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| Product | Description | |
|---|---|---|
| Lapatinib | Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC 50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW572016; GW2016. CAS No. 231277-92-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-50898. |  |
| Lapatinib-13C2,15N | Labeled Lapatinib. Reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic. Group: Biochemicals. Alternative Names: N-[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]-6-[5-[[[2- (methylsulfonyl) ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine-13C2, 15N; GSK 572016-13C2,15N; GW 572016-13C2,15N; GW 572016X-13C2,15N. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| Lapatinib-13C2,15N Ditosylate | Labeled Lapatinib. Reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic. Group: Biochemicals. Alternative Names: N-[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]-6-[5-[[[2- (methylsulfonyl) ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine Bis (4-methyl Benzene sulfonate) -13C2, 15N Ditosylate; GW-572016F-13C2,15N; Tykerb-13C2,15N Ditosylate. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Lapatinib 2-Fluoro Impurity | Synonyms: Lapatinib 2-Fluoro Impurity; 3-Desfluoro 2-Fluoro Lapatinib; N- (3-Chloro-4- ( (2-fluorobenzyl) oxy) phenyl) -6- (5- ( ( (2- (methylsulfonyl) ethyl) amino) methyl) furan-2-yl) quinazolin-4-amine; N-[3-chloro-4-[ (2-fluorophenyl) methoxy]phenyl]-6-[5-[ (2-methylsulfonylethylamino) methyl]furan-2-yl]quinazolin-4-amine; N-[3-Chloro-4-[(2-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine; SCHEMBL11962955; AUSNUFCAWIGPSG-UHFFFAOYSA-N; N-{3-chloro-4-[ (2-fluorobenzyl) oxy]phenyl}-6-[5- ({[2- (methylsulfonyl) ethyl]amino}methyl) furan-2-yl]quinazoline-4-amine. Grades: > 95%. CAS No. 1393112-45-2. Molecular formula: C29H26ClFN4O4S. Mole weight: 581.07. |  |
| Lapatinib 4-Fluoro Impurity | Grades: > 95%. CAS No. 1026818-86-9. Molecular formula: C29H26ClFN4O4S. Mole weight: 581.07. | |
| Lapatinib-d7 ditosylate | Heterocyclic Organic Compound. Alternative Names: N-[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]-6-[5-[[[2- (methylsulfonyl) ethyl-d7]amino]methyl]-2-furanyl]-4-quinazolinamine Bis(4-methylbenzenesulfonate) Ditosylate; GW-572016F-d7 Ditosylate; Tykerb-d7 Ditosylate. CAS No. 1009307-24-7. Molecular formula: C43H35D7ClFN4O10S3. Mole weight: 932.5. Purity: 0.96. IUPACName: N-[3-chloro-4-[ (3-fluorophenyl) methoxy]phenyl]-6-[5-[[[1, 1, 2, 2-tetradeuterio-2- (trideuteriomethylsulfonyl) ethyl]amino]methyl]furan-2-yl]quinazolin-4-amine; 4-methylbenzenesulfonic acid. Canonical SMILES: CC1=CC=C (C=C1)S (=O) (=O)O. CS (=O) (=O)CCNCC1=CC=C (O1)C2=CC3=C (C=C2)N=CN=C3NC4=CC (=C (C=C4)OCC5=CC (=CC=C5)F)Cl. Catalog: ACM1009307247. |  |
| Lapatinib ditosylate | Lapatinib ditosylate (GW572016 ditosylate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC 50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW572016 ditosylate; GW2016 ditosylate. CAS No. 388082-77-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-50898A. | |
| Lapatinib Ditosylate | Lapatinib is a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. Uses: Antineoplastic agents. Synonyms: GW-572016; GW 572016; GW572016. Grades: >98%. CAS No. 388082-77-7. Molecular formula: C29H26ClFN4O4S.2C7H8O3S. Mole weight: 925.46. | |
| Lapatinib Ditosylate | Reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic. Group: Biochemicals. Alternative Names: N-[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]-6-[5-[[[2- (methylsulfonyl) ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine Bis (4-methyl Benzene sulfonate) Ditosylate; GW-572016F Ditosylate; Tykerb Ditosylate. Grades: Highly Purified. CAS No. 388082-77-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Lapatinib ditosylate monohydrate | 100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C29H26ClFN4O4S ·2(C7H8O3S) ·H2O. CAS No. 388082-78-8. Prepack ID 13289809-100mg. Molecular Weight 943.48. See USA prepack pricing. |  |
| Lapatinib ditosylate monohydrate | Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC 50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW572016 ditosylate monohydrate; GW2016 ditosylate monohydrate. CAS No. 388082-78-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-50898B. | |
| Lapatinib, Free Base | ATP-competitive EGFR & ErbB-2 dual tyrosine kinase inhibitor. Lapatinib is an ATP-competitive epidermal growth factor receptor (EGFR) and HER2/neu (ErbB-2) dual tyrosine kinase inhibitor, with IC(50) values of 10.8 and 9.2nm respectively. It is an orally active drug for treatment of breast cancer and other solid tumors. A free base form of Lapatinib Ditosylate. Lapatinib (as the di-p-toluenesulfonate salt) is the active ingredient in the drug sold under the trade names Tykerb in the US and Tyverb in Europe. This drug has been approved in at least one country to treat advanced metastatic breast cancer in conjunction with the chemotherapy drug Xeloda (generic name, capecitabine). Group: Biochemicals. Alternative Names: N-[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]-6-[5-[[[2- (methylsulfonyl) ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine, GSK 572016, GW-572016, GW 572016X, Tykerb, Tyverb. Grades: Highly Purified. CAS No. 231277-92-2. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Lapatinib Hydroxylamine | a complex used in human metabolism of lapatinib which is a dual kinase inhibitor. Synonyms: N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[hydroxy[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine. Grades: > 95%. CAS No. 1360431-86-2. Molecular formula: C29H26ClFN4O5S. Mole weight: 597.07. | |
| Lapatinib Impurity 1 | Lapatinib Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 202197-26-0. Molecular Formula: C13H11ClFNO. Mole Weight: 251.69. Catalog: APB202197260. |  |
| Lapatinib Impurity 10 | Lapatinib Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1393112-45-2. Molecular Formula: C29H26ClFN4O4S. Mole Weight: 581.06. Catalog: APB1393112452. | |
| Lapatinib Impurity 10 | Synonyms: UNII-2T859UZJ2V; Lapatinib IMpurity 10; 1152131-73-1; Lapatinib metabolite M12; 2T859UZJ2V; 5- (4- ( (3-Chloro-4- ( (3-fluorobenzyl) oxy) phenyl) amino) quinazolin-6-yl) furan-2-carboxylic acid; 2-Furancarboxylic acid, 5-(4-((3-chloro-4-((3-fluorophenyl)methoxy)phenyl)amino)-6-quinazolinyl)-; 5-(4-((3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)amino)-6-quinazolinyl)-2-furancarboxylic acid; 5-[4-[3-chloro-4-[ (3-fluorophenyl) methoxy]anilino]quinazolin-6-yl]furan-2-carboxylic acid; SCHEMBL3713537; CHEMBL3526263; ALLDUFLYKPDTCS-UHFFFAOYSA-N; N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-(5-carboxy-2-furyl)-4-quinazolinamine. Grades: > 95%. CAS No. 1152131-73-1. Molecular formula: C26H17ClFN3O4. Mole weight: 489.89. | |
| Lapatinib Impurity 11 | Grades: > 95%. Molecular formula: C55H43Cl2F2N7O6S. Mole weight: 1038.97. | |
| Lapatinib Impurity 11 | Lapatinib Impurity 11. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C55H43Cl2F2N7O6S. Mole Weight: 1038.95. Catalog: APB10712. | |
| Lapatinib Impurity 12 | Grades: > 95%. Molecular formula: C29H27FN4O4S. Mole weight: 546.63. | |
| Lapatinib Impurity 13 | Grades: > 95%. Molecular formula: C29H24ClFN4O4S. Mole weight: 579.05. | |
| Lapatinib Impurity 15 | Lapatinib Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 179246-45-8. Molecular Formula: C13H11ClFNO. Mole Weight: 251.69. Catalog: APB179246458. | |
| Lapatinib Impurity 1 (O-De(3-fluorobenzyl) Lapatinib) | Synonyms: 2-Chloro-4-[[6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinyl]amino]phenol. Grades: > 95%. CAS No. 1268997-70-1. Molecular formula: C22H21ClN4O4S. Mole weight: 472.95. | |
| Lapatinib Impurity 1 (O-De(3-fluorobenzyl) Lapatinib) Ditosylate Salt | Synonyms: 2-Chloro-4-[[6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinyl]amino]phenol Ditosylate Salt. Grades: > 95%. Molecular formula: C36H37ClN4O10S3. Mole weight: 817.35. | |
| Lapatinib Impurity 2 | Grades: > 95%. Molecular formula: C29H24ClFN4O4S. Mole weight: 579.05. | |
| Lapatinib Impurity 2 | Lapatinib Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C13H5D6ClFNO. Mole Weight: 257.72. Catalog: APB10711. | |
| Lapatinib Impurity 23 | Lapatinib Impurity 23. Uses: For analytical and research use. Group: Impurity standards. CAS No. 202197-27-1. Molecular Formula: C13H11ClFNO. Mole Weight: 251.69. Catalog: APB202197271. | |
| Lapatinib Impurity 26 | Lapatinib Impurity 26. Uses: For analytical and research use. Group: Impurity standards. CAS No. 179246-44-7. Molecular Formula: C13H9ClFNO3. Mole Weight: 281.67. Catalog: APB179246447. | |
| Lapatinib Impurity 3 | A reactive metabolite of Lapatinib. Synonyms: N-De[2-(methylsulfonyl)ethyl] Lapatinib; 6-[5-(Aminomethyl)-2-furanyl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-4-quinazolinamine. Grades: > 95%. CAS No. 697299-82-4. Molecular formula: C26H20ClFN4O2. Mole weight: 474.93. | |
| Lapatinib Impurity 3 | Lapatinib Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 320337-10-8. Molecular Formula: C31H30ClFN4O4S. Mole Weight: 609.11. Catalog: APB320337108. | |
| Lapatinib Impurity 4 | Lapatinib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 633370-23-7. Molecular Formula: C29H27FN4O4S. Mole Weight: 546.62. Catalog: APB633370237. | |
| Lapatinib impurity 5 | Lapatinib impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 231278-84-5. Molecular Formula: C26H17ClFN3O3. Mole Weight: 473.89. Catalog: APB231278845. | |
| Lapatinib impurity 7 | Lapatinib impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1360431-86-2. Molecular Formula: C29H26ClFN4O5S. Mole Weight: 597.06. Catalog: APB1360431862. | |
| Lapatinib Impurity 8 | A reactive metabolite of Lapatinib. Synonyms: 6-[5-(hydroxymethyl)-2-furanyl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-4-quinazolinamine. Grades: > 95%. Molecular formula: C26H19ClFN3O3. Mole weight: 475.91. | |
| Lapatinib Impurity 8 | Lapatinib Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 231277-91-1. Molecular Formula: C29H27ClN4O4S. Mole Weight: 563.07. Catalog: APB231277911. | |
| Lapatinib Impurity 9 | Cas No. 231278-84-5. | |
| Lapatinib Impurity 9 | Lapatinib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 320337-48-2. Molecular Formula: C26H19ClFN3O3. Mole Weight: 475.9. Catalog: APB320337482. | |
| N-De[2-(methylsulfonyl)ethyl] lapatinib | N-De[2-(methylsulfonyl)ethyl] lapatinib. Group: Biochemicals. Alternative Names: 6-[5- (Aminomethyl) -2-furanyl]-N-[3-chloro-4-[ (3-fluorophenyl) methoxy]phenyl]-4-quinazolinamine; [6- (5-Aminomethylfuran-2-yl) quinazolin-4-yl][3-chloro-4- (3-fluorobenzyloxy) phenyl]amine. Grades: Highly Purified. CAS No. 697299-82-4. Pack Sizes: 2mg, 5mg, 10mg. Molecular Formula: C26H20ClFN4O2. US Biological Life Sciences. | Worldwide |
| O-De(3-fluorobenzyl) lapatinib | O-De(3-fluorobenzyl) lapatinib. Group: Biochemicals. Alternative Names: 2-Chloro-4- [ [6- [5- [ [ [2- (methylsulfonyl) ethyl] amino] methyl] -2-furanyl] -4-quinazolinyl] amino] phenol. Grades: Highly Purified. CAS No. 1268997-70-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C22H21ClN4O4S. US Biological Life Sciences. | Worldwide |
| O-De(3-fluorobenzyl) Lapatinib Ditosylate Salt | A reactive metabolite of Lapatinib which is associated with various drug toxicities. Lapatinib is metabolized mainly by P450 3A4 to form O- and N-dealkylated metabolites. Group: Biochemicals. Alternative Names: 2-Chloro-4- [ [6- [5- [ [ [2- (methylsulfonyl) ethyl] amino] methyl] -2-furanyl] -4-quinazolinyl] amino] phenol Ditosylate. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 2- (Methylsulfinyl) ethylamine Hydrochloride | 2- (Methylsulfinyl) ethylamine Hydrochloride is used as a reagent in the synthesis of the lapatinib analog L-2 (selatinib) which is a potent dual EGFR/HER-2 inhibitor for the treatment of cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 60501-55-5. Pack Sizes: 1g, 2.5g. Molecular Formula: C3H10ClNOS, Molecular Weight: 143.639999999999. US Biological Life Sciences. | Worldwide |
| [2- (Methylsulfonyl) ethyl]carbamic Acid-13C2,15N Benzyl Ester | Intermediate in the production of labeled Lapatinib. Group: Biochemicals. Alternative Names: [2- (Methylsulfonyl) ethyl]carbamic Acid-13C2,15N Phenylmethyl Ester. Grades: Highly Purified. CAS No. 1215476-69-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 3-Chloro-4- (3-fluorobenzyloxy) aniline | 3-Chloro-4- (3-fluorobenzyloxy) aniline is an intermediate in the synthesis of Lapatinib. Group: Biochemicals. Alternative Names: 3-Chloro-4-[ (3-fluorophenyl) methoxy]benzenamine; 3-Chloro-4-[ (3-fluorobenzyl) oxy]aniline; 3-Chloro-4-[ (3-fluorophenyl) methoxy]aniline; 4-(3-Fluorobenzyloxy)-3-chloroaniline; [3-Chloro-4- (3-fluorobenzyloxy) phenyl]amine. Grades: Highly Purified. CAS No. 202197-26-0. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 4-Chloro-6-iodoquinazoline | 4-Chloro-6-iodoquinazoline is an intermediate in the synthesis of Lapatinib. Group: Biochemicals. Alternative Names: 6-Iodo-4-chloroquinazoline. Grades: Highly Purified. CAS No. 98556-31-1. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 5-[4-[[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]amino]-6-quinazolinyl]-2-furancarboxaldehyde | Lapatinib intermediate. Group: Biochemicals. Alternative Names: [5-[4-[4-[(3-Fluorobenzyl)oxy]-3-chloroanilino]-6-quinazolinyl]-2-furancarboxaldehyde. Grades: Highly Purified. CAS No. 231278-84-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 6-Iodoquinazolin-4-one | 6-Iodoquinazolin-4-one is an intermediate in the synthesis of Lapatinib. Group: Biochemicals. Alternative Names: 6-Iodo-4(3H)-quinazolinone; 6-Iodo-4(1H)-quinazolinone; 6-Iodo-4-quinazolinol; 6-Iodo-1H-quinazolin-4-one; 6-Iodo-3,4-dihydroquinazolin-4-one; 6-Iodo-3H-quinazolin-4-one; 6-Iodo-4(3H)-quinazolinone; 6-Iodo-4-quinazolone; 6-Iodoquinazolin-4-ol. Grades: Highly Purified. CAS No. 16064-08-7. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| N-[3-Chloro-4-[ (3-fluorobenzyl) oxy]phenyl]-6-iodoquinazolin-4-amine | Lapatinib intermediate. Group: Biochemicals. Alternative Names: N-[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]-6-iodo-4-quinazolinamine; 6-Iodo-4-[3-chloro-4- (3-fluorobenzyloxy) anilino]quinazoline. Grades: Highly Purified. CAS No. 231278-20-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| N-[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]-6-[5-[[2- ( (1-Oxyl-2, 2, 5, 5-tetramethylpyrroline-3-yl) carbamido) ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine | N-[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]-6-[5-[[2- ( (1-Oxyl-2, 2, 5, 5-tetramethylpyrroline-3-yl) carbamido) ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine. Group: Biochemicals. Alternative Names: Demethylsulfonyl Lapatinib 1-Oxyl-2,2,5,5-tetramethyl-Æ3-pyrroline deriv. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C37H37ClFN6O4, Molecular Weight: 684.18. US Biological Life Sciences. | Worldwide |
| N- (Benzyloxycarbonyl) ethanolamine-13C2, 15N | Intermediate in the production of labeled Lapatinib. Group: Biochemicals. Alternative Names: N-(2-Hydroxyethyl)carbamic Acid Phenylmethyl Ester-13C2,15N; (2-Hydroxyethyl)carbamic Acid Benzyl Ester-13C2,15N; 2- (Benzyl oxycarbonyl amino) ethanol-13C2, 15N. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Selatinib | Selatinib is a Epidermal growth factor receptor(EGFR) and ERbB-2 receptor antagonist as an analog of the quinazoline lapatinib with potential antineoplastic activity originated by Qilu Pharmaceutical. Upon administration, selatinib reversibly blocks phosphorylation of both EGFR and ErbB-2 and this leads to suppress tumor growth in EGFR/ErbB-2-overexpressing tumor cells. Treatment for lung cancer and breast cancer is in Phase I clinical trials in China. Uses: Lung cancer and breast cancer. Synonyms: UNII-6TLR8U8O3C; N- (3-chloro-4- ( (3-fluorobenzyl) oxy) phenyl) -6- (5- ( ( (2- (methylsulfinyl) ethyl) amino) methyl) furan-2-yl) quinazolin-4-amine. Grades: 98%. CAS No. 1275595-86-2. Molecular formula: C29H26ClFN4O3S. Mole weight: 565.07. | |
| SJF-1521 | SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 contains the EGFR inhibitor lapatinib (HY-50898). SJF-1521 can induce EGFR degradation in OVCAR8 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2230821-40-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131865. | |
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