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| Product | Description | |
|---|---|---|
| Lactacystin | Cell-permeable. A potent and selective inhibitor of the 20S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic beta-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin- like activities. Induces neurite outgrowth in Neuro 2A neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-kB activation (IC50 = 10uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 133343-34-7. Pack Sizes: 200ug. US Biological Life Sciences. |  Worldwide |
| Lactacystin | Lactacystin is a microbial metabolite isolated from streptomyces. It is a 20S proteasome inhibitor. Synonyms: (2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-2-pyrrolidinecarboxy-N-acetyl-L-cysteine thioester. Grades: ≥95%. CAS No. 133343-34-7. Molecular formula: C15H24N2O7S. Mole weight: 376.42. |  |
| Clasto-lactacystin (beta-Clastolactacystin, Clasto-lactacystin b-Lactone, Omuralide) | Cell-permeable. A highly specific, potent and irreversible proteasome inhibitor. Lactacystin acts as a precursor for clasto-lactacystin beta-lactone and the latter compound is at least 10 times more active than the parent Lactacystin. Group: Biochemicals. Grades: Highly Purified. CAS No. 154226-60-5. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| clasto-Lactacystin β-lactone | Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces , acts as an irreversible 20S proteasome inhibitor. Uses: Scientific research. Group: Natural products. Alternative Names: Omuralide; β-Clastolactacystin. CAS No. 154226-60-5. Pack Sizes: 50 μg (2.34 mM * 100 μL in Methyl acetate). Product ID: HY-108549. |  |
| Clasto-Lactacystin β-lactone | Clasto-Lactacystin β-lactone is a microbial metabolite isolated from Streptomyces that is now widely used as a selective inhibitor of the 20S proteasome. Clasto-lactacystin β-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive β-lactone. It is 20-fold more potent than Lactacystin. Synonyms: β-Clastolactacystin; Omuralide. Grades: ≥95%. CAS No. 154226-60-5. Molecular formula: C10H15NO4. Mole weight: 213.23. | |
| Clasto-Lactacystin beta-lactone (Omuralide) | In vitro lactacystin does not react with the proteasome. It rather undergoes a spontaneous conversion (lactonization) to the active metabolite clasto-lactacystin beta-lactone. Potent and selective irreversible and cell permeable proteasome inhibitor. Inhibits the chymotrypsin-like, trypsin-like and caspase-like peptidase activity of the proteasome. The active metabolite of lactacystin with higher potency since it does not require hydrolysis in order to become cell permeable. Calpain and cathepsin inhibitor. Apoptosis inducer. Anticancer compound. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Induces neuritogenesis. Autophagy inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 154226-60-5. Pack Sizes: 100ug. Molecular Formula: C10H15NO4, Molecular Weight: 213.2. US Biological Life Sciences. | Worldwide |
| Clasto-lactacystin (Clasto-lactacystin b-Lactone, Omuralide) | A cell permeable, irreversible proteasome inhibitor. It is 20-fold more p. Group: Biochemicals. Alternative Names: Clasto-lactacystin b-Lactone, Omuralide. Grades: Highly Purified. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Clasto-lactacystin(omuralide) | Clasto-lactacystin (omuralide). Group: Biochemicals. Alternative Names: (1R, 4R, 5S)-1-[(1S)-1-Hydroxy-2-methylpropyl]-4-methyl-6-oxa-2-azabicyclo[3. 2. 0]heptane-3, 7-dione; Clasto-lactacystin b-lactone; Omuralide. Grades: Highly Purified. CAS No. 154226-60-5. Pack Sizes: 1mg. Molecular Formula: C10H15NO4. US Biological Life Sciences. | Worldwide |
| (+)-Lactacystin | (+)-Lactacystin. Group: Biochemicals. Alternative Names: N-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-L-cysteine; Lactacystin. Grades: Highly Purified. CAS No. 133343-34-7. Pack Sizes: 1mg, 2mg. Molecular Formula: C15H24N2O7S. US Biological Life Sciences. | Worldwide |
| (+)-Lactacystin Allyl Ester (Lactacystin Allyl Ester) | (+)-Lactacystin Allyl Ester (Lactacystin Allyl Ester). Group: Biochemicals. Alternative Names: Lactacystin Allyl Ester. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (+)-Lactacystin (Lactacystin) | A selective and potent inhibitor of proteasome-mediated degradation of ubiquitin-tagged proteins. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP: multicatalytic proteinase complex). Group: Biochemicals. Alternative Names: Lactacystin. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Epoxomicin (BU-4061T, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N- [ (1S) -3-methyl-1 [ [ (2R) -2-methyloxiranyl] carbonyl] butyl] -L-threoninamide) | Originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity, Epoxomicin is a potent, cell-permeable, selective and irreversible proteasome inhibitor. More potent inhibitor of the chymotrypsin-like activity of the proteasome than Lactacystin. Blocks also trypsin-like and PGPH activities of the proteasome. Group: Biochemicals. Grades: Highly Purified. CAS No. 134381-21-8. Pack Sizes: 50ug, 250ug. US Biological Life Sciences. | Worldwide |
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