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Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. Alternative Names: Isoproterenol hydrochloride. CAS No. 51-30-9. Pack Sizes: 10 mM * 1 mL; 200 mg; 1 g. Product ID: HY-B0468.
(±)-Nebivolol-d4 is intended for use as an internal standard for the quantification of nebivolol by GC- or LC-MS. Nebivolol is a potent and selective β1-adrenergic receptor (β1-AR) antagonist (IC50s = 7.41 and 251 nM for β1- and β2-ARs, respectively, in a radioligand binding assay using rabbit lung membrane preparations). It is also selective for β1-ARs over serotonin 5-HT1A and 5-HT2, α1- and α2-adrenergic, histamine H1, and dopamine D2 receptors (IC50s = 27.5 and 2,239, 3,162 and >10,000, 5,623, and 10,000 nM, respectively). Nebivolol inhibits cAMP accumulation induced by norepinephrine in primary rat cardiac cells (IC50 = 22 nM) and induces vasodilation in mouse renal arteries via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 μM). It decreases contraction of isolated human left ventricular trabeculae induced by isoproterenol (IC50 = 7.0 μM) but does not exert intrinsic sympathomimetic activity (ISA). Nebivolol inhibits proliferation of human coronary artery smooth muscle cells (HCASMCs) in the presence and absence of growth factors (IC50s = 6.1, 6.8, 6.4, and 7.7 μM for HCASMCs grown in media containing no growth factor, PDGFBB, basic FGF, and TGF-β1, respectively). Formulations containing nebivolol have been used to treat hypertension. Synonyms: (S,R,R,R)-Nebivolol-d4 Hydrochloride; (1R)-2,2-dideuterio-2-[[(2R)-1,1-dideuterio-2-[(2S)-6-fluo
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