinatamab is a glycoforme α immunomodulateur [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2484870-90-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99367.
A 190 kDa enzyme found in several pathogenic species of Streptococcus such as sanguis and pneumoniae. Type example of peptidase family M26. There is also an IgA-specific prolyl endopeptidase of the serine-type (see EC 3.4.21.72, IgA-specific serine endopeptidase). Group: Enzymes. Synonyms: immunoglobulin A1 proteinase; IgA protease; IgA1-specific proteinase; IgA1 protease; IgA1 proteinase. Enzyme Commission Number: EC 3.4.24.13. CAS No. 72231-73-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4294; IgA-specific metalloendopeptidase; EC 3.4.24.13; 72231-73-3; immunoglobulin A1 proteinase; IgA protease; IgA1-specific proteinase; IgA1 protease; IgA1 proteinase. Cat No: EXWM-4294.
IgA-specific serine endopeptidase
Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. Type example of peptidase family S6. Some other bacterial endopeptidases with similar specificity are of metallo- type (see EC 3.4.24.13, IgA-specific metalloendopeptidase). Group: Enzymes. Synonyms: IgA protease; IgA proteinase; IgA-specific proteinase; immunoglobulin A protease; immunoglobulin A proteinase. Enzyme Commission Number: EC 3.4.21.72. CAS No. 55127-02-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4164; IgA-specific serine endopeptidase; EC 3.4.21.72; 55127-02-1; IgA protease; IgA proteinase; IgA-specific proteinase; immunoglobulin A protease; immunoglobulin A proteinase. Cat No: EXWM-4164.
Infliximab is a monoclonal antibody drug that is used for the treatment of rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, Crohn's disease, and ankylosing spondylitis. It binds to tumor necrosis factor alpha (TNF-α), which plays a role in the autoimmune reation. Infliximab may lead to fatal infections yet. Synonyms: Immunoglobulin G, anti-(human tumor necrosis factor) (human-mouse monoclonal cA2 heavy chain), disulfide with human-mouse monoclonal cA2 light chain, dimer; Avakine; Remicade; Remsima. Grades: 95%. CAS No. 170277-31-3.
Insulin efsitora alfa
Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR). Insulin efsitora alfa is a fusion protein composed of human IR agonists fused with the crystallizable (Fc) domain of human immunoglobulin G2 (IgG2) fragment, with a molecular weight of 64.1 kDa. Insulin efsitora alfa is well tolerated and has potential applications in diabetes [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: LY-3209590. CAS No. 2131038-11-2. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P99665.