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| Product | Description | |
|---|---|---|
| Lucitanib | Lucitanib, also known as E-3810, is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types. Synonyms: E3810; E-3810; E 3810; AL3810; AL 3810; AL-3810; Lucitanib. CAS No. 1058137-23-7. Molecular formula: C26H25N3O4. Mole weight: 443.503. |  |
| Lucitanib | Lucitanib (E-3810) is a novel dual inhibitor of VEGFR and FGFR , potently and selectively inhibits VEGFR1 , VEGFR2 , VEGFR3 , FGFR1 and FGFR2 with IC 50 s of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E-3810. CAS No. 1058137-23-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15391. |  |
| E 3810 dihydrochloride | E 3810 dihydrochloride is a dual VEGFR/FGFR tyrosine kinase inhibitor. It suppresses the tumor angiogenesis and tumor cell proliferation via inhibiting VEGFR1, -2, and -3 and FGFR-1 and -2 kinases in the nanomolar range. Uses: Antitumor agent. Synonyms: E 3810 dihydrochloride; E3810 dihydrochloride; E-3810 dihydrochloride; Lucitanib dihydrochloride; 6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide dihydrochloride. Grades: 99%. CAS No. 2108875-91-6. Molecular formula: C26H25N3O4.2HCl. Mole weight: 516.42. | |
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