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1-[(2R)-3-Mercapto-2-methyl-1-oxopropyl]-D-proline is an impurity of Captopril, which is an orally active angiotensin-converting enzyme (ACE) inhibitor used as an antihypertensive agent. Synonyms: (R)-1-(3-Mercapto-2-methyl-1-oxopropyl)-D-proline; 1-(D-3-mercapto-2-methylpropionyl)-L-proline; Captopril Related Compound 8; epi-D-captopril; (R)-1-((R)-3-Mercapto-2-methyl-propionyl)-pyrrolidine-2-carboxylic acid; (2R)-1-((2R)-3-mercapto-2-methylpropanoyl)pyrrolidine-2-carboxylic acid; ((R)-3-mercapto-2-methylpropanoyl)-D-proline. Grades: 98%. CAS No. 112243-88-6. Molecular formula: C9H15NO3S. Mole weight: 217.28.
A useful synthetic intermediate for the preparation of novel antiinflammatory agents. Group: Biochemicals. Alternative Names: 3- (4-Mercaptophenyl) propionic Acid. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences.
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7 β-Spironolactone
7 β-Spironolactone is the 7 β-isomer of Spironolactone. It binds effectively to human plasma proteins. Group: Biochemicals. Alternative Names: (7 β,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic Acid γ-Lactone;17-Hydroxy-7 β-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic Acid γ-Lactone Acetate; 3'-(3-Oxo-7 β-acetylthio-17 β-hydroxyandrost-4-en-17α-yl)-propionic Acid Lactone; 7 β-(Acetylthio)-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic Acid γ-Lactone; SC 11940. Grades: Highly Purified. CAS No. 33784-05-3. Pack Sizes: 1mg. US Biological Life Sciences.
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7-Beta-Spironolactone
the 7β-isomer of Spironolactone. Synonyms: (7β,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic Acid γ-Lactone; 17-Hydroxy-7β-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic Acid γ-Lactone Acetate; 3'-(3-Oxo-7β-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic Acid Lactone; 7β-(Acetyl. Grades: > 95%. CAS No. 33784-05-3. Molecular formula: C24H32O4S. Mole weight: 416.58.
7Beta-Spironolactone
7Beta-Spironolactone. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7β,17α)-, 17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7β-mercapto-3-oxo-, γ-lactone, acetate (8CI), 7β-(Acetylthio)-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone, 3'-(3-Oxo-7β-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone, SC 11940. CAS No. 33784-05-3. IUPAC Name: S-[(7S,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate. Molecular Formula: C24H32O4S. Mole Weight: 416.57. Catalog: APS33784053. SMILES: CC (=O)S[C@H]1CC2=CC (=O)CC[C@]2 (C)[C@H]3CC[C@@]4 (C)[C@@H] (CC[C@@]45CCC (=O)O5)[C@H]13. Format: Neat.
7b-Spironolactone
7b-Spironolactone. Group: Biochemicals. Alternative Names: (7b,17a)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid gamma-lactone; 17-Hydroxy-7b-mercapto-3-oxo-17a-pregn-4-ene-21-carboxylic acid gamma-lactone acetate; 3'-(3-Oxo-7b-acetylthio-17b-hydroxyandrost-4-en-17a-yl)-propionic acid lactone. Grades: Highly Purified. CAS No. 33784-05-3. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C24H32O4S. US Biological Life Sciences.
(d(CH2)51,D-Ile2,Ile4,Arg8,Tyr9)-Vasopressin is an AVP antagonist specifically targeting rat V2 receptors. The amino acid type at position 2 controls rat versus human selectivity to AVP analogues. Synonyms: d(CH2)5[D-Ile2,Ile4,Tyr9]-AVP; β-Mercapto-β,β-cyclopentamethylene-propionyl-D-Ile-Phe-Ile-Asn-Cys-Pro-Arg-Tyr-NH2 (Disulfide bridge: Cys1-Cys6); (d(CH2)51,D-Ile2,Ile4,Arg8,Tyr9)-Vasopressin. CAS No. 114438-90-3. Molecular formula: C56H83N13O11S2. Mole weight: 1178.47.
(d(CH2)51,D-Tyr(Et)2,Val4,Arg8,des-Gly9)-Vasopressin is an antagonist of both the antidiuretic and vasopressor responses of vasopressin. Uses: Hormone antagonists. Synonyms: LS-186846; Mcp-tva-argipressin; SKF 101926; β-Mercapto-β,β-cyclopentamethylene-propionyl-D-Tyr(Et)-Phe-Val-Asn-Cys-Pro-Arg-NH2 (Disulfide bond); d(CH2)5[Tyr(Et)2,Val4,des-Gly9]AVP; 1-((β-Mercapto-β)β-cyclopentamethylenepropionic acid)-2-(O-ethyl-tyr)-4-val-9-des-gly-arginine vasopressin; 1-{[(10R,13S,16S,19S,22R)-13-(2-Amino-2-oxoethyl)-19-benzyl-22-(4-ethoxybenzyl)-16-isopropyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaazaspiro[5.19]pentacos-10-yl]carbonyl}-L-prolyl-N5-(diaminomethylene)-L-ornithinamide; N-[[1-Mercapto(1)-cyclohexyl]acetyl]-O-ethyl-D-Tyr-L-Phe-L-Val-L-Asn-L-Cys(1)-L-Pro-L-Arg-NH2; O-Ethyl-N-[1-mercapto(1)cyclohexylacetyl]-D-Tyr-L-Phe-L-Val-L-Asn-L-Cys(1)-L-Pro-L-Arg-NH2; (d(CH2)51,D-Tyr(Et)2,Val4,Arg8,des-Gly9)-Vasopressin. Grades: 95%. CAS No. 90332-82-4. Molecular formula: C51H74N12O10S2. Mole weight: 1079.34.
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin is a selective vasopressin V1A receptor antagonist. Synonyms: Manning Compound, [Pmp1, Tyr(OMe)2, Arg8] Vasopressin; β-Mercapto-β,β-cyclopentamethylene-propionyl-Tyr(Me)-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 trifluoroacetate salt (Disulfide bond). Grades: >98%. CAS No. 73168-24-8. Molecular formula: C52H74N14O12S2. Mole weight: 1151.38.
(d(CH2)51,Tyr(Me)2,Dab5,Arg8,Tyr9)-Vasopressin
Asn5 can be replaced by isosteric Dab to produce a vasopressin antagonist. Synonyms: d(CH2)5[Tyr(Me)2,Dab5,Arg8,Tyr9]-AVP; β-Mercapto-β,β-cyclopentamethylene-propionyl-Tyr(Me)-Phe-Gln-Dab-Cys-Pro-Arg-Tyr-NH2 (Disulfide bridge: Cys1-Cys6); (d(CH2)51,Tyr(Me)2,Dab5,Arg8,Tyr9)-Vasopressin. Grades: ≥90%. Molecular formula: C59H82N14O12S2. Mole weight: 1243.50.
(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin
Dab isosteric substitution of Asn5 inevitably leads to a significant loss of peptide bioactivity in oxytocin, vasopressin and their analogs. In OT or VP antagonists, the exchange produces highly selective and potent OT and V1a receptor antagonists. Synonyms: d(CH2)5[Tyr(Me)2,Dab5,Arg8]-AVP; (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin; β-Mercapto-β,β-cyclopentamethylene-propionyl-Tyr(Me)-Phe-Gln-Dab-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: Cys1-Cys6); [d(CH2)5,Tyr(Me)2,Dab5]AVP. CAS No. 176714-12-8. Molecular formula: C52H76N14O11S2. Mole weight: 1137.38.
(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin
(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin is a potent oxytocin antagonist with a pA2 of 7.35±0.08. It has been used to support the hypothesis that pituitary secretion of oxytocin is associated with coactivation of centrally projecting brain oxytocin pathways, some of which are causally associated with induced inhibition of food intake. In addition, it competitively inhibits the contraction of arginine vasotocin (AVT) without affecting the efficacy of AVT. Synonyms: [Pmp1,Tyr(OMe)2,Orn8] Vasotocin; β-Mercapto-β,β-cyclopentamethylene-propionyl-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Orn-Gly-NH2 (Disulfide bond); [beta-Mercapto-beta,beta-cyclopentamethylenepropionyl1,O-Me-Tyr2,Orn8]-Oxytocin; 1-{[(10R,13S,16S,19S,22S)-13-(2-Amino-2-oxoethyl)-16-(3-amino-3-oxopropyl)-19-[(2S)-2-butanyl]-22-(4-methoxybenzyl)-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaazaspiro[5.19]pentacos-10-yl]carbonyl}-L-prolyl-L-ornithylglycinamide; (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin. Grades: ≥90% by HPLC. CAS No. 77327-45-8. Molecular formula: C48H74N12O12S2. Mole weight: 1075.32.
A deuterated homolog of Tiopronin. Group: Biochemicals. Alternative Names: 3-Mercapto-2-methyl-propionylamino)-acetic Acid. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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Thiorphan
Thiorphan. Group: Biochemicals. Alternative Names: N-[2-(Mercaptomethyl)-1-oxo-3-phenylpropyl]glycine; 2-Mercapto methyl -3-phenyl propionyl aminoacetic acid; D, L-3-Mercapto-2-benzyl propanoyl glycine. Grades: Highly Purified. CAS No. 76721-89-6. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C12H15NO3S. US Biological Life Sciences.