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100g Pack Size. Group: Building Blocks, Inorganic Chemicals. Formula: PbCrO4. CAS No. 7758-97-6. Prepack ID 65303641-100g. Molecular Weight 323.19. See USA prepack pricing.
Lead(II) Chromate
Lead(II) Chromate is generally used as a pigment or dye in compositions. Dsplays a bright yellow color. Group: Biochemicals. Grades: Highly Purified. CAS No. 7758-97-6. Pack Sizes: 5g, 10g. Molecular Formula: CrO4Pb, Molecular Weight: 323.19. US Biological Life Sciences.
Worldwide
4SC-202 Tosylate
4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones.This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins. Synonyms: 4SC-202; 4SC 202; 4SC202. Grades: 0.98. CAS No. 1186222-89-8. Molecular formula: C30H29N5O6S2. Mole weight: 619.711.
Chidamide
Chidamide, also known as CS055 and HBI-8000, is an orally bioavailable benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Chidamide selectively binds to and inhibits HDAC leading to an increase of acetylation levels of histone protein H3. This agent also inhibits the expression of signaling kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, a class of enzymes that deacetylate chromatin histone proteins, are upregulated in many tumor types and play key roles in gene expression. Compared to some other benzamide type HDAC inhibitors, chidamide is more stable, more resistant to degradation and has a longer half-life. Synonyms: CS055; CS-055; CS 055; HBI-8000; HBI 8000; HBI8000; N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide. CAS No. 743420-02-2. Molecular formula: C22H19FN4O2. Mole weight: 390.418.
Etoposide, 95.0-105.0% (HPLC) USP
Potent anti-cancer compound. Induces apoptosis in normal and tumor cell lines. DNA Topoisomerase II activity inhibitor. Increases Topo II-mediated DNA breakage primarily by inhibiting the ability of the enzyme to religate cleaved nucleic acid molecules. Does not lead to immediate block of DNS synthesis, induces a progressive inhibition of DNA replication. p53 activator. Blocks the cell cycle between the end of the S phase and the early G2 phase. Oncoprotein Mdm2 synthesis inhibitor. Apoptosis inducer through the cytochrome c/Apaf-1/caspase-9 pathway and the Fas-mediated death signaling pathway. Cell cycle checkpoint activator. Affects gene expression at different levels (chromatin remodeling, transcrip- tion and alternative splicing). Chemotherapeutic compound used in cancers. Used in conditioning regimen prior to a bone marrow or blood stem cell transplantation. Highly effective in mobilizing stem cells. Group: Biochemicals. Alternative Names: 4-Des methyl epipodophyllotoxin; VP-16-213, NSC 141540. Grades: USP. CAS No. 33419-42-0. Pack Sizes: 250mg, 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
GSK525762
GSK525762A, also known as I-BET-762 and GSK525762, is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor GSK525762 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomain at the N-terminus, BET proteins, comprising of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth. Synonyms: GSK525762; GSK525762; GSK525762; GSK525762A; GSK-525762A; GSK 525762A; I-BET-762; I-BET762; I-BET 762; molibresib. CAS No. 1260907-17-2. Molecular formula: C22H22ClN5O2. Mole weight: 423.9.
iso-Reserpiline
Reserpine is a plant alkaloid that was first isolated from the roots of Rauwolfia serpentina. It is used in the treatment of high blood pressure and psychosis. Reserpine binds to cholinergic receptors and blocks the release of neurotransmitters, leading to the symptoms of psychosis. Reserpine also acts as an antagonist at dopamine receptors, which may be responsible for its antipsychotic effects. Reserpine has been shown to have potent antitumor activity against a variety of cancer cell lines in vitro and in vivo, including breast carcinoma cells. The mechanism of action is not yet fully understood but may involve inhibition of DNA synthesis or protein synthesis. Reserpine can be synthesized by hydrolysis of iso-reserpiline with hydrochloric acid, followed by chromatographic purification. Iso-reserpiline is a mixture of two compounds: neisosperma and apocynaceae, which are both in. Group: Other alkaloids. CAS No. 572-67-8. Molecular formula: C23H28N2O5. Mole weight: 412.48 g/mol. Canonical SMILES: C[C@H]1[C@@H]2CN3CCC4=C ([C@@H]3C[C@@H]2C (=CO1)C (=O)OC)NC5=CC (=C (C=C45)OC)OC. Catalog: ACM572678.
Jatrorrhizine hydrochloride
Jatrorrhizine hydrochloride is a naturally occurring compound, which has been shown to have hypoglycemic effects and can be used for the treatment of skin cancer. It is an analogue of berberine that inhibits mitochondrial membrane potential, leading to cell death by inhibiting energy metabolism and causing chromatographic analysis. Jatrorrhizine hydrochloride also inhibits the synthesis of proteins required for glycolysis, including hexokinase 2 (HK2), phosphofructokinase 1 (PFK1), and pyruvate kinase M2 (PKM2). This drug is metabolized by esterases or glucuronidases to form benzalkonium chloride or ginsenoside RG3. This active form binds to penicillin-binding protein, which may lead to metabolic disorders such as hepatic steatosis. Group: Other alkaloids. CAS No. 2106804-01-5. Molecular formula: C20H20NO4·HCl. Mole weight: 374.84 g/mol. Canonical SMILES: COC1=C (C2=C[N+]3=C (C=C2C=C1)C4=CC (=C (C=C4CC3)O)OC)OC. [Cl-]. Catalog: ACM2106804015.
Native Bovine α-Chymotrypsinogen A
Chymotrypsinogen is a proteolytic enzyme and a precursor (zymogen) of the digestive enzyme chymotrypsin. It is a single polypetide chain consisting of 245 amino acid residues. It is synthesized in the acinar cells of the pancreas and stored inside membrane-bounded granules at the apex of the acinar cell. The cell is then stimulated by either a hormonal signal or a nerve impulse and the contents of the granules spill into a duct leading into the duodenum. Applications: The enzyme has been used in the non-invasive determination of solid-state protein conformation using near infrared (nir) spectroscopy. it has been used to study the partitioning of protein in polymer/polymer aqueous two-phase systems. the enzyme has also been used for self-interaction chromatography applications, to test the rapid measurement of protein osmotic second virial coefficients. in this technique, the protein is immobilized on chromatographic particles and its retention is measured using isocratic elution. Group: Zymogens. Synonyms: 9035-75-0; Chymotrypsinogen; α-Chymotrypsino. CAS No. 9035-75-0. Chymotrypsinogen A. Activity: > 40 units/mg solid. Storage: -20°C. Form: essentially salt-free, lyophilized powder. Source: Bovine Pancreas. Species: Bovine. 9035-75-0; Chymotrypsinogen; α-Chymotrypsinogen A; Chymotrypsinogen A; Chymotrypsin. Cat No: NATE-0748.
Quisinostat
Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation. Synonyms: JNJ-26481585; JNJ26481585; JNJ 26481585. Grades: >98%. CAS No. 875320-29-9. Molecular formula: C21H26N6O2. Mole weight: 394.479.
Resminostat
Resminostat is an orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity. Resminostat binds to and inhibits HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, inhibition of the transcription of tumor suppressor genes, inhibition of tumor cell division and the induction of tumor cell apoptosis. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins. Synonyms: 4SC201; 4SC-201; 4SC 201; RAS-2410; RAS2410; RAS 2410; Resminostat. CAS No. 864814-88-0. Molecular formula: C16H19N3O4S. Mole weight: 349.405.
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