Metalloproteinase Suppliers USA
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Product | Description | |
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11-Aminoundecanoic acid Quick inquiry Where to buy Suppliers range | 11-Aminoundecanoic Acid is used to prepare thapsigargin analogues targeting apoptosis to prostatic cancer cells. It is also used to synthesize N-carboxyalkylpeptides containing extended alkyl residues at P1'as matrix metalloproteinase inhibitors. Synonyms: ω-Aminoundecanoic acid; Undecanoic acid, 11-amino-; 11-Aminoundecylic acid; 11-amino-undecanoic acid; H-11-Aun-OH. Grades: ≥ 99% (Titration). CAS No. 2432-99-7. Molecular formula: C11H23NO2. Mole weight: 201.31. | |
1-?Biphenyl-?4-?yl-?propan-?2-?one Quick inquiry Where to buy Suppliers range | 1-?Biphenyl-?4-?yl-?propan-?2-?one is a reactant used in the preparation of potent inhibitors of metalloproteinases 2 and 9 (MMP-2, MMP-9). This affects such processes such as homeostatic regulation, tumor progression, etc. Group: Biochemicals. Grades: Highly Purified. CAS No. 5333-1-7. Pack Sizes: 1g, 2.5g. Molecular Formula: C15H14O, Molecular Weight: 210.27. US Biological Life Sciences. | Worldwide |
20(R)-Ginsenoside Rh2-d6 Quick inquiry Where to buy Suppliers range | 20(R)-Ginsenoside Rh2-d6 is the labeled version of 20(R)-Ginsenoside Rh2 (G410215), which is a matrix metalloproteinase inhibitor that acts as a cell antiproliferator. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C36H56D6O8, Molecular Weight: 628.91. US Biological Life Sciences. | Worldwide |
2-(4-Phenoxy-phenyl)-acetamidine Hydrochloride Quick inquiry Where to buy Suppliers range | 2-(4-Phenoxy-phenyl)-acetamidine hydrochloride is a derivative of 4-phenoxyphenyl acetonitri le. 4-Phenoxyphenyl acetonitri le is a reagent that is used in the preparation and inhibition of matrix metalloproteinases MMP-2, -3 and -8. Group: Biochemicals. Grades: Highly Purified. CAS No. 1172966-21-0. Pack Sizes: 100mg, 1g. Molecular Formula: C14H15ClN2O, Molecular Weight: 262.73. US Biological Life Sciences. | Worldwide |
(2R)-TAPI-1 Quick inquiry Where to buy Suppliers range | TAPI-1 is a potent inhibitor of matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase). Synonyms: TAPI 1; TAPI1. Grades: >98%. CAS No. 163847-77-6. Molecular formula: C26H37N5O5. Mole weight: 499.6. | |
3- (p-Carboxyphenyl) propionic Acid Dimethyl Ester Quick inquiry Where to buy Suppliers range | A benzoic acid derivative used in the preparation of potent, selective, orally bioavailable matrix metalloproteinase inhibitors. Group: Biochemicals. Alternative Names: 4- (Methoxycarbonyl) benzenepropanoic Acid Methyl Ester; Methyl 4-(3-Methoxy-3-oxopropyl)benzoate. Grades: Highly Purified. CAS No. 40912-11-6. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
4',6,7-Trihydroxyisoflavone Quick inquiry Where to buy Suppliers range | 4',6,7-Trihydroxyisoflavone is an isoflavone isolated from the seeds of Glycine max with antioxidant activity. It is also a novel inhibitor of PKCα that suppresses solar UV-induced matrix metalloproteinase 1. Synonyms: Demethyltexasin; 6,7,4'-trihydroxyisoflavone; 6-Hydroxydaidzein; 6,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one. Grades: >98%. CAS No. 17817-31-1. Molecular formula: C15H10O5. Mole weight: 270.24. | |
6-(7-Nitro-benzo[2,1,3]oxadiazol-4-ylamino)-hexanoyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys((7-dimethylaminocoumarin-4-yl)-acetyl)-NH2 Quick inquiry Where to buy Suppliers range | It is an excellent fluorogenic substrate for matrix metalloproteinase stromelysin (MMP-3) hydrolysis. The FRET substrate shows high sensitivity and improves accuracy at a lower substrate turnover. It has a kcat/Km value of 2.14·104 M-1s-1 and can be easily detected at 350 nm (excitation) and 465 nm (emission). Therefore, it is a suitable tool for high-throughput inhibitor screening. Synonyms: NBD-ε-aminocaproyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(DMACA)-NH2; L-Lysinamide, N2-[6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-1-oxohexyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-leucyl-L-alanyl-L-norvalyl-L-tryptophyl-N6-[2-[7-(dimethylamino)-2-oxo-2H-1-benzopyran-4-yl]acetyl]-; NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(DMC)-NH2; N2-{6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-leucyl-L-alanyl-L-norvalyl-L-tryptophyl-N6-{[7-(dimethylamino)-2-oxo-2H-chromen-4-yl]acetyl}-L-lysinamide. Grades: ≥95%. CAS No. 945414-97-1. Molecular formula: C78H111N21O16. Mole weight: 1598.87. | |
Abametapir Quick inquiry Where to buy Suppliers range | Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. Uses: 5,5'-dimethyl-2,2'-bipyridine is used in preparation of iron bipyridine acetoacetate complexes. Synonyms: 5,5'-Dimethyl-2,2'-bipyridine; 6,6'-Bi-3-picoline; 5,5'-Dimethyl-2,2'-bipyridyl. Grades: 98 %. CAS No. 1762-34-1. Molecular formula: C12H12N2. Mole weight: 184.24. | |
Abametapir-[d6] Quick inquiry Where to buy Suppliers range | Abametapir-[d6] is an isotopic labelled of Abametapir. Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases, enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. CAS No. 1803416-92-3. Molecular formula: C12H6D6N2. Mole weight: 190.27. | |
ABT-518 Quick inquiry Where to buy Suppliers range | ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis. Synonyms: ABT 518; ABT518; N- ( (S) -1- ( (S) -2, 2-Dimethyl-1, 3-dioxolan-4-yl) -2- ( (4- (4- (trifluoromethoxy) phenoxy) phenyl) sulfonyl) ethyl) -N-hydroxyformamide. CAS No. 286845-00-9. Molecular formula: C21H22F3NO8S. Mole weight: 505.46. | |
ADAMTS-5 inhibitor Quick inquiry Where to buy Suppliers range | ADAMTS-5 (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 5) is an aggrecanase-2. ADAMTS-5 is involved in the catabolism of aggrecan and collagen in the articular cartilage matrix during Osteoarthritis (OA). Synonyms: ADAMTS-5 Inhibitor; ADAMTS 5 Inhibitor; ADAMTS5 Inhibitor; 5-[[5-[(4-chlorophenyl)methylsulfanyl]-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one. Grades: 99%. CAS No. 929634-33-3. Molecular formula: C16H11ClF3N3OS3. Mole weight: 449.92. | |
Aderbasib Quick inquiry Where to buy Suppliers range | Aderbasib is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Aderbasib represses the metalloproteinase "sheddase" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. Synonyms: INCB7839; INCB 7839; INCB-7839; INCB007839; INCB 007839; INCB-007839. CAS No. 791828-58-5. Molecular formula: C21H28N4O5. Mole weight: 416.48. | |
Aderbasib Quick inquiry Where to buy Suppliers range | Aderbasib is a azaspiro[2. 5]octanehydroxamide derivative as inhibitor of metalloproteases for the treatment of disorders such as cancer, arthritis, cardiovascular or skin disorders. Aderbasib, also known as INCB007839, is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A Disintegrin And Metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. Aderbasib represses the metalloproteinase "sheddase" activities of ADAM10 and ADAM17, which may result in the inhibition of tumor cell proliferation. The metalloproteinase domains of ADAMs cleave cell surface proteins at extracellular sites proximal to the cell membrane, releasing or "shedding" soluble protein etcodomains from the cell surface; the disintegrin domains of these multifunctional proteins interact with various components of the extracellular matrix (ECM). Group: Biochemicals. Alternative Names: (6S, 7S) -7-[ (Hydroxyamino) carbonyl]-6-[ (4-phenyl-1-piperazinyl) carbonyl]-5-azaspiro[2. 5]octane-5-carboxylic Acid Methyl Ester; INCB 007839. Grades: Highly Purified. CAS No. 791828-58-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?O?, Molecular Weight: 416.47. US Biological Life Sciences. | Worldwide |
Aluminum Ammonium Sulfate Dodecahydrate Quick inquiry Where to buy Suppliers range | Aluminum Ammonium Sulfate Dodecahydrate is a potent matrix metalloproteinase inhibitor which are key regulators for many pysiological and pathological functions. It is also used in the preparation of antiperspirants and deodorants containing ammonium alum that prevents body odor in humans. Group: Biochemicals. Grades: Highly Purified. CAS No. 7784-26-1. Pack Sizes: 50g, 100g. Molecular Formula: Al (H3N) 2(H2O4S) 12(H2O), Molecular Weight: 26.9817032980812. US Biological Life Sciences. | Worldwide |
Aminocatechol Quick inquiry Where to buy Suppliers range | A phenol derivative with inhibitory activity against matrix metalloproteinase (MMP). Group: Biochemicals. Alternative Names: 4-Aminopyrocatechol; 1-Amino-3,4-dihydroxybenzene; 3,4-Dihydroxyaniline; 3,4-Dihydroxyphenylamine; 4-Amino-1,2-benzenediol; 4-Aminocatechol; A 3253; KYJ 3-018. Grades: Highly Purified. CAS No. 13047-04-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Aminopeptidase N Inhibitor Quick inquiry Where to buy Suppliers range | Membrane alanyl aminopeptidase is also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N), which is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Synonyms: AP-N Inhibitor. Grades: ≥95%. CAS No. 596108-59-7. Molecular formula: C17H10N2O8. Mole weight: 370.27. | |
Ascochlorin (Antibiotic LL-Z 1272 gamma) Quick inquiry Where to buy Suppliers range | The antitumour fungal metabolite ascochlorin specifically inhibits matrix metalloproteinase-9 (MMP9) activity through suppression of activator protein-1 (AP-1) dependent induction of MMP-9 gene expression. Via AP-1 suppression ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors. Ascochlorin also shows activity against Newcastle disease and herpes simplex viruses. Group: Biochemicals. Alternative Names: Antibiotic LL-Z 1272 gamma. Grades: Highly Purified. CAS No. 26166-39-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
(-)-Ascofuranone Quick inquiry Where to buy Suppliers range | (-)-Ascofuranone is an antibiotic with antitumor activity. It suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. (-)-Ascofuranone was effective in the treatment against Trypanosoma brucei brucei infection in mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 38462-04-3. Pack Sizes: 250ug, 500ug. Molecular Formula: C23H29ClO5, Molecular Weight: 420.93. US Biological Life Sciences. | Worldwide |
BAPTA-AM Quick inquiry Where to buy Suppliers range | BAPTA-AM is a lipophilic diester of BAPTA used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE. Group: Biochemicals. Alternative Names: N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]glycine 1,1'-bis[(acetyloxy)methyl] ester; 1,2-Bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid tetraacetoxymethyl ester. Grades: Highly Purified. CAS No. 126150-97-8. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O??, Molecular Weight: 764.68. US Biological Life Sciences. | Worldwide |
Batimastat Quick inquiry Where to buy Suppliers range | Batimastat (also known as BB-94) is a synthetic matrix metalloproteinase inhibitor that has shown antineoplastic and antiangiogenic activity in various tumor models. Batimastat acts as an inhibitor of metalloproteinase activity by binding the zinc ion in the active site of MMPs. Uses: Antineoplastic agents. Synonyms: (2S,3R)-N-Hydroxy-N'-[(2S)-1-methylamino-1-oxo-3-phenylpropan-2-yl]-3-(2-methylpropyl)-2-(thiophen-2-ylsulfanylmethyl)butanediamide; BB94; BB-94; BB 94. Grades: 98%. CAS No. 130370-60-4. Molecular formula: C23H31N3O4S2. Mole weight: 477.638. | |
BE-16627B Quick inquiry Where to buy Suppliers range | BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. Synonyms: BE 16627B; BE16627B; L-N-(N-hydroxy-2-isobutylsuccinamoyl)seryl-L-valine; N-[1, 3-Dihydroxy-2- ({1-hydroxy-2-[2-hydroxy-2- (hydroxyimino) ethyl]-4-methylpentylidene}amino) propylidene]valine. Grades: >98%. CAS No. 137530-61-1. Molecular formula: C31H35Cl2F6N3O3. Mole weight: 375.42. | |
CL 82,198 Quick inquiry Where to buy Suppliers range | CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13). It doesn't have effect against MMP-1, MMP-9 or TNF-α converting enzyme. CL 82,198 is also used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis. Synonyms: CL-82198; N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide. Grades: ≥95%. CAS No. 307002-71-7. Molecular formula: C17H22N2O3. Mole weight: 302.4. | |
CP-471474 Quick inquiry Where to buy Suppliers range | A broad spectrum inhibitor of matrix metalloproteinases that attenuates early left ventricular dilation after experimental myocardial infarction in mice. Studies show that it also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models. Group: Biochemicals. Alternative Names: 2-[[[4- (4-Fluorophenoxy) phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide; CP 471474. Grades: Highly Purified. CAS No. 210755-45-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
CP-544439 Quick inquiry Where to buy Suppliers range | CP-544439 is a selective matrix metalloproteinase-13 inhibitor. Uses: Matrix metalloproteinase inhibitors. Synonyms: 4-[[4-(4-fluorophenoxy)phenyl]sulfonylamino]-N-hydroxyoxane-4-carboxamide; CP-544439; CP 544439; CP544439 ; UNII-516DO4KL5R. Grades: >98%. CAS No. 230954-09-3. Molecular formula: C18H19FN2O6S. Mole weight: 410.42. | |
CTTHWGFTLC, CYCLIC Quick inquiry Where to buy Suppliers range | CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and MMP-9. Uses: Peptide Inhibitors. CAS No. 244082-19-7. Product ID: R1311. | |
CTTHWGFTLC, CYCLIC acetate Quick inquiry Where to buy Suppliers range | CTTHWGFTLC, CYCLIC acetate is a cyclic peptide inhibitor for matrix metalloproteinases (MMP-2) and MMP-9. Synonyms: L-Cysteine, L-cysteinyl-L-threonyl-L-threonyl-L-histidyl-L-tryptophylglycyl-L-phenylalanyl-L-threonyl-L-leucyl-, cyclic (1?10)-disulfide acetate; CTT 1 acetate; H-Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys-OH.CH3CO2H (Disulfide Bridge: Cys1-Cys10); L-cysteinyl-L-threonyl-L-threonyl-L-histidyl-L-tryptophyl-glycyl-L-phenylalanyl-L-threonyl-L-leucyl-L-cysteine (1->10)-disulfide acetic acid acetate. Grades: ≥95%. Molecular formula: C54H75N13O16S2. Mole weight: 1226.39. | |
Cyclothiazomycin Quick inquiry Where to buy Suppliers range | It is produced by the strain of Streptomyces sp. NR0516. It selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. In addition, it has weak antifungal activity. Synonyms: cyclothiazomycin A; 5102-II. CAS No. 133352-26-8. Molecular formula: C59H64N18O14S7. Mole weight: 1473.71. | |
Dnp-PLGMWSR Quick inquiry Where to buy Suppliers range | Dnp-PLGMWSR is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-9. The activity of MMP-2 and MMP-9 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group. Uses: Peptide Inhibitors. CAS No. 135662-07-6. Product ID: R1926. | |
Doxycycline Monohydrate Quick inquiry Where to buy Suppliers range | Doxycycline is a semisynthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity that inhibits metalloproteinase (MMP). Uses: Anti-bacterial agents. Synonyms: alpha-6-deoxy-5-oxytetrccline; Doxycycline hydrate; Adoxa; Vibramycin; Doxycycline Monohydrochloride, 6 epimer; Doxycycline-Chinoin; Doxycycline Monohydrate/Doxycycline base; 4-(DiMethylaMino)-3,5,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrate. Grades: ≥95%. CAS No. 17086-28-1. Molecular formula: C22H24N2O8.H2O. Mole weight: 462.45. | |
Etanercept Quick inquiry Where to buy Suppliers range | Etanercept inhibits in vitro the activity of human TNF and is efficacious in many in vivo models of inflammation, including arthritis. Etanercept competitively inhibits the binding of both TNF-α and TNF-β (lymphotoxin-α) to cell surface TNF receptors, rendering TNF biologically inactive. It also modulates indirectly different biological responses that are induced or regulated by TNF, such as the expression of adhesion molecules E-selectin and to a lesser extent intercellular adhesion molecule 1 (ICAM-1), the production of interleukin-6 (IL-6) and matrix metalloproteinase 3 (MMP-3) (stromelysin), as well as IL1. Synonyms: 1-235-Tumor necrosisfactor receptor (human) fusion protein with 236-467-immunoglobulin G1 (human g1-chain Fc fragment); TNFR-Fc fusion protein; Etanercept; Embrel; Enbrel; rhu-TNFR-Fc. Grades: 95%. CAS No. 185243-69-0. Molecular formula: C2224H3472N618O701S36. | |
Ethyl 1-Boc-3-piperidinecarboxylate Quick inquiry Where to buy Suppliers range | A reagent used in the synthesis of piperidine derivatives, and α-sulfonyl hydroxamic acid derivatives as matrix metalloproteinase (MMP) and TNF-alpha converting enzyme (TACE) inhibitors. Synonyms: Boc-DL-Pic(3)-OEt; Boc-DL-Nipc-Oet; Ethyl N-Boc-piperidine-3-carboxylate; Ethyl N-Boc-3-piperidinecarboxylate; N-(t-Butoxycarbonyl)-DL-nipecotic acid ethyl ester; (±)-1-(t-Butoxycarbonyl)piperidine-3-carboxylic acid ethyl ester. Grades: 97 %. CAS No. 130250-54-3. Molecular formula: C13H23NO4. Mole weight: 257.33. | |
FR-217840 Quick inquiry Where to buy Suppliers range | FR-217840 is a matrix metalloproteinase inhibitor. It can suppress joint destruction. FR217840 may have potential as a novel anti-rheumatic drug. Uses: Anti-rheumatic agent. Synonyms: FR-217840; FR217840; FR 217840. (2S)-1-((5-(4-fluorophenyl)-2-thienyl)sulfonyl)-N-hydroxy-4-(methylsulfonyl)-2-Piperazinecarboxamide. Grades: 98%. CAS No. 848444-16-6. Molecular formula: C16H18FN3O6S3. Mole weight: 463.52. | |
Funalenone Quick inquiry Where to buy Suppliers range | Funalenone is a phenalene compound originally isolated from A. niger. It inhibits HIV-1 integrase and type I collagenase. Funalenone is also a selective inhibitor of matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM). Synonyms: 8-deoxyxanthoherquein; 3,4,7,9-tetrahydroxy-2-methoxy-6-methyl-1H-phenalen-1-one. Grades: ≥95%. CAS No. 259728-61-5. Molecular formula: C15H12O6. Mole weight: 288.25. | |
Funalenone (3,4,7,9-Tetrahydroxy-6-methyl-1H-phenalen-1-one) Quick inquiry Where to buy Suppliers range | Matrix metalloproteinase-1 (MMP-1; Type I collagenase) inhibitor. HIV-1 integrase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 259728-61-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
GM 1489 Quick inquiry Where to buy Suppliers range | GM 1489 is a potent broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. Synonyms: Hexanoic acid, 3- [ [ [ (1S) -1- (1H-indol-3-ylmethyl) -2-oxo-2- [ [ (1S) -1-phenylethyl] amino] ethyl] amino] carbonyl] -5-methyl-, (3R)-; (3R) -3- [ [ [ (1S) -1- (1H-Indol-3-ylmethyl) -2-oxo-2- [ [ (1S) -1-phenylethyl] amino] ethyl] amino] carbonyl] -5-methylhexanoic acid; Hexanoic acid, 3-[[[1- (1H-indol-3-ylmethyl) -2-oxo-2-[ (1-phenylethyl) amino]ethyl]amino]carbonyl]-5-methyl-, [3R-[3R*[S*(S*)]]]-; GM-1489; GM1489. Grades: ≥98%. CAS No. 171347-75-4. Molecular formula: C27H33N3O4. Mole weight: 463.57. | |
GW-3333 Quick inquiry Where to buy Suppliers range | GW-3333 is a dual inhibitors of tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) and matrix metalloproteinases. Synonyms: GW-3333; GW3333; GW 3333; 3-[formyl(hydroxy)amino]-4-methyl-N-[3-methyl-1-oxo-1-(pyridin-2-ylamino)pentan-2-yl]-2-(2-methylpropyl)pentanamide. Grades: >98%. CAS No. 212609-68-2. Molecular formula: C22H36N4O4. Mole weight: 420.55. | |
Halofuginone Quick inquiry Where to buy Suppliers range | Halofuginone is a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. Uses: Semisynthetic quinazolinone alkaloid anticoccidial. Synonyms: Halofuginone; Tempostatin; RU 19110; RU19110; RU-19110. Grades: > 95%. CAS No. 55837-20-2. Molecular formula: C16H17BrClN3O3. Mole weight: 414.684. | |
H-Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys-OH (Disulfide bond) Quick inquiry Where to buy Suppliers range | It is a cyclic peptide inhibitor for matrix metalloproteinases (MMP-2) and MMP-9. Synonyms: CTTHWGFTLC, CYCLIC; L-cysteinyl-L-threonyl-L-threonyl-L-histidyl-L-tryptophyl-glycyl-L-phenylalanyl-L-threonyl-L-leucyl-L-cysteine (1->10)-disulfide; MMP-2/MMP-9 Inhibitor III; Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III. Grades: ≥90%. CAS No. 244082-19-7. Molecular formula: C52H71N13O14S2. Mole weight: 1166.33. | |
Histatin 5 Quick inquiry Where to buy Suppliers range | Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. Uses: Peptide Inhibitors. CAS No. 115966-68-2. Product ID: R1426. | |
Histatin 5 Quick inquiry Where to buy Suppliers range | Histatin 5, a human salivary peptide, has been shown to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. Synonyms: H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-OH; L-alpha-aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidyl-glycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-alpha-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginyl-glycyl-L-tyrosine; Human histatin 5; Peptide F-A (human parotid saliva). Grades: 98%. CAS No. 104339-66-4. Molecular formula: C133H195N51O33. Mole weight: 3036.29. | |
Histatin 5 acetate Quick inquiry Where to buy Suppliers range | Histatin 5, a human salivary peptide, has been shown to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. Synonyms: H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-OH.CH3CO2H; L-α-Aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidylglycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-α-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginylglycyl-L-tyrosine acetate salt; Human histatin 5 acetate salt; Peptide F-A (human parotid saliva) acetate salt. Grades: ≥95%. Molecular formula: C135H199N51O35. Mole weight: 3096.35. | |
Ilomastat Quick inquiry Where to buy Suppliers range | Ilomastat is a broad-spectrum matrix metalloproteinase inhibitor, displaying potential anticancer activity. Ilomastat is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc. Ilomastat inhibits enzymes including thermolysin, peptide deformylase, and anthrax lethal factor endopeptidase (LF) produced by the bacterium Bacillus anthracis. Synonyms: GM6001; GM-6001; GM 6001; Ilomastat; galardin; (2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanedia. Grades: 98%. CAS No. 142880-36-2. Molecular formula: C20H28N4O4. Mole weight: 388.468. | |
Incyclinide Quick inquiry Where to buy Suppliers range | incyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and achemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis. Synonyms: Metastat; 4-dedimethylamino sancycline; CMT-3; CMT 3; CMT3; COL 3; COL3; COL-3. CAS No. 15866-90-7. Molecular formula: C19H17NO7. Mole weight: 371.34. | |
Leukadherin-1 Quick inquiry Where to buy Suppliers range | Leukadherin-1, also known as LA1, is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1. Leukadherin-1 suppresses human innate inflammatory signalling. leukadherin-1 increases CD11b/CD18-dependent adhesion via membrane tethers. It also competitively inhibits YopH (Ki = 1.94 μM), a tyrosine phosphorylase secreted by Y. pestis into immune cells to block signal transduction, and anthrax lethal factor metalloproteinase, a component of anthrax toxin (IC50 = 6 μM). Synonyms: 4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid; Leukadherin-1; Leukadherin 1; Leukadherin1; LA1. CAS No. 344897-95-6. Molecular formula: C22H15NO4S2. Mole weight: 421.48. | |
L-Threitol Quick inquiry Where to buy Suppliers range | L-Threitol is a useful synthetic intermediate. It was used to synthesize novel aza-sugar-based metalloproteinase MMP/ADAM inhibitors. It is also a diastereomer of Erythritol which is a food additive. Synonyms: 1,3,5-orthoformate-myo-inositol; meso-D-myo-inositol-1,3,5-O-orthoformate; L-1,2,3,4-Butanetetrol; myo-inositol 1,3,5-monoorthoformate; (2s,3s)-butane-1,2,3,4-tetraol. Grades: ≥ 95%. CAS No. 2319-57-5. Molecular formula: C4H10O4. Mole weight: 122.12. | |
Matrilysin (96-107) Quick inquiry Where to buy Suppliers range | Matrilysin (MAT) is a member of the matrix metalloproteinase (MMP) family which is believed to degrade components of the extracellular matrix (ECM) during processes of tissue remodeling. Synonyms: MMP7 (96-107). | |
MMP-13 Inhibitor Quick inquiry Where to buy Suppliers range | MMP-13 Inhibitor is a potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 value of 8 nM. Synonyms: Collagenase-3 Inhibitor; Matrix Metalloproteinase-13 Inhibitor; 4,6-Pyrimidinedicarboxamide; N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide. Grades: ≥98%. CAS No. 544678-85-5. Molecular formula: C22H20F2N4O2. Mole weight: 410.4. | |
MMP-2 Inhibitor I Quick inquiry Where to buy Suppliers range | MMP-2 Inhibitor I is a reversible inhibitor of matrix metalloproteinase 2 (MMP-2) with Ki value of 1.6 μM. It attenuates cancer cell migration via inhibition of MMP-2. Synonyms: ?Matrix Metalloproteinase-2 Inhibitor I; cis-9-Octadecenoyl-N-hydroxylamide; Oleylhydroxamate; N-Hydroxyoleamide; OA-Hy; Oleoyl-N-hydroxylamide. Grades: ≥98%. CAS No. 10335-69-0. Molecular formula: C18H35NO2. Mole weight: 297.5. | |
MMP-2 Inhibitor II Quick inquiry Where to buy Suppliers range | MMP-2 Inhibitor II is an irreversible inhibitor of matrix metalloproteinase-2 (MMP-2) with Ki value of 2.4 μM. It also less potently inhibits MMP-1 and MMP-7. Synonyms: ?Matrix Metalloproteinase-2 Inhibitor II; (4- (4- (Methanesulfonamido) phenoxy) phenylsulfonyl) methyloxirane. Grades: ≥98%. CAS No. 869577-51-5. Molecular formula: C16H17NO6S2. Mole weight: 383.4. | |
MMP-2/MMP-7 Substrate, Fluorogenic Quick inquiry Where to buy Suppliers range | Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 1MG. Mole weight: 1093.15. Catalog: IAR42415980. Assay: ≥95% (HPLC). | |
MMP-2/MMP-9 Inhibitor I Quick inquiry Where to buy Suppliers range | MMP-2/MMP-9 inhibitor I is a potent inhibitor of matrix metalloproteinase MMP-2/MMP-9 with IC50 values of 310 and 240 nM, respectively. It blocks MMP-2/MMP-9-dependent invasion, tumor growth, and metastasis in both cell culture and mouse tumor models. Synonyms: Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor I; 3-phenyl-2-[(4-phenylphenyl)sulfonylamino]propanoic acid. Grades: ≥99%. CAS No. 193807-58-8. Molecular formula: C21H19NO4S. Mole weight: 381.4. | |
MMP-2/MMP-9 Inhibitor II Quick inquiry Where to buy Suppliers range | MMP-2/MMP-9 inhibitor II is a potent inhibitor of matrix metalloproteinase MMP-2/MMP-9 with IC50 values of 17 and 30 nM, respectively. It was shown to suppress lung colonization of Lewis lung carcinoma cells and inhibit tumor-induced angiogenesis, tumor growth, and liver metastasis in mouse models. Synonyms: Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor II; (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide. Grades: ≥98%. CAS No. 193807-60-2. Molecular formula: C21H20N2O4S. Mole weight: 396.46. | |
MMP-2/MMP-9 Inhibitor III trifluoroacetate salt Quick inquiry Where to buy Suppliers range | MMP-2/MMP-9 inhibitor III is a cyclic peptide inhibitor of matrix metalloproteinase MMP-2/MMP-9 with IC50 values of 10-20 μM for both. Synonyms: Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III. Grades: ≥95%. Molecular formula: C52H71N13O14S2·xCF3COOH. Mole weight: 1166.33. | |
MMP-3 Inhibitor Quick inquiry Where to buy Suppliers range | MMP-3 inhibitor is a peptide inhibitor of matrix metalloproteinase-3 (MMP-3) with Ki value of 95 nM. Synonyms: Matrix Metalloproteinase-3 Inhibitor; N-acetyl-L-arginyl-L-cysteinyl-glycyl-L-valyl-L-prolyl-L-isoasparagine. Grades: ≥95%. CAS No. 158841-76-0. Molecular formula: C27H46N10O9S. Mole weight: 686.78. | |
MMP-3 Inhibitor VIII Quick inquiry Where to buy Suppliers range | MMP-3 inhibitor VIII is a cell-permeable inhibitor of matrix metalloproteinase-3 (MMP-3) with Ki value of 23 nM. It also inhibits mouse macrophage metalloelastase MME/MMP-12. Synonyms: Matrix Metalloproteinase-3 Inhibitor VIII; Stromelysin-1 Inhibitor VIII; N-Hydroxy-2(R)-{[(4-methoxyphenyl)sulfonyl]-[benzylamino]}-4-methylpentanamide. Grades: ≥95%. CAS No. 208663-26-7. Molecular formula: C20H26N2O5S. Mole weight: 406.5. | |
MMP-8 Inhibitor I Quick inquiry Where to buy Suppliers range | MMP-8 Inhibitor I is a selective and cell-permeable inhibitor of matrix metalloproteinase-8 (MMP-8) with IC50 value of 4 nM. MMP-8 is a neutrophil collagenase that cleaves interstitial collagens. MMP-8 is associated with diseases including arthritis, cancer, osteoporosis and arteriosclerosis. Synonyms: Matrix Metalloproteinase-8 Inhibitor I; N-hydroxy-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxamide. Grades: ≥95%. CAS No. 236403-25-1. Molecular formula: C17H18N2O5S. Mole weight: 362.4. | |
MMP-9 Inhibitor I Quick inquiry Where to buy Suppliers range | MMP-9 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinase-9 (MMP-9) with IC50 value of 5 nM, respectively. Synonyms: Matrix Metalloproteinase-9 Inhibitor I; 2-[Benzyl(4-methoxyphenylsulfonyl)amino]-3-methyl-5-(diethylaminomethyl)benzohydroximic acid. Grades: ≥95%. CAS No. 1177749-58-4. Molecular formula: C27H33N3O5S. Mole weight: 511.6. | |
MMP-9/MMP-13 Inhibitor I Quick inquiry Where to buy Suppliers range | MMP-9/MMP-13 inhibitor I is a selective and cell-permeable inhibitor of matrix metalloproteinases MMP-9/MMP-13 with IC50 values of 0.9 nM for both. It also less potently inhibits MMP-1, MMP-3, and MMP-7. Synonyms: Matrix Metalloproteinase-9/Matrix Metalloproteinase-13 Inhibitor I; N-Hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide. Grades: ≥98%. CAS No. 204140-01-2. Molecular formula: C25H25N3O6S. Mole weight: 495.6. | |
MMP Inhibitor II Quick inquiry Where to buy Suppliers range | MMP Inhibitor II is an inhibitor of matrix metalloproteinase MMP-1/MMP-3/MMP-7/MMP-9 with IC50 values of 24, 18.4, 30 and 2.7 nM, respectively. Synonyms: Matrix Metalloproteinase Inhibitor II; NHDDPC; PG 117025; PGE 4410186; N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-1,3-diazinane-2-carboxamide. Grades: ≥95%. CAS No. 203915-59-7. Molecular formula: C21H27N3O8S2. Mole weight: 513.6. | |
MMP Inhibitor I trifluoroacetate salt Quick inquiry Where to buy Suppliers range | MMP inhibitor I is an inhibitor of matrix metalloproteinase MMP-1/MMP-2/MMP-3 with IC50 values of 1.3, 30, and 150 μM, respectively. Synonyms: FN 439; Matrix Metalloproteinase Inhibitor I. Grades: ≥95%. Molecular formula: C23H35N6O6·xCF3COOH. Mole weight: 491.56. | |
Naphthofluorescein Quick inquiry Where to buy Suppliers range | Naphthofluorescein is a furin inhibitor that inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP), resulting in decreased levels of active MT1-MMP. Naphthofluorescein is a red-emitting fluorescent probe for hydrogen peroxide in living cells. Synonyms: CCG 8295. Grades: ≥98%. CAS No. 61419-02-1. Molecular formula: C28H16O5. Mole weight: 432.4. | |
ND-336 Quick inquiry Where to buy Suppliers range | ND-336 is a selective inhibitor of the gelatinases matrix metalloproteinase MMP-2, MMP-9, and MMP-14 (Ki = 85, 150, and 120 nM, respectively). It has the potential to treat diabetes that accelerates healing of diabetic wounds. Synonyms: 4-[4-[(2-thiiranylmethyl)sulfonyl]phenoxy]-benzenemethanamine hydrochloride. Grades: ≥95%. CAS No. 1807453-83-3. Molecular formula: C16H17NO3S2·HCl. Mole weight: 371.9. | |
NF-κB Activation Inhibitor III Quick inquiry Where to buy Suppliers range | NF-κB activation inhibitor III inhibits TNF-α-induced MMP-9 protein expression via blocking NF-κB activity. It has been used to suppress invasion and metastasis of tumor cells. Uses: Matrix metalloproteinase inhibitors. Synonyms: SM-7368; SM 7368; SM7368; 3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide. Grades: ≥99%. CAS No. 380623-76-7. Molecular formula: C10H5ClN4O5S. Mole weight: 328.7. | |
NNGH Quick inquiry Where to buy Suppliers range | NNGH is a cell-permeable inhibitor of matrix metalloproteinases (MMPs). It has been used to study the role of MMP-3 (stromelysin 1) in biological systems. Synonyms: N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid; ??Matrix Metalloproteinase-3 Inhibitor II; MMP-3 Inhibitor II; N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]acetamide. Grades: ≥99%. CAS No. 161314-17-6. Molecular formula: C13H20N2O5S. Mole weight: 316.4. | |
ONO 4817 Quick inquiry Where to buy Suppliers range | ONO 4817 is a broad spectrum matrix metalloproteinase (MMPs) inhibitor. It shows antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma. Synonyms: ONO 4817; ONO4817; ONO-4817; N-[(1S,3S)-1-[(Ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide. Grades: ≥99% by HPLC. CAS No. 223472-31-9. Molecular formula: C22H28N2O6. Mole weight: 416.47. | |
PD 166793 Quick inquiry Where to buy Suppliers range | PD 166793 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 6.1, 0.047, 0.012, 7.2, 7.9, 0.008, and 0.24 μM for MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13CD, and MMP-14CD, respectively). It displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. In vivo, PD 166793 (2 mg/kg per day, p.o.) reduces left ventricular (LV) peak wall stress in a porcine model of congestive heart failure. Synonyms: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine; PD-166793; PD 166793; PD166793; PD-166793-0000. Grades: ≥99% by HPLC. CAS No. 199850-67-4. Molecular formula: C17H18BrNO4S. Mole weight: 412.3. | |
Prinomastat Quick inquiry Where to buy Suppliers range | Prinomastat is a synthetic hydroxamic acid derivative with potential antineoplastic activity. Prinomastat inhibits matrix metalloproteinases (MMPs) (specifically, MMP-2, 9, 13, and 14), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. As a lipophilic agent, prinomastat crosses the blood-brain barrier. Uses: Matrix metalloproteinase inhibitors. Synonyms: AG3340; AG-3340; AG 3340; KBR-9896; KBR 9896; KBR9896. CAS No. 192329-42-3. Molecular formula: C18H21N3O5S2. Mole weight: 423.50. | |
(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic Acid Methyl Ester Quick inquiry Where to buy Suppliers range | (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic Acid Methyl Ester is a dioxolane derivative used in the preparation of matrix metalloproteinases (MMP) inhibitors. Group: Biochemicals. Alternative Names: (4R)-Methyl 2,2-DFimethyl-1,3-dioxolane-4-carboxylate; (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic Acid Methyl Ester; (R)-2,2-Dimethyl-4-methoxycarbonyl-1,3-dioxolane; 2,2-Dimethyl-(4R)-1,3-dioxolane-4-carboxylic Acid Methyl Ester; 2,3-O-Isopropylidene-D-glyceric Acid Methyl Ester; Methyl (4R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylate; Methyl (R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylate; Methyl (R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylate; Methyl (R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylate. Grades: Highly Purified. CAS No. 52373-72-5. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
Rebimastat Quick inquiry Where to buy Suppliers range | Rebimastat is a sulfhydryl-based second-generation matrix metalloproteinase (MMP) inhibitor with potential antineoplastic activity. Rebimastat selectively inhibits several MMPs (MMP 1, 2, 8, 9, and 14), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. Synonyms: BMS-275291; BMS 275291; BMS275291; N-((2S)-2-Mercapto-1-oxo-4-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3-dimethyl-L-valinamide. CAS No. 259188-38-0. Molecular formula: C23H41N5O5S. Mole weight: 499.67. |