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| Product | Description | |
|---|---|---|
| IRAK inhibitor 4 | IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4( IRAK4 ) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1012104-68-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-13278. |  |
| 1-(4-Amino-3-methoxyphenyl)-4-methylpiperazine | 1-(4-Amino-3-methoxyphenyl)-4-methylpiperazine is a useful synthetic intermediate. It is used to 4,5-dihydro-1H-pyrazolo[4,3-h]quinazolines as orally and selective Polo-like kinase 1 inhibitors. It is also used to synthesize IRAK-4 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 122833-04-9. Pack Sizes: 250mg, 2.5 g. Molecular Formula: C12H19N3O, Molecular Weight: 221.3. US Biological Life Sciences. |  Worldwide |
| AS-2444697 HCl | AS-2444697 is a pootent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM) with 30-fold selectivity for IRAK4 over IRAK1. AS2444697 significantly reduced or showed a decreasing trend in expression and levels of these inflammatory parameters. Synonyms: N-(3-carbamoyl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide hydrochloride; AS-2444697; AS 2444697; AS2444697; AS-2444697 HCl; AS-2444697 hydrochloride. CAS No. 1287665-60-4. Molecular formula: C19H21ClN6O4. Mole weight: 432.86. |  |
| AZ1495 | AZ1495, a weak base, is a potent orally active interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor. AZ1495 has a favorable physicochemical and kinase selectivity for IRAK4 and IRAK1 with IC50 values of 0.005 ?M and 0.023 ?M, respectively. AZ1495 has IRAK4 inhibition with a Kd value of 0.0007 ?M. AZ1495 can be used for the research of diffuse large B-cell lymphoma (DLBCL)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2196204-23-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111101. | |
| BMI-1026 | BMI-1026 is an exceedingly potent and remarkably selective inhibitor utilized in the biomedical sector, specifically zeroes in on the intricate signalling pathway of interleukin-1 receptor-associated kinase 4 (IRAK-4). Synonyms: BMI 1026; BMI1026; 4-(2-Aminopyrimidin-4-yl)-6-(2-aminopyrimidin-4(3H)-ylidene)cyclohexa-2,4-dien-1-one. Grade: >98%. CAS No. 477726-77-5. Molecular formula: C34H60N3O7PS. Mole weight: 280.29. | |
| CA-4948 | CA-4948 is a potent and selective IRAK4 inhibitor that can be used for the treatment of cancers with dysregulated TLR/MYD88/IRAK4 signaling. Synonyms: CA-4948; CA 4948; CA4948; 6'-Amino-N-[2-(4-morpholinyl)oxazolo[4,5-b]pyridin-6-yl][2,3'-bipyridine]-6-carboxamide. Grade: >98%. CAS No. 1801343-74-7. Molecular formula: C21H19N7O3. Mole weight: 417.429. | |
| Edecesertib | Edecesertib (GS-5718) is a selective, potent, orally active IRAK-4 inhibitor. Edecesertib has anti-inflammatory activity. Edecesertib can be used for rheumatoid arthritis (RA) and lupus erythematosus (LE) research[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-5718. CAS No. 2408839-73-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147264. | |
| Emavusertib | Emavusertib, also known as CA-4948 is a potent IRAK4/FLT3 inhibitor with anti-tumor activity. CA-4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CA-4948; CA 4948; CA4948; Emavusertib. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1801344-14-8. Molecular formula: C24H25N7O5. Mole weight: 491.51. Purity: >98%. IUPACName: (R)-N-(5-(3-hydroxypyrrolidin-1-yl)-2-morpholinooxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-4-carboxamide. Canonical SMILES: O=C(C1=COC(C2=CC(C)=NC=C2)=N1)NC3=C(N4C[C@H](O)CC4)N=C5C(OC(N6CCOCC6)=N5)=C3. Product ID: ACM1801344148. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Emavusertib | Emavusertib is an orally bioavailable inhibitor of interleukin-1 receptor-associated kinase 4/FMS-like Tyrosine Kinase 3 (IRAK4/FLT3). Synonyms: CA-4948; CA 4948; CA4948. CAS No. 1801344-14-8. Molecular formula: C24H25N7O5. Mole weight: 491.50. | |
| Ginsenoside Rb1 | Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with an IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-O-beta-glucopyranosyl-(3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl-beta-D-glucopyranoside. Product Category: Inhibitors. Appearance: White powder. CAS No. 41753-43-9. Molecular formula: C54H92O23. Mole weight: 1109.29. Purity: 0.98. IUPACName: (2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol. Canonical SMILES: CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)O)O)O)C. Density: 1.097 g/ml. Product ID: ACM41753439. Alfa Chemistry ISO 9001:2015 Certified. | |
| HPK1-IN-7 | HPK1-IN-7 is a potent, orally active HPK1 inhibitor with excellent family and kinome selectivity. HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM). Synonyms: (S)-5-((4-((2-Hydroxy-1-phenylethyl)amino)-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl)amino)-3,3-dimethylisobenzofuran-1(3H)-one. Grade: 99%. CAS No. 2320462-65-3. Molecular formula: C24H22N6O4. Mole weight: 458.48. | |
| HS271 | HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50 = 7.2 μM), with superior enzymatic and cellular activity, as well as excellent pharmacokinetic properties. Synonyms: 2-Pyridinecarboxamide, N-[2-[2-(dimethylamino)ethyl]-6-(1-hydroxy-1-methylethyl)-2H-indazol-5-yl]-6-(trifluoromethyl)-; N-{2-[2-(Dimethylamino)ethyl]-6-(2-hydroxy-2-propanyl)-2H-indazol-5-yl}-6-(trifluoromethyl)-2-pyridinecarboxamide. Grade: ≥95%. CAS No. 2410393-15-4. Molecular formula: C21H24F3N5O2. Mole weight: 435.44. | |
| JH-X-119-01 | Jh-X-119-01 is a novel potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 irreversibly labels IRAK1 at C302. This compound exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88. Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JH-X-119-01; JH-X119-01; JH-X 119-01; JH-X-11901; JH-X11901; JH-X 11901; JHX-11901; JHX11901; JHX 11901. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2227368-54-7. Molecular formula: C25H20N6O3. Mole weight: 452.47. Purity: >98%. IUPACName: N-(4-(3-Acrylamidobenzamido)phenyl)-6-(1H-pyrazol-5-yl)picolinamide. Canonical SMILES: O=C(NC1=CC=C(NC(C2=CC=CC(NC(C=C)=O)=C2)=O)C=C1)C3=NC(C4=CC=NN4)=CC=C3. Product ID: ACM2227368547. Alfa Chemistry ISO 9001:2015 Certified. | |
| Ketohexokinase Inhibitor (N8-(Cyclopropylmethyl)-N4-(2-(methylthio)phenyl)-2-(1-piperazinyl)-pyrimido[5,4-d]pyrimidine-4,8-diamine, KHK Inhibitor) | An orally bioavailable pyrimidinopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of human hepatic KHK activity (KHK-C isoform; IC50=12nM in a transcreener ADP assay) and efficiently blocks fructose-1-phosphate secretion (IC50 ≤ 400nM in HepG2 cells). Displays ~50-fold lower potency towards metabolic kinases, namely, ribokinase, hexokinase and adenosine kinase, and minimal binding affinities to diverse receptors and ion-channels, and excellent selectivity among a panel of 31-kinases including Akt1, AMPK, CaMKI/II, InsR, IRAK4, PKA and PKCtheta (IC50 >> 10uM). Shown to minimally affect the activities of human cytochrome p450 isozymes (1A2, 2C19, 2D6, 2C9 and 3A4), and exhibit high volume of distribution and high rate of clearance in rats. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?S 2HCl. US Biological Life Sciences. | Worldwide |
| Zimlovisertib | Zimlovisertib (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. Zimlovisertib is used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06650833. CAS No. 1817626-54-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19836. | |
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