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| Product | Description | |
|---|---|---|
| Macitentan | Macitentan (ACT-064992) is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACT-064992. CAS No. 441798-33-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14184. |  |
| Macitentan | Macitentan. Group: Biochemicals. Alternative Names: N-[5- (4-Bromophenyl) -6-[2-[ (5-bromo-2-pyrimidinyl) oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-Sulfamide; ACT 064992. Grades: Highly Purified. CAS No. 441798-33-0. Pack Sizes: 5mg. Molecular Formula: C19H20Br2N6O4S, Molecular Weight: 588.27. US Biological Life Sciences. |  Worldwide |
| Macitentan | Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Uses: Endothelin a receptor antagonists. Synonyms: ACT-064992; ACT064992; ACT 064992. Grades: > 95%. CAS No. 441798-33-0. Molecular formula: C19H20Br2N6O4S. Mole weight: 588.275. |  |
| Macitentan Hydroxy amine Impurity | It is an impurity of Macitentan, a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: Ethanol, 2-((6-amino-5-(4-bromophenyl)pyrimidin-4-yl)oxy); 2-((6-amino-5-(4-bromophenyl)pyrimidin-4-yl)oxy)ethan-1-ol. CAS No. 2211059-05-9. Molecular formula: C12H12BrN3O2. Mole weight: 310.15. | |
| Macitentan Impurity 1 | An impurity of Macitentan, a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: Despropylaminosulfonyl Macitentan; 5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinamine; ACT 080803. Grades: > 95%. CAS No. 1433875-21-8. Molecular formula: C16H13Br2N5O2. Mole weight: 467.11. | |
| Macitentan Impurity 16 | Macitentan Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1393813-42-7. Molecular formula: C13H14BrClN4O2S. Mole weight: 405.7. Catalog: APB1393813427. |  |
| Macitentan Impurity 2 | Macitentan Impurity 2 is an impurity in commercial preparation of Macitentan. Synonyms: 1,2-bis((5-bromopyrimidin-2-yl)oxy)ethane. Grades: > 95%. Molecular formula: C10H8Br2N4O2. Mole weight: 376.01. | |
| Macitentan Impurity 21 | Macitentan Impurity 21. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1393813-43-8. Molecular formula: C15H19BrN4O4S. Mole weight: 431.3. Catalog: APB1393813438. | |
| Macitentan Impurity 29 (Benzyl alcohol) | Macitentan Impurity 29 (Benzyl alcohol). Uses: For analytical and research use. Group: Impurity standards. CAS No. 100-51-6. Molecular formula: C7H8O. Mole weight: 108.14. Catalog: APB100516. | |
| Macitentan Impurity 3 | Grades: > 95%. Molecular formula: C19H20BrClN6O4S. Mole weight: 543.83. | |
| Macitentan Impurity 34 | Macitentan Impurity 34. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1393813-40-5. Molecular formula: C8H18N2O4S. Mole weight: 238.3. Catalog: APB1393813405. | |
| Macitentan Impurity 4 | Macitentan Impurity 4 is an impurity in commercial preparation of Macitentan. Synonyms: {[5-(4-bromophenyl)-6-(2-{[5-(4-bromophenyl)-6- [(propylsulfamoyl)amino]pyrimidin-4- yl]oxy}ethoxy)pyrimidin-4-yl]sulfamoyl}(propyl)amine. Grades: > 95%. Molecular formula: C28H32Br2N8O6S2. Mole weight: 800.54. | |
| Macitentan Impurity 41 | Macitentan Impurity 41. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1246922-88-2. Molecular formula: C6H7BrN2O2. Mole weight: 219.04. Catalog: APB1246922882. | |
| Macitentan Impurity 5 | Desethyl Macitentan is an impurity in commercial preparation of Macitentan. Synonyms: Desethyl Macitentan; {[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4- yl]sulfamoyl}(methyl)amine. Grades: > 95%. Molecular formula: C17H16Br2N6O4S. Mole weight: 560.22. | |
| Macitentan Impurity 6 | Synonyms: {[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2- yl)oxy]ethoxy}pyrimidin-4-yl]sulfamoyl}(ethyl)amine. Grades: > 95%. Molecular formula: C18H18Br2N6O4S. Mole weight: 574.25. | |
| Macitentan Impurity 7 | ACT 373898 is an impurity of Macitentan, an orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: ACT 373898; 2-[[5-(4-Bromophenyl)-6-[[(propylamino)sulfonyl]amino]-4-pyrimidinyl]oxy]-acetic Acid. Grades: > 95%. CAS No. 1433875-14-9. Molecular formula: C15H17BrN4O5S. Mole weight: 445.29. | |
| Macitentan Impurity 8 | S-Despropylamino S-Methyl Macitentan is an impurity of Macitentan, an orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: S-Despropylamino S-Methyl Macitentan; N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]methanesulfonamide. Grades: > 95%. CAS No. 556796-88-4. Molecular formula: C17H15Br2N5O4S. Mole weight: 545.21. | |
| Macitentan Intermediate 3 | Macitentan Intermediate 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1393813-41-6. Molecular formula: C3H9KN2O2S. Mole weight: 176.28. Catalog: APB1393813416. | |
| Macitentan n-butyl analogue | Macitentan n-butyl analogue is a derivative of Macitentan, which is an antagonist/blocker of endothelin receptors on blood vessels and smooth muscle. Uses: A derivative of macitentan. Synonyms: N-[5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]pyrimidin-4-yl]butane-1-sulfonamide. Grades: ≥98%. CAS No. 556797-16-1. Molecular formula: C20H21Br2N5O4S. Mole weight: 587.28. | |
| Macitentan Pyrimidine Dimer | It is an impurity of Macitentan, a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: Macitentan Dimer; O-Desbromo-pyrimidinyl O-[6-N-(N'-propyl)sulfamido-5-(4-bromophenyl)pyrimidin-4-yl] Macitentan; Macitentan Impurity 06; 1,2-bis((5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxy)ethane. CAS No. 2089065-77-8. Molecular formula: C28H32Br2N8O6S2. Mole weight: 800.54. | |
| N-Despropyl-macitentan | N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH). Uses: N-despropyl-macitentan is a dual et receptor antagonist with longer half-life than macitentan. Synonyms: N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-sulfamide, ACT-132577. Grades: > 95%. CAS No. 1103522-45-7. Molecular formula: C16H14Br2N6O4S. Mole weight: 546.19. | |
| O-Desbromo-pyrimidinyl Macitentan-d4 | O-Desbromo-pyrimidinyl Macitentan-d4 is the isotope labelled analog of O-Desbromo-pyrimidinyl Macitentan (D282025), which is an impurity of Macitentan (M105005); a dual orally active and potent endothelin receptor antagonist used for pulmonary arterial hypertension. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C15H15D4BrN4O4S, Molecular Weight: 435.33. US Biological Life Sciences. | Worldwide |
| 2- [ [5- (4-Bromophenyl) -6-chloro-4-pyrimidinyl] oxy] ethanol | 2- [ [5- (4-Bromophenyl) -6-chloro-4-pyrimidinyl] oxy] ethanol is a useful reagent in preparation of macitentan. Group: Biochemicals. Grades: Highly Purified. CAS No. 1642873-04-8. Pack Sizes: 5mg, 25mg. Molecular Formula: C12H10BrClN2O2, Molecular Weight: 329.58. US Biological Life Sciences. | Worldwide |
| 5-(4-bromophenyl)-6-[2-(5-chloropyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine | It is an impurity of Macitentan, a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: N-[5-(4-Bromophenyl)-6-[2-[(5-chloro-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide; Macitentan Impurity 05. CAS No. 2443747-63-3. Molecular formula: C19H20BrClN6O4S. Mole weight: 543.82. | |
| 5-(4-phenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine | It is an impurity of Macitentan, a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: Sulfamide, N-[6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-5-phenyl-4-pyrimidinyl]-N'-propyl-; Macitentan Impurity 10. CAS No. 2300968-87-8. Molecular formula: C19H21BrN6O4S. Mole weight: 509.38. | |
| 5-(4-phenyl)-6-[2-(pyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine | It is an impurity of Macitentan, a dual orally active endothelin receptor antagonist used for pulmonary arterial hypertension. Synonyms: Macitentan Impurity 09. CAS No. 2300968-85-6. Molecular formula: C19H22N6O4S. Mole weight: 430.48. | |
| Aprocitentan | Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC 50 s of 3.4 nM and 987 nM, and pA 2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACT-132577. CAS No. 1103522-45-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15895. | |
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