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| Product | Description | |
|---|---|---|
| Manumycin A | Antibiotic. Potent, selective and competitive cell permeable rasfarnesyltransferase inhibitor (IC50= 30nM). Does not affect geranyl geranyl transferase (IC50=180uM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Neutral sphingomyelinase inhibitor. Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 52665-74-4. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. |  Worldwide |
| Manumycin A (NSC-622141, UFC 1C) | An antibiotic Isolated from Streptomyces parvulus. A Potent, selective and competitive cell permeable rasfarnesyltransferase (FTase) inhibitor (IC50 = 30nM). Does not affect geranyl geranyl transferase (GGTase) (IC50 = 180uM). Blocks insulin-induced MAP kinase activation in rat cardiac myocytes (19uM).uM). Inhibition is competitive with respect to farnesyl pyrophosphate and non-competitive with respect to Ras. Group: Biochemicals. Grades: Highly Purified. CAS No. 52665-74-4. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Deoxymanumycin A | Derivative of the farnesyltransferase inhibitor Manumycin A. This compound has not yet been thoroughly tested for its biological activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Dihydromanumycin A | Derivative of the farnesyltransferase inhibitor Manumycin A. This compound has not yet been thoroughly tested for its biological activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Manumycin | It is produced by the strain of Str. parvullus ETH 25000. It has anti-gram-positive bacterial effect, and has weak antibacterial effect on some mycobacteria and candida. Synonyms: Manumycin A; NSC 622141; Antibiotic UCF 1C; 2,4-Decadienamide, N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2,4,6-trimethyl-, (2E,4E,6R)-; (-)-Manumycin A; Antibiotic TMC 1F. Grades: ≥98%. CAS No. 52665-74-4. Molecular formula: C31H38N2O7. Mole weight: 550.64. |  |
| Manumycin B | Antibiotic and antibacterial. Active against Gram-positive bacteria. Rasfarnesyltransferase and apoptosis (Caspase-1) inhibitor. AChE inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 139023-58-8. Pack Sizes: 1mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| Manumycin E | It is produced by the strain of Str. sp. WB-83. It has anti-gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-gram-negative bacteria, and has no effect on fungi. It inhibits RAS Faraday base transfer with IC50 of 5 μmol/L. It has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC50 is 15.6 μg/mL). Synonyms: Asukamycin E; 2,4,6-Undecatrienamide, N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-10-methyl-, (2E,4E,6E)-. CAS No. 156250-43-0. Molecular formula: C30H34N2O7. Mole weight: 534.61. | |
| Manumycin F | It is produced by the strain of Str. sp. WB-83. It has anti-gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-gram-negative bacteria, and has no effect on fungi. It inhibits RAS Faraday base transfer with IC50 of 5 μmol/L. It has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC50 is 15.6 μg/mL). Synonyms: Asukamycin; asukamycin A1; 2,4,6-Heptatrienamide, 7-cyclohexyl-N-[5-hydroxy-5-[7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-. CAS No. 156317-47-4. Molecular formula: C31H34N2O7. Mole weight: 546.62. | |
| Manumycin G | It is produced by the strain of Str. sp. WB-83. It has anti-gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-gram-negative bacteria, and has no effect on fungi. It inhibits RAS Faraday base transfer with IC50 of 5 μmol/L. It has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC50 is 15.6 μg/mL). Synonyms: 2,4,6-Nonatrienamide, N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-8-methyl-, (2E,4E,6E)-; 2,4,6-Nonatrienamide, N-[5-hydroxy-5-[7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-8-methyl-, [1S-[1a,3(2E,4E,6E),5b,5(1E,3E,5E),6a]]-. Grades: ≥95%. CAS No. 156250-44-1. Molecular formula: C28H30N2O7. Mole weight: 506.55. | |
| Asukamycin | Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 61116-33-4. Pack Sizes: 500 μg. Product ID: HY-118893. |  |
| Asukamycin | Asukamycin, a manumycin-type metabolite, is isolated from Streptomyces nodosus subsp. asukaensis. It exhibits antibiotic properties and inhibits the growth of various tumor cell lines. Synonyms: asukamycin A1; Manumycin F; 2,4,6-Heptatrienamide, 7-cyclohexyl-N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-, (2E,4E,6E)-. Grades: >98%. CAS No. 61116-33-4. Molecular formula: C31H34N2O7. Mole weight: 546.61. | |
| Colabomycin A | It is produced by the strain of Streptomyces griseoflavus. It has anti-gram-positive bacterial activity similar to Manumycin, and has the activity of inhibiting leukemic cell L1210. IC50 is 3.4 μg/mL. Synonyms: (2E,4E,6E,8E)-N-[(1beta,6beta)-5alpha-Hydroxy-5-[(1E,3E,5E,7E)-9-[(2-hydroxy-5-oxo-1-cyclopentene-1-yl)amino]-9-oxo-1,3,5,7-nonatetrenyl]-2-oxo-7-oxabicyclo[4.1.0]hepta-3-ene-3-yl]-2,4,6,8-decatetrenamide. CAS No. 117778-57-1. Molecular formula: C30H30N2O7. Mole weight: 530.57. | |
| TMC-1A | TMC-1A is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 A. Molecular formula: C28H36N2O7. Mole weight: 512.6. | |
| TMC-1B | TMC-1B is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 B. Molecular formula: C28H36N2O7. Mole weight: 512.6. | |
| TMC-1C | TMC-1C is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 C. Molecular formula: C30H38N2O7. Mole weight: 538.6. | |
| TMC-1D | TMC-1D is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 D. Molecular formula: C30H40N2O7. Mole weight: 540.6. | |
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