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| Product | Description | |
|---|---|---|
| Matrix Metalloproteinase-12, Catalytic Domain human | recombinant, expressed in E. coli, ?95% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. |  |
| Matrix Metalloproteinase-13 (HisoTag) from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular pr..., a ca2+- and zn2+- binding catalytic domain, a hinge region, and a c-terminal hemopexin domain. hydrolyzes collagen type ii 5-6 times faster than collagens type i and iii. exhibits high activity towards gelatin and degrades α1-antichymotrypsin and plasminogen activator inhibitor-2. Group: Enzymes. Synonyms: Collagenase-3; Matrix metallopeptidase 13; MMP13; CLG3; MANDP1; MMP-13. Purity: >90% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 60 kDa. Activity: >50 mU/mg protein. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: S. frugiperda. Species: Human. Collagenase-3; Matrix metallopeptidase 13; MMP13; CLG3; MANDP1; MMP-13. Cat No: NATE-0859. |  |
| Matrix Metalloproteinase-1 from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular processe...may also undergo autocatalysis to yield a 27 kda/22 kda active enzyme. expressed by a large number of cell types. cleaves fibrillar type i collagen. must be activated just prior to use. Group: Enzymes. Synonyms: Matrix Metalloproteinase 1; Human Interstitial Collagenase; Collagenase-1; EC 3.4.24.7; vertebrate collagenase. Enzyme Commission Number: EC 3.4.24.7. CAS No. 9001-12-1. Purity: >90% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 56 kDa/52 kDa. Activity: >15 mU/mg protein. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: Human Rheumatoid Synovial Fibroblast. Species: Human. Matrix Metalloproteinase 1; Human Interstitial Collagenase; Collagenase | |
| Matrix Metalloproteinase-1 human | recombinant, expressed in NSO cells, >95% (SDS-PAGE), buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Matrix Metalloproteinase-2 from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular processe... does not interfere with activation. may contain up to 10% timp proteins. during storage, a small portion (less than 10%) of the enzyme may also become activated. Group: Enzymes. Synonyms: 72 kDa Gelatinase; Matrix Metalloproteinase 2; Gelatinase A; EC 3.4.24.24; type IV collagenase; 3/4 collagenase; matrix metalloproteinase 5; 72 kDa gelatinase type A; collagenase IV; collagenase type IV; MMP 2; type IV collagen metalloproteinase; type IV collagenase/gelatinase. Enzyme Commission Number: EC 3.4.24.24. CAS No. 146480-35-5. Purity: >90% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 72 kDa. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: CHO Cells. Spe | |
| Matrix Metalloproteinase-2 from mouse | recombinant, expressed in NSO cells, >95% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Matrix Metalloproteinase-2 human | >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Matrix Metalloproteinase-3 from Human, Recombinant | Matrix metalloproteinase-3 (MMP-3) also known as stromelysin-1 and transin (EC 3.4.24.17) cleaves a number of substrates including cartilage proteoglycan, collagen types II, III, IV, V and IX, fibronectin, laminin, and can activate MMP 1. MMP-3 is secreted as 57 and 59 kDa proenzymes and can be activated in vitro by organomercurials (e.g., 4 aminophenylmercuric acetate, APMA) and in vivo by proteases via intermediate forms to a 45 kDa active MMP 3 enzyme. Further autolysis to a 28 kDa form can also occur. MMP-3 is thought to play an important role in pathophysiological degradation processes associated with conditions such as rheumatoid arthritis and cancer cell invas...C 3.4.24.17; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Enzyme Commission Number: EC 3.4.24.17. CAS No. 79955-99-0. Purity: >95% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 57 kDa. Storage: < -70°C; Avoid freeze/thaw. Form: Lyophilized from 100 mM NaCl, 50 mM HEPES, pH 7.3. Species: Human. Stromelysin 1; EC 3.4.24.17; matrix metalloproteinase 3; proteoglycanase; collagenase activating protein; procollagenase activator; transin; MMP-3; neutral proteoglycanase; stromelysin; collagen-activating protein. Cat No: NATE-0861. | |
| Matrix Metalloproteinase-7 from human, Recombinant | MMP-7 degrades general matrix components and may have a role in processes such as host defense, cell proliferation, and protein turnover as well as tissue remodeling. Group: Enzymes. Synonyms: MMP7; matrix metallopeptidase 7; MMP-7; matrin; uterine metalloendopeptidase; matrix metalloproteinase 7; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 proteinase; PUMP; metalloproteinase pump-1; putative metalloproteinase; MMP. CAS No. 141256-52-2. Matrix Metalloproteinase. Storage: -70°C. Form: buffered aqueous solution, Supplied in a buffer containing the active enzyme in 10 mM HEPES, pH 7.4, 0.15 M sodium chloride, 5 mM calcium chloride. Source: E. coli. Species: Human. MMP7; matrix metallopeptidase 7; MMP-7; matrin; uterine metalloendopeptidase; matrix metalloproteinase 7; putative (or punctuated) metalloproteinase-1; matrix metalloproteinase pump 1; MMP 7; PUMP-1 proteinase; PUMP; metalloproteinase pump-1; putative metalloproteinase; MMP. Cat No: NATE-0451. | |
| Matrix Metalloproteinase-7 human | ~0.1 mg/mL, recombinant, expressed in E. coli, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Matrix Metalloproteinase-8 from Human, Recombinant | Full-length recombinant human neutrophil pro-collagenase (MMP-8), latent form. Matrix metalloproteinase 8 (MMP-8), or neutrophil collagenase, degrades interstitial collagens, acting preferentially on collagen type I. Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8. MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation.Once released and activated through proteolytic or oxidative mechanisms, MMP-8 p...ollagenase activity. Group: Enzymes. Synonyms: Neutrophil collagenase; EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; HNC; CLG1. Enzyme Commission Number: EC 3.4.24.34. CAS No. 9001-12-1. Purity: Greater than 90% as determined by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 75 kDa. Activity: 100 units/ml. Stability: MMP-8 although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. Appearance: Sterile Filtered clear solution. Source: E. coli. Species: Human. Neutrophil collagenase; EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; HNC; CLG1. Cat No: NATE-0862. | |
| Matrix Metalloproteinase-9 from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular processe...(less than 10%) of the enzyme may also become activated. requires activation prior to use. a simple activation protocol is included. Applications: Immunoblotting (1 ug protein/lane) substrate cleavage assay (1 ug protein/lane) zymography (1 ug protein/lane). Group: Enzymes. Synonyms: Gelatinase B; EC 3.4.24.35; 92-kDa gelatinase; matrix metalloproteinase 9; type V collagenase; 92-kDa type IV collagenase; macrophage gelatinase; 95 kDa type IV collagenase/gelatinase; collagenase IV; collagenase type IV; gelatinase MMP 9; MMP 9; type IV collagen metalloproteinase. Enzyme Commission Number: EC 3.4.24.35. CAS No. 146480-36-6. Purity: >90% by SDS-PAGE. Matrix Metalloprotei | |
| Matrix Metalloproteinase-9 human | recombinant, expressed in, >90% (SDS-PAGE), buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-11, N-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-12, Propeptide Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-14, N-Terminal antibody produced in rabbit | 0.5 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-15, Hinge Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-18, C-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-18 Hinge Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-18, N-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-19, Hinge Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-19, N-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-19, Propeptide Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-1 antibody produced in goat | affinity isolated antibody, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-21, C-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-21, Hinge Region antibody produced in rabbit | affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-21, N-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-21, Propeptide Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-22, C-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-22, Hinge Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-22, N-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-22, Propeptide Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-23, C-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-23, Hinge Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-24, Cytoplasmic antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-24, Hinge Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-24, Propeptide Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-25, C-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-25, Hinge Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-25, Propeptide Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-26, Hinge Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-26, N-Terminal Active antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-26, Propeptide Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-27, C-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-27, Hinge Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-27, N-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-27, Propeptide Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-28, Propeptide Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-2 antibody produced in rabbit | ~1 mg/mL, IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-3, Propeptide Region antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-7, N-Terminal of Catalytic Zinc Site antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-9 antibody produced in goat | affinity isolated antibody. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Matrix Metalloproteinase-9, C-Terminal antibody produced in rabbit | ~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| membrane-type matrix metalloproteinase-1 | In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces. Group: Enzymes. Synonyms: matrix metalloproteinase 14. Enzyme Commission Number: EC 3.4.24.80. CAS No. 161384-17-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4364; membrane-type matrix metalloproteinase-1; EC 3.4.24.80; 161384-17-4; matrix metalloproteinase 14. Cat No: EXWM-4364. | |
| 11-Aminoundecanoic acid | 11-Aminoundecanoic Acid is used to prepare thapsigargin analogues targeting apoptosis to prostatic cancer cells. It is also used to synthesize N-carboxyalkylpeptides containing extended alkyl residues at P1'as matrix metalloproteinase inhibitors. Synonyms: ω-Aminoundecanoic acid; Undecanoic acid, 11-amino-; 11-Aminoundecylic acid; 11-amino-undecanoic acid; H-11-Aun-OH. Grade: ≥ 99% (Titration). CAS No. 2432-99-7. Molecular formula: C11H23NO2. Mole weight: 201.31. |  |
| 1, 2-Bis ( (pinacolato) boryl) ethane | An organoboronate derivative with inhibitory activity against Matrix metallo-proteinase (MMP-2). Group: Biochemicals. Alternative Names: 1,2-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethane; 2,2'-(1,2-Ethanediyl)bis[4,4,5,5-tetramethyl-1,3,2-Dioxaborolane. Grades: Highly Purified. CAS No. 364634-18-4. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| 20(R)-Ginsenoside Rh2 | 20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC50 of 2.77 μM for murine MHV-68. Uses: Designed for use in research and industrial production. Additional or Alternative Names: b-D-Glucopyranoside, (3b,12b,20R)-12,20-dihydroxydammar-24-en-3-yl; (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-d-glucopyranoside; 20-(R)-Ginsenoside Rh2; 20(R)-Ginsenoside Rh2; 20(R)-GINSENOSIDERH2; Ginsenoside-Rh2; Ginsenoside Rh2, 20(R)-; 20(R)-Ginsenoside-Rh2; (R) Ginsenoside Rh2. Product Category: Inhibitors. Appearance: Powder. CAS No. 112246-15-8. Molecular formula: C36H62O8. Mole weight: 622.88. Purity: 0.98. IUPACName: (2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol. Canonical SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)O)C)C)O)C)O)C. Product ID: ACM112246158. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 20(R)-Ginsenoside Rh2-d6 | 20(R)-Ginsenoside Rh2-d6 is the labeled version of 20(R)-Ginsenoside Rh2 (G410215), which is a matrix metalloproteinase inhibitor that acts as a cell antiproliferator. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C36H56D6O8, Molecular Weight: 628.91. US Biological Life Sciences. | Worldwide |
| 2-(4-Phenoxy-phenyl)-acetamidine Hydrochloride | 2-(4-Phenoxy-phenyl)-acetamidine hydrochloride is a derivative of 4-phenoxyphenyl acetonitri le. 4-Phenoxyphenyl acetonitri le is a reagent that is used in the preparation and inhibition of matrix metalloproteinases MMP-2, -3 and -8. Group: Biochemicals. Grades: Highly Purified. CAS No. 1172966-21-0. Pack Sizes: 100mg, 1g. Molecular Formula: C14H15ClN2O, Molecular Weight: 262.73. US Biological Life Sciences. | Worldwide |
| (2R)-TAPI-1 | TAPI-1 is a potent inhibitor of matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase). Synonyms: TAPI 1; TAPI1. Grade: >98%. CAS No. 163847-77-6. Molecular formula: C26H37N5O5. Mole weight: 499.6. | |
| 3- (p-Carboxyphenyl) propionic Acid Dimethyl Ester | A benzoic acid derivative used in the preparation of potent, selective, orally bioavailable matrix metalloproteinase inhibitors. Group: Biochemicals. Alternative Names: 4- (Methoxycarbonyl) benzenepropanoic Acid Methyl Ester; Methyl 4-(3-Methoxy-3-oxopropyl)benzoate. Grades: Highly Purified. CAS No. 40912-11-6. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 4-Trifluoromethoxyphenylboronic acid | 4-Trifluoromethoxyphenylboronic acid is a reagent used in the synthesis of orally bioavailable matrix metalloprotinase inhibitors. Also used in the preparation of chromen-4-one inhibitors against DNA dependant protein kinases. Synonyms: (p-Trifluoromethoxyphenyl)boronic Acid; 4-(Trifluoromethoxy)benzeneboronic Acid; 4-Trifluoromethoxyphenylboric Acid; 4-Trifluoromethoxyphenylboronic Acid; [4-[(Trifluoromethyl)oxy]phenyl]boronic Acid; p-(Trifluoromethoxy)phenylboronic Acid; B-[4-(Trifluoromethoxy)phenyl]boronic Acid; MFCD01074648. Grade: > 98 % (HPLC). CAS No. 139301-27-2. Molecular formula: C7H6BF3O3. Mole weight: 205.93. | |
| 6-(7-Nitro-benzo[2,1,3]oxadiazol-4-ylamino)-hexanoyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys((7-dimethylaminocoumarin-4-yl)-acetyl)-NH2 | It is an excellent fluorogenic substrate for matrix metalloproteinase stromelysin (MMP-3) hydrolysis. The FRET substrate shows high sensitivity and improves accuracy at a lower substrate turnover. It has a kcat/Km value of 2.14·104 M-1s-1 and can be easily detected at 350 nm (excitation) and 465 nm (emission). Therefore, it is a suitable tool for high-throughput inhibitor screening. Synonyms: NBD-ε-aminocaproyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(DMACA)-NH2; L-Lysinamide, N2-[6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-1-oxohexyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-leucyl-L-alanyl-L-norvalyl-L-tryptophyl-N6-[2-[7-(dimethylamino)-2-oxo-2H-1-benzopyran-4-yl]acetyl]-; NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(DMC)-NH2; N2-{6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-leucyl-L-alanyl-L-norvalyl-L-tryptophyl-N6-{[7-(dimethylamino)-2-oxo-2H-chromen-4-yl]acetyl}-L-lysinamide. Grade: ≥95%. CAS No. 945414-97-1. Molecular formula: C78H111N21O16. Mole weight: 1598.87. | |
| 72 kDa type IV collagenase (560-568) | 72 kDa type IV collagenase (560-568) is amino acids 560 to 568 fragment of 72 kDa type IV collagenase. 72 kDa type IV collagenase is a ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. Synonyms: 72 kDa gelatinase (560-568); Matrix metalloproteinase-2 (560-568). | |
| 7-Methoxy-1-tetralone | 7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index [1]. Uses: Scientific research. Group: Natural products. CAS No. 6836-19-7. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-W001925. |  |
| 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide | 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide is a fluorogenic substrate for matrix metalloproteinases (MMPs). It is ceaved by an MMP to release the fluorescent moiety 7-methoxycoumarin-4-acetyl (Mca), which can be used to quantify MMP activity. Synonyms: Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2; Mca-PLGL-Dpa-AR-amide. Grade: ≥95%. CAS No. 140430-53-1. Molecular formula: C49H68N14O15. Mole weight: 1093.16. | |
| ABT-518 | ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis. Synonyms: ABT 518; ABT518; N-((S)-1-((S)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl)-N-hydroxyformamide. CAS No. 286845-00-9. Molecular formula: C21H22F3NO8S. Mole weight: 505.46. | |
| Acetyl Tripeptide-30 Citrulline | Acetyl Tripeptide-30 Citrulline is a synthetic peptide that has gained popularity in the cosmetic industry for its skin conditioning properties. It is known for its ability to prevent the degradation of extracellular matrix components that are disrupted during the formation of stretch marks and to prevent the formation of new stretch marks by strengthening the skin's ability to withstand distension. This peptide has been reported to help the skin recover its elasticity, visibly attenuating stretch marks, and contributing to smoother and more even skin. It is also described as a new synthetic tetrapeptide that selectively inhibits human matrix metalloproteinases (MMPs), which are enzymes that can break down proteins in the extracellular matrix, leading to skin aging and other conditions. Synonyms: Acetyl Tripeptide-30 Citruline; Lys-α-Asp-Ile-Citrulline; (2S,5S,15S)-15-Amino-2-((S)-sec-butyl)-5-((S)-2,6-diaminohexanamido)-4,7,10-trioxo-8-oxa-3,9,11-triazahexadecanedioic acid; Lys-Asp-{Ile-Citrulline}; KD-{Ile-Citrulline}; Lys-Asp-{Ile-Cit}. Grade: ≥95%. CAS No. 2098345-00-5. Molecular formula: C22H41N7O9. Mole weight: 547.61. | |
| ADAMTS-5 inhibitor | ADAMTS-5 (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 5) is an aggrecanase-2. ADAMTS-5 is involved in the catabolism of aggrecan and collagen in the articular cartilage matrix during Osteoarthritis (OA). Synonyms: ADAMTS-5 Inhibitor; ADAMTS 5 Inhibitor; ADAMTS5 Inhibitor; 5-[[5-[(4-chlorophenyl)methylsulfanyl]-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one. Grade: 99%. CAS No. 929634-33-3. Molecular formula: C16H11ClF3N3OS3. Mole weight: 449.92. | |
| Aderbasib | Aderbasib is a azaspiro[2. 5]octanehydroxamide derivative as inhibitor of metalloproteases for the treatment of disorders such as cancer, arthritis, cardiovascular or skin disorders. Aderbasib, also known as INCB007839, is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Aderbasib represses the metalloproteinase "sheddase" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. The metalloproteinase domains of ADAMs cleave cell surface proteins at extracellular sites proximal to the cell membrane, releasing or "shedding" soluble protein etcodomains from the cell surface; the disintegrin domains of these multifunctional proteins interact with various components of the extracellular matrix (ECM). Group: Biochemicals. Alternative Names: (6S, 7S) -7-[ (Hydroxyamino) carbonyl]-6-[ (4-phenyl-1-piperazinyl) carbonyl]-5-azaspiro[2. 5]octane-5-carboxylic Acid Methyl Ester; INCB 007839. Grades: Highly Purified. CAS No. 791828-58-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?O?, Molecular Weight: 416.47. US Biological Life Sciences. | Worldwide |
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