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| Product | Description | |
|---|---|---|
| M-110 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| M-110 | M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC 50 =47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC 50 s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC 50 s of 0.6 to 0.9 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1395048-49-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12830. |  |
| PIM3 Kinase Inhibitor VII, M-110 (N- (1- (4-Chloro-2-hydroxyphenyl) propylidene) -2- ( (3-morpholinopropyl) amino) isonicotinohydrazide) | A cell-permeable hydroxyphenyl-propylidene-benzohydrazide compound that acts as a potent, ATP-competitive (Ki = 0.3uM), and highly isoform-selective PIM inhibitor (IC50 = 2.5, 2.5, and 0.047uM against PIM1, PIM2, and PIM3, respectively; [ATP] = 10uM), while affecting CK2alpha2 only at much higher concentrations (IC50 = 5uM, [ATP] = 10uM) and exhibiting little or no activity against a panel of 258 other kinases (<40% inhibition at 5uM). Shown to inhibit PIM3-dependent STAT3 Tyr705 phosphorylation in DU-145 prostate cancer and MiaPaCa2 pancreatic cancer cells (by 73% and 83%, respectively; 10uM for 18h), while displaying little effect toward STAT3 Tyr694 phosphoylation in 22RV1 cultures. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| (2-Aminophenyl)(4-methyl-1-piperidinyl)methanone | (2-Aminophenyl)(4-methyl-1-piperidinyl)methanone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 401589-03-5, 2-[(4-methyl-1-piperidinyl)carbonyl]aniline, 2-(4-methylpiperidine-1-carbonyl)aniline, (2-Amino-phenyl)-(4-methyl-piperidin-1-yl)-methanone, 2-aminophenyl 4-methylpiperidyl ketone, (2-aminophenyl)(4-methylpiperidin-1-yl)methanone, ZINC00539602, AC1LJ1QS, AC1Q2R6P, SureCN10535520, ARONIS008245, STOCK4S-53763, CTK4I2561, MolPort-000-472-483, BBL023367, SBB079887, STK167095, AKOS000111600, AG-F-42094, MCULE-1106399753. Product Category: Heterocyclic Organic Compound. CAS No. 401589-03-5. Molecular formula: C13H18N2O. Mole weight: 218.3. Purity: 0.96. IUPACName: (2-aminophenyl)-(4-methylpiperidin-1-yl)methanone. Canonical SMILES: CC1CCN(CC1)C(=O)C2=CC=CC=C2N. Product ID: ACM401589035. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 5-(4-Bromophenyl)thiophene-2-carboxylic acid | 5-(4-Bromophenyl)thiophene-2-carboxylic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-(4-bromophenyl)thiophene-2-carboxylic acid, 40133-13-9, AC1Q73GT, CTK1D5314, MolPort-000-149-685, BB_SC-7876, ACT08200, BBL021903, SBB077812, STK894620, AKOS002676521, AG-F-41955, MCULE-1103978063, KB-243576, EN300-39306, 2-Thiophenecarboxylicacid, 5-(4-bromophenyl)-, 5-(4-BROMOPHENYL)THIOPHENE-2-CARBOXYLIC&, T6260511. Product Category: Heterocyclic Organic Compound. CAS No. 40133-13-9. Molecular formula: C11H7BrO2S. Mole weight: 283.14. Purity: 0.96. IUPACName: 5-(4-bromophenyl)thiophene-2-carboxylic acid. Canonical SMILES: C1=CC(=CC=C1C2=CC=C(S2)C(=O)O)Br. Density: 1.637g/cm³. Product ID: ACM40133139. Alfa Chemistry ISO 9001:2015 Certified. | |
| Aspartic acid,N-[(phenylmethoxy)carbonyl]-,4-(phenylmethyl)ester | Aspartic acid,N-[(phenylmethoxy)carbonyl]-,4-(phenylmethyl)ester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-oxo-4-phenylmethoxy-2-(phenylmethoxycarbonylamino)butanoic acid, 4-(BENZYLOXY)-2-{[(BENZYLOXY)CARBONYL]AMINO}-4-OXOBUTANOIC ACID, Cbz-Asp(OBzl)-OH, NSC163521, ACMC-209u2l, Z-DL-ASP -OH, MLS000776577, AC1L6T20, SCHEMBL2912589, CHEMBL1609505, MolPort-003-722-576, VUKCNAATVIWRTF-UHFFFAOYSA-N, HMS2691M11, NSC118536, AKOS001569734, MCULE-1109069814, NSC-118536, NSC-163521, VA50244, NCGC00245976-01. Product Category: Heterocyclic Organic Compound. CAS No. 29880-21-5. Molecular formula: C19H19NO6. Mole weight: 357.36. Purity: 0.96. IUPACName: 4-oxo-4-phenylmethoxy-2-(phenylmethoxycarbonylamino)butanoic acid. Canonical SMILES: C1=CC=C(C=C1)COC(=O)CC(C(=O)O)NC(=O)OCC2=CC=CC=C2. Product ID: ACM29880215. Alfa Chemistry ISO 9001:2015 Certified. | |
| BMS-936559 | Anti-PD-L1 monoclonal antibody BMS-936559 binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1), which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. Synonyms: MDX1105; BMS936559; MDX 1105; BMS 936559; MDX-1105; BMS-936559; Anti PD L1; PD-L1 inhibitor -Bristol-Myers Squibb. |  |
| Eldelumab | Eldelumab (BMS-936557) is a human anti-CXCL10 (IP-10) monoclonal antibody (IgG1 type). Eldelumab selectively binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab can be used in studies of autoimmune and auto-inflammatory diseases such as rheumatoid arthritis, ulcerative colitis and crohn's disease[1][2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BMS-936557; MDX-1100. CAS No. 946414-98-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99190. | |
| Eldelumab | Eldelumab is a humanized anti-CXCL10 (IP-10) monoclonal antibody that binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab has been use for the treatment of ulcerative colitis. Synonyms: BMS-936557; MDX-1100. CAS No. 946414-98-8. | |
| Nivolumab | Nivolumab is a programmed death receptor-1 ( PD-1 ) blocking human IgG4 antibody to treat advanced (metastatic) non-small cell lung cancer. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BMS-936558; ONO-4538; MDX-1106. CAS No. 946414-94-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9903. | |
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