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| Product | Description | |
|---|---|---|
| Lithocholic acid | Lithocholic acid is a toxic secondary bile acid that can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is also a FXR antagonist and a PXR/SXR agonist [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 434-13-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0172. |  |
| Lithocholic acid | Lithocholic acid - Product ID: NST-10-125. Category: Steroids. Alternative Names: 3-Hydroxycholan-24-oic acid, 3?-Hydroxy-5?-cholanic acid. Purity: 98%. Test method: HPLC. CAS No. 434-13-9. Pack Sizes: 5g, 10g, 25g, 50g. Appearance: White to off-white Powder. Molecular formula: C24H40O3. Mole weight: 376.57. Storage: +2 +8 °C. |  |
| Lithocholic Acid | A cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: (3α,5 β)-3-Hydroxycholan-24-oic Acid; 17 β - (1-Methyl-3-carboxypropyl) etiocholan-3α -ol; 3-Hydroxycholan-24-oic Acid; 3α-Hydroxy-5 β-cholan-24-oate; 3α-Hydroxy-5 β-cholan-24-oic Acid; 3α-Hydroxy-5 β-cholanic Acid; 3α-Hydroxy-5 β-cholanoic Acid; 3α-Hydroxycholanic Acid; NSC 683770. Grades: Highly Purified. CAS No. 434-13-9. Pack Sizes: 1g. US Biological Life Sciences. |  Worldwide |
| Lithocholic Acid | A cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3α-Hydroxy-5β-cholanic acid. Product Category: Steroidal Compounds. Appearance: White to off-white powder. CAS No. 434-13-9. Molecular formula: C24H40O3. Mole weight: 376.57. Purity: 0.98. IUPACName: (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid. Canonical SMILES: CC(CCC(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C. Density: 1.0454 g/cm³. ECNumber: 207-099-1. Product ID: ACM434139. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Lithocholic Acid 24-Ac-O-β-D-Glucuronide | Lithocholic Acid 24-Ac-O-β-D-Glucuronide is an impurity of Lithocholic Acid (L469180), a cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Synonyms: 1-[(3α,5β)-3-Hydroxycholan-24-oate] β-D-Glucopyranuronic Acid. CAS No. 142780-61-8. Molecular formula: C30H48O9. Mole weight: 552.7. |  |
| Lithocholic acid (3alpha-Hydroxy-5beta-cholan-24-oic acid, 3alpha-Hydroxy-5beta-cholanic acid, 5beta-Cholan-24-oic acid-3alpha-ol, LCA) | Lithocholic acid (LCA) is a hydrophobic secondary bile acid that acts as a detergent to solubilize fats for absorption. Known to display both carcinogenic and apoptotic activities. Also binds to the p53 binding sites of both MDM2 and MDM4 with a five-fold preference for MDM4. Group: Biochemicals. Grades: Highly Purified. CAS No. 434-13-9. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Lithocholic Acid 3-O-Glucuronide | Lithocholic Acid 3-O-Glucuronide is an impurity of Lithocholic Acid, a cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Synonyms: (3α,5β)-23-Carboxy-24-norcholan-3-yl β-D-Glucopyranosiduronic Acid; Lithocholic Acid 3-Glucuronide. Grades: 98%. CAS No. 75239-91-7. Molecular formula: C30H48O9. Mole weight: 552.7. | |
| Lithocholic acid 3-sulfate disodium | Lithocholic acid 3-sulfate disodium salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Sulfolithocholic acid disodium. CAS No. 64936-81-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-113238A. | |
| Lithocholic Acid-d4 | A labeled cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: (3α,5 β)-3-Hydroxycholan-24-oic Acid-d4; 17 β - (1-Methyl-3-carboxypropyl) etiocholan-3α -ol-d4; 3-Hydroxycholan-24-oic Acid-d4; 3α-Hydroxy-5 β-cholan-24-oate-d4; 3α-Hydroxy-5 β-cholan-24-oic Acid-d4; 3α-Hydroxy-5 β-cholanic Acid-d4; 3α-Hydroxy-5 β-cholanoic Acid-d4; 3α-Hydroxycholanic Acid-d4; NSC 683770-d4. Grades: Highly Purified. CAS No. 83701-16-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Lithocholic Acid-d5 | A labelled cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: (3α,5 β)-3-Hydroxycholan-24-oic Acid-d5; 17 β - (1-Methyl-3-carboxypropyl) etiocholan-3α -ol-d5; 3-Hydroxycholan-24-oic Acid-d5; 3α-Hydroxy-5 β-cholan-24-oate-d5; 3α-Hydroxy-5 β-cholan-24-oic Acid-d5; 3α-Hydroxy-5 β-cholanic Acid-d5; 3α-Hydroxy-5 β-cholanoic Acid-d5; 3α-Hydroxycholanic Acid-d5; NSC 683770-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 6-Oxolithocholic acid | 6-Oxolithocholic acid is a bile acid metabolite derived from Lithocholic acid (HY-B0172). 6-Oxolithocholic acid has high cytotoxicity and can induce apoptosis , especially in hepatocytes. 6-Oxolithocholic acid can participate in the regulation of bile acid metabolism and synthesis and affect the metabolic pathway of cholesterol. 6-Oxolithocholic acid can be used to study the role of bile acids in health and disease, especially in the context of digestive and liver diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 6-Ketolithocholic acid. CAS No. 2393-61-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-W587530. | |
| Glycolithocholic acid | Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Lithocholylglycine. CAS No. 474-74-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116374. | |
| Glycolithocholic acid-d4 | Glycolithocholic acid-d 4 is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1][2][3][4]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Lithocholylglycine-d4. CAS No. 2044276-16-4. Pack Sizes: 500 μg; 1 mg. Product ID: HY-116374S. | |
| Glycolithocholic acid sodium | Glycolithocholic acid (Lithocholylglycine) sodium is the sodium salt of Glycolithocholic acid. Glycolithocholic acid is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Lithocholylglycine sodium. CAS No. 24404-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116374A. | |
| Isoallolithocholic acid | Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 3β-Hydroxy-5α-cholanic acid. CAS No. 2276-93-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0172A. | |
| Sulfolithocholic Acid Trimethylamine Salt | Sulfolithocholic Acid is an derivative of Lithocholic Acid (L469180), a cholic acid derivative and TGR5 modulator found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: 3α-Sulfate-5 β-cholan-24-oic Acid Trimethylamine Salt; Lithocholic Acid 3-O-Sulfate Trimethylamine Salt ; Lithocholic Acid 3α-Sulfate Trimethylamine Salt; (3α,5 β)-3-(Sulfooxy)-cholan-24-oic Acid Trimethylamine Salt. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (3a,5b)-23-Carboxy-24-norcholan-3-yl b-D-glucopyranosiduronic acid | (3a,5b)-23-Carboxy-24-norcholan-3-yl b-D-glucopyranosiduronic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Lithocholic acid glucuronide, Lithocholate 3-O-glucuronide, Lithocholate 3-O-beta-D-glucuronide, CID126511, beta-D-Glucopyranosiduronic acid, (3alpha,5beta)-23-carboxy-24-norcholan-3-yl, (SP-4-2)-, 75239-91-7. Product Category: Heterocyclic Organic Compound. CAS No. 75239-91-7. Molecular formula: C30H48O9. Mole weight: 552.696720 [g/mol]. Purity: 0.96. IUPACName: (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[[(3S,5R,8R,9S,10S,13R,14S,17R)-17-[(2R)-5-hydroxy-5-oxopentan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxane-2-carboxylic acid. Product ID: ACM75239917. Alfa Chemistry ISO 9001:2015 Certified. | |
| 3-Oxo-5 β-cholanoic Acid | 3-Oxo-5 β-cholanoic Acid. Group: Biochemicals. Alternative Names: 3-Oxo-5 β-cholan-24-oic Acid; 3-Oxo-5 β-cholanic Acid; 3-Ketolithocholic Acid; 3-Oxo-5 β-cholan-24-oic Acid; 3-Oxo-5 β-cholanic acid; 3-Oxo-5 β-cholanoic Acid; 3-Oxocholanic Acid; 3-Oxolithocholic Acid; 3-keto-5 β-Cholan-24-oic Acid; 3-keto-5 β-Cholanic Acid; 5 β-Cholanic Acid-3-one; Dehydrolithocholic Acid; Dehydro-lithocholic Acid. Grades: Highly Purified. CAS No. 1553-56-6. Pack Sizes: 500mg. Molecular Formula: C24H38O3, Molecular Weight: 374.56. US Biological Life Sciences. | Worldwide |
| 5β-Cholanic acid-3α-ol methyl ester | 5β-Cholanic acid-3α-ol methyl ester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-ALPHA-HYDROXY-5-BETA-CHOLAN-24-OIC ACID METHYL ESTER;5-BETA-CHOLANIC ACID-3-ALPHA-OL METHYL ESTER;5-BETA-CHOLAN-24-OIC ACID 3-ALPHA-OL METHYL ESTER;METHYL LITHOCHOLATE;LITHOCHOLIC ACID METHYL ESTER;5.beta.-Cholan-24-oic acid, 3.alpha.-hydroxy-, methyl. Product Category: Steroidal Compounds. CAS No. 1249-75-8. Molecular formula: C25H42O3. Mole weight: 390.6. Purity: 0.95. IUPACName: 3-α-HYDROXY-5-β-CHOLAN-24-OIC ACID METHYL ESTER. Product ID: ACM1249758. Alfa Chemistry ISO 9001:2015 Certified. | |
| lithocholate 6β-hydroxylase | A heme-thiolate protein (P-450). Expression of the gene for this enzyme is 50-fold higher in male compared to female hamsters. Group: Enzymes. Synonyms: lithocholate 6β-monooxygenase; CYP3A10; 6β-hydroxylase; cytochrome P450 3A10/lithocholic acid 6β-hydroxylase. Enzyme Commission Number: EC 1.14.13.94. CAS No. 9075-83-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0903; lithocholate 6β-hydroxylase; EC 1.14.13.94; 9075-83-6; lithocholate 6β-monooxygenase; CYP3A10; 6β-hydroxylase; cytochrome P450 3A10/lithocholic acid 6β-hydroxylase. Cat No: EXWM-0903. |  |
| Methyl Lithocholate | Methyl Lithocholate is an derivative of Lithocholic Acid (L469180),a cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: Lithocholic Acid Methyl Ester-d7; Methyl 3α-Hydroxy-5 β-cholan-24-oate-d7; Methyl 3α-Hydroxy-5 β-cholanoate-d7; 3α-Hydroxy-5 β-cholanic Acid-d7; 3α-Hydroxy-5 β-cholan-24-oic Acid Methyl Ester-d7; (3α,5 β)-3-Hydroxycholan-24-oic Acid Methyl Ester-d7. Grades: Highly Purified. CAS No. 1249-75-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Methyl Lithocholate-d7 | Isotope labelled derivative of Lithocholic Acid (L469180),a cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones. Group: Biochemicals. Alternative Names: Lithocholic Acid Methyl Ester-d7; Methyl 3α-Hydroxy-5 β-cholan-24-oate-d7; Methyl 3α-Hydroxy-5 β-cholanoate-d7; 3α-Hydroxy-5 β-cholanic Acid-d7; 3α-Hydroxy-5 β-cholan-24-oic Acid Methyl Ester-d7; (3α,5 β)-3-Hydroxycholan-24-oic Acid Methyl Ester-d7. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Nutriacholic Acid | Nutriacholic Acid. Group: Biochemicals. Alternative Names: 3α-Hydroxy-7-oxo-5 β-cholan-24-oic Acid; 3α-Hydroxy-7-oxo-5 β-cholanic Acid; 3α-Hydroxy-7-oxo-5 β-cholanoic Acid; 3α-Hydroxy-7-oxo-5 β-cholic Acid; 5 β-Cholanic Acid-3α-ol-7-one; 7-Ketochenodeoxycholic Acid; 7-Ketolithocholic Acid; 7-Oxo-3α-hydroxycholan-24-oic Acid; 7-Oxolithocholic Acid; 7-Keto-Lithocholic Acid; NSC 226118; 3α-Hydroxy-7-oxo-5 β-cholanic Acid; 3α-Hydroxy-7-oxo-5 β-cholan-24-oic Acid; (3α,5 β)-3-Hydroxy-7-oxo-cholan-24-oic Acid. Grades: Highly Purified. CAS No. 4651-67-6. Pack Sizes: 1g. Molecular Formula: C24H38O4, Molecular Weight: 390.56. US Biological Life Sciences. | Worldwide |
| 3α-hydroxy bile acid-CoA-ester 3-dehydrogenase | This bacterial enzyme is involved in the 7-dehydroxylation process associated with bile acid degradation. The enzyme has very little activity with unconjugated bile acid substrates. It has similar activity with choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA. Group: Enzymes. Synonyms: baiA1 (gene name); baiA2 (gene name); baiA3 (gene name). Enzyme Commission Number: EC 1.1.1.395. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0315; 3α-hydroxy bile acid-CoA-ester 3-dehydrogenase; EC 1.1.1.395; baiA1 (gene name); baiA2 (gene name); baiA3 (gene name). Cat No: EXWM-0315. | |
| 3α-hydroxycholanate dehydrogenase (NAD+) | Also acts on other 3α-hydroxysteroids with an acidic side-chain. cf. EC 1.1.1.392, 3α-hydroxycholanate dehydrogenase (NADP+). Group: Enzymes. Synonyms: α-hydroxy-cholanate dehydrogenase; lithocholate:NAD+ oxidoreductase; 3α-hydroxycholanate dehydrogenase. Enzyme Commission Number: EC 1.1.1.52. CAS No. 9028-57-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0337; 3α-hydroxycholanate dehydrogenase (NAD+); EC 1.1.1.52; 9028-57-3; α-hydroxy-cholanate dehydrogenase; lithocholate:NAD+ oxidoreductase; 3α-hydroxycholanate dehydrogenase. Cat No: EXWM-0337. | |
| bile acid CoA-transferase | The enzyme, characterized from the gut bacterium Clostridium scindens, catalyses the last step in bile acid 7α-dehydroxylation, the removal of the CoA moiety from the products. By using a transferase rather than hydrolase, the bacteria conserve the thioester bond energy, saving ATP molecules. Clostridium scindens possesses two forms of the enzyme, encoded by the baiF and baiK genes. While the enzymes have a broad acceptor specificity and can use allocholate, ursodeoxycholate, and β-muricholate, the donor specificity is more strict. BaiF acts on lithocholoyl-CoA and deoxycholoyl-CoA, and BaiK acts only on the latter. Group: Enzymes. Synonyms: baiF (gene name); baiK (gene name); bile acid coenzyme A transferase. Enzyme Commission Number: EC 2.8.3.25. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3421; bile acid CoA-transferase; EC 2.8.3.25; baiF (gene name); baiK (gene name); bile acid coenzyme A transferase. Cat No: EXWM-3421. | |
| cholate-CoA ligase | Requires Mg2+ for activity. The mammalian enzyme is membrane-bound and catalyses the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates. The bacterial enzyme is soluble and participates in an anaerobic bile acid 7 α-dehydroxylation pathway. Group: Enzymes. Synonyms: BAL; bile acid CoA ligase; bile acid co. Enzyme Commission Number: EC 6.2.1.7. CAS No. 9027-90-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5709; cholate-CoA ligase; EC 6.2.1.7; 9027-90-1; BAL; bile acid CoA ligase; bile acid coenzyme A ligase; choloyl-CoA synthetase; choloyl coenzyme A synthetase; cholic thiokinase; cholate thiokinase; cholic acid:CoA ligase; 3α,7α,12α-trihydroxy-5β-cholestanoyl coenzyme A synthetase; 3α,7α,12α-trihydroxy-5β-cholestanoate-CoA ligase; 3α,7α,12α-trihydroxy-5β-cholestanoate-CoA synthetase; THCA-CoA ligase; 3α,7α,12α-trihydroxy-5β-cholestanate-CoA ligase; 3α,7α,12α-trihydroxy-5β-cholestanate:CoA ligase (AMP-forming); cholyl-CoA synthetase; trihydroxycoprostanoyl-CoA synthetase. Cat No: EXWM-5709. | |
| taurochenodeoxycholate 6α-hydroxylase | A heme-thiolate protein (P-450). Requires cytochrome b5 for maximal activity. Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate. In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid. Group: Enzymes. Synonyms: CYP3A4; CYP4A21; taurochenodeoxycholate 6α-monooxygenase. Enzyme Commission Number: EC 1.14.13.97. CAS No. 105669-85-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0905; taurochenodeoxycholate 6α-hydroxylase; EC 1.14.13.97; 105669-85-0; CYP3A4; CYP4A21; taurochenodeoxycholate 6α-monooxygenase. Cat No: EXWM-0905. | |
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