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| Product | Description | |
|---|---|---|
| Macitentan | Macitentan (ACT-064992) is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACT-064992. CAS No. 441798-33-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14184. |  |
| Macitentan | Macitentan. Group: Biochemicals. Alternative Names: N-[5- (4-Bromophenyl) -6-[2-[ (5-bromo-2-pyrimidinyl) oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-Sulfamide; ACT 064992. Grades: Highly Purified. CAS No. 441798-33-0. Pack Sizes: 5mg. Molecular Formula: C19H20Br2N6O4S, Molecular Weight: 588.27. US Biological Life Sciences. |  Worldwide |
| Macitentan | Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Uses: Endothelin a receptor antagonists. Synonyms: ACT-064992; ACT064992; ACT 064992. Grades: > 95%. CAS No. 441798-33-0. Molecular formula: C19H20Br2N6O4S. Mole weight: 588.275. |  |
| Macitentan-D4 | Macitentan-D4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1258428-05-5. Molecular Formula: C19H16D4Br2N6O4S. Mole Weight: 592.3. Catalog: APB1258428055. |  |
| Macitentan Hydroxy amine Impurity | It is an impurity of Macitentan, a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: Ethanol, 2-((6-amino-5-(4-bromophenyl)pyrimidin-4-yl)oxy); 2-((6-amino-5-(4-bromophenyl)pyrimidin-4-yl)oxy)ethan-1-ol. CAS No. 2211059-05-9. Molecular formula: C12H12BrN3O2. Mole weight: 310.15. | |
| Macitentan Impurity 01 | Macitentan Impurity 01. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1433875-21-8. Molecular Formula: C16H13Br2N5O2. Mole Weight: 467.12. Catalog: APB1433875218. | |
| Macitentan Impurity 02 | Macitentan Impurity 02. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2211054-90-7. Molecular Formula: C10H8Br2N4O2. Mole Weight: 376.01. Catalog: APB2211054907. | |
| Macitentan Impurity 03 | Macitentan Impurity 03. Uses: For analytical and research use. Group: Impurity standards. CAS No. 441798-25-0. Molecular Formula: C17H16Br2N6O4S. Mole Weight: 560.22. Catalog: APB441798250. | |
| Macitentan Impurity 04 | Macitentan Impurity 04. Uses: For analytical and research use. Group: Impurity standards. CAS No. 441796-13-0. Molecular Formula: C18H18Br2N6O4S. Mole Weight: 574.25. Catalog: APB441796130. | |
| Macitentan Impurity 05 | Macitentan Impurity 05. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2443747-63-3. Molecular Formula: C19H20BrClN6O4S. Mole Weight: 543.82. Catalog: APB2443747633. | |
| Macitentan Impurity 06 | Macitentan Impurity 06. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2089065-77-8. Molecular Formula: C28H32Br2N8O6S2. Mole Weight: 800.54. Catalog: APB2089065778. | |
| Macitentan Impurity 07 | Macitentan Impurity 07. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1103522-45-7. Molecular Formula: C16H14Br2N6O4S. Mole Weight: 546.19. Catalog: APB1103522457. | |
| Macitentan Impurity 08 | Macitentan Impurity 08. Uses: For analytical and research use. Group: Impurity standards. CAS No. 556796-88-4. Molecular Formula: C17H15Br2N5O4S. Mole Weight: 545.21. Catalog: APB556796884. | |
| Macitentan Impurity 09 | Macitentan Impurity 09. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2300968-85-6. Molecular Formula: C19H22N6O4S. Mole Weight: 430.48. Catalog: APB2300968856. | |
| Macitentan Impurity 1 | An impurity of Macitentan, a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: Despropylaminosulfonyl Macitentan; 5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinamine; ACT 080803. Grades: > 95%. CAS No. 1433875-21-8. Molecular formula: C16H13Br2N5O2. Mole weight: 467.11. | |
| Macitentan Impurity 10 | Macitentan Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2300968-87-8. Molecular Formula: C19H21BrN6O4S. Mole Weight: 509.38. Catalog: APB2300968878. | |
| Macitentan Impurity 11 | Macitentan Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1642873-04-8. Molecular Formula: C12H10BrClN2O2. Mole Weight: 329.58. Catalog: APB1642873048. | |
| Macitentan Impurity 12 | Macitentan Impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2211054-46-3. Molecular Formula: C10H8BrN3O. Mole Weight: 266.1. Catalog: APB2211054463. | |
| Macitentan Impurity 13 | Macitentan Impurity 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1433875-14-9. Molecular Formula: C15H17BrN4O5S. Mole Weight: 445.29. Catalog: APB1433875149. | |
| Macitentan Impurity 14 | Macitentan Impurity 14. Uses: For analytical and research use. Group: Impurity standards. CAS No. 92577-65-6. Molecular Formula: C11H16N2O4S. Mole Weight: 272.32. Catalog: APB92577656. | |
| Macitentan Impurity 15 | Macitentan Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2211059-00-4. Molecular Formula: C19H21BrN6O4S. Mole Weight: 509.38. Catalog: APB2211059004. | |
| Macitentan Impurity 16 | Macitentan Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1393813-42-7. Molecular Formula: C13H14BrClN4O2S. Mole Weight: 405.7. Catalog: APB1393813427. | |
| Macitentan Impurity 17 | Macitentan Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 615571-91-0. Molecular Formula: C12H10BrNO. Mole Weight: 264.12. Catalog: APB615571910. | |
| Macitentan Impurity 18 | Macitentan Impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2365406-85-3. Molecular Formula: C13H15BrN4O3S. Mole Weight: 387.25. Catalog: APB2365406853. | |
| Macitentan Impurity 19 | Macitentan Impurity 19. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2211059-05-9. Molecular Formula: C12H12BrN3O2. Mole Weight: 310.15. Catalog: APB2211059059. | |
| Macitentan Impurity 2 | Macitentan Impurity 2 is an impurity in commercial preparation of Macitentan. Synonyms: 1,2-bis((5-bromopyrimidin-2-yl)oxy)ethane. Grades: > 95%. Molecular formula: C10H8Br2N4O2. Mole weight: 376.01. | |
| Macitentan Impurity 20 | Macitentan Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2211054-17-8. Molecular Formula: C12H10BrN3O. Mole Weight: 292.14. Catalog: APB2211054178. | |
| Macitentan Impurity 21 | Macitentan Impurity 21. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1393813-43-8. Molecular Formula: C15H19BrN4O4S. Mole Weight: 431.3. Catalog: APB1393813438. | |
| Macitentan Impurity 22 | Macitentan Impurity 22. Uses: For analytical and research use. Group: Impurity standards. CAS No. 441797-83-7. Molecular Formula: C12H12BrClN4O2S. Mole Weight: 391.67. Catalog: APB441797837. | |
| Macitentan Impurity 23 | Macitentan Impurity 23. Uses: For analytical and research use. Group: Impurity standards. CAS No. 441798-36-3. Molecular Formula: C19H20BrClN6O4S. Mole Weight: 543.82. Catalog: APB441798363. | |
| Macitentan Impurity 24 | Macitentan Impurity 24. Uses: For analytical and research use. Group: Impurity standards. CAS No. 149506-35-4. Molecular Formula: C11H11BrO4. Mole Weight: 287.11. Catalog: APB149506354. | |
| Macitentan Impurity 25 | Macitentan Impurity 25. Uses: For analytical and research use. Group: Impurity standards. CAS No. 706811-25-8. Molecular Formula: C10H7BrN2O2. Mole Weight: 267.08. Catalog: APB706811258. | |
| Macitentan Impurity 26 | Macitentan Impurity 26. Uses: For analytical and research use. Group: Impurity standards. CAS No. 146533-41-7. Molecular Formula: C10H5BrCl2N2. Mole Weight: 303.97. Catalog: APB146533417. | |
| Macitentan Impurity 27 | Macitentan Impurity 27. Uses: For analytical and research use. Group: Impurity standards. CAS No. 32779-36-5. Molecular Formula: C4H2BrClN2. Mole Weight: 193.43. Catalog: APB32779365. | |
| Macitentan Impurity 28 | Macitentan Impurity 28. Uses: For analytical and research use. Group: Impurity standards. CAS No. 6313-33-3. Molecular Formula: CH5ClN2. Mole Weight: 80.52. Catalog: APB6313333. | |
| Macitentan Impurity 29 (Benzyl alcohol) | Macitentan Impurity 29 (Benzyl alcohol). Uses: For analytical and research use. Group: Impurity standards. CAS No. 100-51-6. Molecular Formula: C7H8O. Mole Weight: 108.14. Catalog: APB100516. | |
| Macitentan Impurity 3 | Grades: > 95%. Molecular formula: C19H20BrClN6O4S. Mole weight: 543.83. | |
| Macitentan Impurity 31 | Macitentan Impurity 31. Uses: For analytical and research use. Group: Impurity standards. CAS No. 38353-06-9. Molecular Formula: C4H3BrN2O. Mole Weight: 174.98. Catalog: APB38353069. | |
| Macitentan Impurity 32 | Macitentan Impurity 32. Uses: For analytical and research use. Group: Impurity standards. CAS No. 22536-67-0. Molecular Formula: C4H2Cl2N2. Mole Weight: 148.98. Catalog: APB22536670. | |
| Macitentan Impurity 33 | Macitentan Impurity 33. Uses: For analytical and research use. Group: Impurity standards. CAS No. 147000-89-3. Molecular Formula: C5H10ClNO4S. Mole Weight: 215.65. Catalog: APB147000893. | |
| Macitentan Impurity 34 | Macitentan Impurity 34. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1393813-40-5. Molecular Formula: C8H18N2O4S. Mole Weight: 238.3. Catalog: APB1393813405. | |
| Macitentan Impurity 35 | Macitentan Impurity 35. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2130971-14-9. Molecular Formula: C5H11NO5S. Mole Weight: 197.21. Catalog: APB2130971149. | |
| Macitentan Impurity 36 | Macitentan Impurity 36. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2211057-81-5. Molecular Formula: C10H7BrClN3. Mole Weight: 284.54. Catalog: APB2211057815. | |
| Macitentan Impurity 37 | Macitentan Impurity 37. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2253990-09-7. Molecular Formula: C14H15BrN2O4. Mole Weight: 355.19. Catalog: APB2253990097. | |
| Macitentan Impurity 38 | Macitentan Impurity 38. Uses: For analytical and research use. Group: Impurity standards. CAS No. 556797-16-1. Molecular Formula: C20H21Br2N5O4S. Mole Weight: 587.29. Catalog: APB556797161. | |
| Macitentan Impurity 4 | Macitentan Impurity 4 is an impurity in commercial preparation of Macitentan. Synonyms: {[5-(4-bromophenyl)-6-(2-{[5-(4-bromophenyl)-6- [(propylsulfamoyl)amino]pyrimidin-4- yl]oxy}ethoxy)pyrimidin-4-yl]sulfamoyl}(propyl)amine. Grades: > 95%. Molecular formula: C28H32Br2N8O6S2. Mole weight: 800.54. | |
| Macitentan Impurity 41 | Macitentan Impurity 41. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1246922-88-2. Molecular Formula: C6H7BrN2O2. Mole Weight: 219.04. Catalog: APB1246922882. | |
| Macitentan Impurity 42 | Macitentan Impurity 42. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C19H20Br2N6O4S. Mole Weight: 588.28. Catalog: APB08551. | |
| Macitentan Impurity 43 | Macitentan Impurity 43. Uses: For analytical and research use. Group: Impurity standards. CAS No. 36506-46-4. Molecular Formula: C14H12Br2O2. Mole Weight: 372.06. Catalog: APB36506464. | |
| Macitentan Impurity 44 | Macitentan Impurity 44. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H9BrN5O. Mole Weight: 423.07. Catalog: APB08552. | |
| Macitentan Impurity 5 | Desethyl Macitentan is an impurity in commercial preparation of Macitentan. Synonyms: Desethyl Macitentan; {[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4- yl]sulfamoyl}(methyl)amine. Grades: > 95%. Molecular formula: C17H16Br2N6O4S. Mole weight: 560.22. | |
| Macitentan Impurity 6 | Synonyms: {[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2- yl)oxy]ethoxy}pyrimidin-4-yl]sulfamoyl}(ethyl)amine. Grades: > 95%. Molecular formula: C18H18Br2N6O4S. Mole weight: 574.25. | |
| Macitentan Impurity 7 | ACT 373898 is an impurity of Macitentan, an orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: ACT 373898; 2-[[5-(4-Bromophenyl)-6-[[(propylamino)sulfonyl]amino]-4-pyrimidinyl]oxy]-acetic Acid. Grades: > 95%. CAS No. 1433875-14-9. Molecular formula: C15H17BrN4O5S. Mole weight: 445.29. | |
| Macitentan Impurity 8 | S-Despropylamino S-Methyl Macitentan is an impurity of Macitentan, an orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: S-Despropylamino S-Methyl Macitentan; N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]methanesulfonamide. Grades: > 95%. CAS No. 556796-88-4. Molecular formula: C17H15Br2N5O4S. Mole weight: 545.21. | |
| Macitentan Intermediate 1 | Macitentan Intermediate 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 147962-41-2. Molecular Formula: C3H10N2O2S. Mole Weight: 138.19. Catalog: APB147962412. | |
| Macitentan Intermediate 2 | Macitentan Intermediate 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1642873-03-7. Molecular Formula: C3H10N2NaO2S. Mole Weight: 161.17. Catalog: APB1642873037. | |
| Macitentan Intermediate 3 | Macitentan Intermediate 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1393813-41-6. Molecular Formula: C3H9KN2O2S. Mole Weight: 176.28. Catalog: APB1393813416. | |
| Macitentan n-butyl analogue | Macitentan n-butyl analogue is a derivative of Macitentan, which is an antagonist/blocker of endothelin receptors on blood vessels and smooth muscle. Uses: A derivative of macitentan. Synonyms: N-[5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]pyrimidin-4-yl]butane-1-sulfonamide. Grades: ≥98%. CAS No. 556797-16-1. Molecular formula: C20H21Br2N5O4S. Mole weight: 587.28. | |
| Macitentan Pyrimidine Dimer | It is an impurity of Macitentan, a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: Macitentan Dimer; O-Desbromo-pyrimidinyl O-[6-N-(N'-propyl)sulfamido-5-(4-bromophenyl)pyrimidin-4-yl] Macitentan; Macitentan Impurity 06; 1,2-bis((5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxy)ethane. CAS No. 2089065-77-8. Molecular formula: C28H32Br2N8O6S2. Mole weight: 800.54. | |
| N-Despropyl-macitentan | N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH). Uses: N-despropyl-macitentan is a dual et receptor antagonist with longer half-life than macitentan. Synonyms: N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-sulfamide, ACT-132577. Grades: > 95%. CAS No. 1103522-45-7. Molecular formula: C16H14Br2N6O4S. Mole weight: 546.19. | |
| O-Desbromo-pyrimidinyl Macitentan-d4 | O-Desbromo-pyrimidinyl Macitentan-d4 is the isotope labelled analog of O-Desbromo-pyrimidinyl Macitentan (D282025), which is an impurity of Macitentan (M105005); a dual orally active and potent endothelin receptor antagonist used for pulmonary arterial hypertension. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C15H15D4BrN4O4S, Molecular Weight: 435.33. US Biological Life Sciences. | Worldwide |
| 2- [ [5- (4-Bromophenyl) -6-chloro-4-pyrimidinyl] oxy] ethanol | 2- [ [5- (4-Bromophenyl) -6-chloro-4-pyrimidinyl] oxy] ethanol is a useful reagent in preparation of macitentan. Group: Biochemicals. Grades: Highly Purified. CAS No. 1642873-04-8. Pack Sizes: 5mg, 25mg. Molecular Formula: C12H10BrClN2O2, Molecular Weight: 329.58. US Biological Life Sciences. | Worldwide |
| 5-(4-bromophenyl)-6-[2-(5-chloropyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine | It is an impurity of Macitentan, a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: N-[5-(4-Bromophenyl)-6-[2-[(5-chloro-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide; Macitentan Impurity 05. CAS No. 2443747-63-3. Molecular formula: C19H20BrClN6O4S. Mole weight: 543.82. | |
| 5-(4-phenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine | It is an impurity of Macitentan, a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: Sulfamide, N-[6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-5-phenyl-4-pyrimidinyl]-N'-propyl-; Macitentan Impurity 10. CAS No. 2300968-87-8. Molecular formula: C19H21BrN6O4S. Mole weight: 509.38. | |
| 5-(4-phenyl)-6-[2-(pyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine | It is an impurity of Macitentan, a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: Macitentan Impurity 09. CAS No. 2300968-85-6. Molecular formula: C19H22N6O4S. Mole weight: 430.48. | |
| Aprocitentan | Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC 50 s of 3.4 nM and 987 nM, and pA 2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACT-132577. CAS No. 1103522-45-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15895. | |
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