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| Product | Description | |
|---|---|---|
| IMP dehydrogenase | The enzyme acts on the hydroxy group of the hydrated derivative of the substrate. Group: Enzymes. Synonyms: inosine-5'-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5'-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase. Enzyme Commission Number: EC 1.1.1.205. CAS No. 9028-93-7. IMPDH2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0109; IMP dehydrogenase; EC 1.1.1.205; 9028-93-7; inosine-5'-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5'-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase. Cat No: EXWM-0109. |  |
| 1-?(2, ?3, ?5-?Tri-?O-?acetyl-?β -?D-?ribofuranosyl)?-?1, ?2, ?4-?triazole-?3-?carboxylic Acid Methyl Ester | As an IMP dehydrogenase inhibitor, 1-(2,?3,?5-Tri-O-acetyl-β-D-ribofuranosyl)?-1,?2,?4-triazole-3-carboxylic Acid Methyl Ester is a reactant used in the synthesis of azole nucleoside 5'-MP mimics (P1Ms). Synonyms: Methyl 1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)?-1,2,4-triazole-3-carboxylate; 1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylic Acid Methyl Ester. Grades: 96%. CAS No. 39925-10-5. Molecular formula: C15H19N3O9. Mole weight: 385.33. |  |
| 1-?(2,?3,?5-?Tri-?O-?acetyl-? β-?D-?ribofuranosyl)?-?1,?2,?4-?triazole-?3-?carboxylic Acid Methyl Ester | 1-?(2,?3,?5-?Tri-?O-?acetyl-? β-?D-?ribofuranosyl)?-?1,?2,?4-?triazole-?3-?carboxylic Acid Methyl Ester is a reactant used in the synthesis of azole nucleoside 5'-?MP mimics (P1Ms) as IMP dehydrogenase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 39925-10-5. Pack Sizes: 10mg, 100mg. Molecular Formula: C15H19N3O9, Molecular Weight: 385.33. US Biological Life Sciences. |  Worldwide |
| 1-?(2,?3,?5-?Tri-?O-?acetyl-? β-?D-?ribofuranosyl)?-?1,?2,?4-?triazole-?3-?carboxylic Acid Methyl Ester-13C2 | 1-?(2,?3,?5-?Tri-?O-?acetyl-? β-?D-?ribofuranosyl)?-?1,?2,?4-?triazole-?3-?carboxylic Acid Methyl Ester-13C2 is the labeled analogue of 1-?(2,?3,?5-?Tri-?O-?acetyl-? β-?D-?ribofuranosyl)?-?1,?2,?4-?triazole-?3-?carboxylic Acid Methyl Ester (T767035), a reactant used in the synthesis of azole nucleoside 5'-?MP mimics (P1Ms) as IMP dehydrogenase inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C1313C2H19N3O9, Molecular Weight: 387.31. US Biological Life Sciences. | Worldwide |
| 1-O-D-Sorbitol Mycophenolate | 1-O-D-Sorbitol Mycophenolate is an impurity or sugar conjugate of Mycophenolic Acid (M831500), which is an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. It is a selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C23H32O11, Molecular Weight: 484.49. US Biological Life Sciences. | Worldwide |
| (1R, 4R) -4-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester | (1R, 4R) -4-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester is an intermediate in synthesizing trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 168958-19-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C12H19NO4. US Biological Life Sciences. | Worldwide |
| 2-(3,5-Diformyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic Acid | 2-(3,5-Diformyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic Acid s an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C17H17NO5S, Molecular Weight: 347.39. US Biological Life Sciences. | Worldwide |
| 2,3-Xylohydroquinone | 2,3-Xylohydroquinone is a useful synthetic intermediate. It was used in the synthesis of mycophenolic acid analogs with IMP dehydrogenase-inhibiting activities. It is a metabolite of butylamino (dimethylphenoxy) propanol, a new adrenergic β-blocking agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 608-43-5. Pack Sizes: 1g, 2.5g. Molecular Formula: C8H10O2. US Biological Life Sciences. | Worldwide |
| 2-deoxy-scyllo-inosamine dehydrogenase | Requires zinc. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, neomycin and ribostamycin. cf. EC 1.1.99.38, 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent). Group: Enzymes. Synonyms: neoA (gene name); kanK (gene name, ambiguous); kanE (gene name, ambiguous). Enzyme Commission Number: EC 1.1.1.329. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0242; 2-deoxy-scyllo-inosamine dehydrogenase; EC 1.1.1.329; neoA (gene name); kanK (gene name, ambiguous); kanE (gene name, ambiguous). Cat No: EXWM-0242. | |
| 2-Methyl-5-benzofuranamine | 2-Methyl-5-benzofuranamine is a benzofuranamide analogs which potentially exhibit low nanomolar inhibition of Cryptosporidium parvum IMP dehydrogenase (CpIMPDH). Group: Biochemicals. Grades: Highly Purified. CAS No. 26210-75-3. Pack Sizes: 500mg, 2.5g. Molecular Formula: C9H9NO, Molecular Weight: 147.169999999999. US Biological Life Sciences. | Worldwide |
| 2-NH2-6-Cl-5'-PuMP | 2-NH2-6-Cl-5'-PuMP is an analogue of guanosine-5'-O-monophosphate and an inhibitor of IMP dehydrogenase. It is often used as the precursor for 6-modified 5'-GMP derivatives. Synonyms: 2-Amino-6-chloropurine riboside-5'-O-monophosphate, sodium salt. Grades: ≥ 97% by HPLC. CAS No. 16321-98-5. Molecular formula: C10H13ClN5O7P (free acid). Mole weight: 381.67. | |
| 2'-(R)-Hydroxy-2',3'-dihydroabacavir Dihydrochloride | 2'-(R)-Hydroxy-2',3'dihydroabacavir is the impurity of Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C14H20N6O2 2HCl, Molecular Weight: 304.357291999999. US Biological Life Sciences. | Worldwide |
| 3-Nitropropionic Acid | A cell-permeable, irreversible inactivator (~3mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38mg/kg/day) is shown to cause activation of c-Jun kinase in striatum. Group: Biochemicals. Alternative Names: 3-NP, 3-NPA, 3NPA. Grades: Highly Purified. CAS No. 504-88-1. Pack Sizes: 50mg. Molecular Formula: C?H?NO?. US Biological Life Sciences. | Worldwide |
| 3'-O-(2-Methoxyethyl)inosine | 3'-O-(2-Methoxyethyl)inosine, an indispensable compound within the biomedical industry, assumes the role of a nucleoside analog. Widely utilized in the formulation of antiviral agents, it showcases exceptional prospects in combating viral infections, especially those linked to inosine monophosphate dehydrogenase (IMPDH). Grades: ≥95%. Molecular formula: C13H18N4O6. Mole weight: 326.31. | |
| 4-Hydroxynonenal | 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 4-HNE. CAS No. 75899-68-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113466. |  |
| 5,7-dihydroxy-4-methylphthalide | 5,7-dihydroxy-4-methylphthalide is an impurity of Mycophenolate Mofetil. Mycophenolate Mofetil is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. Synonyms: 5,7-dihydroxy-4-methyl-3H-2-benzofuran-1-one. CAS No. 27979-57-3. Molecular formula: C9H8O4. Mole weight: 180.159. | |
| 8-pCPT-5'-AMP | 8-pCPT-5'-AMP is a potential metabolite of 8-pCPT-cAMP that inhibits 5'-IMP dehydrogenase. Synonyms: 8-(4-chlorophenylthio)adenosine-5'-O-monophosphate. Grades: ≥ 97 % by HPLC. CAS No. 78710-84-6. Molecular formula: C16H17ClN5O7PS. Mole weight: 489.83. | |
| Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine | Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine (Abacavir EP Impurity B) is a degradation product of Abacavir Sulfate. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Synonyms: N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; Abacavir USP Related Compound D; Abacavir EP Impurity B; Abacavir Impurities; Abacavir EP Impurity B. CAS No. 1443421-69-9. Molecular formula: C18H21ClN10O. Mole weight: 428.88. | |
| Acetyl Coenzyme A Lithium Salt | Acetyl Coenzyme A Lithium Salt is an important molecule in enzymatic acetyl transfer reactions. It is the source of the phosphopantetheine group that is added as a prosthetic group to acyl carrier proteins and formyltetrahydrofolate dehydrogenase. Synonyms: Lithium acetyl-CoA; Coenzyme A, S-acetate, lithium salt. Grades: ≥95%. CAS No. 32140-51-5. Molecular formula: C23H38N7O17P3S xLi. Mole weight: 809.58. | |
| Acyl-Coenzyme A Dehydrogenase 8 from Human, Recombinant | Acyl CoA dehydrogenase is the enzymeused to catalyzethe first step of β-oxidationin Fatty acid metabolism. Acyl-coenzyme A (CoA) dehydrogenases (ACADs) are a family of mitochondrial enzymes that catalyze the first dehydrogenation step in the bets-oxidation of fatty acyl-CoA derivatives. Several human ACADs exist and all ACADs catalyze the same initial dehydrogenation of the substrate at the beta-carbon atom and require electron transfer flavoprotein as an alectron acceptor. The predicted 415-amino acid ACAD8 protein contains many of the residues conserved in most other ACADs, including an active site glutamic acid residue and residues important for tetramer f...mber 8 mitochondrial; ACAD-8; Isobutyryl-CoA dehydrogenase; Activator-recruited cofactor 42 kDa component; ARC42; FLJ22590. Purity: Greater than 95.0% as determined by SDS-PAGE. ACAD-8. Mole weight: 47.7 kDa. Stability: ACAD8 although stable at 4°C for 1 week, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. Acyl-CoA dehydrogenase family member 8 mitochondrial; ACAD-8; Isobutyryl-CoA dehydrogenase; Activator-recruited cofactor 42 kDa component; ARC42; FLJ22590. Cat No: NATE-0801. | |
| Alanine Dehydrogenase from Bacillus cereus, Recombinant | L-Alanine dehydrogenase is an A-stereospecific dehydrogenase that catalyzes the reversible deamination of L-alanine to pyruvate and ammonium. It is important for the geneRation of pyruvate during sporulation. L-Alanine dehydrogenase from Bacillus subtilis has a predominately ordered kinetic mechanism in which NAD binds before L-alanine. Subsequently, ammonia, pyruvate, and NADH are released in that specific order. Optimal pH for the amination reaction is 8.8-9.0, whereas it is 10-10.5 for the deamination reaction. The enzyme is inactivated by divalent metal ions and p-chloromercuribenzoate, mercuric ion being most effective. The inactivation may be reversed by L-or D-cysteine. Group: Enzymes. Synonyms: L-Alanine Dehydrogenase; Alanine dehydrogenase; EC 1.4.1.1; 9029-06-5; AlaDH; NAD+-linked alanine dehydrogenase; alpha-alanine dehydrogenase; NAD+-dependent alanine dehydrogenase; alanine oxidoreductase; NADH-dependent alan. Enzyme Commission Number: EC 1.4.1.1. CAS No. 9029-6-5. AlaDH. Activity: > 350 units/ml. Storage: -20°C. Source: E. coli. Species: Bacillus cereus. L-Alanine Dehydrogenase; Alanine dehydrogenase; EC 1.4.1.1; 9029-06-5; AlaDH; NAD+-linked alanine dehydrogenase; alpha-alanine dehydrogenase; NAD+-dependent alanine dehydrogenase; alanine oxidoreductase; NADH-dependent alanine dehydrogenase. Cat No: NATE-0044. | |
| aspartate-semialdehyde dehydrogenase | In enzymology, an aspartate-semialdehyde dehydrogenase (EC 1.2.1.11) is an enzyme that is very important in the biosynthesis of amino acids in prokaryotes, fungi, and some higher plants. It forms an early branch point in the metabolic pathway forming lysine, methionine, leucine and isoleucine from aspartate. This pathway also produces diaminopimelate which plays an essential role in bacterial cell wall formation. There is particular interest in ASADH as disabling this enzyme proves fatal to the organism giving rise to the possibility of a new class of antibiotics, fungicides, and herbicides aimed at inhibiting it. Group: Enzymes. Synonyms: aspartate semialdehyde dehydrogenase; aspartic semialdehyde dehydrogenase; L-aspartate-β-semialdehyde:NADP+ oxidoreductase (phosphorylating); aspartic β-semialdehyde dehydrogenase; ASA dehydrogenase. Enzyme Commission Number: EC 1.2.1.11. CAS No. 9000-98-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1117; aspartate-semialdehyde dehydrogenase; EC 1.2.1.11; 9000-98-0; aspartate semialdehyde dehydrogenase; aspartic semialdehyde dehydrogenase; L-aspartate-β-semialdehyde:NADP+ oxidoreductase (phosphorylating); aspartic β-semialdehyde dehydrogenase; ASA dehydrogenase. Cat No: EXWM-1117. | |
| AVN-944 | AVN-944 (VX-944) is an orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only. Synonyms: code name: AVN 944; AVN944; VX-944; VX 944; VX944. Grades: 0.98. CAS No. 297730-17-7. Molecular formula: C25H27N5O5. Mole weight: 477.51. | |
| AZD8329 | AZD8329 is a potent, selective 11β-HSD1 inhibitor (11β-hydroxysteroid dehydrogenase type 1 inhibitor) with reduced acyl glucuronide liability. AZD8329 demonstrates to have improved technical profile in terms of both solubility and pharmacokinetics. The extent of acyl glucuronidation was reduced through structural optimization of both the carboxylic acid and amide substituents, coupled with a reduction in lipophilicity leading to an overall increase in metabolic stability. Synonyms: AZD-8329; AZD 8329; 4-(4-((1r,3r,5r,7r)-adamantan-2-ylcarbamoyl)-5-(tert-butyl)-1H-pyrazol-1-yl)benzoic acid. Grades: 98%. CAS No. 1048668-70-7. Molecular formula: C25H31N3O3. Mole weight: 421.54. | |
| β-Nicotinamide-Adenine Dinucleotide, Reduced Form (β-NADH) | NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, beta-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD+/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease. Group: Coenzymes. Synonyms. Enzyme Commission Number: EC 1.1.1.1. CAS No. 606-68-8. Purity: Dertermined by decrease in absorbance at 340 nm on enzymatic oxidation with ADH* at pH 10.0 > 95% *ADH = Alcohol dehydrogenase (yeast) (EC 1.1.1.1.). β-NADH. Mole weight: 709.41. Storage: Keep tightly stoppered in the dark below 5°C. Moisture will reduce the purity. For prolonged storage, keep below-20°C. Unstable in acids, but relatively stable at pH 10-11. aldehyde reductase; ADH; alcohol dehydrogenase (NAD); aliphatic alcohol dehydrogenase; ethanol dehydrogenase; NAD-dependent alcohol dehydrogenase; NAD-specific aromatic alcohol dehydrogenase; NADH-alcohol dehydrogenase; NADH-aldehyde dehydrogenase; primary alcohol dehydrogenase; yeast alcohol dehydrogenase; EC 1.1.1.1; β-NADH. Cat No: NATE-0786. | |
| BMS-566419 | Potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Synonyms: BMS 566419; BMS566419; N-(1-(6-(4-Ethyl-1-piperazinyl)-3-pyridinyl)-1-methylethyl)-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide. Grades: >98%. CAS No. 566161-24-8. Molecular formula: C28H30FN5O2. Mole weight: 487.57. | |
| Buformin-d9 | Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase. Group: Biochemicals. Alternative Names: N-Butyl-d9-idodicarbonimidic Diamide; 1-Butyl-d9-biguanide; 1-Butylbiguanide-d9; Buformine-d9; Butformin-d9; Butylbiguanid-d9e; Butyldiguanid-d9e; DBV-d9; Dibetos B-d9; Glybigid-d9; H 224-d9; N1-Butylbiguanide-d9; W 37-d9. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Buformin Hydrochloride | Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase. Group: Biochemicals. Alternative Names: N-Butylidodicarbonimidic Diamide Hydrochloride; 1-Butylbiguanide Hydrochloride; 1-Butylbiguanide Hydrochloride; Buformine; Butformin; Butylbiguanide; Butyldiguanide; DBV; Dibetos B; Glybigid; Panformin; Sindiatil; Tidemol; Ziavetine. Grades: Highly Purified. CAS No. 1190-53-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Caspase-9 Inhibitor III | Caspase-9 Inhibitor III is a potent and irreversible inhibitor of caspase-9 with cardioprotective effects. Caspase inhibitors play an important role in investigating biological processes. Caspase-9 can reduce infarct size, lactate dehydrogenase (LDH) and creatine kinase (CK) release, and DNA smearing induced by ischemia and reperfusion in isolated rat hearts. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Synonyms: Ac-LEHD-CMK. Grades: 98%. CAS No. 403848-57-7. Molecular formula: C24H35ClN6O9. Mole weight: 587.02. | |
| Chemically modified Cucurbita species Ascorbate Oxidase | Oxidoreductase that oxidizes ascorbic acid to dehydroascorbate. Take advantage of the improved stability in liquid reagents. Rely on the proven diagnostic quality of this product. Applications: Use ascorbate oxidase, chemically modified, in a variety of diagnostic tests to eliminate the interference of ascorbic acid, since ascorbic acid interferes with the trinder reaction that is widely used for the colorimetric determination of analytes. it is useful in liquid as well as dry chemistry test, e.g., for the determination of uric acid, lactate or creatinine. Group: Enzymes. Synonyms: ascorbase; ascorbic acid oxidase; ascorbate oxidase; ascorbic oxidase; ascorbate dehydrogenase; L-ascorbic acid oxidase; AAO; L-ascorbate: O2 oxidoreductase; AA oxidase; L-ascorbate oxidase. AAO. Mole weight: Approximately 140 kD. Activity: >180 U/mg lyophilizate (+37°C, L-ascorbate); Specific activity (+37°C): >1,800 U/mg protein. Stability: At -15 to -25°C within specification range for 12 months. Store dry. Keep tightly sealed. Appearance: Turquoise lyophilizate. Source: Cucurbita species. ascorbase; ascorbic acid oxidase; ascorbate oxidase; ascorbic oxidase; ascorbate dehydrogenase; L-ascorbic acid oxidase; AAO; L-ascorbate: O2 oxidoreductase; AA oxidase; EC 1.10.3.3; 9029-44-1; L-ascorbate oxidase. Cat No: DIA-283. | |
| cypemycin cysteine dehydrogenase (decarboxylating) | Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a peptide antibiotic, member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides. The enzyme decarboxylates and reduces the C-terminal L-cysteine residue, producing a reactive ethenethiol group that reacts with a dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine loop that is important for the antibiotic activity of the mature peptide. Group: Enzymes. Synonyms: cypemycin decarboxylase; CypD. Enzyme Commission Number: EC 1.3.99.36. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1436; cypemycin cysteine dehydrogenase (decarboxylating); EC 1.3.99.36; cypemycin decarboxylase; CypD. Cat No: EXWM-1436. | |
| D-(-)-3-Phosphoglyceric acid disodium | D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalyzed glycolysis process. D-(-)-3-Phosphoglyceric acid disodium competitively inhibits yeast enolase ( enolase ). D-(-)-3-Phosphoglyceric acid disodium can regulate the activity of phosphoglycerate dehydrogenase ( PHGDH ) to modulate p53 protein and apoptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 3-Phospho-D-glyceric acid disodium. CAS No. 80731-10-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141412. | |
| Dihydroxy Analogue of Mycophenolic Acid | An impurity of Mycophenolic Acid which is a selective inhibitor of inosine monphosphate dehydrogenase. Synonyms: O-Desmethyl Mycophenolic Acid; (4E)-6-(1,3-Dihydro-4,6-dihydroxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid; Demethylmycophenolic Acid; Nor-O-methyl Mycophenolic Acid. Grades: > 95%. CAS No. 31858-65-8. Molecular formula: C16H18O6. Mole weight: 306.32. | |
| Ds(+)-threo-Isocitric acid trisodium salt | Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness. Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome. Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation. Group: Biochemicals. Alternative Names: (1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid; (2R,3S)-Isocitric acid trisodium salt. Grades: Highly Purified. CAS No. 903507-52-8. Pack Sizes: 25mg, 100mg. Molecular Formula: C6H5O7 3Na, Molecular Weight: 258.1. US Biological Life Sciences. | Worldwide |
| ent-Abacavir | ent-Abacavir (Abacavir EP Impurity A) is an enantiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Uses: Anti-hiv agents. Synonyms: (1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol;(1R-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1R,4S)-Abacavir; Abacavir EP Impurity A; Abacavir Impurities; Ent-Abacavir. Grades: 97%. CAS No. 136470-79-6. Molecular formula: C14H18N6O. Mole weight: 286.33. | |
| Glutaryl-L-Carnitine, Lithium Salt | A metabolite of L-Carnitine. Increased formation and excretion of glutarylcarnitin results from a glutaryl-CoA dehydrogenase deficiency, an inborn error of lysine and tryptophan metabolism. Secondary carnitine depletion due to increased formation and urinary excretion of glutarylcarnitine is suggested to play an important role in the neuropathogenesis of glutaryl-CoA dehydrogenase deficiency, inducing excitotoxic neuronal damage and mitochondrial dysfunction. Group: Biochemicals. Alternative Names: (2R)-3-Carboxy-2-(4-carboxy-1-oxobutoxy)-N,N,N-trimethyl-1-propanaminium inner salt; Glutarylcarnitine; L-Carnitine lithium glutarate. Grades: Highly Purified. CAS No. 102636-82-8 (free acid). Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| glycine N-methyltransferase | This enzyme is thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. It is inhibited by 5-methyltetrahydrofolate pentaglutamate. Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3, sarcosine dehydrogenase. Group: Enzymes. Synonyms: glycine methyltransferase; S-adenosyl-L-methionine:glycine methyltransferase; GNMT. Enzyme Commission Number: EC 2.1.1.20. CAS No. 37228-72-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1800; glycine N-methyltransferase; EC 2.1.1.20; 37228-72-1; glycine methyltransferase; S-adenosyl-L-methionine:glycine methyltransferase; GNMT. Cat No: EXWM-1800. | |
| Inosine Monophosphate Dehydrogenase from Staphylococcus aureus, Recombinant | E.coli. Applications: Impdh is a recombinant protein of ca. 53kda cloned by pcr amplification of guab gene of staphylococcus aureus and expressed in e.coli. Group: Enzymes. Synonyms: inosine-5'-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5'-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase; IMP dehydrogenase; IMP:NAD+ oxidoreductase; EC 1.1.1.205; IMPDH. Enzyme Commission Number: EC 1.1.1.205. CAS No. 9028-93-7. IMPDH2. Mole weight: 53kDa. Activity: ≥ 0.3 unit/mg protein. Source: S. aureus. Species: IMPDH2. inosine-5'-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5'-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase; IMP dehydrogenase; IMP:NAD+ oxidoreductase; EC 1.1.1.205; IMPDH. Pack: stable lyophilized form. Cat No: NATE-1739. | |
| Inosine Monophosphate Dehydrogenase Type II from Human, Recombinant | Type II is the predominant IMPDH isoform and is specifically linked to a wide range of cancers and lymphocyte proliferation. Group: Enzymes. Synonyms: inosine-5'-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5'-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase; IMP dehydrogenase; IMP:NAD+ oxidoreductase; EC 1.1.1.205; IMPDH II; IMPDH2; IMPD 2. Enzyme Commission Number: EC 1.1.1.205. CAS No. 231-791-2. IMPDH2. Storage: -70°C. Form: Solution in 20 mM Tris-HCl, pH 8.0, containing 0.5 mM EDTA and 1 mM DTT. Source: E. coli. Species: Human. inosine-5'-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5'-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase; IMP dehydrogenase; IMP:NAD+ oxidoreductase; EC 1.1.1.205; IMPDH II; IMPDH2; IMPD 2. Pack: vial of > 0.002 unit. Cat No: NATE-0352. | |
| Isocitrate dehydrogenase, Porcine heart | Isocitrate dehydrogenase, Porcine heart (ICDH) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P) + to NAD(P)H, it plays important roles in cellular metabolism [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICDH; IDH. CAS No. 9028-48-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2993. | |
| Isoguanosine Hydrate | A useful synthetic intermedate. A naturally occuring, biologically active isomer of guanosine. Reported to stimulate the accumulation of cyclic-AMP in the brain. It is an inhibitor of IMP pyrophosphorylase, and its 5'-di and -tri-phosphates inhibit glutamic acid dehydrogenase. May contain approximately 0.6 moles of water. Synonyms: 2-Hydroxy adenosine hydrate; 1,2-Dihydro-2-oxo-adenosine Hydrate; Crotonosid Hydrate; Isoguanine riboside Hydrate; NSC 1216 Hydrate; 2,3-Dihydro-2-oxoadenosine Hydrate; 6-Amino-9-β-D-ribofuranosyl-9H-Purin-2-ol Hydrate. Grades: ≥95%. CAS No. 359436-55-8. Molecular formula: C10H13N5O5. Mole weight: 283.24. | |
| L-Dihydroorotic acid | L-Dihydroorotic acid is an important intermediate in the metabolism of orotic acid and a substrate of dihydroorotate dehydrogenase ( DHODH ). L-Dihydroorotic acid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 5988-19-2. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W015495. | |
| MitoBloCK-6 (2- ( ( (4-Anilinophenyl) imino) methyl) -4, 6-dichlorophenol, 2, 4-Dichloro-6- ( ( ( ( (phenylamino) phenyl) imino) methyl) phenol) , Mitochondrial Protein Import Blocker from the Carla Koehler Laboratory, MB6, MB-6) | A cell-permeable, stable dichlorosalicylalde hyde Schiff's base that acts as a potent, selective inhibitor of Mia40/Erv1 redox-mediated import pathway (IC50 = 700nM, 900nM, and 1.4uM for ALR, Erv1, and Erv2, respectively). Significantly reduces the import of CX9 proteins, Erv1, Tim23, and ADP/ATP carrier (AAC). However, it does not affect mitochondrial membrane integrity as evidenced by the lack of aconitase, AAC, Tim54, Mia40, and cytochrome c release. Has no effect on protein disulfide isomerase, flavin adenine dinucleotide, and succinate dehydrogenase activities and does not disrupt mitochondrial net work or reduce viability of cells even at high concentrations (~100uM in HeLa and HEK293 cells). Reported to specifically cause cytochrome c release, activate caspase-3, and induce apoptosis in human embryonic stem cells (~20uM), but not in differentiated cells. Reversibly impairs cardiac development and reduces heart rate in zebra fish that is attributed to mitochondrial dysfunction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??Cl?N?O, Primary Target: Erv1. US Biological Life Sciences. | Worldwide |
| Mycophenolate Mofetil | Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation [1]. Uses: Scientific research. Group: Natural products. Alternative Names: RS 61443; TM-MMF. CAS No. 128794-94-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 1 g; 5 g. Product ID: HY-B0199. | |
| Mycophenolate Mofetil-d4 | Mycophenolate Mofetil-d 4 is the deuterium labeled Mycophenolate Mofetil. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1132748-21-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-B0199S. | |
| Mycophenolate Mofetil EP Impurity D | Mycophenolate Mofetil EP Impurity D is a degradation product of Mycophenolate Mofetil, an inhibitor of inosine monophosphate dehydrogenase (IMPDH). Synonyms: O-Methyl Mycophenolate Mofetil; (4E)-6-(1,3-Dihydro-4,6-dimethoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid 2-(4-Morpholinyl)ethyl Ester; 4-Hexenoic acid, 6-(1,3-dihydro-4,6-dimethoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)-; 2-(4-Morpholinyl)ethyl (4E)-6-(1,3-dihydro-4,6-dimethoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate; 2-Morpholinoethyl (E)-6-(1,3-dihydro-4,6-dimethoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate. Grades: ≥95%. CAS No. 1322681-37-7. Molecular formula: C24H33NO7. Mole weight: 447.53. | |
| Mycophenolate mofetil hydrochloride | Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC 50 s of 39 nM and 27 nM, respectively. Uses: Scientific research. Group: Natural products. Alternative Names: RS 61443 hydrochloride; TM-MMF hydrochloride. CAS No. 116680-01-4. Pack Sizes: 50 mg; 100 mg. Product ID: HY-B0199A. | |
| Mycophenolate Mofetil Impurity 2 | An impurity of Mycophenolate mofetil which is a prodrug of mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase (IMPDH). Grades: > 95%. Molecular formula: C23H31NO7. Mole weight: 433.51. | |
| Mycophenolate Mofetil Impurity A HCl | An impurity of Mycophenolate Mofetil which is a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase I/II with IC50 of 39 nM and 27 nM, respectively. Synonyms: O-Desmethyl Impurity HCl. Grades: > 95%. CAS No. 1322681-36-6. Molecular formula: C22H29NO7.HCl. Mole weight: 455.94. | |
| Mycophenolate Mofetil Impurity E | An impurity of Mycophenolate mofetil which is a prodrug of mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase (IMPDH). Synonyms: Methyl mycophenolate; Mycophenolic Acid Methyl Ester. Grades: > 95%. CAS No. 31858-66-9. Molecular formula: C18H22O6. Mole weight: 334.37. | |
| Mycophenolate Mofetil Impurity G | An impurity of Mycophenolate mofetil which is a prodrug of mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase (IMPDH). Grades: > 95%. Molecular formula: C23H31NO8. Mole weight: 449.51. | |
| Mycophenolic acid | Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase ( IMPDH ) inhibitor with an EC 50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Mycophenolate. CAS No. 24280-93-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0421. | |
| Mycophenolic acid acyl-b-D-glucuronide allyl ester | Mycophenolic acid acyl-b-D-glucuronide allyl ester, a highly significant compound extensively employed in the biomedical sector, plays a crucial role in the treatment of autoimmune disorders and the prevention of organ transplant rejection. By effectively impeding the inosine monophosphate dehydrogenase (IMPDH) enzyme, it showcases remarkable immunosuppressive characteristics, thereby curtailing the production of purine nucleotides. Synonyms: 1-[(4E)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate] b-D-glucopyranuronic acid 2-propen-1-yl ester. CAS No. 860615-39-0. Molecular formula: C26H32O12. Mole weight: 536.53. | |
| Mycophenolic Acid Cyclopropane Analogue | An impurity of Mycophenolic Acid which is a selective inhibitor of inosine monphosphate dehydrogenase. Synonyms: 1-Cyclopropane Mycophenolic Acid; 3-(2-((4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)methyl)-1-methylcyclopropyl)propanoic Acid; 2-[(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)methyl]-1-methyl-cyclopropanepropanoic Acid. Grades: > 95%. CAS No. 125198-40-5. Molecular formula: C18H22O6. Mole weight: 334.37. | |
| Mycophenolic Acid Related Compound 1 | An impurity of Mycophenolic which is a selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase. Synonyms: 5,7-Dihydroxy-4 methylphthhalide. Grades: > 95%. Molecular formula: C9H8O4. Mole weight: 180.16. | |
| Mycophenolic acid sodium | Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase ( IMPDH ) inhibitor with an EC 50 of 0.24 μM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Mycophenolate sodium. CAS No. 37415-62-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0421A. | |
| Mycophenolic acid (Standard) | Mycophenolic acid (Standard) is the analytical standard of Mycophenolic acid. This product is intended for research and analytical applications. Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 24280-93-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0421R. | |
| Native Bacillus sp. Hexokinase | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Applications: This enzyme is useful for enzymatic determination of glucose or creatinine kinase activity when coupled with glucose-6-phosphate dehydrogenase. Group: Enzymes. Synonyms: hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; hexokinase; ATP:D-hexose 6-phosphotransferase. Enzyme Commission Number: EC 2.7.1.1. CAS No. 9001-51-8. Hexokinase. Mole weight: 68 kDa (gel filtration). Activity: More than 250 U/mg solid. Appearance: White amorphous powder, lyophilized. Storage: Storage at -20°C in the presence of a desiccant is recommended. Form: Freeze dried powder. Source: Bacillus sp. hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; hexokinase; ATP:D-hexose 6-phosphotransferase; EC 2.7.1.1. Cat No: NATE-1157. | |
| Native Bacillus stearothermophilus Alanine Dehydrogenase | L-Alanine dehydrogenase is a stereospecific dehydrogenase that catalyzes the reversible deamination of L-alanine to pyruvate and ammonium. It is important for the generation of pyruvate during sporulation. Applications: The enzyme is useful for determination of l-alanine. Group: Enzymes. Synonyms: L-Alanine Dehydrogenase; Alanine dehydrogenase; EC 1.4.1.1; 9029-06-5; AlaDH; NAD+-linked alanine dehydrogenase; alpha-alanine dehydrogenase; NAD+-dependent alanine dehydrogenase; alanine oxidoreductase; NADH-dependent alanine dehydrogenase. Enzyme Commission Number: EC 1.4.1.1. CAS No. 9029-6-5. AlaDH. Mole weight: ca. 230,000; Subunit molecular weight : ca. 38,000. Appearance: Lyophilized. Storage: Stable at -20 °C for at least one year. Source: Bacillus stearothermophilus. L-Alanine Dehydrogenase; Alanine dehydrogenase; EC 1.4.1.1; 9029-06-5; AlaDH; NAD+-linked alanine dehydrogenase; alpha-alanine dehydrogenase; NAD+-dependent alanine dehydrogenase; alanine oxidoreductase; NADH-dependent alanine dehydrogenase. Cat No: NATE-1899. | |
| Native Bacillus subtilis L-Alanine Dehydrogenase | L-Alanine dehydrogenase is an A-stereospecific dehydrogenase that catalyzes the reversible deamination of L-alanine to pyruvate and ammonium. It is important for the geneRation of pyruvate during sporulation. L-Alanine dehydrogenase from Bacillus subtilis has a predominately ordered kinetic mechanism in which NAD binds before L-alanine. Subsequently, ammonia, pyruvate, and NADH are released in that specific order. Optimal pH for the amination reaction is 8.8-9.0, whereas it is 10-10.5 for the deamination reaction. The enzyme is inactivated by divalent metal ions and p-chloromercuribenzoate, mercuric ion being most effective. The inactivation may be reversed by L-or D-...genase. Enzyme Commission Number: EC 1.4.1.1. CAS No. 9029-6-5. AlaDH. Activity: Type I, ~30 units/mg protein (Lowry); Type II, > 20 units/mg protein (Lowry). Storage: -20°C. Form: Type I, buffered aqueous glycerol solution, Solution in 50% glycerol containing 10 mM potassium phosphate buffer, pH 7.7; Type II, ammonium sulfate suspension, Suspension in 2.4 M (NH4)2SO4 solution, pH 7.0. Source: Bacillus subtilis. L-Alanine Dehydrogenase; Alanine dehydrogenase; EC 1.4.1.1; 9029-06-5; AlaDH; NAD+-linked alanine dehydrogenase; alpha-alanine dehydrogenase; NAD+-dependent alanine dehydrogenase; alanine oxidoreductase; NADH-dependent alanine dehydrogenase. Cat No: NATE-0043. | |
| Native Candida boidinii Formate Dehydrogenase | Formate dehydrogenase is involved in the stress response of plants and catalyzes the reduction of NAD+ to NADH. Fdh is an abundant enzyme from yeast candida boidinii (cbfdh) that plays an important role in the energy supply of methylotrophic microorganisms and in the stress response of plants. Applications: Formate dehydrogenase (fdh) is used for diagnostics in large scale industrial pr ocesses. its used in the production of an unnatural amino acid, tert-l-leucine, a component of some hiv protease and matrix metalloprotease inhibitors. Group: Enzymes. Synonyms: EC 1.2.1.2; 9028-85-7; formate-NAD oxidoreductase; FDH; FDH I; FDH II; N-FDH; formic hydrogen-lyase; formate hydrogenlyase; hydrogenlyase; NAD-linked formate. Enzyme Commission Number: EC 1.2.1.2. CAS No. 9028-85-7. FDH. Activity: Type I, 5.0-15.0 units/mg protein; Type II, 0.3-0.6 units/mg; Type III, ~50 U/mL. Storage: -20°C. Form: Type I, lyophilized powder; Type II, powder; Type III, clear brown liquid. Source: Candida boidinii. EC 1.2.1.2; 9028-85-7; formate-NAD oxidoreductase; FDH; FDH I; FDH II; N-FDH; formic hydrogen-lyase; formate hydrogenlyase; hydrogenlyase; NAD-linked formate dehydrogenase; NAD-dependent formate dehydrogenase; formate dehydrogenase (NAD); NAD-formate dehydrogenase; formate benzyl-viologen oxidoreductase; formic acid dehydrogenase. Cat No: NATE-0254. | |
| Native Microorganism Glycerol Kinase | The activity of glycerol kinase is found widely in nature. In microorganisms GK makes possible the utilization of glycerol as a carbon source. In mammals the enzyme represents a juncture of sugar and fat metabolism; The enzyme is important to the clinical chemist in the determination of glycerol. GK is also useful in the assay of glyceraldehydes and dihydroxyacetone following their quantitative reduction to glycerol with sodium borohydride. Applications: This enzyme is useful for enzymatic determination of glycerol and triglyceride when coupled with glycerol-3-phosphate dehydrogenase, glycerol-3-phosphate oxidase or pyruvate kinase and lactate dehydrogenase, lipoprotein lipase in clinical analysis. Group: Enzymes. Synonyms: glycerokinase; GK; ATP: glycerol-3-phosphotransferase; glycerol kinase phosphorylating; glyceric kinase; EC 2.7.1.30. Enzyme Commission Number: EC 2.7.1.30. CAS No. 9030-66-4. GK. Mole weight: approx. 220 kDa (by gel filtration). Activity: Grade? 30 U/mg-solid or more. Stability: Stable at-20°C. Appearance: White amorphous powder, lyophilized. Form: Freeze dried powder. Source: Microorganism. glycerokinase; GK; ATP: glycerol-3-phosphotransferase; glycerol kinase phosphorylating; glyceric kinase; EC 2.7.1.30. Cat No: DIA-149. | |
| Native Microorganism Hexokinase | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Applications: The enzyme is useful for enzymatic determination of glucose, adenosine-5'-triphosphate (atp) and creatine phosphokinase when coupled with glucose-6-phosphate dehydrogenase. Group: Enzymes. Synonyms: Hexokinase; EC 2.7.1.1; hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependen. Enzyme Commission Number: EC 2.7.1.1. Mole weight: approx. 82 kDa (by gel filtration). Activity: 150U/mg-solid or more. Appearance: White amorphous powder, lyophilized. Form: Freeze dried powder. Source: Microorganism. Hexokinase; EC 2.7.1.1; hexokinase type IV glucokinase; hexokinase D; hexokinase type IV; hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; ATP: D-hexose 6-phosphotransferase. Cat No: DIA-202. | |
| Native Rhodothermus obamensis Hexokinase | A hexokinase is an enzyme that phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate of hexokinases, and glucose-6-phosphate the most important product. Hexokinase can transfer an inorganic phosphate group from ATP to a substrate. Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are capable of phosphorylating several hexoses, glucokinase acts with a 50-fold lower substrate affinity and its only hexose substrate is glucose. Applications: This enzyme is useful for enzymatic determination of glucose or creatinine kinase activity when coupled with glucose-6-phosphate dehydrogenase. Group: Enzymes. Synonyms: hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; hexokinase; ATP:D-hexose 6-. Enzyme Commission Number: EC 2.7.1.1. CAS No. 9001-51-8. Hexokinase. Mole weight: 140 kDa (gel filtration). Activity: 100 - 400 U/mg. Appearance: White to light grayish lyophilized powder. Storage: Storage at -20°C in the presence of a desiccant is recommended. Form: Freeze dried powder. Source: Rhodothermus obamensis. hexokinase (phosphorylating); ATP-dependent hexokinase; glucose ATP phosphotransferase; hexokinase; ATP:D-hexose 6-phosphotransferase; EC 2.7.1.1. Cat No: NATE-1156. | |
| polyvinyl alcohol dehydrogenase (cytochrome) | A quinoprotein. The enzyme is involved in bacterial polyvinyl alcohol degradation. Some Gram-negative bacteria degrade polyvinyl alcohol by importing it into the periplasmic space, where it is oxidized by polyvinyl alcohol dehydrogenase, an enzyme that is coupled to the respiratory chain via cytochrome c. The enzyme contains a pyrroloquinoline quinone cofactor. Group: Enzymes. Synonyms: PVA dehydrogenase; PVADH. Enzyme Commission Number: EC 1.1.2.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0388; polyvinyl alcohol dehydrogenase (cytochrome); EC 1.1.2.6; PVA dehydrogenase; PVADH. Cat No: EXWM-0388. | |
| PS10 | PS10 is a novel, potent and ATP-competitive pan- PDK inhibitor, inhibits all PDK isoforms with IC 50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 ( K d = 239 nM) than for Hsp90 (K d = 47 μM) [1]. PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy [2].PDK: pyruvate dehydrogenase kinase. Uses: Scientific research. Group: Signaling pathways. CAS No. 1564265-82-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-121744. | |
| Ribavirin | Ribavirin is a nucleoside analog that inhibits the replication of both DNA and RNA viruses, including influenza type A and type B. Ribavirin, as ribavirin 5-phosphate, affects virus-infected cells primarily by inhibiting the enzyme inosine 5-monophosphate (IMP) dehydrogenase. It potently suppresses eIF4E-mediated oncogenic transformation of murine cells in vitro, of tumor growth of a mouse model of eIF4E-dependent human squamous cell carcinoma in vivo, and of colony formation of eIF4E-dependent acute myelogenous leukemia cells derived from human patients. Group: Biochemicals. Alternative Names: 1-ß-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide, ICN-1229, Rebetol, Viramid, Virazid, Virazole. Grades: Highly Purified. CAS No. 36791-04-5. Pack Sizes: 10g, 25g, 50g, 100g, 250g. Molecular Formula: C8H12N4O5, Molecular Weight: 244.2. US Biological Life Sciences. | Worldwide |
| Ribavirin 5'-monophosphate lithium salt | Ribavirin 5'-monophosphate is a metabolite of ribavirin, displaying broad-spectrum antiviral activity. It inhibits viral DNA and RNA replication in vitro via suppression of inosine monophosphate dehydrogenase (IMPDH), resulting in inhibition of guanosine triphosphate synthesis. Synonyms: Dilithium [5-(3-carbamoyl-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate. Grades: ≥95%. CAS No. 66983-94-6. Molecular formula: C8H11N4O8P·2Li. Mole weight: 336.1. | |
| Ribavirin Monophosphate | Ribavirin-5'-monophosphate is a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase. In addition, Ribavirin 5'-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH) (Ki= 270 nM). Uses: Antiviral agents. Synonyms: Sodium salt. Grades: ≥ 95 % by HPLC. CAS No. 40925-28-8. Molecular formula: C8H13N4O8P (free acid). Mole weight: 324.18 (free acid). | |
| Saccharopine | Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: L-Saccharopine. CAS No. 997-68-2. Pack Sizes: 1 mg. Product ID: HY-W040307. | |
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