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| Product | Description | |
|---|---|---|
| Indirubin | Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Couroupitine B; Indigo red; Indigopurpurin. CAS No. 479-41-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-N0117. |  |
| Indirubin | Indirubin. Group: Biochemicals. Alternative Names: Couroupitine B. Grades: Plant Grade. CAS No. 479-41-4. Pack Sizes: 20mg. Molecular Formula: C16H10N2O2, Molecular Weight: 262.262999999999. US Biological Life Sciences. |  Worldwide |
| Indirubin | Indirubin is an inhibitor of GSK-3β and cyclin-dependent kinases (CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, CDK5/p35). Also, Indirubin is a specific Aryl Hydrocarbon receptor (AHR) ligand. Uses: Antibiotics, antineoplastic. Synonyms: Indirubin; C.I. 73200, Couroupitine B, Indigo red, Indigopurpurin, NSC 105327; NSC-105327; NSC105327; Indigopurpurin; Couroupitine B; [2,3'-Biindolinylidene]-2',3-dione; 3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one. Grades: >98%. CAS No. 479-41-4. Molecular formula: C16H10N2O2. Mole weight: 262.268. |  |
| Indirubin-3'-monoxime | Indirubin-3'-monoxime, a chemical derivative of indirubin, is an inhibitor of GSK-3β with dual affinity for CDK1/5 receptor. It significantly inhibited the proliferation and induced apoptosis in all of the RCC cell lines. IC50: GSK-3β= 22nM; CDK1/5= 180/1. Synonyms: 3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one INDIRUBIN-3'-MONOXIME indirubin-3'-oxime 160807-49-8 indirubin-3-oxime Indirubin-3monoxime indirubin-3'-monooxime 3-[3-(Hydroxyamino)-1H-indol-2-yl]indol-2-one Indirubin-3'-monoxime CHEMBL126077 CHEBI:43. CAS No. 160807-49-8. Molecular formula: C16H11N3O2. Mole weight: 277.28. | |
| Indirubin-3'-monoxime | Indirubin-3'-monoxime. Group: Biochemicals. Alternative Names: Indirubin-3'-oxime; 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one. Grades: Highly Purified. CAS No. 160807-49-8. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C16H11N3O2. US Biological Life Sciences. | Worldwide |
| Indirubin-3'-monoxime | Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase , with IC 50 s of 22 nM and 7.8-10 μM, respectively; Indirubin-3'-monoxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC 50 s of 100 and 180 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Indirubin-3'-oxime. CAS No. 160807-49-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19807. | |
| Indirubin-3-monoxime (Indirubin-3-oxime) | A potent inhibitor of GSK-3ß (IC50=22nM). Also inhibits CDK1 (IC50=180nM) and CDK (IC50=100nM). It reversibly arrests asynchronous HBL-100 cells at G2. It induces apoptosis in the mammary carcinoma cell line MCF-7 (10üM). Group: Biochemicals. Alternative Names: Indirubin-3-oxime. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Indirubin-3'-oxime | Indirubin-3'-oxime. Group: Biochemicals. Grades: Purified. CAS No. 160807-49-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GSK-3 Inhibitor IX ((2Z,3E)-6-Bromoindirubin-3-oxime) | A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3a/b (IC50=5nM). Its specificity has been tested against various Cdk's (IC50=83, 300, 320, and 10,000nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50≥10uM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. Group: Biochemicals. Grades: Highly Purified. CAS No. 667463-62-9. Pack Sizes: 1mg, 10mg. US Biological Life Sciences. | Worldwide |
| 7-BIO | 7-BIO is a derivative of indirubin that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation. Furthermore, in contrast to other indirubin derivatives, 7-BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3. Synonyms: 7-Bromoindirubin-3'-oxime; 7-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol. Grades: ≥99%. CAS No. 916440-85-2. Molecular formula: C16H10BrN3O2. Mole weight: 356.2. | |
| Indican | Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4 [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Indoxyl-β-D-glucoside. CAS No. 487-60-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-122009. | |
| Indigopurpurin | Indigopurpurin. Group: Biochemicals. Alternative Names: 3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one; Indirubin; [Δ2,3'-Biindoline]-2',3-dione; C.I. 73200; Couroupitine B; Indigo red; NSC 105327. Grades: Highly Purified. CAS No. 479-41-4. Pack Sizes: 10mg. Molecular Formula: C16H10N2O2, Molecular Weight: 262.26. US Biological Life Sciences. | Worldwide |
| Isoindigo | Isoindigo has proven successful as an electron-accepting building block for the preparation of electroactive materials for organic electronics. Meisoindigo, as a functionalized Isoindigo, has been used as an indirubin substitute for the treatment of chronic myeloid leukemia (CML). Group: Biochemicals. Grades: Highly Purified. CAS No. 476-34-6. Pack Sizes: 1g, 10g. Molecular Formula: C16H10N2O2. US Biological Life Sciences. | Worldwide |
| (l)-N-Benzyloxycarbonyl-β-oxo-tryptophaneamide | (l)-N-Benzyloxycarbonyl-β-oxo-tryptophaneamide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CTK8G0303, AG-L-65828, Indirubin-3-(2,3-dihydroxypropyl)oximether, (L)-N-Benzyloxycarbonyl-|A-oxo-tryptophaneamide, 255371-72-3. Product Category: Heterocyclic Organic Compound. CAS No. 255371-72-3. Molecular formula: C19H17N3O4. Mole weight: 351.36. Purity: 0.96. IUPACName: benzyl N-[(2S)-1-amino-3-(1H-indol-3-yl)-1,3-dioxopropan-2-yl]carbamate. Canonical SMILES: C1=CC=C(C=C1)COC(=O)NC(C(=O)C2=CNC3=CC=CC=C32)C(=O)N. Product ID: ACM255371723. Alfa Chemistry ISO 9001:2015 Certified. |  |
| MeBIO | MeBIO, an analog of 6-bromoindirubin-3'-oxime, has been suggested to possess the structural basis for a potent and selective inhibitor of glycogen synthase kinase-3 (GSK3) and cyclin-dependent kinases. MeBIO displays minimal activity against CDK1/Cyclin B, GSK-3 α/β, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). Synonyms: MeBIO; Me-BIO; Me BIO; (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime; MeBIO; 1-Methyl-6-bromo-indirubin-3'-oxime; Me6BIO. Grades: ≥99% by HPLC. CAS No. 667463-95-8. Molecular formula: C17H12BrN3O2. Mole weight: 370.2. | |
| Methylisoindigotin | Meisoindigo is a derivative of indirubin with antitumor activity, which has been used in China for chronic myeloid leukemia. Meisoindigo is an apoptosis inducer and potential agent for the treatment of AML. It inhibits the growth of leukemic cells by inducing marked apoptosis and moderate cell-cycle arrest at the G(0)/G(1) phase. Synonyms: Methylisoindigotin; N-Methylisoindigotin; (3E)-1-methyl-3-(2-oxo-1H-indol-3-ylidene)indol-2-one. Grades: >98%. CAS No. 97207-47-1. Molecular formula: C17H12N2O2. Mole weight: 276.29. | |
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