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| Product | Description | |
|---|---|---|
| L-Iduronic acid-[1,6-13C2] | L-Iduronic acid-[1,6-13C2] is a valuable biochemical utilized in the biomedical industry for its role in synthesizing drugs used to study diseases related to abnormal glycosaminoglycan metabolism. Its isotopic label, 13C2, aids in research and drug development, facilitating accurate tracing and analysis of metabolic pathways. Synonyms: L-Iduronic acid-1,6-13C2; (1,6-13C2)L-Iduronic acid; Aldehydo-L-iduronic acid-1,6-13C2. Grade: ≥97%; 99% atom 13C. Molecular formula: C4[13C]2H10O7. Mole weight: 196.13. |  |
| 4-Methylumbelliferyl a-L-idopyranosiduronic acid cyclohexylammonium salt | 4-Methylumbelliferyl a-L-idopyranosiduronic acid cyclohexylammonium salt is a key compound used in the biomedical industry for studying lysosomal storage diseases. It serves as a substrate to measure the activity of iduronate-2-sulfatase, an enzyme involved in the degradation of glycosaminoglycans. This product enables precise and sensitive detection of enzyme deficiencies related to Hurler, Hunter, and Sanfilippo syndromes, facilitating disease diagnosis and treatment monitoring. Synonyms: 4-Methylumbelliferyl a-L-iduronic acid cyclohexylammonium salt; 4-MU-a-L-ldoA CHX; Cyclohexanamine (2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)tetrahydro-2H-pyran-2-carboxylate; (4-Methylumbelliferyl)-α-L-iduronide cyclohexylammonium salt; α-L-Idopyranosiduronic acid, 4-methyl-2-oxo-2H-1-benzopyran-7-yl, compd. with cyclohexanamine (1:1). CAS No. 66895-33-8. Molecular formula: C16H16O9.C6H13N. Mole weight: 451.47. | |
| 4-Methylumbelliferyl a-L-idopyranosiduronic acid sodium salt | It is a fluorogenic substrate in the assay of a-L-Iduronidase. Synonyms: Sodium (4-methylumbelliferyl a-L-idopyranosid)uronate; 4-Methylumbelliferyl α-L-Iduronic Acid, Sodium Salt; Sodium 4-methyl-2-oxo-2H-chromen-7-yl α-L-idopyranosiduronate; 2H-1-Benzopyran-2-one, 7-(α-L-idopyranuronosyloxy)-4-methyl-, sodium salt (1:1). Grade: ≥95%. CAS No. 89157-94-8. Molecular formula: C16H15NaO9. Mole weight: 374.27. | |
| α-L-Iduronidase from Human, Recombinant | This enzyme catalyses the hydrolysis of unsulfated α-L-iduronosidic linkages in dermatan sulfate. In lysosomal degradation process α-L-Iduronidase plays a crucial role. It hydrolyzes the non-reducing terminal α-L-iduronic acid residues in GAGs, including dermatan sulfate and heparan sulfate. It is involved in the degeneration of glycosaminoglycans such as dermatan sulfate and heparan sulfate. It is found in the lysosomes of cells. Applications: Α-l-iduronidase may be used for leukocyte assay in the study of a-l-iduronidase deficiency in new born. Group: Enzymes. Synonyms: Iduronidase; EC 3.2.1.76; L-iduronidase; alpha-L-iduronidase); glycosaminoglycan alpha-L-iduronohydrolase; IDUA; α-L-Iduronidase. Enzyme Commission Number: EC 3.2.1.76. IDUA. Mole weight: 71 kDa. Activity: >7,500 units/μg protein. Storage: Store at -20°C. Form: Supplied as a solution in 40 mM sodium acetate , 400 mM NaCl and 20% (v/v) glycerol, pH 5.0. Source: Mouse NSO cells. Species: Human. Iduronidase; EC 3.2.1.76; L-iduronidase; alpha-L-iduronidase); glycosaminoglycan alpha-L-iduronohydrolase; IDUA; α-L-Iduronidase. Cat No: NATE-0930. |  |
| Iduronic acid | L-Iduronic acid is a crucial component in the biomedical industry used for various purposes. It is commonly employed in the synthesis of dermatan sulfate, a polysaccharide found in connective tissues. Additionally, L-Iduronic acid is utilized in the production of heparan sulfate, a glycosaminoglycan involved in different biological processes. Synonyms: d-iduronic acid; 3402-98-0; Iduronic acid, D-; (2S,3R,4R,5S)-2,3,4,5-tetrahydroxy-6-oxohexanoic acid; F5HD8XQ3DP; 8DWF4HK64B; 21675-53-6; UNII-F5HD8XQ3DP; UNII-8DWF4HK64B; IDURONIC ACID, DL-; SCHEMBL147158; DTXSID90187632; IAJILQKETJEXLJ-LECHCGJUSA-N; Q418846; W-202387. Grade: ≥95%. CAS No. 3402-98-0. Molecular formula: C6H10O7. Mole weight: 194.14. | |
| unsaturated chondroitin disaccharide hydrolase | The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1?3) and (1?4) bonds. It prefers the sulfated disaccharides to the unsulfated disaccharides. Group: Enzymes. Synonyms: UGL (ambiguous); unsaturated glucuronyl hydrolase (ambiguous). Enzyme Commission Number: EC 3.2.1.180. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3864; unsaturated chondroitin disaccharide hydrolase; EC 3.2.1.180; UGL (ambiguous); unsaturated glucuronyl hydrolase (ambiguous). Cat No: EXWM-3864. | |
| 1,2-O-Isopropylidene-b-L-idofuranosylurono-6,3-lactone | 1,2-O-Isopropylidene-b-L-idofuranosylurono-6,3-lactone is a multifunctional biomedical compound extensively investigated for its therapeutic potential across a wide range of ailments. Synonyms: L-Iduronolactone acetonide; β-L-Idofuranuronic acid, 1,2-O-(1-methylethylidene)-, γ-lactone; 1,2-O-(1-Methylethylidene)-β-L-idofuranuronic acid γ-lactone; Idofuranuronic acid, 1,2-O-isopropylidene-, γ-lactone, β-L-; 1,2-O-Isopropylidene-b-L-idofuranuronic acid g-lactone; 1,2-O-Isopropylidene-β-L-idofuranuronic acid γ-lactone. CAS No. 29514-28-1. Molecular formula: C9H12O6. Mole weight: 216.19. | |
| 4-Methylumbelliferyl 1,2-O-(dibutylsulfane)-α-L-idopyranuronic acid methyl ester | As an intermediate used in the synthesis of 4-Methylumbelliferyl α-L-Idopyranosiduronic Acid 2-Sulfate Disodium Salt, 4-Methylumbelliferyl 1,2-O-(dibutylsulfane)-α-L-Idopyranuronic Acid Methyl Ester is a fluorogenic substrate in the assay of α-L-Iduronidase. A fluorimetric enzyme assay for the diagnosis of MPS II (Hunter disease). Molecular formula: C25H34O9S. Mole weight: 510.60. | |
| 4-Methylumbelliferyl a-L-idopyranosiduronic acid 2-sulphate disodium salt | 4-Methylumbelliferyl-α-L-iduronide 2-sulfate (4-MU-α-IdoA 2-sulfate) is a fluorogenic substrate for α-L-iduronidase that has been used in an assay to detect Hurler syndrome. It is also a substrate for iduronate-2-sulfatase that can be used for diagnosis of Hunter disease (MPS II). Synonyms: 4-Methylumbelliferyl-α-L-Idopyranosiduronic Acid 2-sulfate disodium salt; 4-MU-α-IdoA 2-sulfate disodium salt; (2R,3S,4S,5R,6S)-3,4-dihydroxy-6-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)-5-(sulfonatooxy)tetrahydro-2H-pyran-2-carboxylate disodium salt. Grade: ≥98%. CAS No. 1045020-74-3. Molecular formula: C16H14Na2O12S. Mole weight: 476.3. | |
| 4-Methylumbelliferyl a-L-iduronide | It is a fluorogenic substrate for α-L-iduronidase. Synonyms: 4-methyl-2-oxo-2H-1-benzopyran-7-yl α-L-idopyranosiduronic acid; 4-Methylumbelliferyl-α-L-Idopyranosiduronic Acid; 4-MU-α-IdoA; MU-α-IdoA?. Grade: ≥90%. CAS No. 66966-09-4. Molecular formula: C16H16O9. Mole weight: 352.29. | |
| L-iduronidase | Iduronidase (EC 3.2.1.76, L-iduronidase, alpha-L-iduronidase, laronidase) is an enzyme with the systematic name glycosaminoglycan alpha-L-iduronohydrolase. This enzyme catalyses the hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate.It is a glycoprotein enzyme found in the lysosomes of cells. It is involved in the degeneration of glycosaminoglycans such as dermatan sulfate and heparan sulfate. The enzyme acts by hydrolyzing the terminal alpha-L-induronic acid residues of these molecules, degrading them. The protein is reported as having a mass of approximately 83 kilodaltons. Group: Enzymes. Synonyms: α-L-iduronidase. Enzyme Commission Number: EC 3.2.1.76. CAS No. 9073-56-7. IDUA. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3940; L-iduronidase; EC 3.2.1.76; 9073-56-7; α-L-iduronidase. Cat No: EXWM-3940. | |
| Native Proteus vulgaris Chondroitinase ABC | Chondroitinase ABC catalyzes the eliminative degradation of polysaccharides containing (1-4)-β-D-hexosaminyl and (1-3)-β-D-glucuronosyl or (1-3)-α-L-iduronosyl linkages to disaccharides containing 4-deoxy-β-D-gluc-4-enuronosyl groups. It acts on chondroitin 4-sulfate, chondroitin 6-sulfate, and dermatan sulfate, and acts slowly on hyaluronate. The molecular weight is found to be approximately 120 kDa with 2 non-identical subunits of molecular masses 86 kDa and 32 kDa. The pH optimum is found to be 8.0 with chondroitin sulfate and 6.8 with hyaluronic acid and tempeRature optimum is 37°C. 1 mM Zn2+ acts as an inhibitor, while 0.05 M acetate is an activ...BC lyase; ChS ABC lyase; chondroitin sulfate ABC endoeliminase; chondroitin sulfate ABC endolyase; ChS ABC lyase I; 9024-13-9. Enzyme Commission Number: EC 4.2.2.4. CAS No. 9024-13-9. Chondroitinase ABC. Activity: 50-250 units/mg protein (using chondroitin sulfate C as substrate); 0.3-3 units/mg solid (using chondroitin sulfate C as substrate). Storage: -20°C. Form: lyophilized powder. Source: Proteus vulgaris. EC 4.2.2.4, chondroitinase; chondroitin ABC eliminase; chondroitinase ABC; chondroitin ABC lyase; chondroitin sulfate ABC lyase; ChS ABC lyase; chondroitin sulfate ABC endoeliminase; chondroitin sulfate ABC endolyase; ChS ABC lyase I; 9024-13-9. Cat No: NATE-0131. | |
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