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ARS-1323 is an inhibitor of mutant K-ras G12C. Synonyms: ARS-1323; ARS 1323; ARS1323; 6-[6-chloro-8-fluoro-4-(4-prop-2-enoylpiperazin-1-yl)-1H-quinazolin-7-ylidene]-5-fluorocyclohexa-2,4-dien-1-one. CAS No. 1698024-73-5. Molecular formula: C21H17ClF2N4O2. Mole weight: 430.84.
ARS-1630
ARS-1630 is the R-enantiomer of ARS-1620. It is an inhibitor of mutant K-ras G12C. Synonyms: ARS-1630; ARS 1630; ARS1630; (R)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one. CAS No. 1698055-86-5. Molecular formula: C21H17ClF2N4O2. Mole weight: 430.84.
KRpep-2d
KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide that has the potential as the treatment of cancers expressing K-Ras(G12C) mutant. Synonyms: s8499. Molecular formula: C108H182N44O25S2. Mole weight: 2561.01.
MDK30165
MDK30165, also known as K-Ras(G12C) Inhibitor 6, is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro. This compound has potential therapeutic application for diseases related to Ras signaling. Synonyms: N-(1-(2-(2,4-dichlorophenoxy)acetyl)piperidin-4-yl)-4-mercaptobutanamide; K-Ras(G12C) Inhibitor 6; MDK30165; MDK-30165; MDK 30165. CAS No. 2060530-16-5. Molecular formula: C17H22Cl2N2O3S. Mole weight: 405.33.
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