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Antibiotic A23187 is a calcium ionophore. It causes rapid influx of calcium in various cells across biological membranes. Calcimycin was isolated from Streptomyces chartreusis in 1974. Calcimycin is a spiroketal substituted by pyrollic and benzoxazolyl groups which afford its high affinity and selectivity for calcium. Calimycin exhibits broad biological activity against bacteria, fungi and protozoa. It has found wide application as a research tool for calcium regulated cellular events. Group: Biochemicals. Alternative Names: Calcimycin, Calcium Ionophore A23187. Grades: Molecular Biology Grade. CAS No. 52665-69-7. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C29H37N3O6, Molecular Weight: 523.6. US Biological Life Sciences.
Magnesium ionophore IV is a lipophilic magnesium ionophore. Synonyms: ETH 7025; N,Nμ,Nμμ-Tris[3-(heptylmethylamino)-3-oxopropionyl]-8,8μ-iminodioctylamine; N,N',N''-Tris[3-(heptylmethylamino)-3-oxopropionyl]-8,8μ-iminodioctylamine. CAS No. 135734-39-3. Molecular formula: C49H94N6O6. Mole weight: 863.31.
Nitrate Ionophore V
Nitrate Ionophore V is an ionophore used for anion-selective electrodes. Group: Biochemicals. Grades: Highly Purified. CAS No. 221011-41-2. Pack Sizes: 50mg, 250mg. Molecular Formula: C26H20N4S2, Molecular Weight: 452.59. US Biological Life Sciences.
Epoxyeicosatrienoic Acid (EET) has antihypertensive and anti-inflammatory properties and play a role in the maintenance of renal vascular function. N,?N'-?dicyclohexylurea (DCU) increased release of 14,15-EET when the cells were stimulated with a calcium ionophore. Also, it is derived from Arachidonic Acid, which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides. Group: Biochemicals. Alternative Names: (5Z,8Z,11Z)-13-(3-Pentyl-2-oxiranyl)-5,8,11-tridecatrienoic Acid; 14(15)-EET; 14(15)-Epoxy-5Z,8Z,11Z-eicosatrienoic Acid; (±)14,15-EET; (±)14,15-EpETrE; (all-Z)-13-(3-Pentyloxiranyl)-5,8,11-tridecatrienoic Acid. Grades: Highly Purified. CAS No. 197508-62-6. Pack Sizes: 50ug, 100ug, 500ug. Molecular Formula: C??H??O?, Molecular Weight: 320.47. US Biological Life Sciences.
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1-Iodopropane-d7
1-Iodopropane-d7 is the labelled analogue of 1-Iodopropane [I718790] which is used in the synthesis of a new class of cesium selective ionophores. Also used to preparation of secondary amines and diamines. Group: Biochemicals. Grades: Highly Purified. CAS No. 59012-23-6. Pack Sizes: 10mg, 50mg. Molecular Formula: C3D7I, Molecular Weight: 177.04. US Biological Life Sciences.
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4-Bromo A23187
4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. 4-Bromo A23187, a calcium modulator, induces apoptosis in different cells, including HL-60 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 76455-48-6. Pack Sizes: 1 mg. Product ID: HY-N6694.
4-Bromo-A23187
4-Bromo-calcimycin, a halogenated analog of A-2318, is a non-fluorescent Ca2+ ionophore which could be commonly used in fluorescent probes experiments as a modutor of the quantitation of free Ca2+. Nonfluorescent calcium ionophore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes. Synonyms: A23187, 4-Bromo; 4-Bromocalcimycin; 4-Benzoxazolecarboxylic acid. Grades: ≥98%. CAS No. 76455-48-6. Molecular formula: C29H36BrN3O6. Mole weight: 602.50.
5-(Phenylmethoxy)-2-pentenoic Acid Ethyl Ester is used in the ionophore antibiotic, routiennocin. Group: Biochemicals. Grades: Highly Purified. CAS No. 128217-53-8. Pack Sizes: 25mg. US Biological Life Sciences.
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A23187 Ca-Mg
A23187 Ca-Mg, the calcium-magnesium salt of A23187, has been found to be a Ca2+ ionophore and shows pro-inflammatory and allergic activities. Uses: Used in cell activation experiments when calcium dose-response data are not required. Synonyms: Calcimycin calcium magnesium salt; Antibiotic A23187 calcium magnesium salt; Ionophore A23187 calcium magnesium salt. Grades: ≥99%. Molecular formula: (C29H36N3O6)2Mg.(C29H36N3O6)2Ca. Mole weight: 2154.87.
AACOCF3
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Arachidonyl trifluoromethyl ketone. CAS No. 149301-79-1. Pack Sizes: 5 mg (28.05 mM * 500 μL in Ethanol); 10 mg (28.05 mM * 1 mL in Ethanol). Product ID: HY-108611.
AM-643
AM-643 is an active molecular. In the Biological Tests, it can inhibit FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 5 hrs by ELISA and the activity value is 0.081μM. It can also Inhibit COX1-mediated TXB2 production in human whole blood after 30 mins by competitive enzyme immunoassay and the activity value is 25μM. Synonyms: AM-643 Free Acid; AM643 Free Acid; UNII-55668SZQ3E;3-(3-(tert-butylthio)-1-(4-(5-methoxypyrimidin-2-yl)benzyl)-5-((5-methylpyridin-2-yl)methoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid. Grades: 98%. CAS No. 1233114-22-1. Molecular formula: C36H40N4O4S. Mole weight: 642.79.
Avenaciolide
It is produced by the strain of Aspergillus avenaceus. A bicyclic bis-butyrolactone; isolated from aspergillus avenaceu; an antifungal agent; inhibits glutamate transport; an atypical ionophore. Synonyms: Avenaciolid; Furo(3,4-b)furan-2,6(3H,4H)-dione, dihydro-3-methylene-4-octyl- (VAN) (8CI). Grades: >95% by HPLC. CAS No. 20223-76-1. Molecular formula: C15H22O4. Mole weight: 266.33.
Bis(2-ethylhexyl) sebacate
Bis(2-ethylhexyl) sebacate, or dioctyl sebacate (DOS), is a non-polar plasticizer that has two ester groups that bond with cationic compounds. It is mainly used in the formation of thin plasticized polyvinyl chloride (PVC) based membranes. Uses: Dos can be used as an aerosol material that can be used to investigate the filtration efficiency of polyvinylidene/silicon oxide (pvdf/sio2) based fibrous membranes. it may be blended with pvc to form membranes that can be deposited on silver (ag) based composites which can be used in the fabrication of ion-selective electrodes for chemical analysis. dos may also be used in combination with pvc, chloride ionophore iii, and tridodecylmethylammonium chloride for the development of chloride sensing films. Group: Plastic additivesplasticizers. Alternative Names: Sebacic acid di(2-ethylhexyl) ester, 'Dioctyl' sebacate, Di(2-ethylhexyl) sebacate. CAS No. 122-62-3. Pack Sizes: 1 kg. Product ID: bis(2-ethylhexyl) decanedioate. Molecular formula: 426.67. Mole weight: C26H50O4. CCCCC (CC)COC (=O)CCCCCCCCC (=O)OCC (CC)CCCC. 1S/C26H50O4/c1-5-9-17-23 (7-3)21-29-25 (27)19-15-13-11-12-14-16-20-26 (28)30-22-24 (8-4)18-10-6-2/h23-24H, 5-22H2, 1-4H3. VJHINFRRDQUWOJ-UHFFFAOYSA-N. 98%.
Calcimycin
Calcimycin is an antibiotic produced by Streptomyces chartreusis. It has weak anti-gram-positive bacteria, negative bacteria and fungi activity. It can form stable complexes with divalent cations and exhibit ionophore effects. It is also used as a fluorescent reagent for detecting the hydrophilicity of proteins and as a coupling agent for oxidative phosphorylation. Synonyms: A-23187. Grades: >99% by HPLC. CAS No. 52665-69-7. Molecular formula: C29H37N3O6. Mole weight: 523.62.
CAY10606
Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme that in humans is encoded by the ALOX5 gene. 5-LO initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM). It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 with IC50 of 1.6 μM. Synonyms: CAY 10606; CAY-10606. Grades: ≥98%. CAS No. 1159576-98-3. Molecular formula: C22H18ClNO3. Mole weight: 379.8.
Cefixime trihydrate
A broad spectrum third generation cephalosporin targeting a wide range of gram-positive and gram-negative organisms. It is especially useful against pathogens responsible for causing ear, nose, and throat infections such as haemophilus influenzae and moraxella. Synonyms: [6R-[6α , 7β (Z)]]-7-[[ (2-Amino-4-thiazolyl)[ (carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-Thia-1-azabicyclo[4. 2. 0]oct-2-ene-2-carboxylic Acid Trihydrate; (E)-cefixime trihydrate; Ytterbium(III) Ionophore I. Grades: ≥97%. CAS No. 125110-14-7. Molecular formula: C16H15N5O7S2.3H2O. Mole weight: 507.50.
Chlortetracycline hydrochloride
Chlortetracycline hydrochloride (7-Chlorotetracycline hydrochloride) is an orally active, effective and selectively methanogenic bacteria inhibitor with bactericidal effects. Chlortetracycline hydrochloride is also a antibiotic that acts by inhibiting bacterial protein synthesis. Additionally, Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic , inhibiting binding of aminoacyl-tRNA to ribosomes [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-Chlorotetracycline hydrochloride. CAS No. 64-72-2. Pack Sizes: 1 g; 5 g. Product ID: HY-B1327.
CJ-13,610
CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC 50 of about 70 nM [1]. PMNL: polymorphonuclear leukocytes; AA: arachidonic acid. Uses: Scientific research. Group: Signaling pathways. CAS No. 179420-17-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106200.
Deethylindanomycin
Deethylindanomycin (omomycin) is an unusual pyrrollic ionophore related to indanomycin with activity against Gram +ve bacteria and coccidia. Lack of availability has limited further investigation of this compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 117615-33-5. Pack Sizes: 1mg. US Biological Life Sciences.
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Dinactin
A member of the macrotetrolide complex produced by a range of streptomyces species; a monovalent cation ionophore with high selectivity for ammonium and potassium; inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-&gamma. It is also resistant to gram-positive bacteria and mycobacteria. Synonyms: GNF-Pf-90; Antibiotic 170t; NSC63925; 4, 13, 22, 31, 37, 38, 39, 40-Octaoxapentacyclo(32.2.1.17, 10.116, 19.125, 28)tetracontane-3, 12, 21, 30-tetrone, 5,23-diethyl-2,11,14,20,29,32-hexamethyl-(VAN) (8CI). Grades: >95% by HPLC. CAS No. 20261-85-2. Molecular formula: C42H68O12. Mole weight: 764.98.
Dinactin (Antibiotic AKD 1C, Antibiotic S 3466A)
Dinactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Dinactin inhibited T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-g. Dinactin has not previously been available for intensive investigation. Group: Biochemicals. Alternative Names: Antibiotic AKD 1C, Antibiotic S 3466A. Grades: Highly Purified. CAS No. 20261-85-2. Pack Sizes: 1mg. US Biological Life Sciences.
EA4 is a rPLA2 inhibitor, and it is a quinone derivative. rPLA2, a calcium-dependent cytosolic phospholipase A2 (cPLA2), was initially isolated and characterized from bovine and human red blood cells (RBCs). EA4 inhibits the ionophore-induced arachidonic acid release from human and bovine red blood cells (RBCs), indicating that rPLA2 is responsible for the Ca2+-dependent release of arachidonic acid from mammalian RBCs. Synonyms: 7-chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione. Grades: ≥95%. CAS No. 389614-94-2. Molecular formula: C19H17ClN2O2. Mole weight: 340.8.
Enniatin A1
A family of depsipeptide ionophores, produced by several fusarium species. It has antibiotic properties. Enniatin A1 is one of four major analogues in the enniatin complex. Enniatin A1 has been found to induce apoptosis in cancer cells, decrease the activation of the cell proliferation kinase, ERK (p44/p42) and inhibit TNF-α-induced NF-κB activation. Synonyms: 2-(N-Methyl-L-valine)enniatin A; Cyclo(D-α-hydroxyisovaleryl-N-methyl-L-isoleucyl-D-α-hydroxyisovaleryl-N-methyl-L-isoleucyl-D-α-hydroxyisovaleryl-N-methyl-L-valyl); cyclo[N-methyl-L-isoleucyl-N-oxa-D-valyl-N-methyl-L-isoleucyl-N-oxa-D-valyl-N-methyl-L-valyl-N-oxa-D-valyl]; Cyclo((2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl). Grades: >99% by HPLC. CAS No. 4530-21-6. Molecular formula: C35H61N3O9. Mole weight: 667.87.
Enniatin A1 (2-(N-Methyl-L-valine) Enniatin A)
Enniatins are a family of depsipeptides produced several Fusarium species. The enniatins have been shown to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin A1 is one of four major analogues of the enniatin complex and has previously not been available for investigation. Group: Biochemicals. Alternative Names: 2-(N-Methyl-L-valine) Enniatin A. Grades: Highly Purified. CAS No. 4530-21-6. Pack Sizes: 1mg. US Biological Life Sciences.
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Enniatin A (Lateritin I)
Enniatins are a family of depsipeptides produced several Fusarium species. The enniatins have been shown to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin A is one of four major analogs of the enniatin complex and has previously not been available for investigation. Cyclohexadepsipeptide mycotoxin. One of four major analogs in the enniatin complex. Commonly found food contaminant in cereals and their products. Ionophore antibiotic. Incorporation into the cell membrane forms dimeric structures that transport monovalent ions across the membrane (especia...:Fusarium sp. MST-FP1765. Group: Biochemicals. Alternative Names: Lateritin I; Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl]; N-(D-2-Hydroxy-3-methylbutyryl)-N-methyl-Isoleucine Trimol. Cyclic Ester; 1,7,13-Trioxa-4,10,16-triazacyclooctadecane Cyclic Peptide Deriv.;Cyclo(D-α-hydroxyisovaleryl-N-methyl-L-isoleucyl-D-α-hydroxyisovaleryl-N-methyl-L-isoleucyl-D-α-hydroxyisovaleryl-N-methyl-L-isoleucyl). Grades: Highly Purified. CAS No. 2503-13-1. Pack Sizes: 500ug. Molecular Formula: C??H??N?O?, Molecular Weight: 681.9. US Biological Life Sciences.
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Enniatin B
Enniatins are a complex of family produced several Fusarium species. The enniatins have been shown to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin B is the most studied of four major analogues of the enniatin complex. Group: Biochemicals. Grades: Highly Purified. CAS No. 917-13-5. Pack Sizes: 1mg. US Biological Life Sciences.
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Enniatin B1 (2-(N-Methyl-L-isoleucine) Enniatin B)
Enniatins are a family of depsipeptides produced several Fusarium species. The enniatins have been shown to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin B1 is one of four major analogues of the enniatin complex and has not previously been available for investigation. Group: Biochemicals. Alternative Names: 2-(N-Methyl-L-isoleucine) Enniatin B. Grades: Highly Purified. CAS No. 19914-20-6. Pack Sizes: 1mg. US Biological Life Sciences.
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Enniatin complex
Enniatins are a complex of depsipeptides produced by several Fusarium species. Typically, the complex contains 4 major components: A, A1, B and B1 together with minor amounts of enniatin C, D, E and F. The enniatins have been shown to act as ionophores. Recently, their effects on acyl-CoA cholesterol transferase, as nematocides and the selectivity of their antitumor action have received more focus. Group: Biochemicals. Grades: Highly Purified. CAS No. 11113-62-5. Pack Sizes: 10mg. US Biological Life Sciences.
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Ferutinin
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC 50 s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca 2+ -ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 41743-44-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-125703.
GI 254023X is a selective ADAM10 metalloprotease inhibitor with over 100-fold higher potency at ADAM10 than ADAM17. GI 254023X inhibits the proliferation of H929 cells, and calcium ionophore-induced betacellulin shedding in IMPE cells. It prevents E-cadherin cleavage in A549 cells, and suppresses ADAM10 mediated neuronal outgrowth of dorsal root ganglion neurons in vitro. Synonyms: GI254023X; GI 254023X; GI-254023X;GI4023; GI-4023; GI 4023. (2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide. Grades: ≥98% by HPLC. CAS No. 260264-93-5. Molecular formula: C21H33N3O4. Mole weight: 391.5.
Glipizide
Glipizide is an oral rapid- and short-acting anti-diabetic drug from the sulfonylurea class. Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. Uses: Hypoglycemic agents. Synonyms: 2-Pyrazinecarboxamide, N- [2- [4- [ [ [ (cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] -5-methyl-; N- [2- [4- [ [ [ (Cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] -5-methyl-2-pyrazinecarboxamide; Pyrazinecarboxamide, N- [2- [4- [ [ [ (cyclohexylamino) carbonyl] amino] sulfonyl] phenyl] ethyl] -5-methyl-; Urea, 1-cyclohexyl-3-[[p-[2- (5-methylpyrazinecarboxamido) ethyl]phenyl]sulfonyl]-; Aldiab; CP 28720; Digrin; Dipazide; Glibenese; Glibetin; Glican; Glidiab; Glipid; Glipizid; Gluco-Rite; Glucolip; Glucotrol; Glucotrol Xl; Glucozide; Glupitel; Glupizide; Glyde; Glydiazinamide; Glynase; K 4024; Melizide; Mindiab; Minidab; Minidiab; Minodiab; N-(4-[β-(5-Methylpyrazine-2-carboxamido)ethyl]benzenesulfonyl)-N'-cyclohexylurea; Napizide; Ozidia; Samarium(III) ionophore I; Semiglynase; Sucrazide; TK 1320. Grades: >98%. CAS No. 29094-61-9. Molecular formula: C21H27N5O4S. Mole weight: 445.54.
Gramicidin A
Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α ( HIF-1α ) [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 11029-61-1. Pack Sizes: 5 mg. Product ID: HY-P2324.
HA1077 (Fasudil Dihydrochloride)
A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK).HA1077 is an inhibitor of ROK/ROCK II (IC50 1.9uM), PRK2 (IC50 4uM), MSK1 (IC50 5uM), Rsk2 (IC50 15uM), PKA, p70 S6 Kinase, CaM Kinase (Ki 1.8nM) and MLCK (Ki 20nM). HA1077 is a calcium antagonist and has antivasospastic properties. Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK. Group: Biochemicals. Alternative Names: Fasudil Dihydrochloride; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine 2HCl; 1-(5-Isoquinolinesulfonyl) homopiperazine 2HCl). Grades: Highly Purified. CAS No. 103745-39-7. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C14H17N3O2S 2HCl, Molecular Weight: 364.29. US Biological Life Sciences.
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Indanomycin
Indanomycin is an antibiotic of the pyrroloketoindane class produced by Streptomyces sp. It is an unusual pyrollic ionophore that is active against gram-positive bacteria and insects. It has antihypertensive properties. It is a growth promoter in ruminants. Synonyms: X-14547A; X 14547A; 2H-Pyran-2-acetic acid, 6-(1-ethyl-4-(1-ethyl-2,3,3a,4,5,7a-hexahydro-4-(1H-pyrrol-2-ylcarbonyl)-1H-inden-5-yl)-1,3-butadienyl)tetrahydro-alpha, 5-dimethyl-, (1S-(1-alpha,3-alpha,beta,4-beta,5-beta(1E(2S*(S*),5R*,6S*),3E),7a-alpha))-; Antibiotic X-14547A. Grades: >95% by HPLC. CAS No. 66513-28-8. Molecular formula: C31H43NO4. Mole weight: 493.68.
Indanomycin
Indanomycin is an unusual pyrollic ionophore active against Gram +ve bacteria and insects. Interestingly, indanomycin has been demonstrated to possess antihypertensive properties. Indanomycin posseses affinity for both mono- and divalent ions and has been reported as a growth promotor in ruminants. Group: Biochemicals. Grades: Highly Purified. CAS No. 66513-28-8. Pack Sizes: 1mg. US Biological Life Sciences.
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: SQ23377. CAS No. 56092-81-0. Pack Sizes: 1 mg (14.1 mM * 100 μL in Ethanol); 5 mg (14.1 mM * 500 μL in Ethanol); 10 mg (14.1 mM * 1 mL in Ethanol). Product ID: HY-13434.
Ionomycin
Ionomycin was isolated from Streptomyces conglobatus as a potent antibiotic selective for Gram +ve bacteria. During the isolation it was recognised that ionomycin exhibits a very high affinity and selectivity for calcium ions suggesting the metabolite acts as a calcium ionophore. More recently, ionomycin has been used in cell biology as a universal calcium ionophore to explore the role of calcium regulation in the cell. Group: Biochemicals. Grades: Highly Purified. CAS No. 56092-81-0. Pack Sizes: 1mg. US Biological Life Sciences.
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Ionomycin calcium
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: SQ23377 calcium. CAS No. 56092-82-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-13434A.
Ionomycin Calcium Salt
Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH range with the resulting complex exhibiting intense UV absorption. Ionomycin Calcium is a polyether antibiotic obtained from Streptomyces conglobatus by solvent extraction. It is different from other antibiotics of its class as it absorbs UV light at 300nm maximum. Gram-positive antibiotic. Group: Biochemicals. Alternative Names: Calcium Ionomycin; (4R, 6S, 8S, 10Z, 12R, 14R, 16E, 18R, 19R, 20S, 21S)-11, 19, 21-Trihydroxy-4, 6, 8, 12, 14, 18, 20-heptamethyl-22-[(2S, 2R, 5S, 5S)-octahydro-5-[(1R)-1-hydroxyethyl]-2, 5-dimethyl[2, 2-bifuran]-5-yl]-9-oxo-10, 16-Docosadienoic Acid Calcium Salt. Grades: Highly Purified. CAS No. 56092-82-1. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C41H70O9 Ca, Molecular Weight: 747.07. US Biological Life Sciences.
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Ionomycin Calcium Salt
The Calcium Salt of Ionomycin, a kind of polyether antibiotic, is a selective calcium ionophore obtained from Streptomyces conglobatus by solvent extraction. It is more effective than A23187 as a calcium ionophore. It is used to study the transport of calcium ions on biological membranes. It can induce apoptotic degeneration of embryonic cortical neurons. Synonyms: Calcium ionophore; Calcium Ionomycin; (4R, 6S, 8S, 10Z, 12R, 14R, 16E, 18R, 19R, 20S, 21S)-11, 19, 21-Trihydroxy-4, 6, 8, 12, 14, 18, 20-heptamethyl-22-[(2S, 2'R, 5S, 5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2, 5'-dimethyl[2, 2'-bifuran]-5-yl]-9-oxo-10, 16-Docosadienoic Acid Calcium Salt; 10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, calcium salt (1:1), (4R, 6S, 8S, 10Z, 12R, 14R, 16E, 18R, 19R, 20S, 21S)-; Ionomycin, calcium salt (1:1). Grades: ≥98%. CAS No. 56092-82-1. Molecular formula: C41H70O9Ca. Mole weight: 747.07.
Ionomycin (Free Acid)
Antibiotic. Potent and highly selective Ca2+ ionophore. Commonly used to modify intracellular calcium levels to study calcium transport across biological membranes and to calibrate fluorescent Ca2+ indicators. Ionomycin also transports Pb2+ and some other divalent cations, as well as several lanthanide series trivalent cations at efficiencies that are greater than or equal to those for Ca2+. Apoptosis inducer. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase and induces central demyelination. Used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2 and IL-4 usually in conjunction with PMA. ADAM10 agonist. Potent inducer of shedding CXCL16. TREK-1 channels inhibitor. PPARy ligand with a unique binding mode. Shows effective glucose-lowering activity in a mouse model of diabetes. Group: Biochemicals. Alternative Names: SQ 23377; EM 94; [2S-[2α[2S*, 5R*(S*)], 5 β(4S*, 6R*, 8R*, 10Z, 12S*, 14S*, 16E, 18S*, 19S*, 20R*, 21R*)]]-11, 19, 21-Trihydroxy-4, 6, 8, 12, 14, 18, 20-heptamethyl-22-[octahydro-5-(1-hydroxyethyl)-2, 5-dimethyl[2, 2-bifuran]-5-yl]-9-oxo-10, 16-docosadienoic Acid; [2S-[2α[2S*, 5R*(S*)], 5 β(4S*, 6R*, 8R*,. Grades: Highly Purified. CAS No. 56092-81-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??O?. US Biological Life Sciences.
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Lasalocid
Lasalocid (Lasalocid-A; Ionophore X-537A; Antibiotic X-537A) is an antibacterial and anticoccidial agent used in feed additives. Uses: Scientific research. Group: Natural products. Alternative Names: Lasalocid-A; Ionophore X-537A; Antibiotic X-537A. CAS No. 25999-31-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1071.
Lasalocid A Sodium
Lasalocid is a polyether ionophore with potent antibacterial activity. Lasalocid was developed as an animal health product for treatment of coccidia. Lasalocid is able to form neutral complexes with monovalent and divalent cations and transport the ions through apolar phase (including lipid bilayer membranes). Interestingly, lasalocid can also transport larger organic cations, e.g. protonated dopamine. Group: Biochemicals. Alternative Names: 6-[(3R,4S,5S,7R)-7-[(2S,3S,5S)-5-Ethyl-5-[(2R,5R,6S)-5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]tetrahydro-3-methyl-2-furanyl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methylbenzoic Acid Sodium Salt; 6-[7-[5-Ethyl-5-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)tetrahydro-3-methyl-2-furyl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-2,3-cresotic Acid Monosodium Salt; (3R*, 4S*, 5S*, 7R*), 3S*, 5S*], 5α, 6 β]]-6-[7-[5-Ethyl-5-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)tetrahydro-3-methyl-2-furanyl]-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methylbenzoic Acid Monosodium Salt; Avatec; Bovatec; Lasalocid Sodium; Lasalocid Sodium Salt; MT 2007; NSC 243046; Ro 2-2985; Sodium Lasalocid; Sodium Lasalocid A. Grades: Highly Purified. CAS No. 25999-20-6. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??NaO?, Molecular Weight: 612.77. US Biological Life Sciences.
Worldwide
Lasalocid sodium
Lasalocid sodium is a cationic ionophore antibiotic obtained from Streptomyces lasaliensis that, among other effects, dissociates the calcium fluxes in muscle fibers. It is used as a coccidiostat, especially in poultry. Synonyms: Lasalocid A Sodium Salt; Avatec; Bovatec. Grades: >95% by HPLC. CAS No. 25999-20-6. Molecular formula: C34H53NaO8. Mole weight: 612.77.
Lasalocid sodium
Lasalocid sodium (Lasalocid-A sodium) is an antibacterial agent. Uses: Scientific research. Group: Natural products. Alternative Names: Lasalocid-A sodium; Ionophore X-537A sodium; Antibiotic X-537A sodium. CAS No. 25999-20-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1071A.
Methyltrioctadecylammonium Bromide
Methyltrioctadecylammonium bromide is an anion exchange ionophore for perchlorate-selective membranes. Group: Other ionic liquidsspecialty synthesis based ionic liquids. Alternative Names: Trioctadecylmethylammonium bromide. CAS No. 18262-86-7. Molecular formula: [CH3(CH2)17]3N(Br)CH3. Mole weight: 869.4. Appearance: Powder. Purity: 0.98. Catalog: ACM18262867.
Monactin
A member of the macrotetrolide complex produced by a range of streptomyces species; a monovalent cation ionophore with high selectivity for ammonium and potassium; inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and IFN-&gamma. It is also resistant to gram-positive bacteria and mycobacteria. Synonyms: 4, 13, 22, 31, 37, 38, 39, 40-Octaoxapentacyclo[32.2.1.17, 10.116, 19.125, 28]tetracontane-3, 12, 21, 30-tetrone, 5-ethyl-2, 11, 14, 20, 23, 29, 32-heptamethyl-, (1R, 2R, 5R, 7R, 10S, 11S, 14S, 16S, 19R, 20R, 23R, 25R, 28S, 29S, 32S, 34S)-; Akd-1B. Grades: >95% by HPLC. CAS No. 7182-54-9. Molecular formula: C41H66O12. Mole weight: 750.95.
Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Unlike nonactin, monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Monactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-gamma. Group: Biochemicals. Alternative Names: 5-demethyl-5-ethylnonactin, Antibiotic AKD 1B. Grades: Highly Purified. CAS No. 7182-54-9. Pack Sizes: 1mg. US Biological Life Sciences.
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Monensin Methyl Ester
A polyether ionophore antibiotic. Widely used in ion selective electrodes. Group: Biochemicals. Alternative Names: Methyl Monensin. Grades: Highly Purified. CAS No. 28636-21-7. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Monensin sodium
Monensin (Monensin A) sodium, an orally active antibiotic , is an ionophore that mediates Na + /H + exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Monensin A sodium. CAS No. 22373-78-0. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-N0150.
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