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One impurity of Tenofovir, which is an acyclic phosphonate nucleotide derivative, could be used in antiviral treatment as an everse transcriptase inhibitor. Synonyms: [[(1R)-2(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl] Isopropyl Phosphonic Acid. Grades: > 95%. CAS No. 1346597-36-1. Molecular formula: C12H20N5O4P. Mole weight: 329.29.
Isopropyl Tenofovir
Tenofovir derivative. Group: Biochemicals. Alternative Names: [[(1R)-2(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl] Isopropyl Phosphonic Acid. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Mono-POC Isopropyl Tenofovir (Mixture of Diastereomers)
Mono-POC Isopropyl Tenofovir (Mixture of Diastereomers). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: [[[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yloxy]methyl](isopropyloxy)phosphoryl]oxymethyl Isopropyl Carbonate, [[[(2R)-3-(6-Amino-9H-purin-9-yl)prop-2-yloxy]methyl]-1-methylethoxyphosphoryl]oxymethyl 1-Methylethyl Carbonate,2,4,7-Trioxa-5-phosphanonanoic acid, 9-(6-amino-9H-purin-9-yl)-8-methyl-5-(1-methylethoxy)-, 1-methylethyl ester, 5-oxide, (8R)-. CAS No. 1246812-40-7. IUPAC Name: [[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-propan-2-yloxyphosphoryl]oxymethyl propan-2-yl carbonate. Molecular formula: C17H28N5O7P. Mole weight: 445.41. Catalog: APS1246812407. SMILES: CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OC(C)C. Format: Neat.
Mono-POC Isopropyl Tenofovir (Mixture of Diastereomers)
Tenofovir impurity. Group: Biochemicals. Alternative Names: (8R)-. Grades: Highly Purified. CAS No. 1246812-40-7. Pack Sizes: 500ug. US Biological Life Sciences.
Worldwide
Mono-POC Tenofovir 6-Isopropyl Carbamate (Mixture of Diastereomers)
Mono-POC Tenofovir 6-Isopropyl Carbamate (Mixture of Diastereomers). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: [(2R)-1-[6-(Isopropyloxycarbonylamino)-9H-purin-9-yl]propan-2-yloxy]methyl(isopropyloxycarbonyloxymethoxy)phosphinic Acid,(8R)-5-hydroxy-8-methyl-9-[6-[[(1-methylethoxy)carbonyl]amino]-9H-purin-9-yl]-2,4,7-trioxa-5-phosphanonanoic acid 1-methylethyl ester 5-oxide, [(2R)-3-[6-(Isopropyloxycarbonylamino)-9H-purin-9-yl]prop-2-yloxy]methyl(isopropyloxycarbonyloxymethoxy)phosphinic Acid, [(1R)-2-[6-(1-(Methyl)ethoxycarbonylamino)-9H-purin-9-yl]-1-(methyl)ethoxy]methyl-(1-(methyl)ethoxycarbonyloxymethoxy)phosphinic Acid, [[[(2R)-1-[6-(Isopropyloxycarbonylamino)-9H-purin-9-yl]propan-2-yloxy]methyl](hydroxy)phosphoryloxy]methyl Isopropyl Carbonate. CAS No. 1244022-56-7. IUPAC Name: [(2R)-1-[6-(propan-2-yloxycarbonylamino)purin-9-yl]propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphinic acid. Molecular formula: C18H28N5O9P. Mole weight: 489.42. Catalog: APS1244022567. SMILES: CC(C)OC(=O)Nc1ncnc2c1ncn2C[C@@H](C)OCP(=O)(O)OCOC(=O)OC(C)C. Format: Neat.
Mono-POC Tenofovir 6-Isopropyl Carbamate (Mixture of Diastereomers)
Tenofovir impurity. Group: Biochemicals. Alternative Names: (8R)-. Grades: Highly Purified. CAS No. 1244022-56-7. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Tenofovir Dibenzyloxy Isopropyl Carbamate
Protected Tenofovir. Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. Group: Biochemicals. Alternative Names: [ [ (1R) -2 (6-Isopropyl aminocarbamate-9H-purin-9-yl) -1-methylethoxy] methyl] phosphonic Acid Dibenzyl Ester. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Tenofovir Isopropyl Carbamate
Protected Tenofovir. Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. Group: Biochemicals. Alternative Names: [ [ (1R) -2 (6-Isopropyl aminocarbamate-9H-purin-9-yl) -1-methylethoxy] methyl] phosphonic Acid. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Tenofovir Isopropyl Ethyl Diester
Tenofovir Isopropyl Ethyl Diester. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, 1-ethyl 9-(1-methylethyl) ester, 5-oxide. CAS No. 1422284-16-9. IUPAC Name: [[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(ethoxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate. Molecular formula: C18H28N5O10P. Mole weight: 505.42. Catalog: APS1422284169. SMILES: CCOC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C. Format: Neat.
Tenofovir isopropyl monoisoproxil hydrochloride
Tenofovir isopropyl monoisoproxil hydrochloride. Group: Biochemicals. Alternative Names: iPr-POC PMPA hydrochloride; Tenofovir disoproxil related compound G. Grades: Highly Purified. CAS No. 1246812-40-7. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C17H28N5O7P·HCl. US Biological Life Sciences.
Worldwide
Adefovir disoproxil
Adefovir disoproxil is an impurity of Tenofovir Disoproxil Fumarate, which is a potent reverse transcriptase inhibitor used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. Synonyms: O,O-Bis(isopropoxycarbonyloxymethyl) [(6-amino-9H-purin-9-yl)ethyloxy]methylphosphonate; Desmethyl Tenofovir Disoproxil; 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-, bis(1-methylethyl) ester, 5-oxide; ( ( (2- (6-amino-9H-purin-9-yl)ethoxy)methyl)phosphoryl)bis (oxy)bis (methylene) isopropyl dicarbonate; [2- (6-aminopurin-9-yl) ethoxymethyl- (isopropoxycarbonyloxymethoxy) phosphoryl]oxymethyl isopropyl carbonate; [[2-(6-Amino-9H-purine-9-yl)ethoxy]methyl]phosphonic acid bis[(isopropoxycarbonyloxy)methyl] ester. Grades: ≥95%. CAS No. 365417-53-4. Molecular formula: C18H28N5O10P. Mole weight: 505.42.
Emtricitabine Tenofovir Monosoproxil
Emtricitabine Tenofovir Monosoproxil is a derivative of Emtricitabine. Emtricitabine is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. Synonyms: ( ( ( ( ( (R)-1- (6- ( ( ( (5-Fluoro-1- ( (2R, 5S)-2- (hydroxymethyl)-1, 3-oxathiolan-5-yl)-2-oxo-1, 2-dihydropyrimidin-4-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl) (hydroxy)phosphoryl)oxy)methyl Isopropyl Carbonate. Grades: 95%. Molecular formula: C23H32FN8O10PS. Mole weight: 662.58.
Emtricitabine Tenofovir Monosoproxil Dimer
Emtricitabine Tenofovir Monosoproxil Dimer is a derivative of Emtricitabine. Emtricitabine is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Synonyms: ( ( ( ( ( (R)-1- (6- ( ( ( (5-Fluoro-1- ( (2R, 5S)-2- (hydroxymethyl)-1, 3-oxathiolan-5-yl)-2-oxo-1, 2-dihydropyrimidin-4-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl) (hydroxy)phosphoryl)oxy)methyl Isopropyl Carbonate. Grades: > 95%. Molecular formula: C23H32FN8O10PS. Mole weight: 662.60.
GS-7340 fumarate
Tenofovir alafenamide fumarate, also known as Tenofovir alafenamide hemifumarate; TAF, GS-7340, is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir. It is under development by Gilead Sciences for use in the treatment of HIV infection. Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate (Viread), Tenofovir alafenamide has greater antiviral activity and better distribution into lymphoid tissues than that agent. Gilead has announced a phase 3 clinical trial evaluating a single-tablet regimen combining GS-7340 with cobicistat, emtricitabine and elvitegravir and plans to coformulate the drug with cobicistat, emtricitabine and the protease inhibitor darunavir. In a 48 week study comparing Elvitegravir / cobicistat / emtricitabine / tenofovir disoproxil fumarate to elvitegravir / cobicistat / emtricitabine / tenofovir alafenamide fumarate, the results showed the prodrug to be non inferior to the established agent, but at much lower dosages and with lower incidence of adverse side effects such as impaired kidney function. Synonyms: GS-7340 fumarate; GS 7340 fumarate; GS7340 fumarate; (S)-isopropyl 2- ( ( (S)- ( ( ( (R)-1- (6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl) (phenoxy)phosphoryl)amino)propanoate fumarate; TAF; GS734; GS-734; GS 7340; Tenofovir alafenamide fumarate; trade name: Genvoya. Grades: >98%. CAS No. 379270-38-9. Molecular formula: C25H33N6O9P. Mole weight: 592.54.
rac-Tenofovir Disoproxil Related Compound G Fumarate
rac-Tenofovir Disoproxil Related Compound G Fumarate is an impurity of Tenofovir Disoproxil Fumarate, which is a potent reverse transcriptase inhibitor used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. Synonyms: 2,4,7-Trioxa-5-phosphanonanoic acid, 9-(6-amino-9H-purin-9-yl)-8-methyl-5-(1-methylethoxy)-, 1-methylethyl ester, 5-oxide, (2E)-2-butenedioate (1:1); O-(Isopropoxycarbonyloxymethyl)-O-isopropyl-{[1-(6-amino-9H-purin-9-yl)propan-2-yloxy]}methylphosphonate fumarate salt; ( ( ( ( (1- (6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl) (isopropoxy)phosphoryl)oxy)methyl isopropyl carbonate fumarate; rac-Mono-POC Isopropyl Tenofovir fumarate. Grades: ≥95%. Molecular formula: C17H28N5O7P.C4H4O4. Mole weight: 561.49.
Tenofovir Alafenamide
Tenofovir Alafenamide is a prodrug of Tenofovir, which is a reverse transcriptase inhibitor used to treat HIV and Hepatitis B. Antiviral. Synonyms: (S)-isopropyl 2- ( ( (S) - ( ( ( (R) -1- (6-amino-9H-purin-9-yl) propan-2-yl) oxy) methyl) (phenoxy) phosphoryl) amino) propanoate; GS7340; GS-7340; GS 7340; Tenofovir alafenamide. Grades: >98%. CAS No. 379270-37-8. Molecular formula: C21H29N6O5P. Mole weight: 476.47.
Tenofovir alafenamide hemifumarate
Tenofovir alafenamide hemifumarate, also known as Tenofovir alafenamide fumarate (2:1), is a nucleotide reverse transcriptase inhibitor (NRTIs) and a novel prodrug of tenofovir. By blocking reverse transcriptase, TAF prevents HIV from multiplying and can reduce the amount of HIV in the body. Synonyms: Isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate hemifumarate; TAF; GS734; GS-734; GS 734; GS 7340; GS-7340; GS7340; Tenofovir alafenamide fumarate (2:1). Grades: > 98%. CAS No. 1392275-56-7. Molecular formula: C46H62N12O14P2. Mole weight: 1069.02.
Tenofovir Disoproxil Related Compound G Fumarate
Tenofovir Disoproxil Related Compound G Fumarate is an impurity of Tenofovir Disoproxil Fumarate, which is a potent reverse transcriptase inhibitor used to treat chronic hepatitis B and to prevent and treat HIV/AIDS. Synonyms: 2,4,7-Trioxa-5-phosphanonanoic acid, 9-(6-amino-9H-purin-9-yl)-8-methyl-5-(1-methylethoxy)-, 1-methylethyl ester, 5-oxide, (8R)-, (2E)-2-butenedioate (1:1); O-(Isopropoxycarbonyloxymethyl)-O-isopropyl-{(R)-[1-(6-amino-9H-purin-9-yl)propan-2-yloxy]}methylphosphonate fumarate salt; ( ( ( ( ( (R)-1- (6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl) (isopropoxy)phosphoryl)oxy)methyl isopropyl carbonate fumarate; Mono-POC Isopropyl Tenofovir fumarate. Grades: ≥95%. CAS No. 1422284-15-8. Molecular formula: C17H28N5O7P.C4H4O4. Mole weight: 561.48.
Tenofovir Related Compound 8
One impurity of Tenofovir, which is an acyclic phosphonate nucleotide derivative, could be used in antiviral treatment as an everse transcriptase inhibitor. Synonyms: Tenofovir Bis(L-alanine Isopropyl Ester) Amide. Grades: > 95%. CAS No. 1883563-86-7. Molecular formula: C21H36N7O6P. Mole weight: 513.54.
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