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Megalomicins are a family of macrolide antibiotics produced by the soil bacterium Micromonospora megalomicea. They exhibit antiparasitic, antiviral and antibacterial activity, and are effective against both Gram-positive and Gram-negative bacteria. CAS No. 129428-69-9.
Megalomicin A
It is produced by the strain of Micromonospora megalomice var. megalomicea NRRL 3274. It is a macrolide antibiotic. It has anti-bacterial and mycobacterium activity, the activity is the strongest under alkaline condition, serum can reduce the activity of 20%-30%. It has protective effect on mice infected with Staphylococcus aureus, pneumococcus, E. coli and Pseudomonas aeruginosa. Synonyms: Megalomicin; Antibiotic XK 41C; Antibiotic W-847-A; Megalomicina; Megalomicine; Megalomicinum; [3R- (3R*, 4S*, 5S*, 6R*, 7R*, 9R*, 11R*, 12R*, 13S*, 14R*) ] -4- [ (2, 6-Dideoxy-3-C-methyl-a-L-ribo-hexopyranosyl) oxy] -14-ethyl-12, 13-dihydroxy-3, 5, 7, 9, 11, 13-hexamethyl-7- [ [2, 3, 6-trideoxy-3- (dimethylamino) -a-L-ribo-hexopyranosyl] oxy] -6- [ [3, 4, 6-trideoxy-3- (dimethylamino) -b-D-xylo-hexopyranosyl] oxy] oxacyclotetradecane-2, 10-dione; Erythromycin, 3''-O-demethyl-6-O-[2,3,6-trideoxy-3-(dimethylamino)-a-L-ribo-hexopyranosyl]-. Grades: ≥95%. CAS No. 28022-11-9. Molecular formula: C44H80N2O15. Mole weight: 877.11.
Megalomicin B
It is produced by the strain of Micromonospora megalomice var. megalomicea NRRL 3274. It is a macrolide antibiotic. It has anti-bacterial and mycobacterium activity, the activity is the strongest under alkaline condition, serum can reduce the activity of 20%-30%. It has protective effect on mice infected with Staphylococcus aureus or pneumococcus. Synonyms: W-847-B; 4'-Acetylmegalomycin A; Antibiotic XK-41B1; Megalomycin A 4'-O-acetate; XK-41-B1. CAS No. 49669-75-2. Molecular formula: C46H82N2O16. Mole weight: 919.15.
Megalomicin C1
It is produced by the strain of Micromonospora megalomice var. megalomicea NRRL 3274. It is a macrolide antibiotic. It has anti-bacterial and mycobacterium activity, the activity is the strongest under alkaline condition, serum can reduce the activity of 20%-30%. It has protective effect on mice infected with Staphylococcus aureus or pneumococcus. Synonyms: Antibiotic XK 41 C1; Antibiotic W847 C1. CAS No. 49669-76-3. Molecular formula: C48H84N2O17. Mole weight: 961.18.
Megalomicin C2
It is produced by the strain of Micromonospora megalomice var. megalomicea NRRL 3274. It is a macrolide antibiotic. It has anti-bacterial and mycobacterium activity, the activity is the strongest under alkaline condition, serum can reduce the activity of 20%-30%. It has protective effect on mice infected with Staphylococcus aureus or pneumococcus. Synonyms: Antibiotic XK 41 C2; Antibiotic W847 C2. CAS No. 49669-77-4. Molecular formula: C49H86N2O17. Mole weight: 975.21.
A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-α-D-desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. The reaction occurs in the reverse direction. Group: Enzymes. Synonyms: desV (gene name); megDII (gene name); eryCI (gene name). Enzyme Commission Number: EC 2.6.1.106. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2846; dTDP-3-amino-3,4,6-trideoxy-α-D-glucose transaminase; EC 2.6.1.106; desV (gene name); megDII (gene name); eryCI (gene name). Cat No: EXWM-2846.
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