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| Product | Description | |
|---|---|---|
| LY294002 | LY294002 Inhibitor. Uses: Scientific use. Product Category: T2008. CAS No. 154447-36-6. |  |
| LY294002 | LY294002 is a broad-spectrum inhibitor of PI3K with IC 50 s of 0.5, 0.57, and 0.97 μM for PI3Kα , PI3Kδ and PI3Kβ , respectively [1]. LY294002 also inhibits CK2 with an IC 50 of 98 nM [2]. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC 50 of 1.4 μM. LY294002 is an apoptosis activator [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 154447-36-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10108. |  |
| LY294002 | LY294002 is a potent inhibitor of phosphoinositide PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively. Synonyms: LY294002; LY-294002; LY 294002; 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; 2-morpholino-8-phenyl-4H-chromen-4-one. Grades: >98%. CAS No. 154447-36-6. Molecular formula: C19H17NO3. Mole weight: 307.349. |  |
| LY294002 | Potent, cell permeable, highly specific PI(3)K (phosphoinositide 3-kinase) inhibitor. Acts on the ATP-binding site of the enzyme. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 154447-36-6. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C19H17NO3. US Biological Life Sciences. |  Worldwide |
| LY294002 hydrochloride | LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC 50 values of 0.5, 0.57, and 0.97 μM for P110α , P110δ and P110β , respectively. LY294002 hydrochloride also inhibits CK2 with an IC 50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 934389-88-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10108A. | |
| LY 294002 - CAS 154447-36-6 | LY294002, CAS 154447-36-6, is a cell-permeable, potent, reversible, and specific inhibitor of PI 3-kinase ((IC?? = 1.4 μM). Acts on the ATP-binding site. Group: Fluorescence/luminescence spectroscopy. |  |
| LY 303511 | LY 303511 is an inactive analogue of the phosphoinositide 3-kinase inhibitor LY294002, but it does not inhibit PI3K. It enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells, and reversibly blocks K+ currents with an IC50 of 64.6±9.1 μM in MIN6 insulinoma cells. Synonyms: EM 101; 8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one; 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 8-phenyl-2-(1-piperazinyl)-; 2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one; NSC736787. Grades: >98%. CAS No. 154447-38-8. Molecular formula: C19H18N2O2. Mole weight: 306.36. | |
| LY 303511 hydrochloride | LY 303511 hydrochloride is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K + currents (IC 50 =64.6±9.1 μM) in MIN6 insulinoma cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-90-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15643A. | |
| PI 828 | PI 828 is a cell permeable 4'-amino derivative which inhibits the p110α, p110β, p110δ, and p110γ subunits of PI 3-kinase. PI-828 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K; IC50s = 9.8, 183, 227, and 1,967 nM for p110β, p110α, p110δ, and p110γ, respectively) that displays higher potency than LY 294002. Synonyms: LY294002,4'-NH2; PI-828; PI 828; PI828. 2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one. Grades: ≥99% by HPLC. CAS No. 942289-87-4. Molecular formula: C19H18N2O3. Mole weight: 322.36. | |
| SC66, Akt Inhibitor XVIII ( (2E, 6E) -2, 6-bis (4-Pyridylmethylene) cyclohexanone) | A cell-permeable pyridine compound that selectively targets Akt, but not PLCd, PH domain, preventing Akt membrane localization / activation and rendering Akt in a conformation susceptible to ubiquitination and subsequent proteasomal degradation. Akti-1/2 competes for Akt PH domain binding and blocks SC66-induced Akt ubiquitination and proteasomal degradation. Effectively inhibits HEK293T growth both in vitro (>99 inhibition at 0.4uM) and in mice in vivo (84% of control tumor size with twice weekly i.p. dose of 30mg/kg), Synergizes with LY294002 in cell death induction in HeLa and HS-Sultan cultures in vitro. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O, Molecular Weight: 276.3. US Biological Life Sciences. | Worldwide |
| SF1126 | SF1126 is a water soluble, small-molecule prodrug containing the pan-PI3K/mTOR inhibitor LY294002/SF1101 conjugated to the RGD-containing tetra-peptide SF1174 with potential antineoplastic and antiangiogenic activities. The targeting peptide SF1174 moiety of pan-PI3K/mTOR inhibitor SF1126 selectively binds to cell surface integrins and, upon cell entry, the agent is hydrolyzed to the active drug SF1101; SF1101 selectively inhibits all isoforms of phosphoinositide-3-kinase (PI3K) and other members of the PI3K superfamily, such as the mammalian target of rapamycin (mTOR) and DNA-PK. By inhibiting the PI3K signaling pathway, this agent may inhibit tumor cell and tumor endothelial cell proliferation and survival. Integrins are transmembrane cell adhesion proteins expressed on the surfaces of endothelial and tumor cells. Synonyms: SF 1126, SF-1126. CAS No. 936487-67-1. Molecular formula: C39H48N8O14. Mole weight: 852.84. | |
| TG101209 | TG101209 is a novel and potent JAK2 inhibitor. The induction of cytotoxicity was associated with inhibition of cell cycle progression and induction of apoptosis in myeloma cell lines and patient-derived plasma cells. Exploring the mechanism of action of TG101209 indicated downregulation of pJak2, pStat3, and Bcl-xl levels with upregulation of pErk and pAkt levels indicating cross talk between signaling pathways. TG101209, when used in combination with the PI3K inhibitor LY294002, demonstrated synergistic cytotoxicity against myeloma cells. Synonyms: TG101209; TG-101209; TG 101209. Grades: 0.98. CAS No. 936091-14-4. Molecular formula: C26H35N7O2S. Mole weight: 509.67. | |
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