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| Product | Description | |
|---|---|---|
| Matrix Metalloproteinase-13 (HisoTag) from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular pr..., a ca2+- and zn2+- binding catalytic domain, a hinge region, and a c-terminal hemopexin domain. hydrolyzes collagen type ii 5-6 times faster than collagens type i and iii. exhibits high activity towards gelatin and degrades α1-antichymotrypsin and plasminogen activator inhibitor-2. Group: Enzymes. Synonyms: Collagenase-3; Matrix metallopeptidase 13; MMP13; CLG3; MANDP1; MMP-13. Purity: >90% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 60 kDa. Activity: >50 mU/mg protein. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: S. frugiperda. Species: Human. Collagenase-3; Matrix metallopeptidase 13; MMP13; CLG3; MANDP1; MMP-13. Cat No: NATE-0859. |  |
| Matrix Metalloproteinase-1 from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular processe...may also undergo autocatalysis to yield a 27 kda/22 kda active enzyme. expressed by a large number of cell types. cleaves fibrillar type i collagen. must be activated just prior to use. Group: Enzymes. Synonyms: Matrix Metalloproteinase 1; Human Interstitial Collagenase; Collagenase-1; EC 3.4.24.7; vertebrate collagenase. Enzyme Commission Number: EC 3.4.24.7. CAS No. 9001-12-1. Purity: >90% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 56 kDa/52 kDa. Activity: >15 mU/mg protein. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: Human Rheumatoid Synovial Fibroblast. Species: Human. Matrix Metalloproteinase 1; Human Interstitial Collagenase; Collagenase | |
| Matrix Metalloproteinase-2 from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular processe... does not interfere with activation. may contain up to 10% timp proteins. during storage, a small portion (less than 10%) of the enzyme may also become activated. Group: Enzymes. Synonyms: 72 kDa Gelatinase; Matrix Metalloproteinase 2; Gelatinase A; EC 3.4.24.24; type IV collagenase; 3/4 collagenase; matrix metalloproteinase 5; 72 kDa gelatinase type A; collagenase IV; collagenase type IV; MMP 2; type IV collagen metalloproteinase; type IV collagenase/gelatinase. Enzyme Commission Number: EC 3.4.24.24. CAS No. 146480-35-5. Purity: >90% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 72 kDa. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: CHO Cells. Spe | |
| Matrix Metalloproteinase-3 from Human, Recombinant | Matrix metalloproteinase-3 (MMP-3) also known as stromelysin-1 and transin (EC 3.4.24.17) cleaves a number of substrates including cartilage proteoglycan, collagen types II, III, IV, V and IX, fibronectin, laminin, and can activate MMP 1. MMP-3 is secreted as 57 and 59 kDa proenzymes and can be activated in vitro by organomercurials (e.g., 4 aminophenylmercuric acetate, APMA) and in vivo by proteases via intermediate forms to a 45 kDa active MMP 3 enzyme. Further autolysis to a 28 kDa form can also occur. MMP-3 is thought to play an important role in pathophysiological degradation processes associated with conditions such as rheumatoid arthritis and cancer cell invas...C 3.4.24.17; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Enzyme Commission Number: EC 3.4.24.17. CAS No. 79955-99-0. Purity: >95% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 57 kDa. Storage: < -70°C; Avoid freeze/thaw. Form: Lyophilized from 100 mM NaCl, 50 mM HEPES, pH 7.3. Species: Human. Stromelysin 1; EC 3.4.24.17; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Cat No: NATE-0861. | |
| Matrix Metalloproteinase-7 from human, Recombinant | MMP-7 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling. Group: Enzymes. Synonyms: MMP7; matrix metallopeptidase 7; MMP-7; matrin; uterine metalloendopeptidase; matrix metalloproteinase 7; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 proteinase; PUMP; metalloproteinase pump-1; putative metalloproteinase; MMP. CAS No. 141256-52-2. Matrix Metalloproteinase. Storage: -70°C. Form: buffered aqueous solution, Supplied in a buffer containing the active enzyme in 10 mM HEPES, pH 7.4, 0.15 M sodium chloride, 5 mM calcium chloride. Source: E. coli. Species: Human. MMP7; matrix metallopeptidase 7; MMP-7; matrin; uterine metalloendopeptidase; matrix metalloproteinase 7; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 proteinase; PUMP; metalloproteinase pump-1; putative metalloproteinase; MMP. Cat No: NATE-0451. | |
| Matrix Metalloproteinase-8 from Human, Recombinant | Full-length recombinant human neutrophil pro-collagenase (MMP-8), latent form. Matrix metalloproteinase 8 (MMP-8), or neutrophil collagenase, degrades interstitial collagens, acting preferentially on collagen type I. Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8. MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation.Once released and activated through proteolytic or oxidative mechanisms, MMP-8 p...ollagenase activity. Group: Enzymes. Synonyms: Neutrophil collagenase; EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; HNC; CLG1. Enzyme Commission Number: EC 3.4.24.34. CAS No. 9001-12-1. Purity: Greater than 90% as determined by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 75 kDa. Activity: 100 units/ml. Stability: MMP-8 although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. Neutrophil collagenase; EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; HNC; CLG1. Cat No: NATE-0862. | |
| Matrix Metalloproteinase-9 from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular processe...(less than 10%) of the enzyme may also become activated. requires activation prior to use. a simple activation protocol is included. Applications: Immunoblotting (1 ug protein/lane) substrate cleavage assay (1 ug protein/lane) zymography (1 ug protein/lane). Group: Enzymes. Synonyms: Gelatinase B; EC 3.4.24.35; 92-kDa gelatinase; matrix metalloproteinase 9; type V collagenase; 92-kDa type IV collagenase; macrophage gelatinase; 95 kDa type IV collagenase/gelatinase; collagenase IV; collagenase type IV; gelatinase MMP 9; MMP 9; type IV collagen metalloproteinase. Enzyme Commission Number: EC 3.4.24.35. CAS No. 146480-36-6. Purity: >90% by SDS-PAGE. Matrix Metalloprotei | |
| membrane-type matrix metalloproteinase-1 | In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces. Group: Enzymes. Synonyms: matrix metalloproteinase 14. Enzyme Commission Number: EC 3.4.24.80. CAS No. 161384-17-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4364; membrane-type matrix metalloproteinase-1; EC 3.4.24.80; 161384-17-4; matrix metalloproteinase 14. Cat No: EXWM-4364. | |
| 11-Aminoundecanoic acid | 11-Aminoundecanoic Acid is used to prepare thapsigargin analogues targeting apoptosis to prostatic cancer cells. It is also used to synthesize N-carboxyalkylpeptides containing extended alkyl residues at P1'as matrix metalloproteinase inhibitors. Synonyms: ω-Aminoundecanoic acid; Undecanoic acid, 11-amino-; 11-Aminoundecylic acid; 11-amino-undecanoic acid; H-11-Aun-OH. Grades: ≥ 99% (Titration). CAS No. 2432-99-7. Molecular formula: C11H23NO2. Mole weight: 201.31. |  |
| 1, 2-Bis ( (pinacolato) boryl) ethane | An organoboronate derivative with inhibitory activity against Matrix metallo-proteinase (MMP-2). Group: Biochemicals. Alternative Names: 1,2-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethane; 2,2'-(1,2-Ethanediyl)bis[4,4,5,5-tetramethyl-1,3,2-Dioxaborolane. Grades: Highly Purified. CAS No. 364634-18-4. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| 20(R)-Ginsenoside Rh2 | 20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC50 of 2.77 μM for murine MHV-68. Group: Inhibitors. Alternative Names: b-D-Glucopyranoside, (3b,12b,20R)-12,20-dihydroxydammar-24-en-3-yl; (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-d-glucopyranoside; 20-(R)-Ginsenoside Rh2; 20(R)-Ginsenoside Rh2; 20(R)-GINSENOSIDERH2; Ginsenoside-Rh2; Ginsenoside Rh2, 20(R)-; 20(R)-Ginsenoside-Rh2; (R) Ginsenoside Rh2. CAS No. 112246-15-8. Molecular formula: C36H62O8. Mole weight: 622.88. Appearance: Powder. Purity: 0.98. IUPACName: (2R, 3R, 4S, 5S, 6R)-2-[[(3S, 5R, 8R, 9R, 10R, 12R, 13R, 14R, 17S)-12-hydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4, 4, 8, 10, 14-pentamethyl-2, 3, 5, 6, 7, 9, 11, 12, 13, 15, 16, 17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3, 4, 5-triol. Canonical SMILES: CC (=CCCC (C) (C1CCC2 (C1C (CC3C2 (CCC4C3 (CCC (C4 (C)C)OC5C (C (C (C (O5)CO)O)O)O)C)C)O)C)O)C. Catalog: ACM112246158. |  |
| 20(R)-Ginsenoside Rh2-d6 | 20(R)-Ginsenoside Rh2-d6 is the labeled version of 20(R)-Ginsenoside Rh2 (G410215), which is a matrix metalloproteinase inhibitor that acts as a cell antiproliferator. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C36H56D6O8, Molecular Weight: 628.91. US Biological Life Sciences. | Worldwide |
| 2-(4-Phenoxy-phenyl)-acetamidine Hydrochloride | 2-(4-Phenoxy-phenyl)-acetamidine hydrochloride is a derivative of 4-phenoxyphenyl acetonitri le. 4-Phenoxyphenyl acetonitri le is a reagent that is used in the preparation and inhibition of matrix metalloproteinases MMP-2, -3 and -8. Group: Biochemicals. Grades: Highly Purified. CAS No. 1172966-21-0. Pack Sizes: 100mg, 1g. Molecular Formula: C14H15ClN2O, Molecular Weight: 262.73. US Biological Life Sciences. | Worldwide |
| (2R)-TAPI-1 | TAPI-1 is a potent inhibitor of matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase). Synonyms: TAPI 1; TAPI1. Grades: >98%. CAS No. 163847-77-6. Molecular formula: C26H37N5O5. Mole weight: 499.6. | |
| 3- (p-Carboxyphenyl) propionic Acid Dimethyl Ester | A benzoic acid derivative used in the preparation of potent, selective, orally bioavailable matrix metalloproteinase inhibitors. Group: Biochemicals. Alternative Names: 4- (Methoxycarbonyl) benzenepropanoic Acid Methyl Ester; Methyl 4-(3-Methoxy-3-oxopropyl)benzoate. Grades: Highly Purified. CAS No. 40912-11-6. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 4',6,7-Trihydroxyisoflavone | 4',6,7-Trihydroxyisoflavone is an isoflavone isolated from the seeds of Glycine max with antioxidant activity. It is also a novel inhibitor of PKCα that suppresses solar UV-induced matrix metalloproteinase 1. Synonyms: Demethyltexasin; 6,7,4'-trihydroxyisoflavone; 6-Hydroxydaidzein; 6,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one. Grades: >98%. CAS No. 17817-31-1. Molecular formula: C15H10O5. Mole weight: 270.24. | |
| 4-Trifluoromethoxyphenylboronic acid | 4-Trifluoromethoxyphenylboronic acid is a reagent used in the synthesis of orally bioavailable matrix metalloprotinase inhibitors. Also used in the preparation of chromen-4-one inhibitors against DNA dependant protein kinases. Synonyms: (p-Trifluoromethoxyphenyl)boronic Acid; 4-(Trifluoromethoxy)benzeneboronic Acid; 4-Trifluoromethoxyphenylboric Acid; 4-Trifluoromethoxyphenylboronic Acid; [4-[(Trifluoromethyl)oxy]phenyl]boronic Acid; p-(Trifluoromethoxy)phenylboronic Acid; B-[4-(Trifluoromethoxy)phenyl]boronic Acid; MFCD01074648. Grades: > 98 % (HPLC). CAS No. 139301-27-2. Molecular formula: C7H6BF3O3. Mole weight: 205.93. | |
| 6-(7-Nitro-benzo[2,1,3]oxadiazol-4-ylamino)-hexanoyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys((7-dimethylaminocoumarin-4-yl)-acetyl)-NH2 | It is an excellent fluorogenic substrate for matrix metalloproteinase stromelysin (MMP-3) hydrolysis. The FRET substrate shows high sensitivity and improves accuracy at a lower substrate turnover. It has a kcat/Km value of 2.14·104 M-1s-1 and can be easily detected at 350 nm (excitation) and 465 nm (emission). Therefore, it is a suitable tool for high-throughput inhibitor screening. Synonyms: NBD-ε-aminocaproyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(DMACA)-NH2; L-Lysinamide, N2-[6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-1-oxohexyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-leucyl-L-alanyl-L-norvalyl-L-tryptophyl-N6-[2-[7-(dimethylamino)-2-oxo-2H-1-benzopyran-4-yl]acetyl]-; NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(DMC)-NH2; N2-{6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-leucyl-L-alanyl-L-norvalyl-L-tryptophyl-N6-{[7-(dimethylamino)-2-oxo-2H-chromen-4-yl]acetyl}-L-lysinamide. Grades: ≥95%. CAS No. 945414-97-1. Molecular formula: C78H111N21O16. Mole weight: 1598.87. | |
| 7-Methoxy-1-tetralone | 7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index [1]. Uses: Scientific research. Group: Natural products. CAS No. 6836-19-7. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-W001925. |  |
| ABT-518 | ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis. Synonyms: ABT 518; ABT518; N- ( (S) -1- ( (S) -2, 2-Dimethyl-1, 3-dioxolan-4-yl) -2- ( (4- (4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) -N-hydroxyformamide. CAS No. 286845-00-9. Molecular formula: C21H22F3NO8S. Mole weight: 505.46. | |
| ADAMTS-5 inhibitor | ADAMTS-5 (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 5) is an aggrecanase-2. ADAMTS-5 is involved in the catabolism of aggrecan and collagen in the articular cartilage matrix during Osteoarthritis (OA). Synonyms: ADAMTS-5 Inhibitor; ADAMTS 5 Inhibitor; ADAMTS5 Inhibitor; 5-[[5-[(4-chlorophenyl)methylsulfanyl]-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one. Grades: 99%. CAS No. 929634-33-3. Molecular formula: C16H11ClF3N3OS3. Mole weight: 449.92. | |
| Aderbasib | Aderbasib is a azaspiro[2. 5]octanehydroxamide derivative as inhibitor of metalloproteases for the treatment of disorders such as cancer, arthritis, cardiovascular or skin disorders. Aderbasib, also known as INCB007839, is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Aderbasib represses the metalloproteinase "sheddase" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. The metalloproteinase domains of ADAMs cleave cell surface proteins at extracellular sites proximal to the cell membrane, releasing or "shedding" soluble protein etcodomains from the cell surface; the disintegrin domains of these multifunctional proteins interact with various components of the extracellular matrix (ECM). Group: Biochemicals. Alternative Names: (6S, 7S) -7-[ (Hydroxyamino) carbonyl]-6-[ (4-phenyl-1-piperazinyl) carbonyl]-5-azaspiro[2. 5]octane-5-carboxylic Acid Methyl Ester; INCB 007839. Grades: Highly Purified. CAS No. 791828-58-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?O?, Molecular Weight: 416.47. US Biological Life Sciences. | Worldwide |
| Aluminum Ammonium Sulfate Dodecahydrate | Aluminum Ammonium Sulfate Dodecahydrate is a potent matrix metalloproteinase inhibitor which are key regulators for many pysiological and pathological functions. It is also used in the preparation of antiperspirants and deodorants containing ammonium alum that prevents body odor in humans. Group: Biochemicals. Grades: Highly Purified. CAS No. 7784-26-1. Pack Sizes: 50g, 100g. Molecular Formula: Al (H3N) 2(H2O4S) 12(H2O), Molecular Weight: 26.9817032980812. US Biological Life Sciences. | Worldwide |
| Aminocatechol | A phenol derivative with inhibitory activity against matrix metalloproteinase (MMP). Group: Biochemicals. Alternative Names: 4-Aminopyrocatechol; 1-Amino-3,4-dihydroxybenzene; 3,4-Dihydroxyaniline; 3,4-Dihydroxyphenylamine; 4-Amino-1,2-benzenediol; 4-Aminocatechol; A 3253; KYJ 3-018. Grades: Highly Purified. CAS No. 13047-04-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Aminopeptidase N Inhibitor | Membrane alanyl aminopeptidase is also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N), which is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Synonyms: AP-N Inhibitor. Grades: ≥95%. CAS No. 596108-59-7. Molecular formula: C17H10N2O8. Mole weight: 370.27. | |
| Andecaliximab | Andecaliximab is a recombinant chimeric IgG4 monoclonal antibody (mAb) targets matrix metalloproteinase 9 ( MMP9 ). Andecaliximab shows the antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. Andecaliximab can be used for the research of gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-MMP9 Reference Antibody (andecaliximab). CAS No. 1518996-49-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99351. | |
| Ascochlorin (Antibiotic LL-Z 1272 gamma) | The antitumour fungal metabolite ascochlorin specifically inhibits matrix metalloproteinase-9 (MMP9) activity through suppression of activator protein-1 (AP-1) dependent induction of MMP-9 gene expression. Via AP-1 suppression ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors. Ascochlorin also shows activity against Newcastle disease and herpes simplex viruses. Group: Biochemicals. Alternative Names: Antibiotic LL-Z 1272 gamma. Grades: Highly Purified. CAS No. 26166-39-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| (-)-Ascofuranone | (-)-Ascofuranone is an antibiotic with antitumor activity. It suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. (-)-Ascofuranone was effective in the treatment against Trypanosoma brucei brucei infection in mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 38462-04-3. Pack Sizes: 250ug, 500ug. Molecular Formula: C23H29ClO5, Molecular Weight: 420.93. US Biological Life Sciences. | Worldwide |
| Astragaloside IV | Astragaloside IV, an active component isolated from Astragalus membranaceus , suppresses the activation of ERK1/2 and JNK , and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Uses: Scientific research. Group: Natural products. CAS No. 84687-43-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0431. | |
| Batimastat | Batimastat (also known as BB-94) is a synthetic matrix metalloproteinase inhibitor that has shown antineoplastic and antiangiogenic activity in various tumor models. Batimastat acts as an inhibitor of metalloproteinase activity by binding the zinc ion in the active site of MMPs. Uses: Antineoplastic agents. Synonyms: (2S,3R)-N-Hydroxy-N'-[(2S)-1-methylamino-1-oxo-3-phenylpropan-2-yl]-3-(2-methylpropyl)-2-(thiophen-2-ylsulfanylmethyl)butanediamide; BB94; BB-94; BB 94. Grades: 98%. CAS No. 130370-60-4. Molecular formula: C23H31N3O4S2. Mole weight: 477.638. | |
| Batimastat (BB-94) | Potent, broad spectrum matrix metalloprotease (MMP) inhibitor (IC?? values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo. Group: Biochemicals. Alternative Names: (2R, 3S) -N4-Hydroxy-N1-[ (1S) -2- (methylamino) -2-oxo-1- (phenylmethyl) ethyl]-2- (2-methylpropyl) -3-[ (2-thienylthio) methyl]butanediamide. Grades: Highly Purified. CAS No. 130370-60-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Batimastat sodium salt | Batimastat sodium salt (BB-94) is a potent, broad spectrum matrix metalloprotease (MMPs) inhibitor with IC50s of 3/4/20/6/4 nM for MMP-1/2/3/7/9 respectively. Synonyms: BB-94 sodium salt; BB 94 sodium salt; BB94 sodium salt. Grades: >98%. CAS No. 130464-84-5. Molecular formula: C23H30N3NaO4S2. Mole weight: 499.62. | |
| Bezisterim | Bezisterim (HE 3286; NE-3107) is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. Bezisterim is an orally active partial NF-κB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. Bezisterim freely penetrates the blood brain barrier in mice. Bezisterim can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis [1] [2] [3]. Bezisterim is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HE 3286; NE-3107. CAS No. 1001100-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108039. | |
| Bis[ (pinacolato) boryl]methane | An organoboronate derivative that is an inhibitor of matrix metallo-proteinase (MMP-2). Group: Biochemicals. Alternative Names: 2,2'-Methylenebis[4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methane. Grades: Highly Purified. CAS No. 78782-17-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Bis(pinacolato)diboron | Bis(pinacolato)diboron is used as a condensation agent in the preparation poly(arylene)s. Bis(pinacolato)diboron is an organoboranate with potential use as matrix metallo-proteinase (MMP-2) inhibitor. Group: Biochemicals. Alternative Names: 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,4',4',5,5,5',5'-Octamethyl-2,2'-bis(1,3,2-dioxaborolane); 4,4',5,5'-Octamethyl-2,2'-bi-1,3,2-dioxaborolane; B2Pin2; Bis (pinacolate)diboron; Bis(pinacolato) diborate; Bis (pinacolato)diborane; Diboron Pinacol Ester; Dipinacoldiboron; Pinacol Diborane. Grades: Highly Purified. CAS No. 73183-34-3. Pack Sizes: 100g, 50g, 100g, 250g. US Biological Life Sciences. | Worldwide |
| Candidalysin | Candidalysin is a cytolytic peptide toxin, which is initially isolated from Candida albicans and exhibits virulent and avirulent characters. Candidalysin activates epithelial cell signaling pathways by interacting with the epithelial growth factor receptor (EGFR) of host cells, activates matrix metalloproteinase ( MMP ) and calcium flux, resulting in inflammatory responses and recruitment of immune cells. Candidalysin exhibits cytotoxicity by dealing membran damage to host cells [1]. Uses: Scientific research. Group: Peptides. CAS No. 1906866-53-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10408. | |
| CL 82,198 | CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13). It doesn't have effect against MMP-1, MMP-9 or TNF-α converting enzyme. CL 82,198 is also used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis. Synonyms: CL-82198; N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide. Grades: ≥95%. CAS No. 307002-71-7. Molecular formula: C17H22N2O3. Mole weight: 302.4. | |
| Collagenase IV, Clostridium histolytica | Collagenase, Type IV (EC 3.4.24.3) is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type IV degrades type IV collagen and type VII collagen, the main components of the basement membrane, and can also decompose basement matrix and elastin. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Collagenase, Type IV. CAS No. 9001-12-1. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-E70005D. | |
| Collagenase, Type II | Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-E70005B. | |
| Collagenase, Type V | Collagenase, Type V is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type V breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-12-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-E70005E. | |
| CP 471474 | CP 471474 a broad spectrum Matrix Metalloprotease inhibitor with sub-nanomolar affinity for MMP-2 and 13 among MMPs (IC50: 1170, 0.7, 16, 13, 0.9 for MMP-1, MMP-2, MMP-3, MMP-9, and MMP-13 respectively). Synonyms: CP-471474; CP 471474; CP471474; UNII-96U47H947L; 2-[[4-(4-fluorophenoxy)phenyl]sulfonylamino]-N-hydroxy-2-methylpropanamide; CP 471474; CP-471474; 210755-45-6; CHEMBL323612. Grades: >97 %. CAS No. 210755-45-6. Molecular formula: C16H17FN2O5S. Mole weight: 368.38. | |
| CP-471474 | A broad spectrum inhibitor of matrix metalloproteinases that attenuates early left ventricular dilation after experimental myocardial infarction in mice. Studies show that it also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models. Group: Biochemicals. Alternative Names: 2-[[[4- (4-Fluorophenoxy) phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide; CP 471474. Grades: Highly Purified. CAS No. 210755-45-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CP-544439 | CP-544439 is a selective matrix metalloproteinase-13 inhibitor. Uses: Matrix metalloproteinase inhibitors. Synonyms: 4-[[4-(4-fluorophenoxy)phenyl]sulfonylamino]-N-hydroxyoxane-4-carboxamide; CP-544439; CP 544439; CP544439 ; UNII-516DO4KL5R. Grades: >98%. CAS No. 230954-09-3. Molecular formula: C18H19FN2O6S. Mole weight: 410.42. | |
| CTTHWGFTLC, CYCLIC acetate | CTTHWGFTLC, CYCLIC acetate is a cyclic peptide inhibitor for matrix metalloproteinases (MMP-2) and MMP-9. Synonyms: L-Cysteine, L-cysteinyl-L-threonyl-L-threonyl-L-histidyl-L-tryptophylglycyl-L-phenylalanyl-L-threonyl-L-leucyl-, cyclic (1?10)-disulfide acetate; CTT 1 acetate; H-Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys-OH.CH3CO2H (Disulfide Bridge: Cys1-Cys10); L-cysteinyl-L-threonyl-L-threonyl-L-histidyl-L-tryptophyl-glycyl-L-phenylalanyl-L-threonyl-L-leucyl-L-cysteine (1->10)-disulfide acetic acid acetate. Grades: ≥95%. Molecular formula: C54H75N13O16S2. Mole weight: 1226.39. | |
| Desmethylglycitein | Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities.Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1). Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes. Group: Inhibitors. CAS No. 17817-31-1. Molecular formula: C15H10O5. Mole weight: 270.24. Purity: 0.95. Catalog: ACM17817311. | |
| Doxycycline Hyclate | A synthetic derivative of oxytetracycline. Acts as a broad spectrum antibiotic and matrix metallo-proteinases (MMP) inhibitor. Useful in studies involving wound healing and tissue remodeling. Group: Biochemicals. Alternative Names: Doxycycline hydrochloride hemiethanolate hemihydrate; (4S, 4aR, 5S, 5aR, 6R, 12aS)-4-(Dimethylamino)-1, 4, 4a, 5, 5a, 6, 11, 12a-octahydro-3, 5, 10, 12, 12a-pentahydroxy-6-methyl-1, 11-dioxo-2-naphthacenecarboxamide Hyclate. Grades: Highly Purified. CAS No. 24390-14-5. Pack Sizes: 10g, 25g, 50g, 100g. Molecular Formula: C22H24N2O8·HCl·0. 5C2H6O·0. 5H2O, Molecular Weight: 512.94. US Biological Life Sciences. | Worldwide |
| Etanercept | Etanercept inhibits in vitro the activity of human TNF and is efficacious in many in vivo models of inflammation, including arthritis. Etanercept competitively inhibits the binding of both TNF-α and TNF-β (lymphotoxin-α) to cell surface TNF receptors, rendering TNF biologically inactive. It also modulates indirectly different biological responses that are induced or regulated by TNF, such as the expression of adhesion molecules E-selectin and to a lesser extent intercellular adhesion molecule 1 (ICAM-1), the production of interleukin-6 (IL-6) and matrix metalloproteinase 3 (MMP-3) (stromelysin), as well as IL1. Synonyms: 1-235-Tumor necrosisfactor receptor (human) fusion protein with 236-467-immunoglobulin G1 (human g1-chain Fc fragment); TNFR-Fc fusion protein; Etanercept; Embrel; Enbrel; rhu-TNFR-Fc. Grades: 95%. CAS No. 185243-69-0. Molecular formula: C2224H3472N618O701S36. | |
| Ethyl 1-Boc-3-piperidinecarboxylate | A reagent used in the synthesis of piperidine derivatives, and α-sulfonyl hydroxamic acid derivatives as matrix metalloproteinase (MMP) and TNF-alpha converting enzyme (TACE) inhibitors. Synonyms: Boc-DL-Pic(3)-OEt; Boc-DL-Nipc-Oet; Ethyl N-Boc-piperidine-3-carboxylate; Ethyl N-Boc-3-piperidinecarboxylate; N-(t-Butoxycarbonyl)-DL-nipecotic acid ethyl ester; (±)-1-(t-Butoxycarbonyl)piperidine-3-carboxylic acid ethyl ester. Grades: 97 %. CAS No. 130250-54-3. Molecular formula: C13H23NO4. Mole weight: 257.33. | |
| FR-217840 | FR-217840 is a matrix metalloproteinase inhibitor. It can suppress joint destruction. FR217840 may have potential as a novel anti-rheumatic drug. Uses: Anti-rheumatic agent. Synonyms: FR-217840; FR217840; FR 217840. (2S)-1-((5-(4-fluorophenyl)-2-thienyl)sulfonyl)-N-hydroxy-4-(methylsulfonyl)-2-Piperazinecarboxamide. Grades: 98%. CAS No. 848444-16-6. Molecular formula: C16H18FN3O6S3. Mole weight: 463.52. | |
| Funalenone | Funalenone is a phenalene compound originally isolated from A. niger. It inhibits HIV-1 integrase and type I collagenase. Funalenone is also a selective inhibitor of matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM). Synonyms: 8-deoxyxanthoherquein; 3,4,7,9-tetrahydroxy-2-methoxy-6-methyl-1H-phenalen-1-one. Grades: ≥95%. CAS No. 259728-61-5. Molecular formula: C15H12O6. Mole weight: 288.25. | |
| Funalenone (3,4,7,9-Tetrahydroxy-6-methyl-1H-phenalen-1-one) | Matrix metalloproteinase-1 (MMP-1; Type I collagenase) inhibitor. HIV-1 integrase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 259728-61-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| GAS OIL (CFPP and CP) | GAS OIL (CFPP and CP). Uses: For analytical and research use. Group: Metallo-organic standards; petroleum physical test standards; petroleum reference materials. Catalog: APS008349. Format: Matrix Material. Shipping: Room Temperature. |  |
| gelatinase A | A secreted endopeptidase in peptidase family M10 (interstitial collagenase family), but possessing an additional fibronectin-like domain. Group: Enzymes. Synonyms: 72-kDa gelatinase; matrix metalloproteinase 2; type IV collagenase (ambiguous); 3/4 collagenase (obsolete); matrix metalloproteinase 5 (obsolete); 72 kDa gelatinase type A; collagenase IV (ambiguous); collagenase type IV (ambiguous); MMP 2; type IV collagen metalloproteinase (ambiguous); type IV collagenase/gelatinase (ambiguous). Enzyme Commission Number: EC 3.4.24.24. CAS No. 146480-35-5. Matrix Metalloproteinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4305; gelatinase A; EC 3.4.24.24; 146480-35-5; 72-kDa gelatinase; matrix metalloproteinase 2; type IV collagenase (ambiguous); 3/4 collagenase (obsolete); matrix metalloproteinase 5 (obsolete); 72 kDa gelatinase type A; collagenase IV (ambiguous); collagenase type IV (ambiguous); MMP 2; type IV collagen metalloproteinase (ambiguous); type IV collagenase/gelatinase (ambiguous). Cat No: EXWM-4305. | |
| gelatinase B | Similar to gelatinase A, but possesses a further domain. In peptidase family M10 (interstitial collagenase family). Group: Enzymes. Synonyms: 92-kDa gelatinase; matrix metalloproteinase 9; type V collagenase; 92-kDa type IV collagenase; macrophage gelatinase; 95 kDa type IV collagenase/gelatinase; collagenase IV (ambiguous); collagenase type IV (ambiguous); gelatinase MMP 9; MMP 9; type IV collagen metalloproteinase (ambiguous). Enzyme Commission Number: EC 3.4.24.35. CAS No. 146480-36-6. Matrix Metalloproteinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4317; gelatinase B; EC 3.4.24.35; 146480-36-6; 92-kDa gelatinase; matrix metalloproteinase 9; type V collagenase; 92-kDa type IV collagenase; macrophage gelatinase; 95 kDa type IV collagenase/gelatinase; collagenase IV (ambiguous); collagenase type IV (ambiguous); gelatinase MMP 9; MMP 9; type IV collagen metalloproteinase (ambiguous). Cat No: EXWM-4317. | |
| GM 1489 | GM 1489 is a potent broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. Synonyms: Hexanoic acid, 3- [ [ [ (1S) -1- (1H-indol-3-ylmethyl) -2-oxo-2- [ [ (1S) -1-phenylethyl] amino] ethyl] amino] carbonyl] -5-methyl-, (3R)-; (3R) -3- [ [ [ (1S) -1- (1H-Indol-3-ylmethyl) -2-oxo-2- [ [ (1S) -1-phenylethyl] amino] ethyl] amino] carbonyl] -5-methylhexanoic acid; Hexanoic acid, 3-[[[1- (1H-indol-3-ylmethyl) -2-oxo-2-[ (1-phenylethyl) amino]ethyl]amino]carbonyl]-5-methyl-, [3R-[3R*[S*(S*)]]]-; GM-1489; GM1489. Grades: ≥98%. CAS No. 171347-75-4. Molecular formula: C27H33N3O4. Mole weight: 463.57. | |
| GW-3333 | GW-3333 is a dual inhibitors of tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) and matrix metalloproteinases. Synonyms: GW-3333; GW3333; GW 3333; 3-[formyl(hydroxy)amino]-4-methyl-N-[3-methyl-1-oxo-1-(pyridin-2-ylamino)pentan-2-yl]-2-(2-methylpropyl)pentanamide. Grades: >98%. CAS No. 212609-68-2. Molecular formula: C22H36N4O4. Mole weight: 420.55. | |
| Halofuginone | Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. Uses: Semisynthetic quinazolinone alkaloid anticoccidial. Synonyms: Halofuginone; Tempostatin; RU 19110; RU19110; RU-19110. Grades: > 95%. CAS No. 55837-20-2. Molecular formula: C16H17BrClN3O3. Mole weight: 414.684. | |
| H-Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys-OH (Disulfide bond) | It is a cyclic peptide inhibitor for matrix metalloproteinases (MMP-2) and MMP-9. Synonyms: CTTHWGFTLC, CYCLIC; L-cysteinyl-L-threonyl-L-threonyl-L-histidyl-L-tryptophyl-glycyl-L-phenylalanyl-L-threonyl-L-leucyl-L-cysteine (1->10)-disulfide; MMP-2/MMP-9 Inhibitor III; Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III. Grades: ≥90%. CAS No. 244082-19-7. Molecular formula: C52H71N13O14S2. Mole weight: 1166.33. | |
| Histatin 5 | Histatin 5, a human salivary peptide, has been shown to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. Synonyms: H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-OH; L-alpha-aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidyl-glycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-alpha-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginyl-glycyl-L-tyrosine; Human histatin 5; Peptide F-A (human parotid saliva). Grades: 98%. CAS No. 104339-66-4. Molecular formula: C133H195N51O33. Mole weight: 3036.29. | |
| Histatin 5 acetate | Histatin 5, a human salivary peptide, has been shown to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. Synonyms: H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-OH.CH3CO2H; L-α-Aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidylglycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-α-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginylglycyl-L-tyrosine acetate salt; Human histatin 5 acetate salt; Peptide F-A (human parotid saliva) acetate salt. Grades: ≥95%. Molecular formula: C135H199N51O35. Mole weight: 3096.35. | |
| Ilomastat | Ilomastat is a broad-spectrum matrix metalloproteinase inhibitor, displaying potential anticancer activity. Ilomastat is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc. Ilomastat inhibits enzymes including thermolysin, peptide deformylase, and anthrax lethal factor endopeptidase (LF) produced by the bacterium Bacillus anthracis. Synonyms: GM6001; GM-6001; GM 6001; Ilomastat; galardin; (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanedia. Grades: 98%. CAS No. 142880-36-2. Molecular formula: C20H28N4O4. Mole weight: 388.468. | |
| Incyclinide | incyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and achemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis. Synonyms: Metastat; 4-dedimethylamino sancycline; CMT-3; CMT 3; CMT3; COL 3; COL3; COL-3. CAS No. 15866-90-7. Molecular formula: C19H17NO7. Mole weight: 371.34. | |
| Incyclinide | Incyclinide (CMT-3, COL-3) is a matrix metalloproteinase ( MMP ) inhibitor and inhibiting angiogenesis, tumor growth and invasion, and metastasis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CMT-3; COL-3. CAS No. 15866-90-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13648. | |
| interstitial collagenase | The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain. However, α-macroglobulins are cleaved much more rapidly. The enzyme is widely distributed in vertebrate animals. Type example of peptidase family M10. Group: Enzymes. Synonyms: vertebrate collagenase; matrix metalloproteinase 1. Enzyme Commission Number: EC 3.4.24.7. CAS No. 9001-12-1. Matrix Metalloproteinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4353; interstitial collagenase; EC 3.4.24.7; 9001-12-1; vertebrate collagenase; matrix metalloproteinase 1. Cat No: EXWM-4353. | |
| Luteolin 7-O-glucuronide | Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC 50 s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Luteolin 7-glucuronide. CAS No. 29741-10-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N1463. | |
| Marimastat ( (2S, 3R) -N4-[ (1S) -2, 2-Dimethyl-1-[ (-[ (methylamino) carbonyl]propyl]-N1, 2-dihydroxy-3- (2-methylpropyl) butanediamide, BB-2516, TA-2516) | A broad spectrum matrix metalloprotease (MMP) inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively. It covalently binds to the zinc(II) ion in the active site of MMPs, thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| matrilysin | Found in rat uterus; at 19 kDa, the smallest member of peptidase family M10 (interstitial collagenase family). Similar in specificity to stromelysin, but more active on azocoll. Group: Enzymes. Synonyms: matrin; uterine metalloendopeptidase; matrix metalloproteinase 7; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 proteinase; PUMP; metalloproteinase pump-1; putative metalloproteinase; MMP. Enzyme Commission Number: EC 3.4.24.23. CAS No. 141256-52-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4304; matrilysin; EC 3.4.24.23; 141256-52-2; matrin; uterine metalloendopeptidase; matrix metalloproteinase 7; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 proteinase; PUMP; metalloproteinase pump-1; putative metalloproteinase; MMP. Cat No: EXWM-4304. | |
| Matrilysin (96-107) | Matrilysin (MAT) is a member of the matrix metalloproteinase (MMP) family which is believed to degrade components of the extracellular matrix (ECM) during processes of tissue remodeling. Synonyms: MMP7 (96-107). | |
| Methylisothiazolinone | Methylothiazolinone is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone can activate matrix metalloproteinases ( MMPs ) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone can cause mitochondrial damage in the endothelium of rat cerebral blood vessels [1] [2] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2682-20-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-W010520. | |
| MMP-13 Inhibitor | MMP-13 Inhibitor is a potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 value of 8 nM. Synonyms: Collagenase-3 Inhibitor; Matrix Metalloproteinase-13 Inhibitor; 4,6-Pyrimidinedicarboxamide; N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide. Grades: ≥98%. CAS No. 544678-85-5. Molecular formula: C22H20F2N4O2. Mole weight: 410.4. | |
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