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| Product | Description | |
|---|---|---|
| indole 2,3-dioxygenase | Enzymes from the plants Tecoma stans, Jasminum grandiflorum and Zea mays are flavoproteins containing copper. They are part of enzyme systems that form either anthranil (2,1-benzoisoxazole) (Tecoma stans), anthranilate (Jasminum grandiflorum) or both (Zea mays) as the final product. A second enzyme from Tecoma stans is not a flavoprotein, does not require copper, and is part of a system that forms anthranilate as the final product. Group: Enzymes. Synonyms: indole oxidase; indoleamine 2,3-dioxygenase (ambiguous); indole:O2 oxidoreductase; indole-oxygen 2,3-oxidoreductase (decyclizing); IDO (ambiguous); indole:oxygen 2,3-oxidoreductase (decyclizing). Enzyme Commission Number: EC 1.13.11.17. CAS No. 37256-57-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0536; indole 2,3-dioxygenase; EC 1.13.11.17; 37256-57-8; indole oxidase; indoleamine 2,3-dioxygenase (ambiguous); indole:O2 oxidoreductase; indole-oxygen 2,3-oxidoreductase (decyclizing); IDO (ambiguous); indole:oxygen 2,3-oxidoreductase (decyclizing). Cat No: EXWM-0536. |  |
| indoleamine 2,3-dioxygenase | A protohemoprotein. Requires ascorbic acid and methylene blue for activity. This enzyme has broader substrate specificity than EC 1.13.11.11, tryptophan 2,3-dioxygenase. It is induced in response to pathological conditions and host-defense mechanisms and its distribution in mammals is not confined to the liver. While the enzyme is more active with D-tryptophan than L-tryptophan, its only known function to date is in the metabolism of L-tryptophan. Superoxide radicals can replace O2 as oxygen donor. Group: Enzymes. Synonyms: IDO (ambiguous); tryptophan pyrrolase (ambiguous); D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing). Enzyme Commission Number: EC 1.13.11.52. CAS No. 9014-51-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0571; indoleamine 2,3-dioxygenase; EC 1.13.11.52; 9014-51-1; IDO (ambiguous); tryptophan pyrrolase (ambiguous); D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing). Cat No: EXWM-0571. | |
| 1-Methyl-D-tryptophan | 1-Methyl-D-tryptophan is used in biological studies to determine the effect of IDO2 enzyme (indoleamine-(2,3)-dioxygenase) activity and IDO2-mediated arrest of human T cell proliferation. It reverses IDO-mediated immune suppression. Group: Biochemicals. Grades: Highly Purified. CAS No. 110117-83-4. Pack Sizes: 250mg, 500mg. Molecular Formula: C12H14N2O2. US Biological Life Sciences. |  Worldwide |
| 1-Methyl-L-tryptophan | 1-Methyl-L-tryptophan is a competitive inhibitor of indoleamine 2,3-dioxygenase (IDO). Synonyms: L-Abrine; 1-Methyl-L-tryptophan; H-Trp(1-Me)-OH; (S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; 1-Methyltryptophan; L-Tryptophan, 1-methyl-; UNII-XD0FY1J13B; XD0FY1J13B; (2S)-2-amino-3-(1-methylindol-3-yl)propanoic acid. Grades: ≥ 98% (Chiral HPLC). CAS No. 21339-55-9. Molecular formula: C12H14N2O2. Mole weight: 218.26. |  |
| 1-(Phenylsulfonyl)-3-indolylboronic Acid Pinacol Ester | 1-(Phenylsulfonyl)-3-indolylboronic Acid Pinacol Ester is used as a reactant in the preparation of 3- (2- (pyridyl) ethenyl) indoles that are tryptophan dioxygenase (TDO) inhibitors and potential anticancer immunomodulators. Group: Biochemicals. Grades: Highly Purified. CAS No. 870717-93-4. Pack Sizes: 500mg, 1g. Molecular Formula: C20H22BNO4S, Molecular Weight: 383.27. US Biological Life Sciences. | Worldwide |
| 2-(4-Nitrobenzyl)-2-thiopseudourea Hydrochloride | 2-(4-Nitrobenzyl)-2-thiopseudourea Hydrochloride is used in preparation of indoleamine dioxygenase and study SAR of benzylisothiourea derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 4357-96-4. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H9N3O2S; HCl, Molecular Weight: 211.243646. US Biological Life Sciences. | Worldwide |
| 3-(1H-1,2,3-Triazol-4-yl)pyridine | 3-(1H-1,2,3-Triazol-4-yl)pyridine is a reactant used in the synthesis of 4-aryl-1H-1,2,3-triazoles which possesses more Indoleamine 2,3-dioxygenase (IDO) inhibitory potency than the most commonly used 1-methyltryptophan. Group: Biochemicals. Grades: Highly Purified. CAS No. 120241-79-4. Pack Sizes: 100mg, 250mg. Molecular Formula: C7H6N4, Molecular Weight: 146.15. US Biological Life Sciences. | Worldwide |
| 7-Methylindole-3-carboxaldehyde | A reactant used for the preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators, antibacterial agents, antiandrogens, anti-bovine viral diarrhea virus (BVDV) agents and so on. Synonyms: 7-Methyl-1H-indole-3-carbaldehyde. CAS No. 4771-50-0. Molecular formula: C10H9NO. Mole weight: 159.19. | |
| abscisic-aldehyde oxidase | Acts on both (+)- and (-)-abscisic aldehyde. Involved in the abscisic-acid biosynthesis pathway in plants, along with EC 1.1.1.288, (xanthoxin dehydrogenase), EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase) and EC 1.14.13.93 [(+)-abscisic acid 8'-hydroxylase]. While abscisic aldehyde is the best substrate, the enzyme also acts with indole-3-aldehyde, 1-naphthaldehyde and benzaldehyde as substrates, but more slowly. Group: Enzymes. Synonyms: abscisic aldehyde oxidase; AAO3; AOd; AO&Delta. Enzyme Commission Number: EC 1.2.3.14. CAS No. 129204-36-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1208; abscisic-aldehyde oxidase; EC 1.2.3.14; 129204-36-0; abscisic aldehyde oxidase; AAO3; AOd; AO&Delta. Cat No: EXWM-1208. | |
| BMS-978587 | BMS-978587 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 ( IDO-1 ) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IDO-IN-4. CAS No. 1629125-65-0. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18769. |  |
| BMS-986205 | BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. It is undergoing a phase I/II clinical trial for the bladder and cervical cancer therapy in combination with nivolumab, an anti-programmed cell death protein 1 (PD-1) monoclonal antibody. Uses: Drug combination with nivolumab. Synonyms: BMS-986205; BMS 986205; BMS986205; (2R)-N-(4-chlorophenyl)-2-[4-(6-fluoroquinolin-4-yl)cyclohexyl]propanamide. CAS No. 1923833-60-6. Molecular formula: C24H24ClFN2O. Mole weight: 410.917. | |
| Brassinin | Brassinin is an inhibitor of indoleamine 2,3-dioxygenase (IDO; Ki = 28 μM for human IDO) with antifungal and anticancer activities. Brassinin also inhibits IL-6-inducible STAT3 activation and attenuates tumor growth in a xenograft lung cancer mouse model. Brassinin is found in brassicas. Synonyms: Brassinine; CCG-208623; CCG208623; CCG 208623; HE-005916; HE005916; HE 005916; HE-292778; HE292778; HE292778; Methyl (1H-indol-3-ylmethyl)carbamodithioate. Grades: 98%. CAS No. 105748-59-2. Molecular formula: C11H12N2S2. Mole weight: 236.36. | |
| Epacadostat | Epacadostat/ INCB24360 is an inhibitor of indoleamine 2,3-dioxygenase-1) (IDO1). An investigational drug for cancer in phase 3. Group: Fluorinated apis. Alternative Names: INCB24360. CAS No. 1204669-58-8. Molecular formula: C11H13BrFN7O4S. Mole weight: 438.23. Purity: 0.98. IUPACName: N'-(3-bromo-4-fluorophenyl)-N-hydroxy-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole-3-carboximidamide. Catalog: OFC1204669588. |  |
| IDO-IN-12 | IDO-IN-12 is an indoleamine 2,3-dioxygenase ( IDO ) inhibitor extracted from patent WO 2017181849 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1888341-29-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115122. | |
| IDO-IN-2 | IDO-IN-2 is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) with IC50 of 3 nM. Synonyms: IDO inhibitor 1; 1-[2-[bis(2-methylpropyl)amino]-5-[2-(2H-tetrazol-5-yl)phenyl]phenyl]-3-(4-methylphenyl)urea. CAS No. 1668565-74-9. Molecular formula: C29H35N7O. Mole weight: 497.63. | |
| INCB024360-analog | Potent competitive inhibitor of IDO1 with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model; This INCB024360-analog decreased kynurenine levels by >50% in plasma and inhibited B16-GM-CSF tumor growth in a dose dependent fashion. Synonyms: INCB-24360; INCB024360; INCB 024360; INCB-024360; indoleamine-2,3-dioxygenase inhibitor INCB024360. Grades: > 98%. CAS No. 914471-09-3. Molecular formula: C9H7ClFN5O2. Mole weight: 271.64. | |
| Indoximod | A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy. Synonyms: NLG8189; NLG 8189; NLG-8189; D-1MT; 1-methyl-D-tryptophan; H-D-Trp(Me)-OH. Grades: > 98%. CAS No. 110117-83-4. Molecular formula: C12H14N2O2. Mole weight: 218.25. | |
| Indoximod | Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase ( IDO ) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Methyl-D-tryptophan; NLG-8189. CAS No. 110117-83-4. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-16724. | |
| Linrodostat | Linrodostat (BMS-986205) is a selective and irreversible indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC 50 value of 1.1 nM in IDO1 -HEK293 cells. Linrodostat is well tolerated with potent pharmacodynamic activity in advanced cancers [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-986205; ONO-7701. CAS No. 1923833-60-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101560. | |
| Navoximod free base | Navoximod, also known as IDO-IN-7 and NLG-1488, is an indoleamine 2,3-dioxygenase (IDO) inhibitor. It is also used as an immunomodulator and an antineoplastic. Group: Inhibitors. Alternative Names: Navoximod; IDO-IN-7; IDOIN7; IDO IN 7; Navoximod Phosphate; NLG-1488; NLG 1488; NLG1488. CAS No. 1402837-78-8. Molecular formula: C18H21FN2O2. Mole weight: 316.38. Appearance: Solid powder. Purity: >98%. IUPACName: (1R,4r)-4-((R)-2-((S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol. Canonical SMILES: O[C@@H] ([C@H]1CC[C@H] (O)CC1)C[C@@H] (C2=C3C=CC=C2F)N4C3=CN=C4. Catalog: ACM1402837788. | |
| Necrostatin-1 | Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Group: Biochemicals. Alternative Names: Nec-1, MTH-Trp, MTH-DL-Tryptophan, Methyl-thiohydantoin DL-tryptophan, 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone. Grades: Highly Purified. CAS No. 4311-88-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?OS. US Biological Life Sciences. | Worldwide |
| NLG-919 | NLG919 is an orally available inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), a cytosolic enzyme responsible for the oxidation of the essential amino acid tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs). Synonyms: GDC0919; GDC-0919; GDC 0919; NLG919; NLG 919; NLG-919; RG6078; RG-6078; RG 6078. Grades: > 98%. CAS No. 1402836-58-1. Molecular formula: C18H22N2O. Mole weight: 282.38. | |
| Palmatine | Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities. Group: Inhibitors. Alternative Names: 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium. CAS No. 3486-67-7. Molecular formula: C21H22NO4. Mole weight: 352.4. Appearance: Powder. Purity: 0.98. IUPACName: 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium. Canonical SMILES: COC1=C (C2=C[N+]3=C (C=C2C=C1)C4=CC (=C (C=C4CC3)OC)OC)OC. Catalog: ACM3486677. | |
| Palmatine chloride | Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC 50 s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC 50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 10605-02-4. Pack Sizes: 10 mM * 1 mL; 250 mg; 1 g. Product ID: HY-N0110. | |
| Palmatine chloride | Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities. Group: Inhibitors. Alternative Names: 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride. CAS No. 10605-02-4. Molecular formula: C21H22ClNO4. Mole weight: 387.86. Appearance: Powder. Purity: 0.98. IUPACName: 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride. Canonical SMILES: COC1=C (C2=C[N+]3=C (C=C2C=C1)C4=CC (=C (C=C4CC3)OC)OC)OC. [Cl-]. Catalog: ACM10605024. | |
| Palmatine hydroxide | Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC 50 s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC 50 of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 131-04-4. Pack Sizes: 10 mM * 1 mL; 250 mg; 1 g. Product ID: HY-N0110B. | |
| (S)-LY-3381916 | (S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC 50 value less than 1.5 μΜ [1]. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S)-IDO1-IN-5. CAS No. 2166616-76-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111540B. | |
| tryptophan 2,3-dioxygenase | A protohemoprotein. In mammals, the enzyme appears to be located only in the liver. This enzyme, together with EC 1.13.11.52, indoleamine 2,3-dioxygenase, catalyses the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism. The enzyme is specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan. Group: Enzymes. Synonyms: tryptophan pyrrolase (ambiguous); tryptophanase; tryptophan oxygenase; tryptamine 2,3-dioxygenase; tryptophan peroxidase; indoleamine 2,3-dioxygenase (ambiguous); indolamine 2,3-dioxygenase (ambiguous); L-tryptophan pyrrolase; TDO; L-tryptophan 2,3-dioxygenase; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing). Enzyme Commission Number: EC 1.13.11.11. CAS No. 9014-51-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0531; tryptophan 2,3-dioxygenase; EC 1.13.11.11; 9014-51-1; tryptophan pyrrolase (ambiguous); tryptophanase; tryptophan oxygenase; tryptamine 2,3-dioxygenase; tryptophan peroxidase; indoleamine 2,3-dioxygenase (ambiguous); indolamine 2,3-dioxygenase (ambiguous); L-tryptophan pyrrolase; TDO; L-tryptophan 2,3-dioxygenase; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing). Cat No: EXWM-0531. | |
| tryptophan 2'-dioxygenase | A hemoprotein. Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan. Group: Enzymes. Synonyms: indole-3-alkane α-hydroxylase; tryptophan side-chain α,β-oxidase; tryptophan side chain oxidase II; tryptophan side-chain oxidase; TSO; indolyl-3-alkan α-hydroxylase; tryptophan side chain oxidase type I; TSO I TSO II; tryptophan side chain oxidase. Enzyme Commission Number: EC 1.13.99.3. CAS No. 64295-81-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0624; tryptophan 2'-dioxygenase; EC 1.13.99.3; 64295-81-4; indole-3-alkane α-hydroxylase; tryptophan side-chain α,β-oxidase; tryptophan side chain oxidase II; tryptophan side-chain oxidase; TSO; indolyl-3-alkan α-hydroxylase; tryptophan side chain oxidase type I; TSO I TSO II; tryptophan side chain oxidase. Cat No: EXWM-0624. | |
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