Ligase Suppliers USA
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Product | Description | |
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DNA Ligase, T4, Recombinant, BioAssay Kit, T4 DNA Ligase Quick inquiry Where to buy Suppliers range | DNA Ligase, T4, Recombinant, BioAssay Kit, T4 DNA Ligase. Group: Molecular Biology. Grades: Purified. Pack Sizes: 20KU. US Biological Life Sciences. | Worldwide |
Hdm2 E3 Ligase Inhibitor II, HLI373 (5- (3-Dimethylaminopropyl amino) -3, 10-dimethyl-10H-pyrimido [4, 5-b] quinoline-2, 4-dione, 2HCl, MDM2 Inhibitor VI, MDM2 E3 Ligase Inhibitor II) Quick inquiry Where to buy Suppliers range | A cell-permeable pyrimidoquinoline-dione compound that acts as an efficient Hdm2 E3 ligase inhibitor, prevents Hdm2-mediated p53 ubiquitination and increases the cellular levels of both p53 and Hdm2 (IC50 ~3uM in RPE cells). Shown to selectively arrest the growth of several tumor cells in a p53-dependent manner and display desirable aqueous solubility. Group: Biochemicals. Grades: Highly Purified. CAS No. 502137-98-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Bmi1-Ring1A E3 Ligase Inhibitor, PRT4165 (2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione) Quick inquiry Where to buy Suppliers range | A cell-permeable indandione compound that inhibits the Bmi1-Ring1A E3 complex ubiquitin ligase activity both in cell-free assays (by 100% against self- and Top2alpha ubiquitination at 25 and 50uM, respectively) and in HeLa cells (by 100% against Bmi1 ubiquitination at 50uM). Shown to greatly potentiate Teniposide (VM26) cancer cytotoxicity (by 10-fold in A375 and A549 cultures at 5.5 and 33uM, respectively) by preventing Top2alpha degradation following VM26 treatment (100% inhibition at 50uM in HeLa cells). Group: Biochemicals. Grades: Highly Purified. CAS No. 31083-55-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
DNA ligase 3 isoform alpha precursor (790-806) Quick inquiry Where to buy Suppliers range | DNA ligase 3. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-172. | |
DNA Ligase T4 Reaction Buffer, 10X Quick inquiry Where to buy Suppliers range | DNA Ligase T4 Reaction Buffer, 10X. Group: Molecular Biology. Grades: Molecular Biology Grade. CAS No. 9015-85-4. Pack Sizes: 1.5ml. US Biological Life Sciences. | Worldwide |
DNA Ligase, T4, Recombinant, BioAssay Kit, 10mM ATP Quick inquiry Where to buy Suppliers range | DNA Ligase, T4, Recombinant, BioAssay Kit, 10mM ATP. Group: Molecular Biology. Grades: Purified. Pack Sizes: 100ul. US Biological Life Sciences. | Worldwide |
DNA Ligase, T4, Recombinant, BioAssay Kit, Reaction Buffer (10X) Quick inquiry Where to buy Suppliers range | DNA Ligase, T4, Recombinant, BioAssay Kit, Reaction Buffer (10X). Group: Molecular Biology. Grades: Purified. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
E3 ligase Ligand-Linker Conjugates 30 Quick inquiry Where to buy Suppliers range | E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrade. Synonyms: 4- ( (2- (2- (2- (2-aminoethoxy) ethoxy) ethoxy) ethyl) amino) -2- (2, 6-dioxopiperidin-3-yl) isoindoline-1, 3-dione; Pomalidomide-PEG3-C2-NH2; SCHEMBL19451340; BCP33441; HY-128716; CS-0099510; Cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30. Grades: > 98%. CAS No. 2093416-31-8. Molecular formula: C21H28N4O7. Mole weight: 448.47. | |
E3 ubiquitin-protein ligase Mdm2 (53-60) Quick inquiry Where to buy Suppliers range | E3 ubiquitin-protein ligase Mdm2. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-368. | |
E3 ubiquitin-protein ligase RNF43 (11-19(20)) Quick inquiry Where to buy Suppliers range | E3 ubiquitin-protein ligase RNF43. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-398. | |
E3 ubiquitin-protein ligase RNF43 (721-729) Quick inquiry Where to buy Suppliers range | E3 ubiquitin-protein ligase RNF43. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-399. | |
E3 ubiquitin-protein ligase UBR4 (329-337) Quick inquiry Where to buy Suppliers range | E3 ubiquitin-protein ligase UBR4. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-234. | |
Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 Quick inquiry Where to buy Suppliers range | The Hdm2 E3 Ligase Inhibitor, also referenced under CAS 414905-09-2, controls the biological activity of Hdm2 E3 Ligase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 414905-09-2. Pack Sizes: 5MG. Mole weight: 350.24. Catalog: AP414905092. Assay: ≥95% (NMR). | |
Hdm2 E3 Ligase Inhibitor II, HLI373 - CAS 502137-98-6 Quick inquiry Where to buy Suppliers range | The Hdm2 E3 Ligase Inhibitor II, HLI373, also referenced under CAS 502137-98-6, controls the biological activity of Hdm2 E3 Ligase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 502137-98-6. Pack Sizes: 5MG. Mole weight: 341.41. Catalog: AP502137986. Assay: ≥98% (HPLC). | |
MDM2 Inhibitor VII, MEL23 (3-Butyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4(1H,3H)-dione, MDM2-MDMX E3 Ligase Inhibitor) Quick inquiry Where to buy Suppliers range | A cell-permeable tetrahydro-b-carbolinylbarbiturate compound that selectively inhibits the E3 ligase activity of Mdm2-MdmX hetero-complex over that of Mdm2-Mdm2 homo-complex (70.6% vs. 17.6% inhibition, respectively, at 100uM), without affecting Mdm2-MdmX complex formation or the activity of two other UbcH5C-utilizing ligase complexes Roc1-Cul1 and BRCA1-BARD1. Effectively inhibits ubiquitination and proteasomal degradation of cellular Mdm2 and p53 (effective conc.=14uM in U2OS, RKO, and HCT116 cultures) and induce RKO and MEF cell death in a p53- and Mdm2-dependent manner. Unlike Nutlin-3, MEL23 does not interfere with Mdm2-p53 interaction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
RNA Ligase T4, 10-20u/ul, 10X Buffer Quick inquiry Where to buy Suppliers range | RNA Ligase T4, 10-20u/ul, 10X Buffer. Group: Molecular Biology. Alternative Names: Supplied with 10x Reaction Buffer, ATP and BSA Solutions. Grades: Molecular Biology Grade. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
RNA Ligase T4, 10-20u/ul, ATP Buffer Quick inquiry Where to buy Suppliers range | RNA Ligase T4, 10-20u/ul, ATP Buffer. Group: Molecular Biology. Alternative Names: Supplied with 10x Reaction Buffer, ATP and BSA Solutions. Grades: Molecular Biology Grade. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
RNA Ligase T4, 10-20u/ul, BSA Buffer Quick inquiry Where to buy Suppliers range | RNA Ligase T4, 10-20u/ul, BSA Buffer. Group: Molecular Biology. Alternative Names: Supplied with 10x Reaction Buffer, ATP and BSA Solutions. Grades: Molecular Biology Grade. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
2-(2-(2-Aminoethoxy)ethoxy)acetic acid Quick inquiry Where to buy Suppliers range | H2N-PEG2-CH2COOH belongs to a polyethylene glycol (PEG) linker covalently bound to E3 Ligase binding group (E3LB) and protein binding group (PB). H2N-PEG2-CH2COOH is a PEG derivative containing an amino group with a terminal carboxylic acid. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. PEG Linkers may be useful in the development of antibody drug conjugates and PROTACs. Synonyms: Amino-PEG2-CH2CO2H; Amino-PEG2-CH2COOH; Amino-PEG2-acetic acid. Grades: ≥95%. CAS No. 134978-97-5. Molecular formula: C6H13NO4. Mole weight: 163.17. | |
2-(2,6-Dioxo-3-piperidinyl)-4-hydroxyisoindoline-1,3-dione Quick inquiry Where to buy Suppliers range | Thalidomide-OH is a ligand for E3 ligase used in PROTAC technology. Synonyms: 4-Hydroxy thalidomide; E3 ligase Ligand 2; Thalidomide-4-OH; 4-Hydroxy thalidomide, (+/-)-; 3-Hydroxythalidomide; 4-Hydroxy-thalidomide; α-(3-Hydroxy-phthalimido)-glutarimid; 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione; 2-(2,6-dioxo-3-piperidinyl)-4-hydroxy-1H-isoindole-1,3(2H)-dione. Grades: > 95 %. CAS No. 5054-59-1. Molecular formula: C13H10N2O5. Mole weight: 274.23. | |
2- (3, 5-Dichlorophenyl) acetonitrile Quick inquiry Where to buy Suppliers range | 2- (3, 5-Dichlorophenyl) acetonitrile is used in the synthesis of 6-arylpyrido[2,3-d]pyrimidines as ATP-competitive inhibitors of bacterial -alanine:-alanine ligase. Group: Biochemicals. Grades: Highly Purified. CAS No. 52516-37-7. Pack Sizes: 1g, 5 g. Molecular Formula: C8H5Cl2N, Molecular Weight: 186.04. US Biological Life Sciences. | Worldwide |
2,?3-?Dichloro-?1,?4-?naphthoquinone Quick inquiry Where to buy Suppliers range | 2,?3-?Dichloro-?1,?4-?naphthoquinone is a reagent used in the preparation of Itch. a HECT domain-E3 ligase and tumor growth supressor seen in multiple myeloma. Used in pesticide formulations. Group: Biochemicals. Grades: Highly Purified. CAS No. 117-80-6. Pack Sizes: 5g, 25g. Molecular Formula: C10H4Cl2O2, Molecular Weight: 227.04. US Biological Life Sciences. | Worldwide |
2-Nitronaphthalene Quick inquiry Where to buy Suppliers range | 2-Nitronaphthalene has been used in the study for naphthalene-?based inhibitors of Trypanosoma brucei RNA Editing Ligase 1. Group: Biochemicals. Grades: Highly Purified. CAS No. 581-89-5. Pack Sizes: 250mg, 1g. Molecular Formula: C10H7NO2, Molecular Weight: 173.17. US Biological Life Sciences. | Worldwide |
3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one Quick inquiry Where to buy Suppliers range | 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one is involved in the pharmacological inactivation of Skp2 E3 ligase. Group: Biochemicals. Grades: Highly Purified. CAS No. 222716-34-9. Pack Sizes: 5mg, 10mg. Molecular Formula: C24H24N2O3S, Molecular Weight: 420.52. US Biological Life Sciences. | Worldwide |
4-Hydroxy Thalidomide Quick inquiry Where to buy Suppliers range | A metabolite of Thalidomide which was prescribed as an anti-nausea agent to help pregnant women with morning sickness but withdrawn from the market when it was discovered to cause birth defects. Synonyms: 4-Hydroxy thalidomide; E3 ligase Ligand 2; 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione; 4-Hydroxythalidomide; Thalidomide-4-OH; 2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindole-1,3-dione; 2-(2,6-Dioxo-3-piperidinyl)-4-hydroxyisoindoline-1,3-dione; 4-Hydroxy-thalidomide; 4-Hydroxy thalidomide, (+/-)-; E3 ligase Ligand 2 (Thalidomide-OH); J344NHC6VB; C13H10N2O5; MFCD03699892; Phthalimide, N-(2,6-dioxo-3-piperidyl)-3-hydroxy-; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-hydroxy-; 2-(2,6-dioxopiperidin-3-yl)-4-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione;2-(2,6-Dioxo-piperidin-3-yl)-4-hydroxy-isoindole-1,3-dione; 2-(2,6-dioxo-piperidine-3-yl)-4-hydroxy-isoindole-1,3-dione; 4-hydroxy-2-(2,6-dioxo(3-piperidyl))isoindoline-1,3-dione. Grades: > 95%. Molecular formula: C13H10N2O5. Mole weight: 274.24. | |
7-Propargylamino-7-deaza-dATP - 6-FAM Quick inquiry Where to buy Suppliers range | 7-Propargylamino-7-deaza-dATP - 6-FAM is a vital tool in the biomedical industry for studying DNA replication and repair mechanisms. It is commonly used as a substrate in enzymatic assays to investigate the activity of DNA polymerases and ligases. Furthermore, this compound plays a crucial role in labeling and detection of DNA during fluorescence-based techniques, assisting in the research of various genetic disorders. Synonyms: 7-Deaza-7-propargylamino-2'-deoxyadenosine-5'-triphosphate, labeled with 6 FAM, Triethylammonium salt. Grades: ≥ 95% by HPLC. Molecular formula: C35H30N5O18P3 (free acid). Mole weight: 901.56 (free acid). | |
8-Bromo-2',5'-pAp Quick inquiry Where to buy Suppliers range | 8-Bromo-2',5'-pAp, a nucleotide analog, is widely applied as a substrate in enzymatic assays to explore RNA polymerase and RNA ligase abilities. Its versatility extends to the development of modified RNA molecules that serve as valuable tools in numerous biomedical fields. These applications include gene therapy for malignancies and genetic dysfunctions. Synonyms: (8Br-2',5'-pAp); 8-Bromo-adenosine-2',5'-bisphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C10H14BrN5O10P2 (free acid). Mole weight: 506.10 (free acid). | |
A01 Quick inquiry Where to buy Suppliers range | A01 is a high affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM), which attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Study showed that it potentiated BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells. Synonyms: Smurf1-IN-A01; Smurf1INA01; Smurf1 IN A01; Smurf1 inhibitor A01; Smurf1-inhibitor-A01; A01; A 01; A-01; [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone; SMURF1 inhibitor A01. Grades: ≥98% by HPLC. CAS No. 1007647-73-5. Molecular formula: C22H20ClF3N4O3S. Mole weight: 512.93. | |
ACBI1 Quick inquiry Where to buy Suppliers range | ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis. Synonyms: ACBI 1; ACBI-1; (2S,4R)-N-(2-(2-(4-((4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide. CAS No. 2375564-55-7. Molecular formula: C49H58FN9O7S. Mole weight: 936.12. | |
ACYL-COENZYME A SYNTHETASE Quick inquiry Where to buy Suppliers range | ACYL-COENZYME A SYNTHETASE. Uses: Used for research and manufacturing. Group: Food Ingredients. Alternative Names: EC 6.2.1.3;ACID: COA LIGASE (AMP-FORMING);ACYL-COENZYME A SYNTHETASE;Synthetase, acyl coenzyme A;ACYL-COENZYME A SYNTHETASE FROM PSEUDO-M ONAS SP., ~2.5U/MG;acyl-coenzyme a synthetase from pseudomonas sp.;Acyl-coenzyme A Synthetase [>=8 units/mg];Acyl-CoA Synthetase. CAS No. 9013-18-7. Pack Sizes: 1 kg. Product ID: CDF4-0057. | |
Alrizomadlin Quick inquiry Where to buy Suppliers range | Alrizomadlin is a highly potent and chemically stable E3 ubiquitin-protein ligase Mdm2 (Hdm2) inhibitor. It is used in the treatment and prevention of osteoarthritis. Synonyms: APG-115; AA-115; 4-((3'R,4'S,5'R)-6''-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic acid; APG115; APG 115; NSC831270. Grades: >98%. CAS No. 1818393-16-6. Molecular formula: C34H38Cl2FN3O4. Mole weight: 642.59. | |
Anaphase-Promoting Complex Inhibitor Negative Control, AAME (AAME Hydrochloride) Quick inquiry Where to buy Suppliers range | An acetyl-L-arginine analog of TAME that serves as a negative control. TAME is an ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation. Group: Biochemicals. Grades: Highly Purified. CAS No. 1784-05-0. Pack Sizes: 50mg. Molecular Formula: C?H??N?O? · HCl, Molecular Weight: 266.7. US Biological Life Sciences. | Worldwide |
Anaphase-Promoting Complex Inhibitor, TAME (TAME Hydrochloride) Quick inquiry Where to buy Suppliers range | TAME is a potent ubiquitin ligase inhibitor that specifically blocks Anaphase-Promoting Complex (APC) activation by directly binding to APC and disrupts the IR-tail-dependent interactions between APC and its activator proteins Cdc20 or Cdh1. It stabilizes APC substrates and is shown to inhibit cyclin proteolysis in mitotic Xenopus egg extract with an IC50=12uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 1784-03-8. Pack Sizes: 50mg. Molecular Formula: C??H??N?O?S · HCl, Molecular Weight: 378.87. US Biological Life Sciences. | Worldwide |
Apcin Quick inquiry Where to buy Suppliers range | Apcin is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C), which is a large multimeric complex. It functions as a ubiquitin ligase, initiating the metaphase-anaphase transition and regulating ordered transitions through the cell cycle by controlling the ubiquitin-mediated proteolysis of cell cycle proteins. It competitively binds to the D-box binding site of Cdc20 and prevents substrate recognition and ubiquitylation required for continuation of mitosis. It synergistically increases apoptosis in multiple myeloma cells in combination with proTAME (prodrug of TAME). It also prolongs mitotic duration in RPE1 cells in combination with proTAME in vitro. It blocks mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe. Synonyms: 3-(2-Methyl-5-nitro-imidazol-1-yl)-N-(2,2,2-trichloro-1-phenylamino-ethyl)-propionamide; 2-(2-Methyl-5-nitroimidazol-1-yl)ethyl N-[2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate; [2,2,2-trichloro-1-(2-pyrimidinylamino)ethyl]-carbamic acid, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester. Grades: ≥98% by HPLC. CAS No. 300815-04-7. Molecular formula: C13H14Cl3N7O4. Mole weight: 438.65. | |
Ara-CTP Quick inquiry Where to buy Suppliers range | ara-Cytidine-5'-triphosphate (ara-CTP) is an inhibitor of DNA synthesis, DNA ligases and polymerases that is used for the treatment of acute myeloid leukemia. Uses: Nucleic acid synthesis inhibitors. Synonyms: 1-β-D-arabinofuranosylcytosine TP; Aracytidine-5'-Triphosphate; ara-Cytidine-5'-triphosphate; Arabinofuranosylcytosine triphosphate. Grades: ≥90% by AX-HPLC. CAS No. 13191-15-6. Molecular formula: C9H16N3O14P3 (free acid). Mole weight: 483.15 (free acid). | |
ARD-266 Quick inquiry Where to buy Suppliers range | ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces the degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines (DC50s = 0.2-1 nM). Synonyms: 2-Pyrrolidinecarboxamide, N- [ (1S) -3- [4- [2- [4- [ [ [trans-3- (3-chloro-4-cyanophenoxy) -2, 2, 4, 4-tetramethylcyclobutyl] amino] carbonyl] phenyl] ethynyl] -1-piperidinyl] -3-oxo-1-phenylpropyl] -4-hydroxy-1- [ (2R) -3-methyl-2- (3-methyl-5-isoxazolyl) -1-oxobutyl] -, (2S,4R)-; (2S, 4R) -N- ( (S) -3- (4- ( (4- ( ( (1r, 3r) -3- (3-chloro-4-cyanophenoxy) -2, 2, 4, 4-tetramethylcyclobutyl) carbamoyl) phenyl) ethynyl) piperidin-1-yl) -3-oxo-1-phenylpropyl) -4-hydroxy-1- ( (R) -3-methyl-2- (3-methylisoxazol-5-yl) butanoyl) pyrrolidine-2-carboxamide; (2S, 4R) -N- [ (1S) -3- [4- [2- [4- [ [ [trans-3- (3-Chloro-4-cyanophenoxy) -2, 2, 4, 4-tetramethylcyclobutyl] amino] carbonyl] phenyl] ethynyl] -1-piperidinyl] -3-oxo-1-phenylpropyl] -4-hydroxy-1- [ (2R) -3-methyl-2- (3-methyl-5-isoxazolyl) -1-oxobutyl] -2-pyrrolidinecarboxamide. Grades: ≥95%. CAS No. 2666951-70-6. Molecular formula: C52H59ClN6O7. Mole weight: 915.51. | |
ARF-binding protein 1 (757-766) Quick inquiry Where to buy Suppliers range | E3 ubiquitin-protein ligase HUWE1. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-131. | |
ARV-471 Quick inquiry Where to buy Suppliers range | ARV-471, an oral estrogen receptor PROTAC protein degrader for the treatment of breast cancer, is an heterobifunctional molecule that promotes the interaction between estrogen receptor alpha and intracellular E3 ligase complexes. It leads to ubiquitylation and subsequent degradation of estrogen receptors through the proteasome. In ER positive breast cancer cell lines, it has a strong ability to degrade ER with a half-maximal degradation concentration (DC50) of ~2 nM. Synonyms: ARV471; ARV 471; (S)-3-(5-(4-((1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-; Vepdegestrant; (3S)-3-[1,3-Dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione. Grades: ≥95%. CAS No. 2229711-68-4. Molecular formula: C45H49N5O4. Mole weight: 723.90. | |
ARV-771 Quick inquiry Where to buy Suppliers range | ARV-771 is a potent BET bromodomain PROTAC® Degrader based on von Hippel-Lindau (VHL) E3 ligase, consisting of a BRD4-binding moiety bound to a VHL ligand via a linker. Synonyms: ARV 771; ARV771; (2S,4R)-1-((S)-2-(tert-butyl)-15-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,14-dioxo-6,10-dioxa-3,13-diazapentadecanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide; L-Prolinamide, N- [2- [3- [2- [ [2- [ (6S) -4- (4-chlorophenyl) -2, 3, 9-trimethyl-6H-thieno [3, 2-f] [1, 2, 4] triazolo [4, 3-a] [1, 4] diazepin-6-yl] acetyl] amino] ethoxy] propoxy] acetyl] -3-methyl-L-valyl-4-hydroxy-N- [ (1S) -1- [4- (4-methyl-5-thiazolyl) phenyl] ethyl] -, (4R)-; N- ({3-[2- ({[ (6S) -4- (4-Chlorophenyl) -2, 3, 9-trimethyl-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepin-6-yl]acetyl}amino) ethoxy]propoxy}acetyl) -3-methyl-L-valyl- (4R) -4-hydroxy-N-{ (1S) -1-[4- (4-methyl-1, 3-thiazol-5-yl) phenyl]ethyl}-L-prolinamide. Grades: ≥95%. CAS No. 1949837-12-0. Molecular formula: C49H60ClN9O7S2. Mole weight: 986.64. | |
ARV-825 Quick inquiry Where to buy Suppliers range | ARV-825 is a BRD4 inhibitor based on PROTAC technology. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4. In post-myeloproliferative neoplasm secondary (s) AML cell lines, treatment with ARV-825 induces apoptosis and inhibits cell proliferation. Synonyms: 2- ( (S) -4- (4-chlorophenyl) -2, 3, 9-trimethyl-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepin-6-yl) -N- (4- (2- (2- (2- (2- ( (2- (2, 6-dioxopiperidin-3-yl) -1, 3-dioxoisoindolin-4-yl) amino) ethoxy) ethoxy) ethoxy) ethoxy) phenyl) acetamide. Grades: ≥98%. CAS No. 1818885-28-7. Molecular formula: C46H47ClN8O9S. Mole weight: 923.44. | |
AT-406 Quick inquiry Where to buy Suppliers range | AT-406 is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3 (with Ki of 66.4 nM), cIAP1-BIR3(with Ki of 1.9 nM) and cIAP2-BIR3 (with Ki of 5.1 nM), respectively. Synonyms: AT406; AT 406; SM-406; SM 406; SM406; ARRY-334543; ARRY 334543; ARRY334543. Grades: >98%. CAS No. 1071992-99-8. Molecular formula: C32H43N5O4. Mole weight: 561.71. | |
Autophagy Compound Library Quick inquiry Where to buy Suppliers range | A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Targets include Autophagy inducers, Autophagy inhibitors, Proteasome, HIF, HDAC, Aurora Kinase, E3 Ligase, mTOR, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L3200. Categories: Autophagy Compounds Libraries. | |
Azido-Thalidomide Quick inquiry Where to buy Suppliers range | Azido-Thalidomide is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand thalidomide conjugated to an alkyl linker with terminal azide group. Synonyms: E3 ligase Ligand-Linker Conjugates 18; N-(4-azidobutyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide. Grades: ≥98%. CAS No. 2098488-36-7. Molecular formula: C19H20N6O6. Mole weight: 428.405. | |
β-Nicotinamide Adenine Dinucleotide Sodium Salt Hydrate Quick inquiry Where to buy Suppliers range | β-Nicotinamide Adenine Dinucleotide is a coeznyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate group. β-Nicotinamide Adenine Dinucleotide acts as a coenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleotide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. Synonyms: Adenosine 5'-(Trihydrogen Diphosphate), P'?5'-Ester with 3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium Hydroxide Sodium Salt Hydrate; Adenine-nicotinamide Dinucleotide Sodium Salt Hydrate; CO-I Sodium Salt Hydrate; Codehydrase I Sodium Salt Hydrate; Codehydrogenase I Sodium Salt Hydrate; Coenzyme I Sodium Salt Hydrate; Cozymase I Sodium Salt Hydrate; DPN Sodium Salt Hydrate; Diphosphopyridine Nucleotide Sodium Salt Hydrate; Enzopride Sodium Salt Hydrate; NAD Sodium Salt Hydrate; NAD+ Sodium Salt Hydrate; NSC 20272 Sodium Salt Hydrate; Nadide Sodium Salt Hydrate; Nicotinamide-adenine Dinucleotide Sodium Salt Hydrate; Oxidized diphosphopyridine Nucleotide Sodium Salt Hydrate; β-Diphosphopyridine Nucleotide Sodium Salt Hydrate; β-NAD Sodium Salt Hydrate; β-NAD+ Sodium Salt Hydrate. Grades: 95%. Molecular formula: C21H26N7NaO14P2 X(H2O). Mole weight: 685.41. | |
BI-3802 Quick inquiry Where to buy Suppliers range | BI-3802 is a highly potent BCL6 degrader that inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ≤3 nM. It induces BCL6 polymerization and degradation via E3 ligase SIAH1, showing antitumor activity. Grades: ≥98% by HPLC. CAS No. 2166387-65-9. Molecular formula: C24H29ClN6O3. Mole weight: 484.98. | |
BSJ-03-123 Quick inquiry Where to buy Suppliers range | BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions; induces differential E3 ligase recruitment and ensuing degradation of CDK6, but not CDK4. Synonyms: BSJ 03-123; BSJ 03 123; BSJ-03 123; BSJ03123; N-[2- (2-{2-[2- (4-{6-[ (6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7, 8-dihydropyrido[2, 3-d]pyrimidin-2-yl) amino]-3-pyridinyl}-1-piperazinyl) ethoxy]ethoxy}ethoxy) ethyl]-2-{[2- (2, 6-dioxo-3-piperidinyl) -1, 3-dioxo-2, 3-dihydro-1H-isoindol-4-yl]oxy}acetamide; Acetamide, N- [2- [2- [2- [2- [4- [6- [ (6-acetyl-8-cyclopentyl-7, 8-dihydro-5-methyl-7-oxopyrido [2, 3-d] pyrimidin-2-yl) amino] -3-pyridinyl] -1-piperazinyl] ethoxy] ethoxy] ethoxy] ethyl] -2- [ [2- (2, 6-dioxo-3-piperidinyl) -2, 3-dihydro-1, 3-dioxo-1H-isoindol-4-yl] oxy] -. Grades: ≥95%. CAS No. 2361493-16-3. Molecular formula: C47H56N10O11. Mole weight: 937.01. | |
Cdc25A (80-93) (human) Quick inquiry Where to buy Suppliers range | Cdc25A abundance fluctuates periodically during the cell division cycle and is mainly regulated by the ubiquitin-proteasome system, through the action of two ubiquitin ligase complexes, which later promote complex/cyclosome and Skp1/Cul1/F-box proteins. Due to the presence of the destruction motif (KEN-box) in Cdc25A, ubiquitination and degradation occur at the mitotic outlet and G1, while phosphorylation events modulate the stability of Cdc25A protein in the S phase, both in undisturbed cells and in cells exposed to DNA damage agents or DNA replication inhibitors. Synonyms: H-Thr-Asp-Ser-Gly-Phe-Cys-Leu-Asp-Ser-Pro-Gly-Pro-Leu-Asp-OH. Grades: ≥95%. CAS No. 851538-67-5. Molecular formula: C60H90N14O24S. Mole weight: 1423.52. | |
Eragidomide Quick inquiry Where to buy Suppliers range | Eragidomide is a modulator of the E3 ligase cereblon and has antineoplastic activity. Synonyms: rac-2-(4-chlorophenyl)-N-({2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide; CC-90009; Cereblon modulator 1; NSC828250; CC 90009; CC90009; 4-chloro-N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α,α-difluoro-benzeneacetamide. Grades: ≥98% by HPLC. CAS No. 1860875-51-9. Molecular formula: C22H18ClF2N3O4. Mole weight: 461.85. | |
Glycinamide ribonucleotide Quick inquiry Where to buy Suppliers range | Glycineamide ribonucleotide (or GAR) is an intermediate in de novo purine biosynthesis. It is formed from phosphoribosylamine by the enzyme phosphoribosylamine-glycine ligase. In the next step of purine biosynthesis the enzyme phosphoribosylglycinamide formyltransferase acts on GAR to form FGAR. GAR formation is stimulated by Luteinizing hormone (LH) and Chorionic gonadotropin (HCG) via activation of Glc-6-P-dehydrogenase. Synonyms: 5'-Phosphoribosylglycinamide; N1-(5-Phospho-D-ribosyl)glycinamide; [(2R,3S,4R,5R)-5-[(2-aminoacetyl)amino]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate; n-glycyl-5-o-phosphono-|A-d-ribofuranosylamine; 5'-phosphoribosylglycinamide; GAR; N1-(5-Phospho-D-ribosyl)glycinamide; N1-(5-phospho-beta-D-ribosyl)glycinamide. CAS No. 10074-18-7. Molecular formula: C7H15N2O8P. Mole weight: 286.18. | |
GS 143 Quick inquiry Where to buy Suppliers range | GS 143 is a β-TrCP1 ligase inhibitor. GS 143 exhibits inhibitory effects on IκBα ubiquitination (IC50 = 5.2 μM), LPS-induced expression of inflammatory cytokines in human myelomonocytic cells, antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice. Synonyms: GS-143; GS 143; GS143; 4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 916232-21-8. Molecular formula: C28H19FN2O4. Mole weight: 466.46. | |
Heclin Quick inquiry Where to buy Suppliers range | Heclin is an HECT E3 ubiquitin ligase inhibitor. It also inhibits Nedd4, Smurf2 and WWP1 (IC50 = 6.3, 6.8 and 6.9 μM, respectively). Uses: Enzyme inhibitors. Synonyms: N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide. Grades: ≥98% by HPLC. CAS No. 890605-54-6. Molecular formula: C17H17NO3. Mole weight: 283.32. | |
HLI 373 Quick inquiry Where to buy Suppliers range | HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53 and activates p53-dependent transcription. HLI 373 has a therapeutic effect in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS. Synonyms: HLI373; HLI-373; HLI 373; NSC-373989; NSC 373989; NSC373989. 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride. Grades: ≥99% by HPLC. CAS No. 502137-98-6. Molecular formula: C18H23N5O2.2HCl. Mole weight: 414.33. | |
L189 Quick inquiry Where to buy Suppliers range | L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. Synonyms: L189; L 189; L-189. Grades: 98%. CAS No. 64232-83-3. Molecular formula: C11H10N4OS. Mole weight: 246.29. | |
L67 Quick inquiry Where to buy Suppliers range | L67 is a DNA Ligase Inhibitor. L67 inhibited DNA ligases I and III. L67 is a simple competitive inhibitor with respect to nicked DNA. L67 inhibits DNA ligases I and III with IC50 values of 10 μM and 10 μM.). Synonyms: L67; L-67; L 67. Grades: 98%. CAS No. 325970-71-6. Molecular formula: C16H14Br2N4O4. Mole weight: 486.12. | |
Lenalidomide Quick inquiry Where to buy Suppliers range | Cereblon binder; induces ubiquitination and degradation of CK1a and transcription factors IKZF1, IKZF3 and SALL4 by E3 ubiquitin ligase. Synonyms: CC5013; CC-5013; CC 5013; IMiD1; Lenalidomide; US brand name: Revlimid. Grades: ≥98% (HPLC). CAS No. 191732-72-6. Molecular formula: C13H13N3O3. Mole weight: 259.26. | |
Mant-dATP Quick inquiry Where to buy Suppliers range | Mant-dATP is a vital tool acting as a modified form of deoxyadenosine triphosphate (dATP) labeled with the mant fluorophore. Mant-dATP is beneficial for studying various enzymatic activities, including DNA polymerases, DNA ligases and helicases, due to its ability to monitor nucleotide incorporation during DNA synthesis. Additionally, it plays a crucial role in investigating diseases related to DNA replication and repair mechanisms. Synonyms: 3'-O-(N-Methyl-anthraniloyl)-2'-deoxyadenosine-5'-triphosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. CAS No. 128113-53-1. Molecular formula: C18H23N6O13P3(free acid). Mole weight: 624.33 (free acid). | |
Melanoma-associated antigen C2 (43-57) Quick inquiry Where to buy Suppliers range | Melanoma-associated antigen C2 (43-57) is a 15-aa peptide. Melanoma-associated antigen C2 is proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Synonyms: MAGE-C2 antigen (43-57); Cancer/testis antigen 10 (43-57); Hepatocellular carcinoma-associated antigen 587 (43-57). | |
Mezigdomide Quick inquiry Where to buy Suppliers range | Mezigdomide is a new type of protein degrading agent, a cereblon E3 ubiquitin ligase modulating drug, with potential immunomodulatory and anti-tumor activity. Synonyms: CC-92480; CC 92480; CC92480. Grades: >98% by HPLC. CAS No. 2259648-80-9. Molecular formula: C32H30FN5O4. Mole weight: 567.6. | |
N106 Quick inquiry Where to buy Suppliers range | N106 is an activator of SUMO-activating enzyme, E1 ligase. It can improve ventricular function in animal models. Synonyms: N106; N 106; N-106; 4-Methoxy-N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl-2-benzothiazolamine. Grades: ≥98% by HPLC. CAS No. 862974-25-2. Molecular formula: C17H14N4O3S. Mole weight: 354.38. | |
N6-(6-Amino)hexyl-dATP - 5-FAM Quick inquiry Where to buy Suppliers range | N6-(6-Amino)hexyl-dATP - 5-FAM, a fluorescently labeled nucleotide analog, finds its remarkable applicability in molecular biology for DNA synthesis, repair, and replication studies. One can efficiently detect polymerases, nicking enzymes, DNA ligases, and helicases, besides employing it in real-time PCR (polymerase chain reaction) and DNA sequencing. Remarkably, it can serve as a facile substrate for DNA polymerases in DNA synthesis reactions, making it a versatile compound paving new avenues for intriguing scientific pursuits. Synonyms: N; -(6-Amino)hexyl-2'-deoxyadenosine-5'-triphosphate, labeled with 5 FAM, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C37H39N6O18P3(free acid). Mole weight: 948.66 (free acid). | |
NAB 2 Quick inquiry Where to buy Suppliers range | NAB 2 can protect against α-synuclein toxicity. It can reverse the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons and promote E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport. Synonyms: alphaSYN-IN-NAB2; alphaSYN IN NAB2; alphaSYNINNAB2; alphaSYN inhibitor NAB2; alphaSYN inhibitor-NAB2; NAB2; α-Synuclein inhibitor NAB2; αSyn-reversor-NAB2; Rsp5/Nedd4 actovator NAB2; NAB2; NAB 2; NAB-2; N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide. Grades: ≥98% by HPLC. CAS No. 1504588-00-4. Molecular formula: C23H20ClN3O. Mole weight: 389.88. | |
NAE Inhibitor, MLN4924 Quick inquiry Where to buy Suppliers range | A cell-permeable AMP mimetic that targets the NEDD8-activating E1 enzyme NAE nucleotide-binding site and undergoes a NAE-catalyzed covalent NEDD8 adduct formation, the adduct in turn acts as a tight-binding, ATP-competitive NAE inhibitor (IC50 = 4.7nM), exhibiting much reduced or little potency against UAE/UBA1, UBA6/UBE1L2, SAE, ATG7, adenosine receptors A1/A2A/A2B/A3, or a panel of 12 cellular kinases. Selectively reduces cellular Ubc12-NEDD8, but not Ubc9-SUMO or Ubc10-Ub, thioester formation (ICmax = 90nM in HCT-116 cultures in 24h), resulting in cullin-RING ligases substrates elevation. Shown to inhibit the growth of various cancer cells both in cultures (IC50 from 50nM to 1.03uM) in vitro and in murine xenograft models (30 to 60mg/kg via s.c.) in vivo via apoptosis induction. CAS Number:951950-33-7. Group: Biochemicals. Alternative Names: NEDD8-Activating Enzyme Inhibitor; ( (1S, 2S, 4R) -4- (4- ( (1S) -2, 3-Dihydro-1H-inden-1-ylamino) -7H-pyrrolo[2, 3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl) methyl sulfamate. Grades: Highly Purified. CAS No. 951950-33-7. Pack Sizes: 5mg. Molecular Formula: C21H25N5O4S. US Biological Life Sciences. | Worldwide |
Nicotinic Acid Adenine Dinucleotide Quick inquiry Where to buy Suppliers range | Nicotinic Acid Adenine Dinucleotide is an analog of β-Nicotinamide Adenine Dinucleotide; a coenzyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate groups. β-Nicotinamide Adenine Dinucleotide acts as a coenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleotide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. Synonyms: Adenosine 5'-(trihydrogen diphosphate), P'?5'-ester with 3-carboxy-1-β-D-ribofuranosylpyridinium, inner salt; 3-Carboxy-1-β-D-ribofuranosylpyridinium hydroxide, 5'-ester with adenosine 5'-pyrophosphate, inner salt; Pyridinium, 3-carboxy-1-β-D-ribofuranosyl-, hydroxide, 5'?5'-ester with adenosine 5'-(trihydrogen pyrophosphate), inner salt; 1: PN: WO2006081329 PAGE: 47 claimed sequence; Adenine-nicotinic Acid Dinucleotide; Codehydrogenase I, carboxy deamido analog; Codehydrogenase I, nicotinic acid analog; Deamido-NAD; Deamidodiphosphopyridine Nucleotide; Desamido NAD; Nicotinate Adenine Dinucleotide; Nicotinic Acid-adenine Dinucleotide. CAS No. 6450-77-7. Molecular formula: C21H26N6O15P2. Mole weight: 664.41. | |
NSC 207895 Quick inquiry Where to buy Suppliers range | NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase. Synonyms: NSC 207895; NSC-207895; NSC207895; XI-006; XI006; XI 006. Grades: >98%. CAS No. 58131-57-0. Molecular formula: C11H13N5O4. Mole weight: 279.25. | |
Penicillin DF Quick inquiry Where to buy Suppliers range | Penicillin DF is used to characterize phenylacetate-CoA ligase from Penicillium chrysogenum. Group: Biochemicals. Grades: Highly Purified. CAS No. 4493-18-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C14H22N2O4S, Molecular Weight: 314.399999999999. US Biological Life Sciences. | Worldwide |
Pomalidomide-C2-NH2 Quick inquiry Where to buy Suppliers range | Pomalidomide-C2-NH2 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. Synonyms: 4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; SCHEMBL17884390; TQP0427; Cereblon Ligand-Linker Conjugates 15; HY-128846; Pomalidomide-C2-NH2; Pomalidomide-alkylC2-amine; E3 ligase Ligand 17; 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride. Grades: > 98%. CAS No. 1957235-66-3. Molecular formula: C15H16N4O4. Mole weight: 316.31. | |
Pomalidomide-C4-NH2 Quick inquiry Where to buy Suppliers range | Pomalidomide-C4-NH2 is a synthetic E3 ligase ligand-linker conjugate that incorporates Pomalidomide-based CRBN ligands and linkers used in PROTAC technology. Synonyms: 4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione; 4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[(4-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-; Thalidomide-NH-C4-NH2. Grades: ≥95%. CAS No. 1957236-34-8. Molecular formula: C17H20N4O4. Mole weight: 344.37. | |
Pomalidomide-PEG1-C2-NH2 Quick inquiry Where to buy Suppliers range | Pomalidomide-PEG1-C2-NH2 is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation. Synonyms: Thalidomide-NH-PEG1-NH2; 4-((2-(2-aminoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-{[2-(2-Aminoethoxy)ethyl]amino}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-. Grades: ≥95%. CAS No. 2138439-12-8. Molecular formula: C17H20N4O5. Mole weight: 360.36. | |
Pomalidomide-PEG2-C2-NH2 Quick inquiry Where to buy Suppliers range | Pomalidomide-PEG2-C2-NH2 is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation. Synonyms: Thalidomide-NH-PEG2-NH2; 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 4-({2-[2-(2-Aminoethoxy)ethoxy]ethyl}amino)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-; 4-({2-[2-(2-aminoethoxy)ethoxy]ethyl}amino)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione; Thalidomide-NH-PEG2-C2-NH2. Grades: ≥95%. CAS No. 2093416-32-9. Molecular formula: C19H24N4O6. Mole weight: 404.42. | |
Pomalidomide-PEG3-C2-NH2 hydrochloride Quick inquiry Where to buy Suppliers range | Pomalidomide-PEG3-C2-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate containing a cereblon ligand based on Pomalidomide and a PEG linker of 3 O(CH2)2 units with terminal amine, as a part of a variety of functionalized PROTAC molecules for binding to a target protein ligand. Synonyms: Cereblon Ligand-Linker Conjugates 5 hydrochloride; E3 ligase Ligand-Linker Conjugates 30 hydrochloride. CAS No. 2446474-09-3. Molecular formula: C21H29ClN4O7. Mole weight: 484.93. |