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| Product | Description | |
|---|---|---|
| IRAK inhibitor 4 | IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4( IRAK4 ) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1012104-68-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-13278. |  |
| IRAK inhibitor 4 | IRAK inhibitor 4 is interleukin-1 receptor associated kinase inhibitor. Grades: >98%. CAS No. 1012104-68-5. Molecular formula: C33H35F3N6O3. Mole weight: 620.66. |  |
| IRAK-1-4 Inhibitor I | IRAK-1-4 Inhibitor I is a novel benzimidazole that is a potent inhibitor of interleukin-1 receptor-associated kinases 1-4 (IRAK 1-4). Synonyms: Benzamide, N-[1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitro-. Grades: >98%. CAS No. 509093-47-4. Molecular formula: C20H21N5O4. Mole weight: 395.41. | |
| 1-(4-Amino-3-methoxyphenyl)-4-methylpiperazine | 1-(4-Amino-3-methoxyphenyl)-4-methylpiperazine is a useful synthetic intermediate. It is used to 4,5-dihydro-1H-pyrazolo[4,3-h]quinazolines as orally and selective Polo-like kinase 1 inhibitors. It is also used to synthesize IRAK-4 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 122833-04-9. Pack Sizes: 250mg, 2.5 g. Molecular Formula: C12H19N3O, Molecular Weight: 221.3. US Biological Life Sciences. |  Worldwide |
| AS-2444697 HCl | AS-2444697 is a pootent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM) with 30-fold selectivity for IRAK4 over IRAK1. AS2444697 significantly reduced or showed a decreasing trend in expression and levels of these inflammatory parameters. Synonyms: N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride; AS-2444697; AS 2444697; AS2444697; AS-2444697 HCl; AS-2444697 hydrochloride. CAS No. 1287665-60-4. Molecular formula: C19H21ClN6O4. Mole weight: 432.86. | |
| BMI-1026 | BMI-1026 is an exceedingly potent and remarkably selective inhibitor utilized in the biomedical sector, specifically zeroes in on the intricate signalling pathway of interleukin-1 receptor-associated kinase 4 (IRAK-4). Synonyms: BMI 1026; BMI1026; 4-(2-Aminopyrimidin-4-yl)-6-(2-aminopyrimidin-4(3H)-ylidene)cyclohexa-2,4-dien-1-one. Grades: >98%. CAS No. 477726-77-5. Molecular formula: C34H60N3O7PS. Mole weight: 280.29. | |
| CA-4948 | CA-4948 is a potent and selective IRAK4 inhibitor that can be used for the treatment of cancers with dysregulated TLR/MYD88/IRAK4 signaling. Synonyms: CA-4948; CA 4948; CA4948; 6'-Amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl][2,3'-bipyridine]-6-carboxamide. Grades: >98%. CAS No. 1801343-74-7. Molecular formula: C21H19N7O3. Mole weight: 417.429. | |
| Emavusertib | Emavusertib, also known as CA-4948 is a potent IRAK4/FLT3 inhibitor with anti-tumor activity. CA-4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CA-4948; CA 4948; CA4948; Emavusertib. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1801344-14-8. Molecular formula: C24H25N7O5. Mole weight: 491.51. Purity: >98%. IUPACName: (R)-N-(5-(3-hydroxypyrrolidin-1-yl)-2-morpholinooxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide. Canonical SMILES: O=C(C1=COC(C2=CC(C)=NC=C2)=N1)NC3=C(N4C[C@H](O)CC4)N=C5C(OC(N6CCOCC6)=N5)=C3. Product ID: ACM1801344148. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Ginsenoside Rb1 | Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-O-beta-glucopyranosyl-(3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl-beta-D-glucopyranoside. Product Category: Inhibitors. Appearance: White powder. CAS No. 41753-43-9. Molecular formula: C54H92O23. Mole weight: 1109.29. Purity: 0.98. IUPACName: (2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol. Canonical SMILES: CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)O)O)O)C. Density: 1.097 g/ml. Product ID: ACM41753439. Alfa Chemistry ISO 9001:2015 Certified. | |
| Irak4-IN-1 | Irak4-IN-1 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4). Synonyms: Irak4-IN-1; Irak4 IN 1; 4-[(4-morpholin-4-ylcyclohexyl)amino]quinazoline-6-carbonitrile. CAS No. 1820787-94-7. Molecular formula: C19H23N5O. Mole weight: 337.427. | |
| IRAK4-IN-3 | IRAK4-IN-3 is a compound with exceptional potency and selectivity against interleukin-1 receptor-associated kinase 4 (IRAK4), an inflammation-linked kinase. This compound has displayed tremendous promise in the treatment of autoimmune conditions, including rheumatoid arthritis and systemic lupus erythematosus. As such, it represents a significant advance in the field of molecular therapeutics targeting inflammatory disorders. Synonyms: IRAK4-IN-3 is an IRAK4 inhibitor. CAS No. 2196204-23-4. Molecular formula: C21H31N5O2. Mole weight: 385.5. | |
| IRAK inhibitor 1 | IRAK inhibitor 1 is interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor. Synonyms: IRAK inhibitor 1; 1042224-63-4; CHEMBL258004; 6-imidazo[1,2-a]pyridin-3-yl-N-piperidin-4-ylpyridin-2-amine; 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine; 6-(Imidazo[1,2-a]pyridin-3-yl)-N-(piperidin-4-yl)pyridin-2-amine; irak inhibitor; CS-0603; SCHEMBL18427792; DTXSID60659159; BCP30783; EX-A3209; BDBM50240128; AKOS030526218; NCGC00379036-01; HY-13275; MS-24200; F84607; A920481; 6-(H-imidazo[1,2-a]pyridin-3-yl)-N-(piperidin-4-yl)pyridin-2-amine. Grades: >98%. CAS No. 1042224-63-4. Molecular formula: C17H19N5. Mole weight: 293.37. | |
| IRAK inhibitor 2 | IRAK inhibitor 2 is interleukin-1 receptor associated kinase inhibitor. Synonyms: Phenol, 4-[6-[(2-furanylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl]-. Grades: >98%. CAS No. 928333-30-6. Molecular formula: C17H14N4O2. Mole weight: 306.32. | |
| IRAK inhibitor 3 | IRAK inhibitor 3 is interleukin-1 receptor associated kinase inhibitor. Synonyms: IRAK inhibitor 3; 1012343-93-9; 4-[[[3-(3,4-dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino]methyl]benzenesulfonamide; 4-(((3-(3,4-Dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl)amino)methyl)benzenesulfonamide; SCHEMBL1053021; DTXSID00648709; GLXC-25274; AKOS030526199; CS-0605; NCGC00379067-01; HY-13277; MS-27885; F84609; A921718; SR-01000377174; SR-01000377174-1; 4-({[3-(3,4-Dimethoxyphenyl)imidazo[1,2-b]pyridazin-6-yl]amino}methyl)benzene-1-sulfonamide. Grades: >98%. CAS No. 1012343-93-9. Molecular formula: C21H21N5O4S. Mole weight: 439.49. | |
| IRAK inhibitor 6 | IRAK inhibitor 6 is interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor. Synonyms: IRAK-IN-6; IRAK IN 6; IRAKIN6; IRAK inhibitor 6. Grades: >98%. CAS No. 1042672-97-8. Molecular formula: C20H20N4O3S. Mole weight: 396.46. | |
| JH-X-119-01 | Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JH-X-119-01; JH-X119-01; JH-X 119-01; JH-X-11901; JH-X11901; JH-X 11901; JHX-11901; JHX11901; JHX 11901. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2227368-54-7. Molecular formula: C25H20N6O3. Mole weight: 452.47. Purity: >98%. IUPACName: N-(4-(3-Acrylamidobenzamido)phenyl)-6-(1H-pyrazol-5-yl)picolinamide. Canonical SMILES: O=C(NC1=CC=C(NC(C2=CC=CC(NC(C=C)=O)=C2)=O)C=C1)C3=NC(C4=CC=NN4)=CC=C3. Product ID: ACM2227368547. Alfa Chemistry ISO 9001:2015 Certified. | |
| JH-X-119-01 hydrochloride | A potent IRAK1 inhibitor. Synonyms: JH-X-119-01 (hydrochloride). CAS No. 2591344-30-6. Molecular formula: C25H21ClN6O3. Mole weight: 488.93. | |
| JNK-IN-7 | Covalent modification of IRAK1 by JNK-IN-7 is a possibility and subsequent biochemical kinase assay revealed anIC50 of ~10 nM against IRAK1. JNK-IN-7 exhibited binding inhibition of 95% or more to approximately 14 kinases at the concentration of 1.0 μM. JNK-IN-7 was next tested for its ability to inhibit the enzymatic activity of a panel of 121 kinases at a concentration of 1.0 μM. Synonyms: JNK-IN-7; JNK inhibitor;JNKIN7; JNK IN 7; JNK-IN-7. Grades: >98%. CAS No. 1408064-71-0. Molecular formula: C28H27N7O2. Mole weight: 493.56. | |
| Ketohexokinase Inhibitor (N8-(Cyclopropylmethyl)-N4-(2-(methylthio)phenyl)-2-(1-piperazinyl)-pyrimido[5,4-d]pyrimidine-4,8-diamine, KHK Inhibitor) | An orally bioavailable pyrimidinopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of human hepatic KHK activity (KHK-C isoform; IC50=12nM in a transcreener ADP assay) and efficiently blocks fructose-1-phosphate secretion (IC50 ≤ 400nM in HepG2 cells). Displays ~50-fold lower potency towards metabolic kinases, namely, ribokinase, hexokinase and adenosine kinase, and minimal binding affinities to diverse receptors and ion-channels, and excellent selectivity among a panel of 31-kinases including Akt1, AMPK, CaMKI/II, InsR, IRAK4, PKA and PKCtheta (IC50 >> 10uM). Shown to minimally affect the activities of human cytochrome p450 isozymes (1A2, 2C19, 2D6, 2C9 and 3A4), and exhibit high volume of distribution and high rate of clearance in rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?S 2HCl. US Biological Life Sciences. | Worldwide |
| PF-06650833 | PF-06650833 is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), which is an omnipresently expressed serine/threonine kinase involved in the regulation of innate immunity. PF-06650833 is useful for the treatment of autoimmune and inflammatory diseases associated with lnterleukin-1 Receptor Associated Kinase (IRAK) and more particularly modulates the function of IRAK. It is undergoing testing in a Phase II clinical study. Synonyms: zimlovisertib; PF 06650833; PF06650833. CAS No. 1817626-54-2. Molecular formula: C18H20FN3O4. Mole weight: 361.373. | |
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