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2- (2- ( (t-Butyldimethylsilyl) methoxy) ethyl) -5- (2- ( (tert-butyldimethylsilyl) oxy) ethyl) pyrazine is an intermediate in synthesizing 3-Methyl-2,5-bis-(2-hydroxyethyl)pyrazine (M295340), which is a degradation product of Clavulanic Acid (C563750), a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C20H40N2O2Si2. US Biological Life Sciences.
2- (2- ( (t-Butyldimethylsilyl) methoxy) ethyl) -5- (2- ( (tert-butyldimethylsilyl) oxy) ethyl) pyrazine N-Oxide is an intermediate in synthesizing 3-Methyl-2,5-bis-(2-hydroxyethyl)pyrazine (M295340), which is a degradation product of Clavulanic Acid (C563750), a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H42N2O3Si2. US Biological Life Sciences.
Used in the preparation of spirocyclic compounds for the treatment of bacterial infections. Group: Biochemicals. Grades: Highly Purified. CAS No. 1211533-01-5. Pack Sizes: 1g. US Biological Life Sciences.
6-ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide. Uses: Designed for use in research and industrial production. Product Category: Pyrazines. Appearance: White Powder. CAS No. 1254053-43-4. Molecular formula: C29H44N8O3. Mole weight: 552.7. Purity: 0.95. Product ID: ACM1254053434. Alfa Chemistry ISO 9001:2015 Certified. Categories: Gilteritinib.
Pyrazine,2-methoxy-5-methyl-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-methoxy-5-methylpyrazine;Pyrazine, 2-methoxy-5-methyl-;METHOXY-3-METHYLPYRAZINE. Product Category: Heterocyclic Organic Compound. CAS No. 2882-22-6. Molecular formula: C6H8N2O. Mole weight: 124.14052. Product ID: ACM2882226. Alfa Chemistry ISO 9001:2015 Certified.
Pyrazine, 3-methoxy-2-methyl-5-(1-methylethyl)- (9CI). Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pyrazine, 3-methoxy-2-methyl-5-(1-methylethyl)- (9CI). Product Category: Heterocyclic Organic Compound. CAS No. 245757-84-0. Molecular formula: C9H14N2O. Mole weight: 166.22026. Product ID: ACM245757840. Alfa Chemistry ISO 9001:2015 Certified. Categories: 5-isopropyl-3-methoxy-2-methylpyrazine.
2-sec-Butyl-3-methoxypyrazine
A compound contents in musts and wines from Vitis vinifera variety Cabernet Sauvignon. Group: Biochemicals. Alternative Names: 2-Methoxy-3-(1-methylpropyl)pyrazine; 2-Methoxy-3-sec-butylpyrazine; 3-sec-Butyl-2-methoxypyrazine. Grades: Highly Purified. CAS No. 24168-70-5. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Bevenopran
Bevenopran is a peripherally selective μ- and δ-opioid receptor antagonist. It is used for the treatment of chronic opioid-induced constipation. It was developed by Cubist Pharmaceuticals and was in clinical phase 3 trial, but now it is terminated. Uses: Bevenopran is used for the treatment of chronic opioid-induced constipation. Synonyms: 5- (2-Methoxy-4- ( ( (2- (tetrahydro-2H-pyran-4-yl) ethyl) amino) methyl) phenoxy) pyrazine-2-carboxamide; CB-5945, CB5945, CB 5945, ADL-5945, ADL5945, ADL 5945, MK2402, MK 2402, MK-2402,OpRA III; Bevenopran. Grades: 98%. CAS No. 676500-67-7. Molecular formula: C20H26N4O4. Mole weight: 386.45.
CCT244747
CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies. Synonyms: CCT-244747; CCT 244747; 3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile; 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile; (R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile. Grades: ≥98%. CAS No. 1404095-34-6. Molecular formula: C20H24N8O2. Mole weight: 408.46.
Evixapodlin
Evixapodlin is a human programmed cell death ligand 1 (PD-1/PD-L1) protein/protein interaction inhibitor with an IC50 of 0.213 nM. It has anticancer and antiviral functions. Synonyms: (12S,122S)-62,72-dichloro-53,86-dimethoxy-3,10-diaza-5,8(2,5)-dipyrazina-1,12(2)-dipyrrolidina-6,7(1,3)-dibenzenadodecaphane-15,125-dione; (5S, 5'S)-5, 5'- ( ( ( (5, 5'- (2, 2'-dichloro-[1, 1'-biphenyl]-3, 3'-diyl)bis (3-methoxypyrazine-5, 2-diyl))bis (methylene))bis (azanediyl))bis (methylene))bis (pyrrolidin-2-one); 2-Pyrrolidinone, 5, 5'-[ (2, 2'-dichloro[1, 1'-biphenyl]-3, 3'-diyl) bis[ (3-methoxy-5, 2-pyrazinediyl) methyleneiminomethylene]]bis-, (5S,5'S)-; PD-1/PD-L1-IN 7. Grades: ≥98%. CAS No. 2374856-75-2. Molecular formula: C34H36Cl2N8O4. Mole weight: 691.61.
An derivative of Pyrazine.Pyrazine is a heterocyclic aromatic organic compound. Synonyms: Dimethyl 3,3'-(pyrazine-2,5-diyl)dipropanoate; 77479-01-7; methyl 3-[5-(3-methoxy-3-oxopropyl)pyrazin-2-yl]propanoate; Methyl-3-[5-(2-methoxycarbonylethyl)pyrazin-2-yl]propionate; DTXSID10345691; CAVDNRICPLKYEH-UHFFFAOYSA-N; AKOS015999873; Propanoic acid, 3-[5-(3-methoxy-3-oxopropyl)-2-pyrazinyl]-, methyl ester; AM806624; 2,5-Pyrazinedipropanoic Acid Dimethyl Ester; CS-0455630; Dimethyl3,3'-(pyrazine-2,5-diyl)dipropanoate; Dimethyl 3,3'-(pyrazine-2,5-diyl)dipropionate; A865224. Grades: > 95%. CAS No. 77479-01-7. Molecular formula: C12H16N2O4. Mole weight: 252.27.
Spirotryprostatin B
It is a mammalian cell cycle inhibitor produced by the strain of Aspergillus fumigatus. 12.5 μg/mL of Spirotryprostatin B can inhibit the G2/M phase of the cell cycle in tsFT210 cells. Synonyms: (3S,3'S,5'aS)-6-Methoxy-3'-(2-methylprop-1-enyl)spiro[1H-indole-3,2'-5a,6,7,8-tetrahydro-3H-dipyrrolo[1,2-c:1',3'-f]pyrazine]-2,5',10'-trione; Spiro[5H,10H-dipyrrolo[1,2-a:1',2'-d]pyrazine-2(3H), 3'-[3H]indole]-2',5,10(1'H)-trione, 5a,6,7,8-tetrahydro-3-(2-methyl-1-propen-1-yl)-, (2S,3S,5aS)-. CAS No. 182234-26-0. Molecular formula: C21H21N3O3. Mole weight: 363.41.
(2,3-Dichlorophenyl)[(6S)-5,6-dihydro-3-(4-methoxy-2-pyridinyl)-6-methyl-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]methanone was used in preparation of P2X7 antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1799971-15-5. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C19H17Cl2N5O2, Molecular Weight: 418.28. US Biological Life Sciences.
6-Methoxy-3-(methoxymethyl)-5-methylpyrazin-2-amine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pyrazinamine, 6-methoxy-3-(methoxymethyl)-5-methyl- (9CI);6-METHOXY-3-(METHOXYMETHYL)-5-METHYLPYRAZIN-2-AMINE. Product Category: Heterocyclic Organic Compound. CAS No. 91678-86-3. Molecular formula: C8H13N3O2. Mole weight: 183.21. Density: 1.162 g/cm³. Product ID: ACM91678863. Alfa Chemistry ISO 9001:2015 Certified.
Fumitremorgin B
Fumitremorgin B is a natural compound isolated from the fermentation broth of Aspergillus fumigatus LN-4. Fumitremorgin B is a tremorgenic mycotoxin that is active against the phytopathogenic fungi. It has antifeedant activity against armyworm (M. separata) larvae when applied to fresh wheat leaves. Synonyms: Lanosulin; 5H, 14H-Pyrrolo(1'', 2'':4', 5')pyrazino(1', 2':1, 6)pyrido(3, 4-b)indole-5, 14-dione, 1,2,3,5a,6,11,12,14a-octahydro-5a,6-dihydroxy-9-methoxy-11-(3-methyl-2-butenyl)-12-(2-methyl-1-propenyl)-, (5aR-(5a-alpha,6-alpha,12-beta,14a-alpha))-. Grades: 98.5%. CAS No. 12626-17-4. Molecular formula: C27H33N3O5. Mole weight: 479.57.
Fumitremorgin C
Fumitremorgin C, isolated from Aspergillus fumigatus, is a potent and specific inhibitor of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter. It reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro. Synonyms: tryproquivaline D (2'S-(2'alpha,9'alpha(4R*(S*)),9'abeta))-isomer; tryproquivaline L (9'R-(9'alpha(R*),9'abeta))-isomer; tryproquivaline M (2'S-(2'alpha,9'alpha(4R*(S*)),9'abeta))-isomer; tryproquivaline N (2'S-(2'alpha,9'alpha(R*),9'abeta))-isomer; tryptoquivaline; (5aS, 12S, 14aS)-1, 2, 3, 5a, 6, 11, 12, 14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H, 14H-pyrrolo[1'', 2'':4', 5']pyrazino[1', 2':1, 6]pyrido[3, 4-b]indole-5, 14-dione. Grades: ≥95%. CAS No. 118974-02-0. Molecular formula: C22H25N3O3. Mole weight: 379.45.
NGD 98-2 hydrochloride
NGD 98-2 hydrochloride is a corticotropin-releasing factor receptor 1 antagonist. Synonyms: N-(1-Ethylpropyl)-3-methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-2-pyrazinamine hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C19H24F3N3O3.HCl. Mole weight: 435.87.
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