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| Product | Description | |
|---|---|---|
| Lonidamine | Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor ( K i : 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AF-1890; Diclondazolic Acid; DICA. CAS No. 50264-69-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0486. |  |
| Lonidamine | Lonidamine. Group: Biochemicals. Grades: Purified. CAS No. 50264-69-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Lonidamine | mitochondrial hexokinase inhibitor. Group: Fluorescence/luminescence spectroscopy. |  |
| (2R)-2-[6-(4-Chlorophenoxy)hexyl]-oxiranecarboxylic Acid Sodium Salt | (2R)-2-[6-(4-Chlorophenoxy)hexyl]-oxiranecarboxylic Acid Sodium Salt is a carnitine palmatoyltransferase 1 inhibitor. It is also a chemo-sensitizing agent that is able to induce apoptosis in HL60 cells when used with glycolytic inhibitors such as 2-deoxy-D-glucose (D239000) and lonidamine (L469458). Group: Biochemicals. Grades: Highly Purified. CAS No. 828934-41-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C15H18ClNaO4, Molecular Weight: 320.74. US Biological Life Sciences. | Worldwide |
| Adjudin | Adjudin, formerly called as AF-2364, an analog of lonidamine, attenuates microglia activation by suppression of the NF-κB pathway. Adjudin has potent anti-spermatogenic activity in animals. Synonyms: 1-[(2,4-dichlorophenyl)methyl]indazole-3-carbohydrazide1-(2,4-dichlorobenzyl)indazole-3-carbohydrazideadjudinAF-2364AF2364; AF 2364. CAS No. 252025-52-8. Molecular formula: C15H12Cl2N4O. Mole weight: 335.19. |  |
| Mitochondria-Targeted Compound Library | A unique collection of 447 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine; - Targets include mitochondria related targets, such as ATPase, mitochondria-associated hexokinase, Bcl-2, NADP, etc. and inhibitors for the autophagy initiating factor, ULK1, also include other promising mitochondria-targeted compounds such as lonidamine, paclitaxel, etc; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L5300. Categories: Mitochondria-Targeted Compounds Libraries. |  |
| Mito-LND | Mito-LND (Mito-Lonidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS). Mito-LND inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species, and induces autophagic cell death in lung cancer cells[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mito-Lonidamine. CAS No. 2361564-49-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134832. | |
| PROTAC HK2 Degrader-1 | PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3033812-84-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155008. | |
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