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Z-O-tert-butyl-D-serinemethyl ester. Group: Biochemicals. Alternative Names: Z-D-Ser(tBu)-OMe. Grades: Highly Purified. CAS No. 93204-37-6. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences.
Worldwide
Z-O-tert-butyl-D-serinemethyl ester ≥97% (HPLC)
Z-O-tert-butyl-D-serinemethyl ester ≥97% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g. US Biological Life Sciences.
Worldwide
Boc-Gln-Arg-Arg-AMC
Boc-QRR-AMC is a substrate for the transmembrane serine protease hepsin, also is used for assaying kexin. Synonyms: Boc-Gln-Arg-Arg-Mca; tert-butyl (S)-5-amino-1-((S)-5-guanidino-1-((S)-5-guanidino-1-(4-methyl-2-oxo-2H-chromen-7-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1,5-dioxopentan-2-ylcarbamate; Boc-QRR-AMC. Grades: 95%. CAS No. 109376-05-8. Molecular formula: C32H49N11O8. Mole weight: 715.81.
Bortezomib USP Impurity G is an isomer of Bortezomib. It has been demonstrated to inhibit serine proteases shown to lower cellular Aβ concentrations, associated with Alzheimer's or hypertension. Synonyms: (1S,2S)-Bortezomib; ( (S) -3-Methyl-1- ( (S) -3-phenyl-2- (pyrazine-2-carboxamido) propanamido) butyl) boronic acid. Grades: 95%. CAS No. 1132709-14-8. Molecular formula: C19H25BN4O4. Mole weight: 384.243.
Cbz-L-tert-Leucine
Leucine derivative used in the preparation of various pharmaceutical agents such as TRPV4 antagonists, HIV-1 protease inhibitors and serine protease inhibitors. Group: Biochemicals. Alternative Names: 3-Methyl-N-[ (phenylmethoxy) carbonyl]-L-valine; N-Carbobenzoxy-(S)-tert-leucine; 2S-Benzyloxycarbonylamino-3,3-dimethylbutyric Acid; Z-L-tert-Leucine; Benzyloxycarbonyl-L-tert-leucine; N-(Benzyloxycarbonyl)-L-tert-butylglycine; N-Benzyloxycarbonyl-L-tert-leucine; N-Benzyloxycarbonyl-tert-leucine. Grades: Highly Purified. CAS No. 62965-10-0. Pack Sizes: 2.5g. US Biological Life Sciences.
Worldwide
Fmoc-O-tert-butyl-L>-serine N-carboxy anh ydride
Heterocyclic Organic Compound. Alternative Names: FMOC-O-TERT-BUTYL-L-SERINE N-CARBOXY ANH YDRIDE;Fmoc-Ser(tBu)-NCA;(S)-(9H-fluoren-9-yl)methyl 4-(tert-butoxymethyl)-2,5-dioxooxazolidine-3-carboxylate. CAS No. 129288-44-4. Molecular formula: C23H23NO6. Mole weight: 409.436. Catalog: ACM129288444.
Isotocin
Isotocin is a peptide hormone particularly used in the research of psychiatric afflictions, drug addiction and post-traumatic stress disorder. Synonyms: (Ser4,Ile8)-Oxytocin; H-Cys-Tyr-Ile-Ser-Asn-Cys-Pro-Ile-Gly-NH2 (Disulfide bridge: Cys1-Cys6); L-cysteinyl-L-tyrosyl-L-isoleucyl-L-seryl-L-asparagyl-L-cysteinyl-L-prolyl-L-isoleucyl-glycinamide (1->6)-disulfide; [4-Serine,8-Isoleucine]Oxytocin; 4-L-serine-8-L-isoleucineoxytocin; (2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxo-ethyl)-10-(hydroxymethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-sec-butyl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(1S,2S)-1-[(2-amino-2-oxo-ethyl)carbamoyl]-2-methyl-butyl]pyrrolidine-2-carboxamide. Grades: ≥95%. CAS No. 550-21-0. Molecular formula: C41H63N11O12S2. Mole weight: 966.14.
ML-211 is a dual inhibitor of LYPLA1 and the related LYPLA2 with IC50 of 17 and 30 nm. ML-211 could inhibit the serine hydrolase ABHD11 with IC50 of 10 nM but was over 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases. Synonyms: Methanone, [4-(1,1-dimethylethyl)-1-piperidinyl][4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-; [4-(1,1-Dimethylethyl)-1-piperidinyl][4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]methanone; {4-[Hydroxy(diphenyl)methyl]-2H-1,2,3-triazol-2-yl}[4-(2-methyl-2-propanyl)-1-piperidinyl]methanone; (4-(tert-butyl)piperidin-1-yl)(4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)methanone. Grades: >98%. CAS No. 2205032-89-7. Molecular formula: C25H30N4O2. Mole weight: 418.53.
Telaprevir is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC50] = 354 nM) and in human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280 nM). Telaprevir forms a covalent but reversible complex with the genotype 1a HCV NS3-4A protease in a slow-on, slow-off process with a steady-state inhibition constant (K(I)*) of 7 nM. Dissociation of the covalent enzyme-inhibitor complex of Telaprevir and genotype 1a HCV protease has a half-life of almost an hour. A >4-log10 reduction in the HCV RNA levels was observed after a 2-week incubation of replicon cells with Telaprevir, with no rebound of viral RNA observed after withdrawal of the inhibitor. In several animal species, Telaprevir exhibits a favorable pharmacokinetic profile with high exposure in the liver. In a recently developed HCV protease mouse model, Telaprevir showed excellent inhibition of HCV NS3-4A protease activity in the liver. Uses: Oligopeptides. Synonyms: Telavic; VRT 111950; VX 950; Incivek; Incivo; LY 570310; MP 424; S-Telaprevir; (1S, 3aR, 6aS) - (2S) -2-Cyclohexyl-N- (2-pyrazinylcarbonyl) glycyl-3-methyl-L-valyl-N- [ (1S) -1- [2- (cyclopropylamino) -2-oxoacetyl]butyl]octahydrocyclopenta [c]pyrrole-1-carboxamide. Grades: ≥98% (HPLC). CAS No. 402957-28-2. Molecular formula: C36H53N7O6. Mole weight: 679.85.
Fmoc-Ser(tBu)-Ser[Psi(Me,Me)Pro]-OH is used as a reactant in the synthesis of peptides and proteins. Synonyms: Fmoc-Ser(tBu)-Ser[Ψ(Me,Me)Pro]-OH; (S)-3-[Nα-(9-Fluorenylmethyloxycarbonyl)-O-tert-butyl-L-serinyl]-2,2-dimethyloxazolidine-4-carboxylic acid; Fmoc-Ser(Tbu)-Ser(Psime,Mepro)-OH; (4S)-3-[(2S)-3-(tert-butoxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoyl]-2,2-dimethyl-1,3-oxazolidine-4-carboxylic acid; Fmoc-L-Ser(tBu)-L-Ser(Psi(Me,Me)pro)-OH; (S)-3-((S)-2-(((E)-((9H-fluoren-9-yl)methoxy)(hydroxy)methylene)amino)-3-(tert-butoxy)propanoyl)-2,2-dimethyloxazolidine-4-carboxylic acid. Grades: ≥ 98.5% (HPLC). CAS No. 1000164-43-1. Molecular formula: C28H34N2O7. Mole weight: 510.58.