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Product | Description | |
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INCB 3284 Quick inquiry Where to buy Suppliers range | INCB 3284 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 of 3.7 nM. Synonyms: N-(2-(((R)-1-((1r,4R)-4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl)pyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide dimethanesulfonate; INCB3284; INCB 3284; INCB-3284; INCB3284 mesylate; INCB3284 dimesylate. CAS No. 887401-92-5. Molecular formula: C26H31F3N4O4. Mole weight: 520.54. | |
INCB 3284 dimesylate Quick inquiry Where to buy Suppliers range | INCB 3284 dimesylate. Group: Biochemicals. Grades: Purified. CAS No. 887401-93-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
INCB 3284 dimesylate Quick inquiry Where to buy Suppliers range | INCB 3284 dimesylate is a potent, selective and orally bioavailable CCR2 antagonist with IC50 of 3.7 nM. Synonyms: INCB 3284 dimesylate; INCB3284 dimesylate; INCB-3284 dimesylate; N-[2-[[(3R)-1-[trans-4-hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide, dimethanesulfonate. CAS No. 887401-93-6. Molecular formula: C26H31F3N4O4.2CH4O3S. Mole weight: 712.76. | |
INCB-9471 Dihydrochloride Quick inquiry Where to buy Suppliers range | INCB-9471 HCl is an allosteric non-competitive small molecule antagonist of C-C chemokine receptor 5, which has strong inhibitory activity on monocyte migration and HIV-1 infection. Synonyms: Methanone,(4,6-Dimethyl-5-Pyrimidinyl)[4-[(3S)-4-[(1R,2R)-2-Ethoxy-2,3-Dihydro-5-(Trifluoromethyl)-1H-Inden-1-Yl]-3-Methyl-1-Piperazinyl]-4-Methyl-1-Piperidinyl]-,Hydrochloride (1:2). Grades: 98%. CAS No. 869725-27-9. Molecular formula: C30H42Cl2F3N5O2. Mole weight: 632.6. | |
Aderbasib Quick inquiry Where to buy Suppliers range | Aderbasib is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Aderbasib represses the metalloproteinase "sheddase" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. Synonyms: INCB7839; INCB 7839; INCB-7839; INCB007839; INCB 007839; INCB-007839. CAS No. 791828-58-5. Molecular formula: C21H28N4O5. Mole weight: 416.48. | |
Aderbasib Quick inquiry Where to buy Suppliers range | Aderbasib is a azaspiro[2. 5]octanehydroxamide derivative as inhibitor of metalloproteases for the treatment of disorders such as cancer, arthritis, cardiovascular or skin disorders. Aderbasib, also known as INCB007839, is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Aderbasib represses the metalloproteinase "sheddase" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. The metalloproteinase domains of ADAMs cleave cell surface proteins at extracellular sites proximal to the cell membrane, releasing or "shedding" soluble protein etcodomains from the cell surface; the disintegrin domains of these multifunctional proteins interact with various components of the extracellular matrix (ECM). Group: Biochemicals. Alternative Names: (6S, 7S) -7-[ (Hydroxyamino) carbonyl]-6-[ (4-phenyl-1-piperazinyl) carbonyl]-5-azaspiro[2. 5]octane-5-carboxylic Acid Methyl Ester; INCB 007839. Grades: Highly Purified. CAS No. 791828-58-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?O?, Molecular Weight: 416.47. US Biological Life Sciences. | Worldwide |
Baricitinib Quick inquiry Where to buy Suppliers range | Baricitinib. Group: Biochemicals. Alternative Names: INCB 028050; LY 3009104; 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile. Grades: Highly Purified. CAS No. 1187594-09-7. Pack Sizes: 5mg. Molecular Formula: C16H17N7O2S, Molecular Weight: 371.42. US Biological Life Sciences. | Worldwide |
Baricitinib phosphate Quick inquiry Where to buy Suppliers range | Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM). Baricitinib has been approved by FDA for the treatment of rheumatoid arthritis (RA). Synonyms: INCB 028050; LY 3009104; INCB028050; LY3009104; LY-3009104; INCB-028050. Grades: >98%. CAS No. 1187595-84-1. Molecular formula: C16H20N7O6PS. Mole weight: 469.41. | |
Capmatinib Quick inquiry Where to buy Suppliers range | Capmatinib, also known as INCB28060 and INC280, is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. It selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis. It has been granted Breakthrough Therapy Designation by FDA as a first-line treatment for patients with metastatic MET exon14 skipping-mutated non-small cell lung cancer (NSCLC). Synonyms: INCB28060; INC-280; INC280. CAS No. 1029712-80-8. Molecular formula: C23H17FN6O. Mole weight: 412.43. | |
Dimesylate Quick inquiry Where to buy Suppliers range | Dimesylate. Group: Biochemicals. Alternative Names: N-[2-[[(3R)-1-[Trans-4-hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide Methanesulfonate; INCB 3284. Grades: Highly Purified. CAS No. 887401-93-6. Pack Sizes: 5mg. Molecular Formula: C28H37F3N4O10S2, Molecular Weight: 710.74. US Biological Life Sciences. | Worldwide |
Epacadostat Quick inquiry Where to buy Suppliers range | Epacadostat, also known as INCB024360 or INCB24360, is a potent and selective IDO1 inhibitor with IC50 of 71.8 nM±17.5 nM, with potential immunomodulating and antineoplastic activities. It has been shown to promote T and natural killer-cell growth, to increase IFN-γ production, and to reduce conversion to regulatory T (Treg)-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells. Synonyms: IDO inhibitor 1; 1,2,5-Oxadiazole-3-carboximidamide, 4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-, [C(Z)]-; [C(Z)]-4-[[2-[(Aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide; ICBN 24360; ICBN-24360; ICBN24360; INCB 024360; INCB024360; INCB-024360. Grades: ≥95%. CAS No. 1204669-58-8. Molecular formula: C11H13BrFN7O4S. Mole weight: 438.23. | |
INCB024360 Quick inquiry Where to buy Suppliers range | INCB024360. Group: Biochemicals. Alternative Names: (E)-4-amino-N-(3-Chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide. Grades: Highly Purified. CAS No. 914471-09-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
INCB024360-analog Quick inquiry Where to buy Suppliers range | Potent competitive inhibitor of IDO1 with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model; This INCB024360-analog decreased kynurenine levels by >50% in plasma and inhibited B16-GM-CSF tumor growth in a dose dependent fashion. Synonyms: INCB-24360; INCB024360; INCB 024360; INCB-024360; indoleamine-2,3-dioxygenase inhibitor INCB024360. Grades: > 98%. CAS No. 914471-09-3. Molecular formula: C9H7ClFN5O2. Mole weight: 271.64. | |
INCB054329 Quick inquiry Where to buy Suppliers range | INCB054329 is a novel bromodomain and extraterminal domain (BET) inhibitor. It induces vulnerabilities in myeloma cells by inhibition of BET protein. Uses: Antineoplastic agents. Synonyms: INCB-054329; INCB-54329; 7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one. CAS No. 1628607-64-6. Molecular formula: C19H16N4O3. Mole weight: 348.36. | |
INCB057643 Quick inquiry Where to buy Suppliers range | INCB057643 is a bromodomain and extraterminal domain (BET) inhibitor. It binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones. Synonyms: INCB-057643; 2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one. CAS No. 1820889-23-3. Molecular formula: C20H21N3O5S. Mole weight: 415.46. | |
INCB16562 Quick inquiry Where to buy Suppliers range | INCB16562 is a novel, selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3. Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced phosphorylation of STAT3. INCB16562 abrogated the protective effects of recombinant cytokines or bone marrow stromal cells and sensitized myeloma cells to cell death by exposure to dexamethasone, melphalan, or bortezomib. Oral administration of INCB16562 antagonized the growth of myeloma xenografts in mice and enhanced the antitumor activity of relevant agents in combination studies. INCB16562 is a potent JAK1/2 inhibitor and that mitigation of JAK/STAT signaling by targeting JAK1 and JAK2 will be beneficial in the treatment of myeloma patients, particularly in combination with other agents. Synonyms: INCB-16562; INCB 16562; 2-(2,6-dichlorophenyl)-1,8-dihydroimidazo[4,5-d]dipyrido[2,3-b:4',3'-f]azepine. CAS No. 933768-63-9. Molecular formula: C19H11Cl2N5. Mole weight: 380.23. | |
INCB3344 Quick inquiry Where to buy Suppliers range | INCB3344 is a potent CCR2 antagonist with IC50 of 5.1 nM and 9.5 nM for hCCR2 and mCCR2, respectively. Synonyms: INCB3344; INCB 3344; INCB-3344; N-(2-(((3S,4S)-1-(4-(Benzo[d][1,3]dioxol-5-yl)-4-hydroxycyclohexyl)-4-ethoxypyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide. CAS No. 1262238-11-8. Molecular formula: C29H34F3N3O6. Mole weight: 577.59. | |
Itacitinib Quick inquiry Where to buy Suppliers range | Itacitinib is a potent and selective JAK1 inhibitor developed for the treatment of Graft-versus-host disease and non-small cell lung cancer. Synonyms: INCB 039110; 2-[1-[1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile. Grades: >98%. CAS No. 1334298-90-6. Molecular formula: C26H23F4N9O. Mole weight: 553.51. | |
Pemigatinib Quick inquiry Where to buy Suppliers range | Pemigatinib is an inhibitor of fibroblast growth factor receptor types 1, 2, and 3 (FGFR1/2/3). Under the brand name Pemazyre, it is used as a medication for the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma. Synonyms: INCB054828. CAS No. 1513857-77-6. Molecular formula: C24H27F2N5O4. Mole weight: 487.5. | |
PF-4136309 Quick inquiry Where to buy Suppliers range | PF-4136309 is a potent, selective, and orally bioavailable antagonist of CCR2, a chemokine receptor of the super family of seven-transmembrane G-protein-coupled receptors (GPCRs). Synonyms: (S)-N-(2-(3-((4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide; PF4136309; PF 4136309; PF04136309; PF-04136309; INCB8761; INCB 8761; INCB-8761. CAS No. 1341224-83-6. Molecular formula: C29H31F3N6O3. Mole weight: 568.59. | |
Ruxolitinib Quick inquiry Where to buy Suppliers range | Ruxolitinib. Group: Heterocyclic Organic Compound. Alternative Names: Ruxolitinib;(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile;(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile;1H-Pyrazole-1-propanenitrile.beta.-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-,(.beta.R)-;(3R)-3-(4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile;(3R)-3-cyclopentyl-3-(4-{7H-pyrrolo[2,3-d]pyriMidin-4-yl}-1H-pyrazol-1-yl)propanenitrile;INCB018424 (Ruxolitinib);Jakafi. CAS No. 941678-49-5. Product ID: ACM941678495. Molecular formula: C17H18N6. Mole weight: 306.371. Density: 1.40. | |
Ruxolitinib Quick inquiry Where to buy Suppliers range | Ruxolitinib is a potent and selective JAK1/2 inhibitor with IC50 values of 3.3 nM and 2.8 nM respectively in cell-free assays, and has > 130-fold selectivity for JAK1/2 versus JAK3. Synonyms: (R)-Ruxolitinib; INCB018424; R-INCB018424; (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile. Grades: >98%. CAS No. 941678-49-5. Molecular formula: C17H18N6. Mole weight: 306.37. | |
Ruxolitinib, Free Base Quick inquiry Where to buy Suppliers range | Ruxolitinib is a potent and selective Janus kinase (JAK) inhibitor with with IC50's of 2.7 and 4.5nm for JAK1 and JAK2, respectively. Displays clinically significant activity in myelofibrosis. Group: Biochemicals. Alternative Names: (b-R)-b-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile; INCB018424, INC18424, NCB018424, NCB18424. Grades: Purified. CAS No. 941678-49-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
Ruxolitinib phosphate Quick inquiry Where to buy Suppliers range | Ruxolitinib phosphate is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Synonyms: INCB018424 phosphate; INCB 018424 phosphate; INCB-018424 phosphate. Grades: >98%. CAS No. 1092939-17-7. Molecular formula: C17H21N6O4P. Mole weight: 404.36. | |
Ruxolitinib sulfate Quick inquiry Where to buy Suppliers range | Ruxolitinib sulfate (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Synonyms: Ruxolitinib sulfate; 1092939-16-6; INCB018424 sulfate; beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(betaR)-1H-pyrazole-1-propanenitrile, (2Z)-2-butenedioate); SCHEMBL22127335; BCP27733; FT-0770538; 1092939-15-5; A921922; INCB018424 sulfate; INCB 018424 sulfate; INCB-018424 sulfate; 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile; sulfuric acid. Grades: >98%. CAS No. 1092939-16-6. Molecular formula: C17H20N6O4S. Mole weight: 404.44. | |
(S)-Ruxolitinib Quick inquiry Where to buy Suppliers range | Ruxolitinib S enantiomer, the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor to enter the clinic. It was initially developed to target the constitutive activation of the JAK-STAT pathway. It maintains its anti-JAK activity by competitive inhibition of the ATP-binding catalytic site of the kinase domain. It is well absorbed at above 95%. Synonyms: (S)-INCB018424; S-Ruxolitinib; SRuxolitinib; S Ruxolitinib; INCB-18424. Grades: >98%. CAS No. 941685-37-6. Molecular formula: C17H18N6. Mole weight: 306.37. |