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| Product | Description | |
|---|---|---|
| Indirubin | Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Couroupitine B; Indigo red; Indigopurpurin. CAS No. 479-41-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-N0117. |  |
| Indirubin | Indirubin. Group: Biochemicals. Alternative Names: Couroupitine B. Grades: Plant Grade. CAS No. 479-41-4. Pack Sizes: 20mg. Molecular Formula: C16H10N2O2, Molecular Weight: 262.262999999999. US Biological Life Sciences. |  Worldwide |
| Indirubin | Indirubin is an inhibitor of GSK-3β and cyclin-dependent kinases (CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p35). Also, Indirubin is a specific Aryl Hydrocarbon receptor (AHR) ligand. Uses: Antibiotics, antineoplastic. Synonyms: Indirubin; C.I. 73200, Couroupitine B, Indigo red, Indigopurpurin, NSC 105327; NSC-105327; NSC105327; Indigopurpurin; Couroupitine B; [2,3'-Biindolinylidene]-2',3-dione; 3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one. Grade: >98%. CAS No. 479-41-4. Molecular formula: C16H10N2O2. Mole weight: 262.268. |  |
| Indirubin-3'-monoxime | Indirubin-3'-monoxime. Group: Biochemicals. Alternative Names: Indirubin-3'-oxime; 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one. Grades: Highly Purified. CAS No. 160807-49-8. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C16H11N3O2. US Biological Life Sciences. | Worldwide |
| Indirubin-3'-monoxime | Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase , with IC 50 s of 22 nM and 7.8-10 μM, respectively; Indirubin-3'-monoxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC 50 s of 100 and 180 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Indirubin-3'-oxime. CAS No. 160807-49-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19807. | |
| Indirubin-3?-monoxime-5-sulphonic Acid - CAS 331467-05-1 | A potent, reversible, and selective inhibitor of Cdk1 (IC?? = 5 nM) and Cdk5 (IC?? = 7 nM) and glycogen synthase kinase-3? (GSK-3?; IC?? = 80 nM). Group: Fluorescence/luminescence spectroscopy. |  |
| Indirubin-3?-monoxime - CAS 160807-49-8 | A potent, reversible, and ATP-compatible inhibitor of GSK-3? (glycogen synthase kinase 3?), Cdk1 (cyclin-dependent kinase1) and Cdk5 (IC?? = 22 nM, 180 nM, and 100 nM, respectively). Group: Fluorescence/luminescence spectroscopy. | |
| Indirubin-3-monoxime (Indirubin-3-oxime) | A potent inhibitor of GSK-3ß (IC50=22nM). Also inhibits CDK1 (IC50=180nM) and CDK (IC50=100nM). It reversibly arrests asynchronous HBL-100 cells at G2. It induces apoptosis in the mammary carcinoma cell line MCF-7 (10üM). Group: Biochemicals. Alternative Names: Indirubin-3-oxime. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Indirubin-3-oxime | Indirubin-3?-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3? (GSK3?). Indirubin-3?-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 ?M, 1.4 ?M, and 1.0 ?M, respectively. Indirubin-3?-oxime can enhance height growth via activation of Wnt/?-catenin signaling in chondrocytes[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IDR3O; I3O. CAS No. 667463-82-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139254. | |
| Indirubin-3?-oxime | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| Indirubin-3'-oxime | Indirubin-3'-oxime. Group: Biochemicals. Grades: Purified. CAS No. 160807-49-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| (2'Z)-Indirubin | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| 5-Iodo-indirubin-3'-monoxime | 5-Iodo-indirubin-3'-monoxime is a potent inhibitor of GSK-3β, CDK5/P25 and CDK1/cyclin B that competes with ATP to bind to the catalytic site of the kinase with IC50s of 9, 20 and 25 nM, respectively. Synonyms: 2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-5-iodo-; 3-[3-(Hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-5-iodo-1,3-dihydro-2H-indol-2-one. Grade: ≥95%. CAS No. 331467-03-9. Molecular formula: C16H10IN3O2. Mole weight: 403.17. | |
| GSK-3 Inhibitor IX ((2Z,3E)-6-Bromoindirubin-3-oxime) | A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3a/b (IC50=5nM). Its specificity has been tested against various Cdk's (IC50=83, 300, 320, and 10,000nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50≥10uM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 667463-62-9. Pack Sizes: 1mg, 10mg. US Biological Life Sciences. | Worldwide |
| 7-BIO | 7-BIO is a derivative of indirubin that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation. Furthermore, in contrast to other indirubin derivatives, 7-BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3. Synonyms: 7-Bromoindirubin-3'-oxime; 7-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol. Grade: ≥99%. CAS No. 916440-85-2. Molecular formula: C16H10BrN3O2. Mole weight: 356.2. | |
| Indican | Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Indoxyl-β-D-glucoside. CAS No. 487-60-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-122009. | |
| Indigopurpurin | Indigopurpurin. Group: Biochemicals. Alternative Names: 3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one; Indirubin; [Δ2,3'-Biindoline]-2',3-dione; C.I. 73200; Couroupitine B; Indigo red; NSC 105327. Grades: Highly Purified. CAS No. 479-41-4. Pack Sizes: 10mg. Molecular Formula: C16H10N2O2, Molecular Weight: 262.26. US Biological Life Sciences. | Worldwide |
| Isoindigo | Isoindigo has proven successful as an electron-accepting building block for the preparation of electroactive materials for organic electronics. Meisoindigo, as a functionalized Isoindigo, has been used as an indirubin substitute for the treatment of chronic myeloid leukemia (CML). Group: Biochemicals. Grades: Highly Purified. CAS No. 476-34-6. Pack Sizes: 1g, 10g. Molecular Formula: C16H10N2O2. US Biological Life Sciences. | Worldwide |
| (l)-N-Benzyloxycarbonyl-β-oxo-tryptophaneamide | (l)-N-Benzyloxycarbonyl-β-oxo-tryptophaneamide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CTK8G0303, AG-L-65828, Indirubin-3-(2,3-dihydroxypropyl)oximether, (L)-N-Benzyloxycarbonyl-|A-oxo-tryptophaneamide, 255371-72-3. Product Category: Heterocyclic Organic Compound. CAS No. 255371-72-3. Molecular formula: C19H17N3O4. Mole weight: 351.36. Purity: 0.96. IUPACName: benzyl N-[(2S)-1-amino-3-(1H-indol-3-yl)-1,3-dioxopropan-2-yl]carbamate. Canonical SMILES: C1=CC=C(C=C1)COC(=O)NC(C(=O)C2=CNC3=CC=CC=C32)C(=O)N. Product ID: ACM255371723. Alfa Chemistry ISO 9001:2015 Certified. |  |
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