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| Product | Description | |
|---|---|---|
| Lonafarnib | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyenzyme activators, inhibitors & substrates. |  |
| Lonafarnib | Lonafarnib. Group: Biochemicals. Alternative Names: 4-[2-[4-[(11R)-3, 10-Dibromo-8-chloro-6, 11-dihydro-5H-benzo[5, 6]cyclohepta[1, 2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide; Sarasar; Sch 66336. Grades: Highly Purified. CAS No. 193275-84-2. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C27H31Br2ClN4O2. US Biological Life Sciences. |  Worldwide |
| Lonafarnib | Lonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. Uses: Enzyme inhibitors. Synonyms: SCH 66336; SCH-66336; SCH66336; Sarasar. Grades: > 95%. CAS No. 193275-84-2. Molecular formula: C27H31Br2ClN4O2. Mole weight: 638.829. |  |
| Lonafarnib | Lonafarnib (Sch66336) is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras , K-ras and N-ras with IC 50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sch66336. CAS No. 193275-84-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15136. |  |
| 3, 10-Dibromo-8-chloro-6, 11-dihydro-5H-benzo[5, 6]cyclohepta[1, 2-b]pyridine | 3, 10-Dibromo-8-chloro-6, 11-dihydro-5H-benzo[5, 6]cyclohepta[1, 2-b]pyridine is used in the synthetic preparation of lonafarnib, a potential anticancer agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 272107-22-9. Pack Sizes: 500mg, 1g. Molecular Formula: C14H10Br2ClN, Molecular Weight: 387.5. US Biological Life Sciences. | Worldwide |
| AZD-3409 | AZD-3409 is a potent prenyl transferase inhibitor. AZD-3409 showed higher potency than lonafarnib. AZD3409 inhibits farnesylation to a higher extent than geranylgeranylation. AZD3409 might be active in gefitinib-resistant breast carcinoma. Synonyms: AZD-3409; AZD 3409; AZD3409. Grades: 98%. CAS No. 345915-10-8. Molecular formula: C34H41FN4O4S2. Mole weight: 652.844. | |
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