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| Product | Description | |
|---|---|---|
| LY294002 | LY294002 Inhibitor. Uses: Scientific use. Product Category: T2008. CAS No. 154447-36-6. |  |
| LY294002 | LY294002 is a broad-spectrum inhibitor of PI3K with IC 50 s of 0.5, 0.57, and 0.97 μM for PI3Kα , PI3Kδ and PI3Kβ , respectively [1]. LY294002 also inhibits CK2 with an IC 50 of 98 nM [2]. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC 50 of 1.4 μM. LY294002 is an apoptosis activator [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 154447-36-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10108. |  |
| LY294002 | Potent, cell permeable, highly specific PI(3)K (phosphoinositide 3-kinase) inhibitor. Acts on the ATP-binding site of the enzyme. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 154447-36-6. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C19H17NO3. US Biological Life Sciences. |  Worldwide |
| LY294002 hydrochloride | LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC 50 values of 0.5, 0.57, and 0.97 μM for P110α , P110δ and P110β , respectively. LY294002 hydrochloride also inhibits CK2 with an IC 50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 934389-88-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10108A. | |
| LY 294002 - CAS 154447-36-6 | LY294002, CAS 154447-36-6, is a cell-permeable, potent, reversible, and specific inhibitor of PI 3-kinase ((IC?? = 1.4 μM). Acts on the ATP-binding site. Group: Fluorescence/luminescence spectroscopy. |  |
| LY 303511 hydrochloride | LY 303511 hydrochloride is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K + currents (IC 50 =64.6±9.1 μM) in MIN6 insulinoma cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-90-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15643A. | |
| Mytoxin B | Mytoxin B is a satratoxin-type trichothecene macrolide and is similar to the effect of LY294002. Mytoxin B induces cell apoptosis via PI3K/Akt pathway. An ADC cytotoxin. Synonyms: mytoxin B; 105049-15-8; (1'Z,2S,6'R,11'R,13'R,15'S,16'R,19'Z,23'R,27'R)-23'-acetyl-27'-hydroxy-9',15'-dimethyl-4',12',17',24'-tetraoxaspiro[oxirane-2,14'-pentacyclo[21.3.1.1. 0. 0,octacosane]-1',9',19'-triene-3',18'-dione. Grade: ≥95%. CAS No. 105049-15-8. Molecular formula: C29H36O9. Mole weight: 528.59. |  |
| SC66, Akt Inhibitor XVIII ( (2E, 6E) -2, 6-bis (4-Pyridylmethylene) cyclohexanone) | A cell-permeable pyridine compound that selectively targets Akt, but not PLCd, PH domain, preventing Akt membrane localization / activation and rendering Akt in a conformation susceptible to ubiquitination and subsequent proteasomal degradation. Akti-1/2 competes for Akt PH domain binding and blocks SC66-induced Akt ubiquitination and proteasomal degradation. Effectively inhibits HEK293T growth both in vitro (>99 inhibition at 0.4uM) and in mice in vivo (84% of control tumor size with twice weekly i.p. dose of 30mg/kg), Synergizes with LY294002 in cell death induction in HeLa and HS-Sultan cultures in vitro. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??N?O, Molecular Weight: 276.3. US Biological Life Sciences. | Worldwide |
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