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| Product | Description | |
|---|---|---|
| M-110 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| M-110 | M-110, a PIM kinases inhibitor, has been found to restrain the proliferation of prostate cancer cell lines and also influence the signaling of Wnt/β-catenin. IC50: 0.6 to 0.9 uM. Uses: M-110 is a pim kinases inhibitor that has been found to restrain the proliferation of prostate cancer cell lines and also influence the signaling of wnt/β-catenin. Synonyms: M-110; M 110; M110; SCHEMBL16410885; SCHEMBL17821539; N'-[(1E)-1-(4-chloro-6-oxocyclohexa-2,4-dien-1-ylidene)propyl]-2-(3-morpholin-4-ylpropylamino)pyridine-4-carbohydrazide. Grades: 98%. CAS No. 1395048-49-3. Molecular formula: C22H28ClN5O3. Mole weight: 445.95. |  |
| M-110 | M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC 50 =47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC 50 s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC 50 s of 0.6 to 0.9 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1395048-49-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12830. |  |
| PIM3 Kinase Inhibitor VII, M-110 (N- (1- (4-Chloro-2-hydroxyphenyl) propylidene) -2- ( (3-morpholinopropyl) amino) isonicotinohydrazide) | A cell-permeable hydroxyphenyl-propylidene-benzohydrazide compound that acts as a potent, ATP-competitive (Ki = 0.3uM), and highly isoform-selective PIM inhibitor (IC50 = 2.5, 2.5, and 0.047uM against PIM1, PIM2, and PIM3, respectively; [ATP] = 10uM), while affecting CK2alpha2 only at much higher concentrations (IC50 = 5uM, [ATP] = 10uM) and exhibiting little or no activity against a panel of 258 other kinases (<40% inhibition at 5uM). Shown to inhibit PIM3-dependent STAT3 Tyr705 phosphorylation in DU-145 prostate cancer and MiaPaCa2 pancreatic cancer cells (by 73% and 83%, respectively; 10uM for 18h), while displaying little effect toward STAT3 Tyr694 phosphoylation in 22RV1 cultures. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| (2-Aminophenyl)(4-methyl-1-piperidinyl)methanone | (2-Aminophenyl)(4-methyl-1-piperidinyl)methanone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 401589-03-5, 2-[(4-methyl-1-piperidinyl)carbonyl]aniline, 2-(4-methylpiperidine-1-carbonyl)aniline, (2-Amino-phenyl)-(4-methyl-piperidin-1-yl)-methanone, 2-aminophenyl 4-methylpiperidyl ketone, (2-aminophenyl)(4-methylpiperidin-1-yl)methanone, ZINC00539602, AC1LJ1QS, AC1Q2R6P, SureCN10535520, ARONIS008245, STOCK4S-53763, CTK4I2561, MolPort-000-472-483, BBL023367, SBB079887, STK167095, AKOS000111600, AG-F-42094, MCULE-1106399753. Product Category: Heterocyclic Organic Compound. CAS No. 401589-03-5. Molecular formula: C13H18N2O. Mole weight: 218.3. Purity: 0.96. IUPACName: (2-aminophenyl)-(4-methylpiperidin-1-yl)methanone. Canonical SMILES: CC1CCN(CC1)C(=O)C2=CC=CC=C2N. Product ID: ACM401589035. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 5-(4-Bromophenyl)thiophene-2-carboxylic acid | 5-(4-Bromophenyl)thiophene-2-carboxylic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-(4-bromophenyl)thiophene-2-carboxylic acid, 40133-13-9, AC1Q73GT, CTK1D5314, MolPort-000-149-685, BB_SC-7876, ACT08200, BBL021903, SBB077812, STK894620, AKOS002676521, AG-F-41955, MCULE-1103978063, KB-243576, EN300-39306, 2-Thiophenecarboxylicacid, 5-(4-bromophenyl)-, 5-(4-BROMOPHENYL)THIOPHENE-2-CARBOXYLIC&, T6260511. Product Category: Heterocyclic Organic Compound. CAS No. 40133-13-9. Molecular formula: C11H7BrO2S. Mole weight: 283.14. Purity: 0.96. IUPACName: 5-(4-bromophenyl)thiophene-2-carboxylic acid. Canonical SMILES: C1=CC(=CC=C1C2=CC=C(S2)C(=O)O)Br. Density: 1.637g/cm³. Product ID: ACM40133139. Alfa Chemistry ISO 9001:2015 Certified. | |
| Aspartic acid,N-[(phenylmethoxy)carbonyl]-,4-(phenylmethyl)ester | Aspartic acid,N-[(phenylmethoxy)carbonyl]-,4-(phenylmethyl)ester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4-oxo-4-phenylmethoxy-2-(phenylmethoxycarbonylamino)butanoic acid, 4-(BENZYLOXY)-2-{[(BENZYLOXY)CARBONYL]AMINO}-4-OXOBUTANOIC ACID, Cbz-Asp(OBzl)-OH, NSC163521, ACMC-209u2l, Z-DL-ASP -OH, MLS000776577, AC1L6T20, SCHEMBL2912589, CHEMBL1609505, MolPort-003-722-576, VUKCNAATVIWRTF-UHFFFAOYSA-N, HMS2691M11, NSC118536, AKOS001569734, MCULE-1109069814, NSC-118536, NSC-163521, VA50244, NCGC00245976-01. Product Category: Heterocyclic Organic Compound. CAS No. 29880-21-5. Molecular formula: C19H19NO6. Mole weight: 357.36. Purity: 0.96. IUPACName: 4-oxo-4-phenylmethoxy-2-(phenylmethoxycarbonylamino)butanoic acid. Canonical SMILES: C1=CC=C(C=C1)COC(=O)CC(C(=O)O)NC(=O)OCC2=CC=CC=C2. Product ID: ACM29880215. Alfa Chemistry ISO 9001:2015 Certified. | |
| BMS-936559 | Anti-PD-L1 monoclonal antibody BMS-936559 binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1), which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. Synonyms: MDX1105; BMS936559; MDX 1105; BMS 936559; MDX-1105; BMS-936559; Anti PD L1; PD-L1 inhibitor -Bristol-Myers Squibb. | |
| Eldelumab | Eldelumab is a humanized anti-CXCL10 (IP-10) monoclonal antibody that binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab has been use for the treatment of ulcerative colitis. Synonyms: BMS-936557; MDX-1100. CAS No. 946414-98-8. | |
| MCP110 | MCP110 is a Ras/Raf-1 interaction inhibitor. The Ras signaling pathway is activated either by direct mutation of Ras or its effector B-Raf. MCP110 was shown to inhibit proliferation of tumor cells. Synonyms: MCP110; MCP-110; MCP 110; N-(4-(benzyloxy)-3-methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanamide. CAS No. 521310-51-0. Molecular formula: C33H36N2O3. Mole weight: 508.662. | |
| MJN110 | MJN110 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor that modulates the synaptic processes. MJN110 has the potential for the treatment of acute nausea and vomiting as well as anticipatory nausea by elevation of endogenous cannabinoid 2-arachidonoylglycerol (2-AG) levels in the brain. Uses: Antihyperalgesic agent. Synonyms: MJN-110; MJN 110; MJN110;2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate. Grades: 98%. CAS No. 1438416-21-7. Molecular formula: C22H21Cl2N3O4. Mole weight: 462.33. | |
| nivolumab | Nivolumab, marketed as Opdivo, is a humanized IgG4 anti-PD-1 monoclonal antibody used to treat cancer. Nivolumab works as a checkpoint inhibitor, blocking a signal that would have prevented activated T cells from attacking the cancer, thus allowing the immune system to clear the cancer. Synonyms: Opdivo; ONO-4538; BMS-936558; MDX1106; ONO4538; BMS936558; MDX 1106; ONO 4538; BMS 936558; MDX-1106. CAS No. 946414-94-4. | |
| Nivolumab | Nivolumab is a programmed death receptor-1 ( PD-1 ) blocking human IgG4 antibody to treat advanced (metastatic) non-small cell lung cancer. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BMS-936558; ONO-4538; MDX-1106. CAS No. 946414-94-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9903. | |
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