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leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Synonyms: IST5-002; IST5 002; IST5002; Benzyl-AMP; N6-Benzyladenosine-5'-phosphate; Folinic acid calcium salt; Calcium Folinate. Grades: >98%. CAS No. 1492-18-8. Molecular formula: C20H21N7O7.Ca. Mole weight: 513.52.
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Leucovorin calcium pentahydrate
Leucovorin is a derivative of folic acid, which can be used to increase levels of folic acid under conditions favoring folic acid inhibition. Synonyms: Folinic acid. Grades: >98%. CAS No. 6035-45-6. Molecular formula: C21H25CaN7O7.5H2O. Mole weight: 601.58.
An intermediate product of the metabolism of Folic Acid; the active form into which that acid is converted in the body, ascorbic acid being a necessary factor in the conversion process. Group: Biochemicals. Alternative Names: N-[4-[[ (2-Amino-5-formyl-1, 4, 5, 6, 7, 8-hexahydro-4-oxo-6-pteridinyl) methyl]amino]benzoyl]-L-glutamic Acid Calcium Salt Pentahydrate; Calcium Folinate; Folaren; Foliben; Folidan; Folinic Acid Calcium Salt Pentahydrate; Lederfolat; Lederfolin. Grades: Highly Purified. CAS No. 6035-45-6. Pack Sizes: 100mg, 500mg, 1g. Molecular Formula: C20H31CaN7O12, Molecular Weight: 601.58. US Biological Life Sciences.
Worldwide
Leucovorin-d4 Calcium Salt Pentahydrate
An labeled intermediate product of the metabolism of Folic Acid. This compound is a mixture of diastereomers. Group: Biochemicals. Alternative Names: N-[4-[[ (2-Amino-5-formyl-1, 4, 5, 6, 7, 8-hexahydro-4-oxo-6-pteridinyl) methyl]amino]benzoyl-d4]-L-glutamic Acid Calcium Salt Pentahydrate; Calcium Folinate-d4; Folaren-d4; Foliben-d4; Folidan-d4; Folinic Acid-d4 Calcium Salt Pentahydrate. Grades: Highly Purified. Pack Sizes: 250ug. US Biological Life Sciences.
Worldwide
Calcium Folinate Pentahydrate
When administered after methotrexate, supplies cells with tetrahydrofolate and diminishes methotrexate toxicity without abolishing the antitumor effect. Group: Biochemicals. Alternative Names: 5-Formyl-5,6,7,8-tetrahydrofolic acid, calcium salt Leucovorin. Grades: Highly Purified. CAS No. 41927-89-3. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C20H21CaN7O7·5H2O, Molecular Weight: 601.58. US Biological Life Sciences.
Worldwide
Folinic acid
Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate. It is a 5-formyl derivative of tetrahydrofolic acid and readily converted to other reduced folic acid derivatives, thus, has vitamin activity that is equivalent to that of folic acid. Since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. Synonyms: leucovorin. Grades: >98%. CAS No. 58-05-9. Molecular formula: C20H23N7O7. Mole weight: 473.44.
Folinic acid
Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: leucovorin. CAS No. 58-05-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17556.
Folinic acid calcium
Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Leucovorin calcium; Calcium folinate. CAS No. 1492-18-8. Pack Sizes: 50 mg; 100 mg; 500 mg. Product ID: HY-13664.
Folinic acid calcium salt
Folinic acid calcium salt offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. Calcium folinate is also used in mutagenisis and cancer research. Applications: A compound that reduces the effect of folic acid antagonists. Group: Coenzymes. Synonyms: Leucovorin calcium salt; Citrovorum factor calcium salt; Calcium folinate. CAS No. 1492-18-8. Purity: ≥98%. Mole weight: 511.5. Appearance: Powder. Form: Solid. Leucovorin calcium salt; Citrovorum factor calcium salt; Calcium folinate; Folinic acid calcium salt; 1492-18-8. Cat No: COEC-033.
Folinic Acid, Calcium Salt
Folinic Acid is an intermediate product of the metabolism of folic acid and is used as a tissue culture additive. Folinic acid is an antidote to folic acid antagonists such as methotrexate which block the conversion of folic acid into folinic acid. Group: Biochemicals. Alternative Names: L-N- [p- [ [ (2-amino-5-formyl-5, 6, 7, 8-tetrahydro-4-hydroxy-6-pteridinyl) methyl] amino] benzoyl] glutamic Acid Calcium Salt; Calcium 5-formyltetra hydrofolate; Calcium L-Folinate; Calcium Folinate; Calcium Leucovorin; Folidan; Folinic Acid Calcium Salt; Lederfoline; Leucovorin Calcium; Leucovorin Calcium Salt; NSC 3590; Rescuvolin; Wellcovorin; USP Folic Acid Related Compound A. Grades: Cell Culture Grade. CAS No. 1492-18-8. Pack Sizes: 500mg, 1g, 5g. Molecular Formula: C??H??CaN?O?, Molecular Weight: 511.51. US Biological Life Sciences.
Worldwide
Folinic acid calcium salt pentahydrate
Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Leucovorin calcium salt pentahydrate. CAS No. 6035-45-6. Pack Sizes: 100 mg; 500 mg. Product ID: HY-B0080.
Folitixorin
Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 5,10-Methylenetetrafolate; ANX-510 free acid. CAS No. 3432-99-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-14769.
Oxaliplatin
Oxaliplatin is a a third-generation, diaminocyclohexane-containing platinum anti-cancer drug. It is typically used in combination with fluorouracil (5-FU) and leucovorin, known as FOLFOX, for the treatment of colorectal cancer. The leucovorin-modulated single-agent 5-FU regimens achieved a median overall survival of 15 months or less. Combination regimens of FOLFOX consistently lead to median survivals in the 15-20 month range. Group: Biochemicals. Alternative Names: [SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N')[ethanedioato(2-)-O,O']platinum; (SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kN,kN'][ethanedioato(2-)-kO1,kO2]platinum; (1R-trans)-1,2-Cyclohexanediamine Platinum Complex; Dacplat; Eloxatin; Elplat; Lipoxal; Oxalatoplatinum. Grades: Highly Purified. CAS No. 61825-94-363121-00-6. Pack Sizes: 25mg, 50mg, 100mg, 300mg, 500mg. Molecular Formula: C8H14N2O4Pt, Molecular Weight: 397.29. US Biological Life Sciences.
Worldwide
Pyrimidine Related Compound 1
An impuritiy of Pyrimethamine.Pyrimethamine can be used with leucovorin to treat toxoplasmosis and cystoisosporiasis. It is also used with dapsone as a second line option to prevent Pneumocystis jiroveci pneumonia in people with HIV/AIDS. Synonyms: 2-Chloro-N, N-diethyl-5-[[4-[2-[4-[[ (methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]benzenesulfonamide. Grades: > 95%. CAS No. 1402452-15-6. Molecular formula: C27H28ClN7O3S. Mole weight: 566.09.
Tegafur-Uracil
Tegafur-Uracil (UFT; BMS-200604) is an effective oral chemotherapy drug based on fluoropyrimidine. Tegafur-Uracil inhibits thymidylate synthase. Tegafur-Uracil can be used in combination with leucovorin (LV) and polysaccharide K (PSK) for research on solid tumors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UFT; BMS-200604. CAS No. 74578-38-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16110.
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