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| Product | Description | |
|---|---|---|
| malonate decarboxylase holo-[acyl-carrier protein] synthase | The Δ subunit of malonate decarboxylase serves as an an acyl-carrier protein (ACP) and contains the prosthetic group 2-(5-triphosphoribosyl)-3-dephospho-CoA. Two reactions are involved in the production of the holo-ACP form of this enzyme. The first reaction is catalysed by EC 2.4.2.52, triphosphoribosyl-dephospho-CoA synthase. The resulting prosthetic group is then attached to the ACP subunit via a phosphodiester linkage to a serine residue, thus forming the holo form of the enzyme, in a manner analogous to that of EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase. Group: Enzymes. Synonyms: holo ACP synthase (ambiguous); 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo ACP 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA transferase; MdcG; 2'-(5''-triphos. Enzyme Commission Number: EC 2.7.7.66. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3277; malonate decarboxylase holo-[acyl-carrier protein] synthase; EC 2.7.7.66; holo ACP synthase (ambiguous); 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo ACP 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA transferase; MdcG; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-malonate-decarboxylase adenylyltransferase; holo-malonate-decarboxylase synthase (incorrect). Cat No: EXWM-3277. |  |
| biotin-dependent malonate decarboxylase | Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes. The enzyme described here is a biotin-dependent, Na+-translocating enzyme that includes both soluble and membrane-bound components. The other type is a biotin-independent cytosolic protein (cf. EC 4.1.1.88, biotin-independent malonate decarboxylase). As free malonate is chemically rather inert, it has to be activated prior to decarboxylation. Both enzymes achieve this by exchanging malonate with an acetyl group bound to an acyl-carrier protiein (ACP), to form malonyl-ACP and acetate, with subsequent decarboxylation regenerating the acetyl-bound form of the enzyme. The ACP su...nyl-S-ACP:biotin-protein carboxyltransferase) and MadH (EC 6.2.1.35, ACP-SH:acetate ligase). Two other components that are involved are MadE, the acyl-carrier protein and MadF, the biotin protein. The carboxy group is lost with retention of configuration. Group: Enzymes. Synonyms: malonate decarboxylase (with biotin); malonate decarboxylase (ambiguous). Enzyme Commission Number: EC 4.1.1.89. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4838; biotin-dependent malonate decarboxylase; EC 4.1.1.89; malonate decarboxylase (with biotin); malonate decarboxylase (ambiguous). Cat No: EXWM-4838. | |
| biotin-independent malonate decarboxylase | Two types of malonate decarboxylase are currently known, both of which form multienzyme complexes. This enzyme is a cytosolic protein that is biotin-independent. The other type is a biotin-dependent, Na+-translocating enzyme that includes both soluble and membrane-bound components (cf. EC 4.1.1.89, biotin-dependent malonate decarboxylase). As free malonate is chemically rather inert, it has to be activated prior to decarboxylation. In both enzymes, this is achieved by exchanging malonate with an acetyl group bound to an acyl-carrier protiein (ACP), to form malonyl-ACP and acetate, with subsequent decarboxylation regenerating the acetyl-ACP. The ACP subunit of both enzyme...enzyme complex are EC 2.3.1.187 (acetyl-S-ACP:malonate ACP transferase), EC 2.3.1.39 ([acyl-carrier-protein] S-malonyltransferase) and EC 4.1.1.87 (malonyl-S-ACP decarboxylase). The carboxy group is lost with retention of configuration. Group: Enzymes. Synonyms: malonate decarboxylase (without biotin); malonate decarboxylase (ambiguous); MDC. Enzyme Commission Number: EC 4.1.1.88. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4837; biotin-independent malonate decarboxylase; EC 4.1.1.88; malonate decarboxylase (without biotin); malonate decarboxylase (ambiguous); MDC. Cat No: EXWM-4837. | |
| 2-Methyl-2-(thiophen-2-yl)malonic Acid | 2-Methyl-2-(thiophen-2-yl)malonic Acid is a substrate for arylmalonate decarboxylasesrom Alcaligenes bronchisepticus KU1201 and Achromobacter sp. KU1311. Group: Biochemicals. Grades: Highly Purified. CAS No. 126899-44-3. Pack Sizes: 50mg, 500mg. Molecular Formula: C8H8O4S, Molecular Weight: 200.21. US Biological Life Sciences. |  Worldwide |
| 2-Methyl-d3--2-(thiophen-2-yl)malonic Acid | 2-Methyl-d3--2-(thiophen-2-yl)malonic Acid is the labeled analog of 2-Methyl-2-(thiophen-2-yl)malonic Acid (M330640), a substrate for arylmalonate decarboxylasesrom Alcaligenes bronchisepticus KU1201 and Achromobacter sp. KU1311. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C8H5D3O4S, Molecular Weight: 203.23. US Biological Life Sciences. | Worldwide |
| acetylenecarboxylate hydratase | The reaction is effectively irreversible, favouring oxopropanoate (malonic semialdehyde) and its tautomers. Also acts on but-3-ynoate forming acetoacetate. The mechanism appears to involve hydration of the acetylene to 3-hydroxypropenoate, which will spontaneously tautomerize to 3-oxopropanoate. It is thus analogous to EC 4.1.1.78, acetylenedicarboxylate decarboxylase, in its mechanism. Group: Enzymes. Synonyms: acetylenemonocarboxylate hydratase; alkynoate hydratase; acetylenemonocarboxylate hydrase; acetylenemonocarboxylic acid hydrase; malonate-semialdehyde dehydratase; 3-oxopropanoate hydro-lyase. Enzyme Commission Number: EC 4.2.1.27. CAS No. 9024-26-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5018; acetylenecarboxylate hydratase; EC 4.2.1.27; 9024-26-4; acetylenemonocarboxylate hydratase; alkynoate hydratase; acetylenemonocarboxylate hydrase; acetylenemonocarboxylic acid hydrase; malonate-semialdehyde dehydratase; 3-oxopropanoate hydro-lyase. Cat No: EXWM-5018. | |
| acetyl-S-ACP:malonate ACP transferase | This is the first step in the catalysis of malonate decarboxylation and involves the exchange of an acetyl thioester residue bound to the activated acyl-carrier protein (ACP) subunit of the malonate decarboxylase complex for a malonyl thioester residue. This enzyme forms the α subunit of the multienzyme complexes biotin-independent malonate decarboxylase (EC 4.1.1.88) and biotin-dependent malonate decarboxylase (EC 4.1.1.89). The enzyme can also use acetyl-CoA as a substrate but more slowly. Group: Enzymes. Synonyms: acetyl-S-ACP:malonate ACP-SH transferase; acetyl-S-acyl-carrier protein:malonate acyl-carrier-protein-transferase; MdcA; MadA; ACP transferase; malonate/acetyl-CoA transferase; malonate:ACP transferase; acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase. Enzyme Commission Number: EC 2.3.1.187. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2129; acetyl-S-ACP:malonate ACP transferase; EC 2.3.1.187; acetyl-S-ACP:malonate ACP-SH transferase; acetyl-S-acyl-carrier protein:malonate acyl-carrier-protein-transferase; MdcA; MadA; ACP transferase; malonate/acetyl-CoA transferase; malonate:ACP transferase; acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase. Cat No: EXWM-2129. | |
| ACP-SH:acetate ligase | This enzyme, from the anaerobic bacterium Malonomonas rubra, is a component of the multienzyme complex EC 4.1.1.89, biotin-dependent malonate decarboxylase. The enzyme uses the energy from hydrolysis of ATP to convert the thiol group of the acyl-carrier-protein-bound 2'-(5-phosphoribosyl)-3'-dephospho-CoA prosthetic group into its acetyl thioester. Group: Enzymes. Synonyms: HS-acyl-carrier protein:acetate ligase; [acyl-carrier protein]:acetate ligase; MadH. Enzyme Commission Number: EC 6.2.1.35. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5693; ACP-SH:acetate ligase; EC 6.2.1.35; HS-acyl-carrier protein:acetate ligase; [acyl-carrier protein]:acetate ligase; MadH. Cat No: EXWM-5693. | |
| [acyl-carrier-protein] S-malonyltransferase | This enzyme, along with EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, is essential for the initiation of fatty-acid biosynthesis in bacteria. This enzyme also provides the malonyl groups for polyketide biosynthesis. The product of the reaction, malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis. In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7, holo-[acyl-carrier-protein] synthase) is the preferred substrate. This enzyme also forms part of the multienzyme complexes EC 4.1.1.88 (biotin-independent malonate decarboxylase) and EC 4.1.1.89 (biotin-dependent malonate decarboxylase). Malonylation of ACP is immediately followed by d... malonyl coenzyme A-acyl carrier protein transacylase; malonyl transacylase; malonyl transferase; malonyl-CoA-acyl carrier protein transacylase; malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase; malonyl-CoA:ACP transacylase; malonyl-CoA:ACP-SH transacylase; malonyl-CoA:AcpM transacylase; malonyl-CoA:acyl carrier protein transacylase; malonyl-CoA:acyl-carrier-protein transacylase; malonyl-CoA/dephospho-CoA acyltransferase; MAT; MCAT; MdcH. Enzyme Commission Number: EC 2.3.1.39. CAS No. 37257-17-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2217; [acyl-carrier-protein] S-malon | |
| carboxybiotin decarboxylase | The integral membrane protein MadBfrom the anaerobic bacterium Malonomonas rubra is a component of the multienzyme complex EC 4.1.1.89, biotin-dependent malonate decarboxylase. The free energy of the decarboxylation reaction is used to pump Na+ out of the cell. The enzyme is a member of the Na+-translocating decarboxylase family, other members of which include EC 4.1.1.3 (oxaloacetate decarboxylase) and EC 4.1.1.41 (methylmalonyl-CoA decarboxylase). Group: Enzymes. Synonyms: MadB; carboxybiotin protein decarboxylase. Enzyme Commission Number: EC 7.2.4.1 (Formerly EC 4.3.99.2). Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5309; carboxybiotin decarboxylase; EC 4.3.99.2; MadB; carboxybiotin protein decarboxylase. Cat No: EXWM-5309. | |
| malonate CoA-transferase | The enzyme from Pseudomonas ovalis also catalyses the reaction of EC 4.1.1.9 malonyl-CoA decarboxylase. Group: Enzymes. Synonyms: malonate coenzyme A-transferase. Enzyme Commission Number: EC 2.8.3.3. CAS No. 9026-18-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3422; malonate CoA-transferase; EC 2.8.3.3; 9026-18-0; malonate coenzyme A-transferase. Cat No: EXWM-3422. | |
| malonate-semialdehyde dehydrogenase (acetylating) | This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating). This enzyme is also called malonic semialdehyde oxidative decarboxylase. This enzyme participates in 4 metabolic pathways: inositol metabolism, alanine and aspartate metabolism, beta-alanine metabolism, and propanoate metabolism. Group: Enzymes. Synonyms: malonic semialdehyde oxidative decarboxylase. Enzyme Commission Number: EC 1.2.1.18. CAS No. 9028-97-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1123; malonate-semialdehyde dehydrogenase (acetylating); EC 1.2.1.18; 9028-97-1; malonic semialdehyde oxidative decarboxylase. Cat No: EXWM-1123. | |
| malonyl-CoA decarboxylase | Specific for malonyl-CoA. The enzyme from Pseudomonas ovalis also catalyses the reaction of EC 2.8.3.3 malonate CoA-transferase. Group: Enzymes. Synonyms: malonyl coenzyme A decarboxylase; malonyl-CoA carboxy-lyase. Enzyme Commission Number: EC 4.1.1.9. CAS No. 9024-99-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4839; malonyl-CoA decarboxylase; EC 4.1.1.9; 9024-99-1; malonyl coenzyme A decarboxylase; malonyl-CoA carboxy-lyase. Cat No: EXWM-4839. | |
| malonyl-S-ACP:biotin-protein carboxyltransferase | Derived from the components MadC and MadD of the anaerobic bacterium Malonomonas rubra, this enzyme is a component of EC 4.1.1.89, biotin-dependent malonate decarboxylase. The carboxy group is transferred from malonate to the prosthetic group of the biotin protein (MadF) with retention of configuration. Similar to EC 4.1.1.87, malonyl-S-ACP decarboxylase, which forms part of the biotin-independent malonate decarboxylase (EC 4.1.1.88), this enzyme also follows on from EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase, and results in the regeneration of the acetyl-[acyl-carrier protein]. Group: Enzymes. Synonyms: malonyl-S-acyl-carrier protein:biotin-protein carboxyltransferase; MadC/MadD; MadC,D; malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxyltransferase. Enzyme Commission Number: EC 2.1.3.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2012; malonyl-S-ACP:biotin-protein carboxyltransferase; EC 2.1.3.10; malonyl-S-acyl-carrier protein:biotin-protein carboxyltransferase; MadC/MadD; MadC,D; malonyl-[acyl-carrier protein]:biotinyl-[protein] carboxyltransferase. Cat No: EXWM-2012. | |
| malonyl-S-ACP decarboxylase | This enzyme comprises the β and γ subunits of EC 4.1.1.88 (biotin-independent malonate decarboxylase) but is not present in EC 4.1.1.89 (biotin-dependent malonate decarboxylase). It follows on from EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase, and results in the regeneration of the acetylated form of the acyl-carrier-protein subunit of malonate decarboxylase. The carboxy group is lost with retention of configuration. Group: Enzymes. Synonyms: malonyl-S-acyl-carrier protein decarboxylase; MdcD/MdcE; MdcD,E. Enzyme Commission Number: EC 4.1.1.87. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4836; malonyl-S-ACP decarboxylase; EC 4.1.1.87; malonyl-S-acyl-carrier protein decarboxylase; MdcD/MdcE; MdcD,E. Cat No: EXWM-4836. | |
| triphosphoribosyl-dephospho-CoA synthase | ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP. The reaction involves the formation of a new α (1''?2') glycosidic bond between the two ribosyl moieties, with concomitant displacement of the adenine moiety of ATP. The 2'-(5-triphosphoribosyl)-3'-dephospho-CoA produced can be transferred by EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase, to the apo-acyl-carrier protein subunit (γ-subunit) of EC 4.1.3.6, citrate (pro-3S) lyase, thus converting it from an apo-enzyme into a holo-enzyme. Alternatively, it can be transferred to the apo-ACP subunit of malonate decarboxylase by the action of EC 2.7.7.66, malonate decarboxylase holo-[acyl-carrier protein] synthase. Group: Enzymes. Synonyms: 2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase; ATP:dephospho-CoA 5-triphosphoribosyl transferase; CitG; ATP:depho. Enzyme Commission Number: EC 2.4.2.52. CAS No. 313345-38-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2682; triphosphoribosyl-dephospho-CoA synthase; EC 2.4.2.52; 313345-38-9; 2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase; ATP:dephospho-CoA 5-triphosphoribosyl transferase; CitG; ATP:dephospho-CoA 5'-triphosphoribosyl transferase; MdcB; ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase; MadG. Cat No: EXWM-2682. | |
| 4-Trifluoroacetylaniline | Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors. Group: Biochemicals. Alternative Names: 1-(4-Aminophenyl)-2,2,2-trifluoroethanone; 4'-Amino-2,2,2-trifluoroacetophenone; 4-Aminophenyl Trifluoromethyl Ketone; 4'-Amino-2,2,2-trifluoroacetophenone; p- (Trifluoroacetyl) aniline. Grades: Highly Purified. CAS No. 23516-79-2. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Adipic acid | Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism. Uses: Scientific research. Group: Natural products. CAS No. 124-04-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W017522. |  |
| Adipic acid-13C6 | Adipic acid- 13 C 6 is the 13 C labeled Adipic acid[1]. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism[2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 942037-55-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W017522S1. | |
| Adipic acid (Standard) | Adipic acid (Standard) is the analytical standard of Adipic acid. This product is intended for research and analytical applications. Adipic acid is found to be associated with HMG-CoA lyase deficiency, carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, and medium Chain acyl-CoA dehydrogenase deficiency, which are inborn errors of metabolism. Uses: Scientific research. Group: Natural products. CAS No. 124-04-9. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-W017522R. | |
| CBM 301940 | Malonyl-CoA decarboxylase (MCD) is found from bacteria to humans, which has important roles in regulating fatty acid metabolism and food intake. CBM 301940 is a potent malonyl-CoA decarboxylase (MCD) inhibitor with IC50 of 23 nM. It suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Synonyms: (2S,3R,4S)-3-ethenyl-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-4-(2-oxoethyl)-2H-pyran-5-carboxylic acid, methyl ester; CBM301940; CBM-301940. Grades: ≥98%. CAS No. 902146-11-6. Molecular formula: C15H20F6N2O5. Mole weight: 422.32. |  |
| Ethylmalonic acid | Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency. Uses: Scientific research. Group: Natural products. CAS No. 601-75-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-34740. | |
| N-(2-Cyanoethyl)-N-ethylamine | N-(2-Cyanoethyl)-N-ethylamine is a reactant used in the preparation of heteroaryl-substituted bis-trifluoromethyl carbinols and trifluoroacetophenone derivatives malonyl-CoA decarboxylase (MCD) inhibitors. Group: Biochemicals. Alternative Names: 3- (Ethylamino) propanenitrile; 3- (Ethylamino) propionitrile; N-Ethyl-2-cyanoethylamine; NSC 66681. Grades: Highly Purified. CAS No. 21539-47-9. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
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