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| Product | Description | |
|---|---|---|
| MALT1 inhibitor | MALT1 inhibitor Inhibitor. Uses: Scientific use. Product Category: T2350. CAS No. 1047953-91-2. |  |
| MALT1 Inhibitor I, MI-2 (ALB-H03200218, 2-Chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide) | A cell-permeable chloromethyl amide that inhibits MALT1 proteolytic activity (IC50 = 5.84uM against MALT1 paracaspase domain dimer-catalyzed Ac-LRSR-AMC hydrolysis) in an irreversible manner via covalent interaction, displaying little or no activity against caspase-3, -8, or -9. Due to irreversible binding and effective intracellular accumulation (HBL-1 intracellular [MI-2]t = 2h = 5uM; Medium [MI-2]t = 0 = 0.2uM), MI-2 is at least 250-times more effective than Z-VRPR-FMK in blocking constitutive NF-kappaB activity and c-Rel nuclear translocation in HBL-1 cultures (equal or better blockage by 200nM MI-2 than by 50uM Z-VRPR-FMK). Shown to selectively inhibit MALT1-dependent ABC-DLBCL proliferation, but not the MALT1-independent growths of ABC- (HLY-1 and U2932) or GCB-DLBCL (OCI-Ly1 and OCI-Ly7) cells, both in cultures in vitro (GI50 in 48h = 200, 400, 400, and 500nM, respectively, against HBL-1, OCI-Ly3, OCI-Ly10, and TMD8) and in mice in vivo (65%,, 61%, and 0% suppression, respective Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| MI 2 (MALT1 inhibitor) | MI 2 (MALT1 inhibitor). Group: Biochemicals. Grades: Purified. CAS No. 1047953-91-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MI-2 (MALT1 inhibitor) | MI-2 (350 mg/kg) is nontoxic to mice. MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM. Synonyms: MI-2; MI 2; MI2. Grades: >98%. CAS No. 1047953-91-2. Molecular formula: C19H17Cl3N4O3. Mole weight: 455.72. |  |
| Mepazine | Mepazine (Pecazine) is a potent and selective MALT1 protease inhibitor with IC 50 s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine affects viability of ABC-DLBCL cells by enhancing apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pecazine. CAS No. 60-89-9. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-121282. |  |
| Mepazine hydrochloride | Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective MALT1 protease inhibitor with IC 50 s of 0.83 and 0.42 μM for GSTMALT1 full length and GSTMALT1 325-760, respectively. Mepazine hydrochloride affects viability of ABC-DLBCL cells by enhancing apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pecazine hydrochloride. CAS No. 2975-36-2. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-121282A. | |
| MLT-747 | MLT-747 is a potent and selective malt1 peptide cleavage inhibitor. Synonyms: AC-31545; HY-124587; MLT 747; MLT747. Grades: ≥98% by HPLC. CAS No. 2097853-86-4. Molecular formula: C20H21Cl2N7O3. Mole weight: 478.3. | |
| MLT-748 | MLT-748 is a potent and selective malt1 peptide cleavage inhibitor. Synonyms: 1-(5-Chloro-6-(2H-1,2,3-Triazol-2-Yl)Pyridin-3-Yl)-3-(2-Chloro-7-((1R,2R)-1,2-Dimethoxypropyl)Pyrazolo[1,5-A]Pyrimidin-6-Yl)Urea. Grades: ≥98% by HPLC. CAS No. 1832578-30-9. Molecular formula: C19H19Cl2N9O3. Mole weight: 492.3. | |
| SGR-1505 | SGR-1505 is an orally active MALT1 allosteric inhibitor. SGR-1505 inhibits MALT1 enzymatic activity and shows anti-proliferative activity in BTK inhibitor (BTKi)-sensitive and BTKi-resistant activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines. SGR-1505 can be used for research of B-cell lymphomas [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2661481-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160698. | |
| Z-Val-Arg-Pro-DL-Arg-fluoromethylketone | Z-Val-Arg-Pro-DL-Arg-fluoromethylketone, a cell-permeable and irreversible inhibitor of para-caspase MALT1, is based on the sequence of a published optimal tetrapeptide substrate for the A. thaliana metacaspase AtMC9. Synonyms: MALT1 Inhibitor; Z-VRPR-FMK; L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-(2-fluoroacetyl)butyl]-; Cbz-Val-Arg-Pro-DL-Arg-CH2F; N-[(Phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-(2-fluoroacetyl)butyl]-L-prolinamide. Grades: ≥95%. CAS No. 1926163-57-6. Molecular formula: C31H49FN10O6. Mole weight: 676.79. | |
| Z-VRPR-FMK trifluoroacetate salt | Z-VRPR-FMK trifluoroacetate salt is an irreversible and cell-permeable MALT1 inhibitor. Z-VRPR-FMK dose-dependently inhibits T cell activation-induced cleavage of Bcl-10. Z-VRPR-FMK reduces NF-κB-dependent gene expression in lymphocytes. Synonyms: Z-Val-Arg-Pro-DL-Arg-FMK. Grades: >90%. Molecular formula: C31H49FN10O6.CF3CO2H. Mole weight: 790.81. | |
| Z-VRPR-FMK (Z-Val-Arg-Pro-DL-Arg-FMK. TFA) | Selective cell permeable and irreversible MALT1 inhibitor. Inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei. Group: Biochemicals. Grades: Purified. CAS No. 1381885-28-4 (free base). Pack Sizes: 500ug, 1mg. US Biological Life Sciences. | Worldwide |
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