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Ledipasvir Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A , with EC 50 s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CL pro inhibitor with an IC 50 of 1.62 μM [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-5885. CAS No. 1256388-51-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15602. MedChemExpress MCE
Ledipasvir-[13C2,d6] Ledipasvir-[13C2,d6] is the labelled derivative of Ledipasvir, an inhibitor of hepatitis C virus (HCV) non-structural protein 5A (NS5A). Synonyms: N-[(1S)?-1-[[(6S)?-6-[5-[9,?9-Difluoro-7-[2-[(1R,?3S,?4S)?-2-[(2S)?-2-[(methoxycarbonyl)?amino]?-3-methyl-1-oxobutyl]?-2-azabicyclo[2.2.1]?hept-3-yl]?-1H-benzimidazol-6-yl]?-9H-fluoren-2-yl]?-1H-imidazol-2-yl]?-5-azaspiro[2.4]?hept-5-yl]?carbonyl]?-2-methylpropyl]?-carbamic Acid Methyl Ester-13C2,D6; Ledipasvir 13C2,D6. Grade: ≥90% by CP. Molecular formula: C47[13C]2H48D6F2N8O6. Mole weight: 897.04. BOC Sciences 2
Ledipasvir D-tartrate Ledipasvir D-tartrate is an inhibitor of the hepatitis C virus NS5A , with EC 50 values of 34 pM against GT1a and 4 pM against GT1b replicon. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-5885 D-tartrate. CAS No. 1502654-87-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15602B. MedChemExpress MCE
1-Octanol-[d17] 1-Octanol-[d17] is the isotope labelled analog of 1-Octadecanol, which is intended for use as an internal standard for the quantification of ledipasvir by GC- or LC-MS. 1-Octanol is a fatty acid alcohol that is used industrially to form various synthetic intermediate and pharmaceuticals. Synonyms: 1-Octan-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-d17-ol; Octyl Alcohol-d17; 1-Hydroxyoctane-d17; Caprylic Alcohol-d17; Heptyl Carbinol-d17; Octanol-d17; Octilin-d17; Sipol L8-d17; n-Octan-1-ol-d17; n-Octanol-d17; n-Octyl Alcohol-d17. Grade: 98% by CP; 98% atom D. CAS No. 153336-13-1. Molecular formula: C8HD17O. Mole weight: 147.33. BOC Sciences
(1R, 3S, 4S)-2-(tert-Butoxycarbonyl)-2-azabicyclo[2. 2. 1]heptane-3-carboxylic Acid (1R, 3S, 4S)-2-(tert-Butoxycarbonyl)-2-azabicyclo[2. 2. 1]heptane-3-carboxylic Acid is a building block in the synthesis of Ledipasvir, a potent, once-?daily oral NS5A inhibitor for the treatment of Hepatitis C Virus infection. It is also used to prepare potent direct inhibitors of factor Xa which carries significant promise for developing effective and safe anticoagulants. Group: Biochemicals. Grades: Highly Purified. CAS No. 291775-59-2. Pack Sizes: 250mg, 1g. Molecular Formula: C12H19NO4, Molecular Weight: 241.28. US Biological Life Sciences. USBiological 9
Worldwide
(2-((1R, 3S, 4S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2. 2. 1]heptan-3-yl)-1H-benzo[d]imidazol-5-yl)boronic Acid (2-((1R, 3S, 4S)-2-(tert-butoxycarbonyl)-2-azabicyclo[2. 2. 1]heptan-3-yl)-1H-benzo[d]imidazol-5-yl)boronic Acid can be obtained from (1R, 3S, 4S)-2-(tert-Butoxycarbonyl)-2-azabicyclo[2. 2. 1]heptane-3-carboxylic Acid (B694100) which is a building block in the synthesis of Ledipasvir, a potent, once-?daily oral NS5A inhibitor for the treatment of Hepatitis C Virus infection. It is also used to prepare potent direct inhibitors of factor Xa which carries significant promise for developing effective and safe anticoagulants. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C18H24BN3O4, Molecular Weight: 357.21. US Biological Life Sciences. USBiological 9
Worldwide
2-Amino-4'-bromoacetophenone Hydrochloride 2-Amino-4'-bromoacetophenone Hydrochloride is used as a reagent in the synthesis of Ledipasvir (L320100); a potent, once-daily oral NS5A inhibitor used for treatment of hepatitis C virus infection. 2-Amino-4'-bromoacetophenone Hydrochloride is also used in the preparation of the β-receptor agonists (-)-Denopamine (D231485) and (-)-Arbutamine (A766300). Group: Biochemicals. Grades: Highly Purified. CAS No. 5467-72-1. Pack Sizes: 250mg, 1g. Molecular Formula: C8H9BrClNO, Molecular Weight: 250.52. US Biological Life Sciences. USBiological 9
Worldwide
[(2R,3R,4R)-3-(Benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl]methyl Benzoate An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: benzoic acid [(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-2-oxolanyl]methyl ester; D-erythro-Pentonic acid, 2-deoxy-2-fluoro-2-methyl-, γ-lactone, 3,5-dibenzoate, (2R)-; (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid γ-lactone 3,5-dibenzoate. Grade: ≥95%. CAS No. 874638-80-9. Molecular formula: C20H17FO6. Mole weight: 372.34. BOC Sciences 3
((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methyltetrahydrofuran-2-yl)methyl benzoate An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: ((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidine-1(2H)-yl )-4-methyltetrahydrofuran-2-pyridin-3-yl)methyl benzoate. Grade: 98%. CAS No. 1496551-71-3. Molecular formula: C24H21ClN2O7. Mole weight: 484.89. BOC Sciences 2
(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-chloro-4-methyltetrahydrofuran-3-yl benzoate An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxopyrimidine-1(2H)-yl)-2-((benzoyloxy)methyl)-4-Chloro-4-methyltetrahydrofuran-3-ylbenzoate. Grade: 95%. CAS No. 1496551-70-2. Molecular formula: C31H26ClN3O7. Mole weight: 588.01. BOC Sciences 3
(2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-hydroxy-4-methyltetrahydrofuran-3-yl benzoate An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grade: 95%. CAS No. 863329-64-0. Molecular formula: C31H27N3O8. Mole weight: 569.56. BOC Sciences 3
(2S)-Isopropyl 2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: Propan-2-yl (2S)-2-{[pentafluorophenoxy(phenoxy)phosphoryl]amino}propanoate; N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)Phenoxyphosphinyl]-L-Alanine 1-Methylethyl Ester; N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine1-methylethyl ester. CAS No. 1256490-52-4. Molecular formula: C18H17F5NO5P. Mole weight: 453.302. BOC Sciences 3
L-Arginine-[5-13C,4,4,5,5-d4] L-Arginine-[5-13C,4,4,5,5-d4] is the labelled analogue of L-Arginine, which is intended for use as an internal standard for the quantification of ledipasvir by GC-or LC-MS. Synonyms: L-Arginine-5-13C,4,4,5,5-d4; S-2-Amino-5-guanidinopentanoic acid-5-13C,4,4,5,5-d4; L-Arginine-13C,d4; L-(+)-Arginine-13C,d4; H-Arg-OH-13C,d4. Grade: 98% by CP; 99% atom 13C; 97% atom D. Molecular formula: C5[13C]H10D4N4O2. Mole weight: 179.22. BOC Sciences 2
MOC-L-Valine MOC-L-valine (S)-2-((methoxycarbonyl) amino)-3-methylbutyric acid, a key synthetic intermediate of ledipasvir, is indicated for the treatment of chronic hepatitis C Virus (HCV) infection in adults and adolescents aged 12 to <18 years. CAS No. 74761-42-5. Product ID: PAP-0015. Molecular formula: C7H13NO4. Category: Amino acid. Product Keywords: Amino Acid Series; MOC-L-Valine; PAP-0015; Amino acid; C7H13NO4; 74761-42-5. Color: White to Almost white. Physical State: powder to crystal. Storage: Sealed in dry,Room Temperature. Applications: Moc-l-valine, also known as (S)-2-((methoxycarbonyl) amino) -3-methylbutyric acid, is a key synthetic intermediate for the treatment of chronic hepatitis C virus (HCV) infection in adults and adolescents aged 12 to <18 years. Boiling Point: 315.9±25.0 °C(Predicted). Melting Point: 109.0 to 113.0 °C. Density: 1.154±0.06 g/cm3(Predicted). Product Description: Moc-l-valine, also known as (S)-2-((methoxycarbonyl) amino) -3-methylbutyric acid, is a key synthetic intermediate for the treatment of chronic hepatitis C virus (HCV) infection in adults and adolescents aged 12 to <18 years. CD Formulation
Sofosbuvir-[13C,d3] Sofosbuvir-[13C,d3] is the labelled analogue of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: Sofosbuvir 13CD3. Grade: 95% by HPLC; 95% atom 13C; 95% atom D. CAS No. 2070009-25-3. Molecular formula: C21[13C]H26D3FN3O9P. Mole weight: 533.46. BOC Sciences 2
Sofosbuvir metabolite GS-566500-[13C,d3] An isotope labelled impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: (2S)-2-(((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)amino)propanoic-13CD3 Acid; O-Desisopropyl O-Desphenyl Sofosbuvir-13C,D3; PSI 352707-13C,D3. Grade: > 95%. CAS No. 1256490-46-6. Molecular formula: [13C]C12H16FN3O9PD3. Mole weight: 415.29. BOC Sciences 2

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